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KEGG   PATHWAY: hsa00561
Entry
hsa00561                    Pathway                                
Name
Glycerolipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
Pathway map
hsa00561  Glycerolipid metabolism
hsa00561

Module
hsa_M00089  Triacylglycerol biosynthesis [PATH:hsa00561]
hsa_M00098  Acylglycerol degradation [PATH:hsa00561]
Drug
D02047  Dextran sulfate sodium (JAN)
D03343  Dextran sulfate sodium sulfur 5 (JP18)
D03747  Ibrolipim (USAN/INN)
D04028  Orlistat (JAN/USP/INN)
D04268  Elastase ES
D05255  Omega-3-acid ethyl esters (USP)
D09208  Cetilistat (JAN/USAN/INN)
D10657  Pradigastat sodium (USAN)
D10664  Pradigastat (USAN)
D12390  Caficrestat (USAN/INN)
Other DBs
GO: 0046486
Organism
Homo sapiens (human) [GN:hsa]
Gene
132158  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
231  AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]
57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
441282  AKR1B15; aldo-keto reductase family 1 member B15 [KO:K00011] [EC:1.1.1.21]
10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
26007  TKFC; triokinase and FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
2712  GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
2710  GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
2713  GK3; glycerol kinase 3 [KO:K00864] [EC:2.7.1.30]
57678  GPAM; glycerol-3-phosphate acyltransferase, mitochondrial [KO:K00629] [EC:2.3.1.15]
150763  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
128966744  glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
137964  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
84803  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
10554  AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 [KO:K13509] [EC:2.3.1.51]
10555  AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase 2 [KO:K13509] [EC:2.3.1.51]
56894  AGPAT3; 1-acylglycerol-3-phosphate O-acyltransferase 3 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
56895  AGPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 4 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
55326  AGPAT5; 1-acylglycerol-3-phosphate O-acyltransferase 5 [KO:K19007] [EC:2.3.1.51]
253558  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
154141  MBOAT1; membrane bound O-acyltransferase domain containing 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129642  MBOAT2; membrane bound O-acyltransferase domain containing 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
23175  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
64900  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
9663  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
84513  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
196051  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
8525  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
8527  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
9162  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
1606  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
8526  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
1607  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
160851  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
1608  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
1609  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
139189  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
8694  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
84649  DGAT2; diacylglycerol O-acyltransferase 2 [KO:K11160] [EC:2.3.1.20 2.3.1.75]
346606  MOGAT3; monoacylglycerol O-acyltransferase 3 [KO:K14456] [EC:2.3.1.20 2.3.1.22]
1056  CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
57104  PNPLA2; patatin like phospholipase domain containing 2 [KO:K16816] [EC:3.1.1.3]
80339  PNPLA3; patatin like phospholipase domain containing 3 [KO:K13534] [EC:3.1.1.3 2.3.1.-]
5406  PNLIP; pancreatic lipase [KO:K14073] [EC:3.1.1.3]
5407  PNLIPRP1; pancreatic lipase related protein 1 [KO:K14074] [EC:3.1.1.3]
5408  PNLIPRP2; pancreatic lipase related protein 2 (gene/pseudogene) [KO:K14075] [EC:3.1.1.3]
119548  PNLIPRP3; pancreatic lipase related protein 3 [KO:K14076] [EC:3.1.1.3]
3990  LIPC; lipase C, hepatic type [KO:K22283] [EC:3.1.1.3]
8513  LIPF; lipase F, gastric type [KO:K14452] [EC:3.1.1.3]
9388  LIPG; lipase G, endothelial type [KO:K22284] [EC:3.1.1.3]
4023  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
55750  AGK; acylglycerol kinase [KO:K09881] [EC:2.7.1.94]
11343  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
7920  ABHD16A; abhydrolase domain containing 16A, phospholipase [KO:K25824] [EC:3.1.1.23 3.1.-.-]
116255  MOGAT1; monoacylglycerol O-acyltransferase 1 [KO:K14458] [EC:2.3.1.22]
80168  MOGAT2; monoacylglycerol O-acyltransferase 2 [KO:K14457] [EC:2.3.1.22]
2717  GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
Compound
C00029  UDP-glucose
C00040  Acyl-CoA
C00093  sn-Glycerol 3-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00116  Glycerol
C00162  Fatty acid
C00173  Acyl-[acyl-carrier protein]
C00184  Glycerone
C00197  3-Phospho-D-glycerate
C00258  D-Glycerate
C00416  Phosphatidate
C00422  Triacylglycerol
C00577  D-Glyceraldehyde
C00631  2-Phospho-D-glycerate
C00641  1,2-Diacyl-sn-glycerol
C00681  1-Acyl-sn-glycerol 3-phosphate
C00969  3-Hydroxypropanal
C01885  1-Acylglycerol
C02133  Acyl phosphate
C02457  Propane-1,3-diol
C03692  1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
C04046  3-D-Glucosyl-1,2-diacylglycerol
C04315  2-Acyl-3-O-(beta-D-galactosyl)-sn-glycerol
C04872  1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
C05401  3-beta-D-Galactosyl-sn-glycerol
C06037  Digalactosyl-diacylglycerol
C06038  Acyl1-monogalactosyl-diacylglycerol
C06040  Diglucosyldiacylglycerol
C06041  Glycerophosphoglycoglycerolipid
C06042  Lipoteichoic acid
C06364  1,2-Diacyl-3-alpha-D-glucosyl-sn-glycerol
C06365  alpha-Kojibiosyldiacylglycerol
C11521  UDP-6-sulfoquinovose
C13508  Sulfoquinovosyldiacylglycerol
C20897  Glycerophosphoglycoglycerolipid
C20898  Lipoteichoic acid
C20991  1,2-Diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol
Reference
PMID:8662716
  Authors
Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L.
  Title
Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
  Journal
J Biol Chem 271:13875-81 (1996)
DOI:10.1074/jbc.271.23.13875
Reference
PMID:8995384
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A.
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
DOI:10.1074/jbc.272.2.929
Reference
PMID:11294844
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A.
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
DOI:10.1074/jbc.M102576200
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00071  Fatty acid degradation
hsa00564  Glycerophospholipid metabolism
KO pathway
ko00561   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (65)   
   KEGG GENES (65)   
All databases (66)   

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