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About: Norgestimate

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. The medication is available in combination with an estrogen and is not available alone. It is taken by mouth.

Property Value
dbo:abstract
  • Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. The medication is available in combination with an estrogen and is not available alone. It is taken by mouth. Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others. Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has very weak androgenic activity and no other important hormonal activity. The medication is a prodrug of norelgestromin and to a lesser extent of levonorgestrel in the body. Norgestimate was patented in 1965 and introduced for medical use, specifically in birth control pills, in 1986. It was introduced for use in menopausal hormone therapy in the United States in 1999. Norgestimate is sometimes referred to as a "third-generation" progestin. It is marketed in birth control pills widely throughout the world, whereas it is available for use in menopausal hormone therapy only in the United States and Brazil. Norgestimate is available as a generic medication. In 2020, the version with ethinylestradiol was the 63rd most commonly prescribed medication in the United States, with more than 10 million prescriptions. (en)
  • Il norgestimato è un farmaco progestinico (agonista progestinico di terza generazione) usato nei contraccettivi orali combinati, COCs. (it)
dbo:alternativeName
  • Cilest, Ortho-Cyclen, Prefest, others (en)
dbo:atcCode
  • (only combinations withestrogens)
dbo:casNumber
  • 35189-28-7
dbo:chEBI
  • 50815
dbo:chEMBL
  • 1200934
dbo:class
dbo:drugbank
  • DB00957
dbo:fdaUniiCode
  • C291HFX4DY
dbo:kegg
  • D05209
dbo:medlinePlus
  • a601050
dbo:pubchem
  • 6540478
dbo:thumbnail
dbo:wikiPageExternalLink
dbo:wikiPageID
  • 2444149 (xsd:integer)
dbo:wikiPageLength
  • 34178 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1123033271 (xsd:integer)
dbo:wikiPageWikiLink
dbp:atcPrefix
  • G03 (en)
dbp:atcSuffix
  • AA11 (en)
dbp:bioavailability
  • Unknown (en)
dbp:c
  • 23 (xsd:integer)
dbp:casNumber
  • 35189 (xsd:integer)
dbp:chebi
  • 50815 (xsd:integer)
dbp:chembl
  • 1200934 (xsd:integer)
dbp:chemspiderid
  • 5022837 (xsd:integer)
dbp:class
dbp:drugbank
  • DB00957 (en)
dbp:eliminationHalfLife
  • -115200.0 (dbd:second)
  • -133200.0 (dbd:second)
  • • Norgestimate: very short (en)
dbp:excretion
  • Feces: 37% (en)
  • Urine: 47% (en)
dbp:h
  • 31 (xsd:integer)
dbp:image
  • Norgestimate molecule ball.png (en)
dbp:iupacName
  • [-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate (en)
dbp:iupharLigand
  • 7091 (xsd:integer)
dbp:kegg
  • D05209 (en)
dbp:legalUs
  • Rx-only (en)
dbp:medlineplus
  • a601050 (en)
dbp:meltingHigh
  • 218 (xsd:integer)
dbp:meltingPoint
  • 214 (xsd:integer)
dbp:metabolism
  • Liver, intestines (en)
dbp:metabolites
  • • Levonorgestrel (en)
  • • Levonorgestrel acetate (en)
  • • Norelgestromin (en)
dbp:n
  • 1 (xsd:integer)
dbp:o
  • 3 (xsd:integer)
dbp:pregnancyCategory
  • Use is contraindicated (en)
dbp:proteinBound
  • • Levonorgestrel acetate: ? (en)
  • • Levonorgestrel: 98% (en)
  • • Norelgestromin: 99% (en)
dbp:pubchem
  • 6540478 (xsd:integer)
dbp:routesOfAdministration
dbp:smiles
  • O=CC (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • KIQQMECNKUGGKA-NMYWJIRASA-N (en)
dbp:synonyms
  • NGM; ORF-10131; Levonorgestrel acetate oxime; Levonorgestrel 17β-acetate 3-oxime; 17α-Ethynyl-18-methyl-19-nortestosterone 3-oxime 17β-acetate; 17α-Ethynyl-18-methylestr-4-en-17β-ol-3-one 3-oxime 17β-acetate (en)
dbp:tradename
  • Cilest, Ortho-Cyclen, Prefest, others (en)
dbp:unii
  • C291HFX4DY (en)
dbp:verifiedfields
  • verified (en)
dbp:verifiedrevid
  • 462263110 (xsd:integer)
dbp:watchedfields
  • verified (en)
dbp:width
  • 250 (xsd:integer)
dbp:wikiPageUsesTemplate
dct:subject
gold:hypernym
rdf:type
rdfs:comment
  • Il norgestimato è un farmaco progestinico (agonista progestinico di terza generazione) usato nei contraccettivi orali combinati, COCs. (it)
  • Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. The medication is available in combination with an estrogen and is not available alone. It is taken by mouth. (en)
rdfs:label
  • Norgestimato (it)
  • Norgestimate (en)
rdfs:seeAlso
owl:differentFrom
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is owl:differentFrom of
is foaf:primaryTopic of
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