S-15,535

S-15,535
IUPAC ime
	1-(2,3-dihidro-1,4-benzodioksin-8-il)-4-(2,3-dihidro-1H-inden-2-il)piperazin
Identifikatori
CAS broj	146998-34-7
ATC kod	none
PubChem	CID 132787
IUPHAR/BPS	26
ChEMBL	CHEMBL49247
Hemijski podaci
Formula	C21H24N2O2
Molarna masa	336,427 g/mol
	SMILES C1CN(CCN1C2CC3=CC=CC=C3C2)C4=C5C(=CC=C4)OCCO5; ;

S-15535 je fenilpiperazinski lek koji je potentan i visoko selektivan ligand 5-HT_1A receptor. On je agonist i antagonist (slab parcijalni agonist) na presinaptičkim i postsinaptičkim 5-HT_1A receptorima, respektivno.^[1]^[2]^[3]^[4] On ima anksiolitička svojstva.^[4]^[5]

Reference

^ Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL (1993). „S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively”. Eur J Pharmacol. 230 (1): 99—102. PMID 8381359. doi:10.1016/0014-2999(93)90416-F.
^ Millan MJ; Canton H; Gobert A; Lejeune F; Rivet JM; Bervoets K; Brocco M; Widdowson P; Mennini T; Audinot V; et al. (1994). „Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists”. J Pharmacol Exp Ther. 268 (1): 337—352. PMID 8301575.
^ Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A (1997). „S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity”. J Pharmacol Exp Ther. 282 (1): 132—147. PMID 9223549.
^ ^а ^б Lejeune F, Millan MJ (1998). „Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535”. Synapse. 30 (2): 172—180. PMID 9723787. doi:10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9.
^ Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ (2000). „The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents”. Psychopharmacology (Berl). 152 (1): 55—66. PMID 11041316. doi:10.1007/s002130000449.

Vidi još

Fenilpiperazin

Spoljašnje veze

[pmid8381359-1] Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL (1993). „S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively”. Eur J Pharmacol. 230 (1): 99—102. PMID 8381359. doi:10.1016/0014-2999(93)90416-F.

[pmid8301575-2] Millan MJ; Canton H; Gobert A; Lejeune F; Rivet JM; Bervoets K; Brocco M; Widdowson P; Mennini T; Audinot V; et al. (1994). „Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists”. J Pharmacol Exp Ther. 268 (1): 337—352. PMID 8301575.

[pmid9223549-3] Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A (1997). „S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity”. J Pharmacol Exp Ther. 282 (1): 132—147. PMID 9223549.

[pmid9723787-4] а ^б Lejeune F, Millan MJ (1998). „Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535”. Synapse. 30 (2): 172—180. PMID 9723787. doi:10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9.

[pmid11041316-5] Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ (2000). „The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents”. Psychopharmacology (Berl). 152 (1): 55—66. PMID 11041316. doi:10.1007/s002130000449.

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