SB-216,641

SB-216,641
(IUPAC) ime
	N-[3-[3-(dimetilamino)etoksi]-4-metoksifenil]-2'-metil-4'-(5-metil-1,2,4-oksadiazol-3-il)-[1,1'-bifenil]-4-karboksamid
Klinički podaci
Identifikatori
CAS broj	170230-39-4
ATC kod	nije dodeljen
PubChem	3292447
Hemijski podaci
Formula	C28H30N4O4
Mol. masa	486,561 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33) ; Key: JRNUKVFYILMMLX-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-216,641 je lek, koji je selektivni antagonist za serotoninski receptor 5-HT_1B, sa oko 25x većom selektivnošću u odnosu na srodni 5-HT_1D receptor.^[3] On se koristi u naučnim istraživanjima,^[4]^[5]^[6] i pokazano je da ima anksiolitsko dejstvo u životinjskim studijama.^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Price, GW; Burton, MJ; Collin, LJ; Duckworth, M; Gaster, L; Göthert, M; Jones, BJ; Roberts, C i dr.. (1997). „SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors”. Naunyn-Schmiedeberg's archives of pharmacology 356 (3): 312–20. DOI:10.1007/PL00005056. PMID 9303567.
↑ Matsuoka, T; Hasuo, H; Akasu, T (2004). „5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus”. Neuroscience research 48 (3): 229–38. DOI:10.1016/j.neures.2003.11.004. PMID 15154669.
↑ Yan, QS; Zheng, SZ; Yan, SE (2004). „Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis”. Brain Research 1021 (1): 82–91. DOI:10.1016/j.brainres.2004.06.053. PMID 15328035.
↑ Lee, JJ; Hahm, ET; Lee, CH; Cho, YW (2008). „Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons”. Neuropsychopharmacology 33 (2): 340–52. DOI:10.1038/sj.npp.1301396. PMID 17392733.
↑ Tatarczyńska, E; Kłodzińska, A; Stachowicz, K; Chojnacka-Wójcik, E (2004). „Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression”. Behavioural Pharmacology 15 (8): 523–34. DOI:10.1097/00008877-200412000-00001. PMID 15577451.
↑ Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E (2005). „The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action”. The Journal of pharmacy and pharmacology 57 (2): 253–7. DOI:10.1211/0022357055399. PMID 15720791.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Price, GW; Burton, MJ; Collin, LJ; Duckworth, M; Gaster, L; Göthert, M; Jones, BJ; Roberts, C i dr.. (1997). „SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors”. Naunyn-Schmiedeberg's archives of pharmacology 356 (3): 312–20. DOI:10.1007/PL00005056. PMID 9303567.

[4] Matsuoka, T; Hasuo, H; Akasu, T (2004). „5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus”. Neuroscience research 48 (3): 229–38. DOI:10.1016/j.neures.2003.11.004. PMID 15154669.

[5] Yan, QS; Zheng, SZ; Yan, SE (2004). „Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis”. Brain Research 1021 (1): 82–91. DOI:10.1016/j.brainres.2004.06.053. PMID 15328035.

[6] Lee, JJ; Hahm, ET; Lee, CH; Cho, YW (2008). „Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons”. Neuropsychopharmacology 33 (2): 340–52. DOI:10.1038/sj.npp.1301396. PMID 17392733.

[7] Tatarczyńska, E; Kłodzińska, A; Stachowicz, K; Chojnacka-Wójcik, E (2004). „Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression”. Behavioural Pharmacology 15 (8): 523–34. DOI:10.1097/00008877-200412000-00001. PMID 15577451.

[8] Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E (2005). „The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action”. The Journal of pharmacy and pharmacology 57 (2): 253–7. DOI:10.1211/0022357055399. PMID 15720791.

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