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ZW12388A1 - Immunomodulatory azaspiranes - Google Patents

Immunomodulatory azaspiranes

Info

Publication number
ZW12388A1
ZW12388A1 ZW123/88A ZW12388A ZW12388A1 ZW 12388 A1 ZW12388 A1 ZW 12388A1 ZW 123/88 A ZW123/88 A ZW 123/88A ZW 12388 A ZW12388 A ZW 12388A ZW 12388 A1 ZW12388 A1 ZW 12388A1
Authority
ZW
Zimbabwe
Prior art keywords
azaspiranes
immunomodulatory
immunomodulatory azaspiranes
formulae
chem
Prior art date
Application number
ZW123/88A
Other languages
English (en)
Inventor
Mary Badger Alison
John Dimartino Michael
Kevin Mirabelli Christopher
Aaron Schwartz David
Nicholas Cheeseman Elaine
Woodrow Dorman James
Harold Picker Donald
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZW12388A1 publication Critical patent/ZW12388A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZW123/88A 1987-09-28 1988-09-21 Immunomodulatory azaspiranes ZW12388A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes

Publications (1)

Publication Number Publication Date
ZW12388A1 true ZW12388A1 (en) 1989-01-04

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
ZW123/88A ZW12388A1 (en) 1987-09-28 1988-09-21 Immunomodulatory azaspiranes

Country Status (24)

Country Link
US (1) US4963557A (sv)
EP (1) EP0310321B1 (sv)
JP (1) JP2582888B2 (sv)
KR (1) KR0166336B1 (sv)
CN (1) CN1031618C (sv)
AT (1) ATE114463T1 (sv)
AU (1) AU619780B2 (sv)
CA (1) CA1313189C (sv)
CY (1) CY1955A (sv)
DE (1) DE3852266T2 (sv)
DK (1) DK170042B1 (sv)
ES (1) ES2064356T3 (sv)
FI (1) FI93006C (sv)
GR (1) GR3014931T3 (sv)
HK (1) HK1006274A1 (sv)
HU (1) HU208809B (sv)
IE (1) IE67891B1 (sv)
IL (1) IL87908A (sv)
MX (1) MX9203765A (sv)
NO (1) NO173824C (sv)
NZ (1) NZ226354A (sv)
PT (1) PT88603B (sv)
WO (1) WO1989002889A1 (sv)
ZW (1) ZW12388A1 (sv)

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DE69129459T2 (de) * 1990-08-10 1998-10-15 Anormed Inc Immunosuppressive zusammensetzungen
US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
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PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
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US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
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US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
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GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
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GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
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GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
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GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US5939450A (en) * 1995-07-13 1999-08-17 Anormed Inc. N,N-dimethyl-8,8-dipropyl-2-azaspiro 4.5!decane-2-propanamine dimaleate
AU6636996A (en) * 1995-07-13 1997-02-10 Anormed Inc. 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate
SG43383A1 (en) * 1995-07-13 1997-10-17 Smithkline Beecham Corp N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
SK156698A3 (en) * 1996-05-17 1999-06-11 Anormed Inc Use of substituted azaspirane in the treatment of asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
EP1610806A4 (en) * 2003-03-10 2006-04-19 Callisto Pharmaceuticals Inc METHOD FOR THE TREATMENT OF CANCER WITH AZASPIRANE COMPOSITIONS
EP2583678A3 (en) 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
EP1802601A1 (en) * 2004-09-20 2007-07-04 Targacept, Inc. Azaspiroalkene and azapiroalkane compounds with nicotinic cholinergic receptor activity
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Also Published As

Publication number Publication date
DE3852266D1 (de) 1995-01-12
CY1955A (en) 1997-05-16
KR890701562A (ko) 1989-12-20
AU619780B2 (en) 1992-02-06
KR0166336B1 (ko) 1999-01-15
US4963557A (en) 1990-10-16
PT88603A (pt) 1988-10-01
EP0310321A3 (en) 1991-02-06
AU2533388A (en) 1989-04-18
NO173824C (no) 1994-02-09
HU208809B (en) 1995-06-28
ATE114463T1 (de) 1994-12-15
CN1032437A (zh) 1989-04-19
FI901530A0 (sv) 1990-03-27
CA1313189C (en) 1993-01-26
PT88603B (pt) 1992-12-31
HU885889D0 (en) 1991-11-28
CN1031618C (zh) 1996-04-24
HK1006274A1 (en) 1999-02-19
DK170042B1 (da) 1995-05-08
FI93006B (sv) 1994-10-31
EP0310321B1 (en) 1994-11-30
NO901392L (no) 1990-03-27
HUT57722A (en) 1991-12-30
ES2064356T3 (es) 1995-02-01
DE3852266T2 (de) 1995-05-18
DK77090A (da) 1990-03-23
IL87908A (en) 1993-02-21
NZ226354A (en) 1991-02-26
WO1989002889A1 (en) 1989-04-06
IE882929L (en) 1989-03-28
IE67891B1 (en) 1996-05-01
NO173824B (no) 1993-11-01
GR3014931T3 (en) 1995-05-31
IL87908A0 (en) 1989-03-31
NO901392D0 (no) 1990-03-27
MX9203765A (es) 1992-07-01
DK77090D0 (da) 1990-03-23
FI93006C (sv) 1995-02-10
EP0310321A2 (en) 1989-04-05
JPH03500290A (ja) 1991-01-24
JP2582888B2 (ja) 1997-02-19

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