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FI901530A0 - Förfarande för framställning av immunomodulerande azaspiraner - Google Patents

Förfarande för framställning av immunomodulerande azaspiraner

Info

Publication number
FI901530A0
FI901530A0 FI901530A FI901530A FI901530A0 FI 901530 A0 FI901530 A0 FI 901530A0 FI 901530 A FI901530 A FI 901530A FI 901530 A FI901530 A FI 901530A FI 901530 A0 FI901530 A0 FI 901530A0
Authority
FI
Finland
Prior art keywords
azaspiranes
preparing
preparing immunomodulatory
immunomodulatory azaspiranes
formulae
Prior art date
Application number
FI901530A
Other languages
English (en)
Finnish (fi)
Other versions
FI93006B (sv
FI93006C (sv
Inventor
Alison Mary Badger
Elaine Nicholas Cheeseman
Michael John Dimartino
James Woodrow Dorman
Christopher Kevin Mirabelli
Donald Harold Picker
David Aaron Schwartz
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI901530A0 publication Critical patent/FI901530A0/sv
Publication of FI93006B publication Critical patent/FI93006B/sv
Application granted granted Critical
Publication of FI93006C publication Critical patent/FI93006C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ceramic Engineering (AREA)
  • Structural Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI901530A 1987-09-28 1990-03-27 Förfarande för framställning av immunomodulerande azaspiraner FI93006C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US10170487 1987-09-28
US24422988 1988-09-13
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes
US8803323 1988-09-27
PCT/US1988/003323 WO1989002889A1 (en) 1987-09-28 1988-09-27 Immunomodulatory azaspiranes

Publications (3)

Publication Number Publication Date
FI901530A0 true FI901530A0 (sv) 1990-03-27
FI93006B FI93006B (sv) 1994-10-31
FI93006C FI93006C (sv) 1995-02-10

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
FI901530A FI93006C (sv) 1987-09-28 1990-03-27 Förfarande för framställning av immunomodulerande azaspiraner

Country Status (24)

Country Link
US (1) US4963557A (sv)
EP (1) EP0310321B1 (sv)
JP (1) JP2582888B2 (sv)
KR (1) KR0166336B1 (sv)
CN (1) CN1031618C (sv)
AT (1) ATE114463T1 (sv)
AU (1) AU619780B2 (sv)
CA (1) CA1313189C (sv)
CY (1) CY1955A (sv)
DE (1) DE3852266T2 (sv)
DK (1) DK170042B1 (sv)
ES (1) ES2064356T3 (sv)
FI (1) FI93006C (sv)
GR (1) GR3014931T3 (sv)
HK (1) HK1006274A1 (sv)
HU (1) HU208809B (sv)
IE (1) IE67891B1 (sv)
IL (1) IL87908A (sv)
MX (1) MX9203765A (sv)
NO (1) NO173824C (sv)
NZ (1) NZ226354A (sv)
PT (1) PT88603B (sv)
WO (1) WO1989002889A1 (sv)
ZW (1) ZW12388A1 (sv)

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ATE166228T1 (de) * 1990-08-10 1998-06-15 Anormed Inc Immunosuppressive zusammensetzungen
WO1992004899A1 (en) * 1990-09-24 1992-04-02 Smithkline Beecham Corporation Methods
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
DK0717987T3 (da) * 1991-12-18 2001-11-12 Minnesota Mining & Mfg Suspension-aerosol-formuleringer
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
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GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
DE69432749T2 (de) * 1993-03-26 2004-04-08 The Beth Israel Hospital Association, Boston Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
JP2001519754A (ja) * 1995-07-13 2001-10-23 アノーメッド・インコーポレイテッド ２−［２−（ジメチルアミノ）エチル］−８，８−ジプロピル−２−アザスピロ［４．５］デカンジマレイン酸塩
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KR20000010933A (ko) * 1996-05-17 2000-02-25 위샤르트 아이 시 천식 치료용으로서의 치환 아자스피란의 용도
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
US20070015780A1 (en) * 2003-03-10 2007-01-18 Picker Donald H Method of treating cancer with azaspirane compositions
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
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AU2006226018B2 (en) 2005-03-23 2012-07-12 Idorsia Pharmaceuticals Ltd Hydrogenated benzo (C) thiophene derivatives as immunomodulators
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ES2335242T3 (es) 2006-01-24 2010-03-23 Actelion Pharmaceuticals Ltd. Derivados novedosos de piridina.
US7973011B2 (en) * 2006-02-13 2011-07-05 The Board Of Trustees Of The Leland Stanford Junior University Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
CN101677954A (zh) 2007-02-11 2010-03-24 Map药物公司 治疗性施用dhe用于快速减轻偏头痛而使副作用分布最小化的方法

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US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
US3282947A (en) * 1962-05-17 1966-11-01 Geschickter Fund Med Res Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds
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DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
BE788490A (fr) * 1971-09-08 1973-01-02 Geschickter Fund Med Res Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant
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US4654333A (en) * 1986-02-18 1987-03-31 Unimed, Inc. Treatment of multiple sclerosis

Also Published As

Publication number Publication date
US4963557A (en) 1990-10-16
KR890701562A (ko) 1989-12-20
WO1989002889A1 (en) 1989-04-06
FI93006B (sv) 1994-10-31
NO173824B (no) 1993-11-01
GR3014931T3 (en) 1995-05-31
CN1031618C (zh) 1996-04-24
MX9203765A (es) 1992-07-01
ZW12388A1 (en) 1989-01-04
NO173824C (no) 1994-02-09
AU619780B2 (en) 1992-02-06
KR0166336B1 (ko) 1999-01-15
IL87908A0 (en) 1989-03-31
HU208809B (en) 1995-06-28
PT88603B (pt) 1992-12-31
EP0310321B1 (en) 1994-11-30
IE67891B1 (en) 1996-05-01
DK77090D0 (da) 1990-03-23
DK77090A (da) 1990-03-23
EP0310321A2 (en) 1989-04-05
NZ226354A (en) 1991-02-26
HU885889D0 (en) 1991-11-28
HUT57722A (en) 1991-12-30
CA1313189C (en) 1993-01-26
DE3852266T2 (de) 1995-05-18
ES2064356T3 (es) 1995-02-01
CY1955A (en) 1997-05-16
DE3852266D1 (de) 1995-01-12
IE882929L (en) 1989-03-28
CN1032437A (zh) 1989-04-19
IL87908A (en) 1993-02-21
PT88603A (pt) 1988-10-01
JPH03500290A (ja) 1991-01-24
FI93006C (sv) 1995-02-10
DK170042B1 (da) 1995-05-08
HK1006274A1 (en) 1999-02-19
JP2582888B2 (ja) 1997-02-19
NO901392L (no) 1990-03-27
EP0310321A3 (en) 1991-02-06
ATE114463T1 (de) 1994-12-15
NO901392D0 (no) 1990-03-27
AU2533388A (en) 1989-04-18

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Legal Events

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PC Transfer of assignment of patent

Owner name: ANORMED INC.

PC Transfer of assignment of patent

Owner name: ANORMED INC.

FG Patent granted

Owner name: ANORMED INC.

MA Patent expired