ZA983608B - Leptin as an inhibitor of tumor cell proliferation - Google Patents

Leptin as an inhibitor of tumor cell proliferation

Info

Publication number: ZA983608B
Authority: ZA; South Africa
Prior art keywords: leptin; inhibitor; cell proliferation; tumor cell; tumor
Prior art date: 1997-04-29

Application number

ZA983608A

Other languages

English (en)

Inventor

Dalit Barkan

Batya Cohen

Menachem Rubinstein

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-29

Filing date

1998-04-29

Publication date

1998-11-02

1998-04-29 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1998-11-02 Publication of ZA983608B publication Critical patent/ZA983608B/xx

Links

102000016267 Leptin Human genes 0.000 title 1
108010092277 Leptin Proteins 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
229940039781 leptin Drugs 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA983608A 1997-04-29 1998-04-29 Leptin as an inhibitor of tumor cell proliferation ZA983608B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL12073397A IL120733A0 (en)	1997-04-29	1997-04-29	Leptin as an inhibitor of cell proliferation

Publications (1)

Publication Number	Publication Date
ZA983608B true ZA983608B (en)	1998-11-02

Family

ID=11070075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA983608A ZA983608B (en)	1997-04-29	1998-04-29	Leptin as an inhibitor of tumor cell proliferation

Country Status (26)

Country	Link
US (1)	US7109159B1 (fr)
EP (1)	EP0981365B1 (fr)
JP (1)	JP4330662B2 (fr)
KR (1)	KR100507731B1 (fr)
CN (1)	CN1168497C (fr)
AR (1)	AR012626A1 (fr)
AT (1)	ATE283702T1 (fr)
AU (1)	AU742927B2 (fr)
BG (1)	BG63490B1 (fr)
CA (1)	CA2288238A1 (fr)
CZ (1)	CZ299872B6 (fr)
DE (1)	DE69827942T2 (fr)
EA (1)	EA002353B1 (fr)
EE (1)	EE04801B1 (fr)
ES (1)	ES2232944T3 (fr)
HK (1)	HK1028350A1 (fr)
HU (1)	HUP0002427A3 (fr)
IL (2)	IL120733A0 (fr)
NO (1)	NO322304B1 (fr)
NZ (1)	NZ500589A (fr)
PL (1)	PL195275B1 (fr)
PT (1)	PT981365E (fr)
SK (1)	SK284848B6 (fr)
UA (1)	UA66793C2 (fr)
WO (1)	WO1998048831A1 (fr)
ZA (1)	ZA983608B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7208572B2 (en)	1998-08-21	2007-04-24	Albany Medical College	Leptin-related peptides
US6777388B1 (en)	1998-08-21	2004-08-17	Clf Medical Technology Acceleration Program, Inc.	Leptin-related peptides
US20050272652A1 (en)	1999-03-29	2005-12-08	Gault Victor A	Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) *	1999-09-05	2001-03-19	Yeda Res & Dev	Use of leptin in inhibition of endothelial cell proliferation
KR20120034237A (ko)	2004-02-11	2012-04-10	아밀린 파마슈티칼스, 인크.	선택가능한 특성을 갖는 하이브리드 폴리펩티드
US8076288B2 (en)	2004-02-11	2011-12-13	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides having glucose lowering activity
US7863240B2 (en) *	2004-10-08	2011-01-04	Enzo Therapeutics, Inc.	Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en)	2004-10-08	2015-03-03	Enzo Therapeutics, Inc.	Methods for decreasing leptin levels or activity for treating inflammation
US20090286723A1 (en)	2005-02-11	2009-11-19	Amylin Pharmaceuticals, Inc.	Hybrid Polypeptides with Selectable Properties
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
EP2390264A1 (fr)	2005-02-11	2011-11-30	Amylin Pharmaceuticals Inc.	Analogues de GIP et polypeptides hybrides de GIP aux propriétés sélectionnables
EP2330125A3 (fr)	2005-08-11	2012-12-12	Amylin Pharmaceuticals, Inc.	Polypeptides hybrides ayant des propriétés sélectionnables
US8227408B2 (en) *	2005-09-07	2012-07-24	Neurotez, Inc.	Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en)	2006-08-17	2013-07-30	Amylin Pharmaceuticals, Llc	DPP-IV resistant GIP hybrid polypeptides with selectable properties
EP3103880A1 (fr) *	2008-02-08	2016-12-14	Ambrx, Inc.	Polypeptides d'insuline modifiés et utilisations de ceux-ci
CN102099048A (zh) *	2008-05-21	2011-06-15	纽若泰兹公司	用于治疗与神经原纤维缠结有关的进行性认知障碍的方法
KR20120024529A (ko) *	2008-11-04	2012-03-14	니콜라오스 테자프시디스	신경섬유 매듭 및 아밀로이드 베타의 축적으로부터 기인하는 진행성 인지 기능 장애의 치료용 렙틴 조성물 및 치료 방법
WO2010146059A2 (fr)	2009-06-16	2010-12-23	F. Hoffmann-La Roche Ag	Biomarqueurs pour une thérapie par inhibiteur d'igf-1r
TWI752920B (zh)	2015-10-12	2022-01-21	美商再生元醫藥公司	活化瘦素受體的抗原結合蛋白
MX2019005397A (es)	2016-11-08	2019-10-09	Regeneron Pharma	Proteinas de union a antigeno que antagonizan el receptor de leptina.
JP2021509021A (ja)	2017-12-18	2021-03-18	リジェネロン・ファーマシューティカルズ・インコーポレイテッド	レプチン受容体および／またはｇｐ１３０に結合する二重特異性抗原結合分子、ならびにその使用方法
EP3773713A1 (fr)	2018-04-06	2021-02-17	Regeneron Pharmaceuticals, Inc.	Anticorps agoniste du récepteur de la leptine destiné à être utilisé dans le traitement d'un dysfonctionnement métabolique ou d'une hypoleptinémie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL122718A0 (en) *	1995-06-30	1998-08-16	Lilly Co Eli	Methods for treating diabetes
WO1997011192A1 (fr) *	1995-09-19	1997-03-27	Eli Lilly And Company	Adn codant des proteines medicinales
DE69735477T2 (de) *	1996-01-23	2006-11-30	Indevus Pharmaceuticals, Inc., Lexington	Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen

1997
- 1997-04-29 IL IL12073397A patent/IL120733A0/xx unknown
1998
- 1998-04-26 JP JP54678798A patent/JP4330662B2/ja not_active Expired - Fee Related
- 1998-04-26 DE DE69827942T patent/DE69827942T2/de not_active Expired - Lifetime
- 1998-04-26 UA UA99116415A patent/UA66793C2/uk unknown
- 1998-04-26 AU AU70762/98A patent/AU742927B2/en not_active Ceased
- 1998-04-26 CZ CZ0384899A patent/CZ299872B6/cs not_active IP Right Cessation
- 1998-04-26 ES ES98917580T patent/ES2232944T3/es not_active Expired - Lifetime
- 1998-04-26 PT PT98917580T patent/PT981365E/pt unknown
- 1998-04-26 HU HU0002427A patent/HUP0002427A3/hu unknown
- 1998-04-26 KR KR10-1999-7009705A patent/KR100507731B1/ko not_active IP Right Cessation
- 1998-04-26 US US09/403,897 patent/US7109159B1/en not_active Expired - Fee Related
- 1998-04-26 WO PCT/IL1998/000196 patent/WO1998048831A1/fr active IP Right Grant
- 1998-04-26 NZ NZ500589A patent/NZ500589A/xx not_active IP Right Cessation
- 1998-04-26 CA CA002288238A patent/CA2288238A1/fr not_active Abandoned
- 1998-04-26 EE EEP199900510A patent/EE04801B1/xx not_active IP Right Cessation
- 1998-04-26 PL PL98336582A patent/PL195275B1/pl not_active IP Right Cessation
- 1998-04-26 EA EA199900981A patent/EA002353B1/ru not_active IP Right Cessation
- 1998-04-26 AT AT98917580T patent/ATE283702T1/de active
- 1998-04-26 CN CNB988066920A patent/CN1168497C/zh not_active Expired - Fee Related
- 1998-04-26 SK SK1471-99A patent/SK284848B6/sk not_active IP Right Cessation
- 1998-04-26 EP EP98917580A patent/EP0981365B1/fr not_active Expired - Lifetime
- 1998-04-29 AR ARP980102003A patent/AR012626A1/es unknown
- 1998-04-29 ZA ZA983608A patent/ZA983608B/xx unknown
1999
- 1999-10-25 BG BG103832A patent/BG63490B1/bg unknown
- 1999-10-28 NO NO19995267A patent/NO322304B1/no not_active IP Right Cessation
- 1999-10-28 IL IL132633A patent/IL132633A/en not_active IP Right Cessation
2000
- 2000-12-07 HK HK00107866A patent/HK1028350A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2001524968A (ja)	2001-12-04
EP0981365B1 (fr)	2004-12-01
KR20010012080A (ko)	2001-02-15
AU742927B2 (en)	2002-01-17
AU7076298A (en)	1998-11-24
NO995267D0 (no)	1999-10-28
HUP0002427A3 (en)	2003-02-28
CZ384899A3 (cs)	2000-06-14
HUP0002427A2 (hu)	2000-12-28
ATE283702T1 (de)	2004-12-15
BG103832A (en)	2000-10-31
EE04801B1 (et)	2007-04-16
NZ500589A (en)	2001-03-30
SK147199A3 (en)	2000-06-12
IL132633A (en)	2007-07-04
CA2288238A1 (fr)	1998-11-05
NO322304B1 (no)	2006-09-11
NO995267L (no)	1999-12-28
KR100507731B1 (ko)	2005-08-10
JP4330662B2 (ja)	2009-09-16
PL336582A1 (en)	2000-07-03
EA199900981A1 (ru)	2000-04-24
ES2232944T3 (es)	2005-06-01
CN1261802A (zh)	2000-08-02
CZ299872B6 (cs)	2008-12-17
UA66793C2 (uk)	2004-06-15
WO1998048831A1 (fr)	1998-11-05
EA002353B1 (ru)	2002-04-25
CN1168497C (zh)	2004-09-29
BG63490B1 (bg)	2002-03-29
SK284848B6 (sk)	2006-01-05
DE69827942T2 (de)	2005-12-08
PL195275B1 (pl)	2007-08-31
HK1028350A1 (en)	2001-02-16
AR012626A1 (es)	2000-11-08
DE69827942D1 (de)	2005-01-05
EP0981365A1 (fr)	2000-03-01
US7109159B1 (en)	2006-09-19
PT981365E (pt)	2005-03-31
IL120733A0 (en)	1997-08-14
EE9900510A (et)	2000-06-15

Publication	Publication Date	Title
ZA983608B (en)	1998-11-02	Leptin as an inhibitor of tumor cell proliferation
EP0934404A4 (fr)	2002-08-07	Inhibition de la proliferation des cellules
PL331254A1 (en)	1999-07-05	Phosphonianic inhibitors of matrix metaloproteases
EP0971723A4 (fr)	2001-10-24	Compositions et procedes destines a inhiber la proliferation cellulaire
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
EG24027A (en)	2008-03-26	Pyrrolotriazine inhibitors of kinases
PL339738A1 (en)	2001-01-02	Novel lactamic inhibitors of metaloproteinases
AU1536799A (en)	1999-06-16	Bishydroxyureas as inhibitors of the 5-lipoxygenase
EP1119365A4 (fr)	2003-08-13	Compositions et procedes permettant d'utiliser les cellules tumorales
AU4296397A (en)	1998-02-20	Substituted bisindolylmaleimides for the inhibition of cell proliferation
AU3769097A (en)	1998-02-20	Substituted bisindolylmaleimides for the inhibition of cell proliferation
PL342964A1 (en)	2001-07-16	Substituted bisindolymaleimides for the inhibition of cell proliferation
PL337331A1 (en)	2000-08-14	Cyanoguanidines as cell proliferation inhibitors
PL337091A1 (en)	2000-07-31	Cyanoguanidines as inhibitors of cell proliferation
AU9312598A (en)	1999-03-29	Inhibitors of collagen assembly
AU5333298A (en)	1998-07-31	Compositions and methods for tumour therapy
PL337031A1 (en)	2000-07-31	Cyanoguanidines as inhibitors of cell proliferation
AU9018598A (en)	1999-03-08	Prognostic compositions for prostate cancer and methods of use thereof
AU3459497A (en)	1998-02-09	Cancer cell proliferation inhibitors
IL132633A0 (en)	2001-03-19	Leptin as an inhibitor of tumor cell proliferation
SI0981365T1 (en)	2005-04-30	Leptin as an inhibitor of tumor cell proliferation
AU8492598A (en)	1999-02-10	Methods and compositions for tumor reduction
AU2001290241A1 (en)	2002-04-02	Tumor cell proliferation inhibitors
PL336896A1 (en)	2000-07-17	Cyanoamidines as inhibitors of cell proliferation
AU2086597A (en)	1997-09-22	Inhibition of proliferation of cells