HUP0002427A3 - Leptin as an inhibitor of tumor cell proliferation and use of leptin - Google Patents

Leptin as an inhibitor of tumor cell proliferation and use of leptin

Info

Publication number: HUP0002427A3
Authority: HU; Hungary
Prior art keywords: leptin; inhibitor; cell proliferation; tumor cell; tumor
Prior art date: 1997-04-29

Application number

HU0002427A

Other languages

English (en)

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-29

Filing date

1998-04-26

Publication date

2003-02-28

1998-04-26 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2000-12-28 Publication of HUP0002427A2 publication Critical patent/HUP0002427A2/hu

2003-02-28 Publication of HUP0002427A3 publication Critical patent/HUP0002427A3/hu

Links

102000016267 Leptin Human genes 0.000 title 2
108010092277 Leptin Proteins 0.000 title 2
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 2
229940039781 leptin Drugs 0.000 title 2
230000004663 cell proliferation Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HU0002427A 1997-04-29 1998-04-26 Leptin as an inhibitor of tumor cell proliferation and use of leptin HUP0002427A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL12073397A IL120733A0 (en)	1997-04-29	1997-04-29	Leptin as an inhibitor of cell proliferation

Publications (2)

Publication Number	Publication Date
HUP0002427A2 HUP0002427A2 (hu)	2000-12-28
HUP0002427A3 true HUP0002427A3 (en)	2003-02-28

Family

ID=11070075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0002427A HUP0002427A3 (en)	1997-04-29	1998-04-26	Leptin as an inhibitor of tumor cell proliferation and use of leptin

Country Status (26)

Country	Link
US (1)	US7109159B1 (hu)
EP (1)	EP0981365B1 (hu)
JP (1)	JP4330662B2 (hu)
KR (1)	KR100507731B1 (hu)
CN (1)	CN1168497C (hu)
AR (1)	AR012626A1 (hu)
AT (1)	ATE283702T1 (hu)
AU (1)	AU742927B2 (hu)
BG (1)	BG63490B1 (hu)
CA (1)	CA2288238A1 (hu)
CZ (1)	CZ299872B6 (hu)
DE (1)	DE69827942T2 (hu)
EA (1)	EA002353B1 (hu)
EE (1)	EE04801B1 (hu)
ES (1)	ES2232944T3 (hu)
HK (1)	HK1028350A1 (hu)
HU (1)	HUP0002427A3 (hu)
IL (2)	IL120733A0 (hu)
NO (1)	NO322304B1 (hu)
NZ (1)	NZ500589A (hu)
PL (1)	PL195275B1 (hu)
PT (1)	PT981365E (hu)
SK (1)	SK284848B6 (hu)
UA (1)	UA66793C2 (hu)
WO (1)	WO1998048831A1 (hu)
ZA (1)	ZA983608B (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7208572B2 (en)	1998-08-21	2007-04-24	Albany Medical College	Leptin-related peptides
US6777388B1 (en)	1998-08-21	2004-08-17	Clf Medical Technology Acceleration Program, Inc.	Leptin-related peptides
US20050272652A1 (en)	1999-03-29	2005-12-08	Gault Victor A	Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) *	1999-09-05	2001-03-19	Yeda Res & Dev	Use of leptin in inhibition of endothelial cell proliferation
US8076288B2 (en)	2004-02-11	2011-12-13	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides having glucose lowering activity
CN103897066A (zh)	2004-02-11	2014-07-02	安米林药品有限责任公司	具有可选择特性的杂合多肽
US7863240B2 (en) *	2004-10-08	2011-01-04	Enzo Therapeutics, Inc.	Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en)	2004-10-08	2015-03-03	Enzo Therapeutics, Inc.	Methods for decreasing leptin levels or activity for treating inflammation
EP2392595A1 (en)	2005-02-11	2011-12-07	Amylin Pharmaceuticals Inc.	GIP analog and hybrid polypeptides with selectable properties
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
EP2330125A3 (en)	2005-08-11	2012-12-12	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides with selectable properties
EP1922336B1 (en)	2005-08-11	2012-11-21	Amylin Pharmaceuticals, LLC	Hybrid polypeptides with selectable properties
US8227408B2 (en) *	2005-09-07	2012-07-24	Neurotez, Inc.	Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en)	2006-08-17	2013-07-30	Amylin Pharmaceuticals, Llc	DPP-IV resistant GIP hybrid polypeptides with selectable properties
NZ620606A (en)	2008-02-08	2015-08-28	Ambrx Inc	Modified leptin polypeptides and their uses
WO2009143380A2 (en) *	2008-05-21	2009-11-26	Neurotez, Inc.	Methods for treating progressive cognitive disorders related to neurofibrillary tangles
AU2009313562B2 (en) *	2008-11-04	2012-11-15	Neurotez, Inc.	Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
WO2010146059A2 (en)	2009-06-16	2010-12-23	F. Hoffmann-La Roche Ag	Biomarkers for igf-1r inhibitor therapy
TWI824372B (zh)	2015-10-12	2023-12-01	美商再生元醫藥公司	活化瘦素受體的抗原結合蛋白
KR102563568B1 (ko)	2016-11-08	2023-08-04	리제너론 파마슈티칼스 인코포레이티드	렙틴 수용체에 길항하는 항원-결합 단백질
CA3084385A1 (en)	2017-12-18	2019-06-27	Regeneron Pharmaceuticals, Inc.	Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
KR20200141461A (ko)	2018-04-06	2020-12-18	리제너론 파마슈티칼스 인코포레이티드	렙틴 수용체 작용제 항체를 사용한 치료 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2225454A1 (en) *	1995-06-30	1997-01-23	Thomas Wesley Stephens	Methods for treating diabetes
JPH11512296A (ja) *	1995-09-19	1999-10-26	イーライ・リリー・アンド・カンパニー	医療用タンパク質をコードしているｄｎａ
ES2260784T3 (es) *	1996-01-23	2006-11-01	Indevus Pharmaceuticals, Inc.	Metodos de utilizacion del gen obese y su producto genico para estimular el desarrolo hematopoyetico.

1997
- 1997-04-29 IL IL12073397A patent/IL120733A0/xx unknown
1998
- 1998-04-26 AT AT98917580T patent/ATE283702T1/de active
- 1998-04-26 PL PL98336582A patent/PL195275B1/pl not_active IP Right Cessation
- 1998-04-26 EA EA199900981A patent/EA002353B1/ru not_active IP Right Cessation
- 1998-04-26 CN CNB988066920A patent/CN1168497C/zh not_active Expired - Fee Related
- 1998-04-26 PT PT98917580T patent/PT981365E/pt unknown
- 1998-04-26 AU AU70762/98A patent/AU742927B2/en not_active Ceased
- 1998-04-26 UA UA99116415A patent/UA66793C2/uk unknown
- 1998-04-26 EE EEP199900510A patent/EE04801B1/xx not_active IP Right Cessation
- 1998-04-26 ES ES98917580T patent/ES2232944T3/es not_active Expired - Lifetime
- 1998-04-26 CZ CZ0384899A patent/CZ299872B6/cs not_active IP Right Cessation
- 1998-04-26 WO PCT/IL1998/000196 patent/WO1998048831A1/en active IP Right Grant
- 1998-04-26 HU HU0002427A patent/HUP0002427A3/hu unknown
- 1998-04-26 JP JP54678798A patent/JP4330662B2/ja not_active Expired - Fee Related
- 1998-04-26 DE DE69827942T patent/DE69827942T2/de not_active Expired - Lifetime
- 1998-04-26 EP EP98917580A patent/EP0981365B1/en not_active Expired - Lifetime
- 1998-04-26 CA CA002288238A patent/CA2288238A1/en not_active Abandoned
- 1998-04-26 KR KR10-1999-7009705A patent/KR100507731B1/ko not_active IP Right Cessation
- 1998-04-26 NZ NZ500589A patent/NZ500589A/xx not_active IP Right Cessation
- 1998-04-26 US US09/403,897 patent/US7109159B1/en not_active Expired - Fee Related
- 1998-04-26 SK SK1471-99A patent/SK284848B6/sk not_active IP Right Cessation
- 1998-04-29 ZA ZA983608A patent/ZA983608B/xx unknown
- 1998-04-29 AR ARP980102003A patent/AR012626A1/es unknown
1999
- 1999-10-25 BG BG103832A patent/BG63490B1/bg unknown
- 1999-10-28 NO NO19995267A patent/NO322304B1/no not_active IP Right Cessation
- 1999-10-28 IL IL132633A patent/IL132633A/en not_active IP Right Cessation
2000
- 2000-12-07 HK HK00107866A patent/HK1028350A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA199900981A1 (ru)	2000-04-24
EE04801B1 (et)	2007-04-16
KR20010012080A (ko)	2001-02-15
PL195275B1 (pl)	2007-08-31
EA002353B1 (ru)	2002-04-25
US7109159B1 (en)	2006-09-19
HK1028350A1 (en)	2001-02-16
BG63490B1 (bg)	2002-03-29
AR012626A1 (es)	2000-11-08
SK147199A3 (en)	2000-06-12
JP4330662B2 (ja)	2009-09-16
HUP0002427A2 (hu)	2000-12-28
CN1168497C (zh)	2004-09-29
EE9900510A (et)	2000-06-15
JP2001524968A (ja)	2001-12-04
DE69827942D1 (de)	2005-01-05
AU742927B2 (en)	2002-01-17
EP0981365A1 (en)	2000-03-01
PL336582A1 (en)	2000-07-03
NO995267L (no)	1999-12-28
ZA983608B (en)	1998-11-02
CN1261802A (zh)	2000-08-02
CZ384899A3 (cs)	2000-06-14
NO995267D0 (no)	1999-10-28
IL120733A0 (en)	1997-08-14
NO322304B1 (no)	2006-09-11
NZ500589A (en)	2001-03-30
DE69827942T2 (de)	2005-12-08
CA2288238A1 (en)	1998-11-05
AU7076298A (en)	1998-11-24
PT981365E (pt)	2005-03-31
UA66793C2 (uk)	2004-06-15
SK284848B6 (sk)	2006-01-05
ATE283702T1 (de)	2004-12-15
BG103832A (en)	2000-10-31
EP0981365B1 (en)	2004-12-01
WO1998048831A1 (en)	1998-11-05
CZ299872B6 (cs)	2008-12-17
ES2232944T3 (es)	2005-06-01
KR100507731B1 (ko)	2005-08-10
IL132633A (en)	2007-07-04

Publication	Publication Date	Title
HUP0002427A3 (en)	2003-02-28	Leptin as an inhibitor of tumor cell proliferation and use of leptin
EP1009415A4 (en)	2000-10-25	INHIBITORS OF $ g (b) -LACTAMASES AND THEIR USES
HUP9700602A3 (en)	2000-04-28	New inhibitors of bone-resorption and vitronectine-receptor-antagonists
IL133962A0 (en)	2001-04-30	Combination therapy comprising atorvastatin and an antihypertensive agent
PL331254A1 (en)	1999-07-05	Phosphonianic inhibitors of matrix metaloproteases
EP1018987A4 (en)	2004-12-15	NEO-CARTILAGE AND ITS METHODS OF USE
ZA984976B (en)	1999-04-19	Solid-state fluorometer and methods of use therefore
AU1194799A (en)	1999-05-10	Portable sink apparatus and methods of manufacture and use thereof
HUP0000053A3 (en)	2003-02-28	Hppd gene and inhibitors
EP0934404A4 (en)	2002-08-07	INHIBITION OF CELL PROLIFERATION
PL333434A1 (en)	1999-12-06	Aminoguanidines and alkoxyguanidines as inhibitors of proteases
EP0999876A4 (en)	2001-11-14	STEREOTAXIC RADIOTHERAPY AND PREVENTION OF RESTENOSIS
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
PL331047A1 (en)	1999-06-21	Novel amidinic derivatives and their application as inhibitors of thrombosin
AU6340600A (en)	2001-01-22	Telomerase inhibitors and methods of their use
EP1119365A4 (en)	2003-08-13	COMPOSITIONS AND METHODS FOR USING TUMOR CELLS
IL136110A0 (en)	2001-05-20	Methods and compositions for the treatment of psoriasis
AU9016898A (en)	1999-03-01	Methods and compositions for treatment of restenosis
PL329855A1 (en)	1999-04-12	Inhibitors of s-cd23 formation and tumour necrosis factor release
AU6450398A (en)	1998-09-22	Sr-bi regulatory sequences and therapeutic methods of use
ZA9811346B (en)	1999-06-14	Substituted heterocyclic benzocycloalkenes and their use as an analgesic
AU9018598A (en)	1999-03-08	Prognostic compositions for prostate cancer and methods of use thereof
IL128031A0 (en)	1999-11-30	Pyranoindole and carbazole inhibitors of cox-2
EP1070141A4 (en)	2003-05-14	IMMEDIATE EARLY GENES AND METHODS OF USE
IL132633A0 (en)	2001-03-19	Leptin as an inhibitor of tumor cell proliferation

Legal Events

Date	Code	Title	Description
2011-02-28	FD9A	Lapse of provisional protection due to non-payment of fees