ZA931647B - Therapeutic nucleosides - Google Patents

Therapeutic nucleosides

Info

Publication number: ZA931647B
Authority: ZA; South Africa
Prior art keywords: substituted; benzimidazole base; therapeutic nucleosides; hepatitis; halogen
Prior art date: 1992-03-09

Application number

ZA931647A

Other languages

English (en)

Inventor

Leroy B Townsend

John Charles Drach

Steven Spencer Good

Susan Mary Daluge

Michael Tolar Martin

Original Assignee

Wellcome Found

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-09

Filing date

1993-03-08

Publication date

1994-09-08

1993-03-08 Application filed by Wellcome Found, Univ Michigan filed Critical Wellcome Found

1994-09-08 Publication of ZA931647B publication Critical patent/ZA931647B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA931647A 1992-03-09 1993-03-08 Therapeutic nucleosides ZA931647B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929205071A GB9205071D0 (en)	1992-03-09	1992-03-09	Therapeutic nucleosides

Publications (1)

Publication Number	Publication Date
ZA931647B true ZA931647B (en)	1994-09-08

Family

ID=10711750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA931647A ZA931647B (en)	1992-03-09	1993-03-08	Therapeutic nucleosides

Country Status (20)

Country	Link
US (1)	US5534535A (ja)
EP (1)	EP0630368B1 (ja)
JP (1)	JP3450854B2 (ja)
KR (2)	KR950700887A (ja)
AT (1)	ATE170846T1 (ja)
AU (1)	AU672597B2 (ja)
CA (1)	CA2131693A1 (ja)
CZ (1)	CZ209494A3 (ja)
DE (1)	DE69320945T2 (ja)
DK (1)	DK0630368T3 (ja)
ES (1)	ES2123048T3 (ja)
FI (1)	FI944134A (ja)
GB (1)	GB9205071D0 (ja)
HU (1)	HUT68445A (ja)
IL (1)	IL104976A (ja)
NZ (1)	NZ249554A (ja)
RU (1)	RU2141952C1 (ja)
TW (1)	TW366339B (ja)
WO (1)	WO1993018009A1 (ja)
ZA (1)	ZA931647B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides
GB9413724D0 (en) *	1994-07-07	1994-08-24	Wellcome Found	Therapeutic nucleosides
AU3692895A (en) *	1994-09-09	1996-03-27	Regents Of The University Of Michigan, The	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
US5811073A (en) *	1995-06-19	1998-09-22	President And Fellows Of Harvard College	Method for radioisotopic detection and localization of inflammation in a host
US5912356A (en) *	1995-09-11	1999-06-15	Glaxo Wellcome Inc.	Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) *	1996-01-05	1996-03-06	Wellcome Found	Chemical compounds
GB9600143D0 (en)	1996-01-05	1996-03-06	Wellcome Found	Therapeutic compounds
CA2280761A1 (en)	1997-02-13	1998-08-20	Stanley Dawes Chamberlain	Benzimidazole derivatives
SK284810B6 (sk) *	1997-05-13	2005-12-01	Lonza Ag	Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu
TR199903053T2 (xx)	1997-06-10	2000-11-21	Glaxo Group Limited	Benzimidazol t�revleri.
US6455506B1 (en)	1997-07-30	2002-09-24	Smithkline Beecham Corporation	Lyxofuranosyl benzimidazoles as antiviral agents
US6514979B1 (en)	1999-03-03	2003-02-04	University Of Maryland Biotechnology Institute	Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
GB0008939D0 (en)	2000-04-11	2000-05-31	Glaxo Group Ltd	Process for preparing substituted benzimidazole compounds
BR0110023A (pt)	2000-04-13	2003-12-30	Pharmasset Ltd	Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite
TW200831081A (en)	2006-12-25	2008-08-01	Kyorin Seiyaku Kk	Glucokinase activator
EP2540726B1 (en)	2007-08-02	2019-10-09	Millennium Pharmaceuticals, Inc.	Intermediates for the synthesis of E1 activity activating enzyme inhibitors
PT2275414E (pt)	2008-04-28	2015-09-09	Teijin Pharma Ltd	Derivado de amida do ácido ciclopentacrílico
US11499722B2 (en) *	2020-04-30	2022-11-15	Bsh Home Appliances Corporation	Household cooking appliance having an oven door with an interior camera

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996308A (en) *	1988-03-25	1991-02-26	Merrell Dow Pharmaceuticals Inc.	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Novel neplanocin derivatives
GB8826205D0 (en) *	1988-11-09	1988-12-14	Wellcome Found	Heterocyclic compounds
GB8926417D0 (en) *	1989-11-22	1990-01-10	Wellcome Found	Heterocyclic compounds
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
US5248672A (en) *	1990-11-01	1993-09-28	The Regents Of The University Of Michigan	Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides

1992
- 1992-03-09 GB GB929205071A patent/GB9205071D0/en active Pending
1993
- 1993-03-08 DE DE69320945T patent/DE69320945T2/de not_active Expired - Fee Related
- 1993-03-08 EP EP93905536A patent/EP0630368B1/en not_active Expired - Lifetime
- 1993-03-08 HU HU9402582A patent/HUT68445A/hu unknown
- 1993-03-08 AU AU36432/93A patent/AU672597B2/en not_active Ceased
- 1993-03-08 WO PCT/GB1993/000479 patent/WO1993018009A1/en active IP Right Grant
- 1993-03-08 JP JP51547193A patent/JP3450854B2/ja not_active Expired - Fee Related
- 1993-03-08 CZ CZ942094A patent/CZ209494A3/cs unknown
- 1993-03-08 IL IL10497693A patent/IL104976A/en not_active IP Right Cessation
- 1993-03-08 ES ES93905536T patent/ES2123048T3/es not_active Expired - Lifetime
- 1993-03-08 ZA ZA931647A patent/ZA931647B/xx unknown
- 1993-03-08 RU RU94043771A patent/RU2141952C1/ru active
- 1993-03-08 CA CA002131693A patent/CA2131693A1/en not_active Abandoned
- 1993-03-08 AT AT93905536T patent/ATE170846T1/de not_active IP Right Cessation
- 1993-03-08 DK DK93905536T patent/DK0630368T3/da active
- 1993-03-08 NZ NZ249554A patent/NZ249554A/en unknown
- 1993-05-27 TW TW082104263A patent/TW366339B/zh active
1994
- 1994-09-08 FI FI944134A patent/FI944134A/fi unknown
- 1994-09-09 KR KR1019940703149A patent/KR950700887A/ko not_active Application Discontinuation
- 1994-09-09 US US08/304,006 patent/US5534535A/en not_active Expired - Lifetime
1995
- 1995-09-11 KR KR1019970701554A patent/KR970705547A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
RU94043771A (ru)	1996-08-10
DE69320945T2 (de)	1999-02-04
IL104976A0 (en)	1993-07-08
NZ249554A (en)	1996-05-28
US5534535A (en)	1996-07-09
FI944134A0 (fi)	1994-09-08
KR970705547A (ko)	1997-10-09
EP0630368A1 (en)	1994-12-28
CA2131693A1 (en)	1993-09-16
EP0630368B1 (en)	1998-09-09
KR950700887A (ko)	1995-02-20
AU672597B2 (en)	1996-10-10
CZ209494A3 (en)	1995-11-15
ATE170846T1 (de)	1998-09-15
RU2141952C1 (ru)	1999-11-27
ES2123048T3 (es)	1999-01-01
JPH07506816A (ja)	1995-07-27
WO1993018009A1 (en)	1993-09-16
HU9402582D0 (en)	1994-11-28
JP3450854B2 (ja)	2003-09-29
AU3643293A (en)	1993-10-05
GB9205071D0 (en)	1992-04-22
IL104976A (en)	1998-10-30
HUT68445A (en)	1995-06-28
FI944134A (fi)	1994-11-07
TW366339B (en)	1999-08-11
DK0630368T3 (da)	1999-06-07
DE69320945D1 (de)	1998-10-15

Publication	Publication Date	Title
ZA931647B (en)	1994-09-08	Therapeutic nucleosides
AU5989090A (en)	1990-11-08	Antiviral pyrimidine nucleoside
UA29382C2 (uk)	2000-11-15	Карбоциклічні нуклеозиди 6-заміщеного пурину
AU4690989A (en)	1990-06-21	Antiviral cytosine and guanine derivatives
DE3780581D1 (de)	1992-08-27	Antiviralen phosphonomethoxyalkylen-purin- und -pyrimidin-derivate.
EP0348446A4 (en)	1991-09-25	Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides
MX9203217A (es)	1992-07-01	Nucleosidos terapeuticos.
EP0453247A3 (en)	1991-11-06	Anti-viral compounds