[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ZA893075B - Aprotinin analogues and process for the production thereof - Google Patents

Aprotinin analogues and process for the production thereof

Info

Publication number
ZA893075B
ZA893075B ZA893075A ZA893075A ZA893075B ZA 893075 B ZA893075 B ZA 893075B ZA 893075 A ZA893075 A ZA 893075A ZA 893075 A ZA893075 A ZA 893075A ZA 893075 B ZA893075 B ZA 893075B
Authority
ZA
South Africa
Prior art keywords
production
aprotinin analogues
analogues
aprotinin
serine proteases
Prior art date
Application number
ZA893075A
Other languages
English (en)
Inventor
Kjeld Norris
Norris Kjeld
Lars Christian Petersen
Christian Petersen Lars
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA893075B publication Critical patent/ZA893075B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA893075A 1988-04-26 1989-04-26 Aprotinin analogues and process for the production thereof ZA893075B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK225488A DK225488D0 (da) 1988-04-26 1988-04-26 Polypeptid

Publications (1)

Publication Number Publication Date
ZA893075B true ZA893075B (en) 1989-12-27

Family

ID=8111114

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893075A ZA893075B (en) 1988-04-26 1989-04-26 Aprotinin analogues and process for the production thereof

Country Status (14)

Country Link
US (1) US5373090A (da)
EP (1) EP0339942B1 (da)
JP (1) JP2810743B2 (da)
AT (1) ATE103295T1 (da)
AU (1) AU619553B2 (da)
DE (1) DE68914022T2 (da)
DK (1) DK225488D0 (da)
ES (1) ES2061983T3 (da)
FI (1) FI93964C (da)
IE (1) IE64230B1 (da)
NO (1) NO302950B1 (da)
NZ (1) NZ228896A (da)
WO (1) WO1989010374A1 (da)
ZA (1) ZA893075B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP1279731B1 (en) 1991-03-01 2007-05-30 Dyax Corporation Process for the development of binding mini-proteins
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
CA2139945A1 (en) * 1992-07-13 1994-01-20 Ignace Lasters Bovine pancreatic trypsin inhibitor derived inhibitors of factor xa
JPH08504568A (ja) * 1992-09-25 1996-05-21 コルバス・インターナショナル、インコーポレイテッド ウシ膵トリプシン阻害因子から誘導される因子ＶＩＩａ−組織因子複合体の阻害因子
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2375561T3 (es) * 1994-01-11 2012-03-02 Dyax Corporation Inhibidores de la plasmina humana derivados de dominios kunitz y �?cidos nucleicos que codifican los mismos.
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en) * 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE528014T1 (de) 2002-06-07 2011-10-15 Dyax Corp Polypeptid mit modifizierten kunitz domains
CA2496789C (en) 2002-08-28 2013-12-17 Dyax Corp. Methods for preserving organs and tissues
PT1587907E (pt) * 2003-01-07 2011-04-08 Dyax Corp Biblioteca de domínios de kunitz
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
JP4739207B2 (ja) * 2003-08-29 2011-08-03 ダイアックス コーポレーション ポリペグ化されたプロテアーゼインヒビター
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
PL1830924T3 (pl) * 2004-12-23 2013-08-30 Csl Behring Gmbh Zapobieganie tworzeniu i/lub stabilizacji skrzepu
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
PT3459564T (pt) * 2010-01-06 2022-01-31 Takeda Pharmaceuticals Co Proteínas de ligação à calicreína plasmática
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

Also Published As

Publication number Publication date
FI905275A0 (fi) 1990-10-25
WO1989010374A1 (en) 1989-11-02
AU619553B2 (en) 1992-01-30
AU3560389A (en) 1989-11-24
JPH03504009A (ja) 1991-09-05
FI93964C (fi) 1995-06-26
IE64230B1 (en) 1995-07-26
EP0339942A3 (en) 1990-05-30
NO904622L (no) 1990-12-18
DE68914022T2 (de) 1994-07-07
EP0339942B1 (en) 1994-03-23
ATE103295T1 (de) 1994-04-15
DK225488D0 (da) 1988-04-26
ES2061983T3 (es) 1994-12-16
NO904622D0 (no) 1990-10-25
IE891334L (en) 1989-10-26
NO302950B1 (no) 1998-05-11
EP0339942A2 (en) 1989-11-02
NZ228896A (en) 1991-08-27
FI93964B (fi) 1995-03-15
DE68914022D1 (de) 1994-04-28
JP2810743B2 (ja) 1998-10-15
US5373090A (en) 1994-12-13

Similar Documents

Publication Publication Date Title
IE891334L (en) Aprotinin analogues and a process for the production thereof
SG45290A1 (en) A process for the production of 1,3-propanediol
HU912541D0 (en) Serine protease inhibitors
AU582740B2 (en) Pattern recognizing self-tuning controller
GR3019168T3 (en) A process for the manufacture of two-wheeled-vehicle tires and tires obtained thereby.
EG20366A (en) Process for the production of a strip, a prestrip or slab
GB2237523B (en) A process for the production of a valve
GB2287429B (en) Process for the manufacture of a profile part
EP0252057A3 (en) Serine protease inhibitors
EP0428849A3 (en) Retroviral protease inhibitors
GB2225137B (en) Method for extending the life of a plant.
BR9006093A (pt) Processo de montagem de um compressor de caracol e o respectivo compressor de caracol
RS49598B (sr) Intermedijari i proces za dobijanje olanzapina
GB2238807B (en) Building block
GR81852B (da)
GB8928378D0 (en) A diffuser
NZ229705A (en) Process for the production of 2,6-diethylnaphthalene
GB2234316B (en) A diffuser
ZA898261B (en) Method for the operation of a claus plant
ZA902342B (en) Method for the operation of a claus plant
EP0402561A3 (en) Process for the manufacture of anilinofumarate via chloromaleate or chlorofumarate or mixtures thereof
EP0426860A4 (en) New protease inhibitor and production thereof
AU6619790A (en) Process for the production of a white fine-grained material of urea-formaldehyde resin or a modified urea-formaldehyde resin
EP0498452A3 (en) Process for the production of protease c
HRP931129A2 (en) Process for the production of protease c