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DK225488D0 - Polypeptid - Google Patents

Polypeptid

Info

Publication number
DK225488D0
DK225488D0 DK225488A DK225488A DK225488D0 DK 225488 D0 DK225488 D0 DK 225488D0 DK 225488 A DK225488 A DK 225488A DK 225488 A DK225488 A DK 225488A DK 225488 D0 DK225488 D0 DK 225488D0
Authority
DK
Denmark
Prior art keywords
polypeptide
serine proteases
profile against
inhibition profile
against serine
Prior art date
Application number
DK225488A
Other languages
English (en)
Inventor
Kjeld Norris
Lars Christian Petersen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK225488A priority Critical patent/DK225488D0/da
Publication of DK225488D0 publication Critical patent/DK225488D0/da
Priority to ES89304122T priority patent/ES2061983T3/es
Priority to DE68914022T priority patent/DE68914022T2/de
Priority to EP89304122A priority patent/EP0339942B1/en
Priority to AU35603/89A priority patent/AU619553B2/en
Priority to AT89304122T priority patent/ATE103295T1/de
Priority to PCT/DK1989/000096 priority patent/WO1989010374A1/en
Priority to IE133489A priority patent/IE64230B1/en
Priority to JP1505101A priority patent/JP2810743B2/ja
Priority to US07/598,737 priority patent/US5373090A/en
Priority to NZ228896A priority patent/NZ228896A/xx
Priority to ZA893075A priority patent/ZA893075B/xx
Priority to NO904622A priority patent/NO302950B1/no
Priority to FI905275A priority patent/FI93964C/fi
Priority to DK257990A priority patent/DK171417B1/da
Priority to US08/084,718 priority patent/US5591603A/en
Priority to US08/443,977 priority patent/US5621074A/en
Priority to US08/443,976 priority patent/US5618915A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK225488A 1987-08-28 1988-04-26 Polypeptid DK225488D0 (da)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DK225488A DK225488D0 (da) 1988-04-26 1988-04-26 Polypeptid
US07/598,737 US5373090A (en) 1988-04-26 1989-04-25 Aprotinin analogues and a process for the production thereof
JP1505101A JP2810743B2 (ja) 1988-04-26 1989-04-25 アプロチニン同族体およびその製造方法
DE68914022T DE68914022T2 (de) 1988-04-26 1989-04-25 Aprotinin-Analoge und Verfahren zu ihrer Herstellung.
EP89304122A EP0339942B1 (en) 1988-04-26 1989-04-25 Aprotinin analogues and process for the production thereof
AU35603/89A AU619553B2 (en) 1988-04-26 1989-04-25 Aprotinin analogues and a process for the production thereof
AT89304122T ATE103295T1 (de) 1988-04-26 1989-04-25 Aprotinin-analoge und verfahren zu ihrer herstellung.
PCT/DK1989/000096 WO1989010374A1 (en) 1988-04-26 1989-04-25 Aprotinin analogues and a process for the production thereof
IE133489A IE64230B1 (en) 1988-04-26 1989-04-25 Aprotinin analogues and process for the production thereof
ES89304122T ES2061983T3 (es) 1988-04-26 1989-04-25 Analogos de aprotinina y procedimiento para su produccion.
ZA893075A ZA893075B (en) 1988-04-26 1989-04-26 Aprotinin analogues and process for the production thereof
NZ228896A NZ228896A (en) 1988-04-26 1989-04-26 Aprotinin analogues having a selected inhibition profile against serine proteases, the analogues are produced recombinantly in a suitable yeast strain
NO904622A NO302950B1 (no) 1988-04-26 1990-10-25 Fremgangsmåte for fremstilling av aprotininanaloger
FI905275A FI93964C (fi) 1988-04-26 1990-10-25 Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi
DK257990A DK171417B1 (da) 1988-04-26 1990-10-26 Aprotininalaloger med Ala eller Gly i position 17 og fremgangsmåde til fremstilling deraf
US08/084,718 US5591603A (en) 1987-08-28 1993-06-23 Process for preparing aprotinin and aprotinin analogs in yeast cells
US08/443,977 US5621074A (en) 1987-08-28 1995-05-18 Aprotinin analogs
US08/443,976 US5618915A (en) 1987-08-28 1995-05-18 Aprotinin analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK225488A DK225488D0 (da) 1988-04-26 1988-04-26 Polypeptid

Publications (1)

Publication Number Publication Date
DK225488D0 true DK225488D0 (da) 1988-04-26

Family

ID=8111114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK225488A DK225488D0 (da) 1987-08-28 1988-04-26 Polypeptid

Country Status (14)

Country Link
US (1) US5373090A (da)
EP (1) EP0339942B1 (da)
JP (1) JP2810743B2 (da)
AT (1) ATE103295T1 (da)
AU (1) AU619553B2 (da)
DE (1) DE68914022T2 (da)
DK (1) DK225488D0 (da)
ES (1) ES2061983T3 (da)
FI (1) FI93964C (da)
IE (1) IE64230B1 (da)
NO (1) NO302950B1 (da)
NZ (1) NZ228896A (da)
WO (1) WO1989010374A1 (da)
ZA (1) ZA893075B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP1279731B1 (en) 1991-03-01 2007-05-30 Dyax Corporation Process for the development of binding mini-proteins
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
CA2139945A1 (en) * 1992-07-13 1994-01-20 Ignace Lasters Bovine pancreatic trypsin inhibitor derived inhibitors of factor xa
JPH08504568A (ja) * 1992-09-25 1996-05-21 コルバス・インターナショナル、インコーポレイテッド ウシ膵トリプシン阻害因子から誘導される因子ＶＩＩａ−組織因子複合体の阻害因子
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2375561T3 (es) * 1994-01-11 2012-03-02 Dyax Corporation Inhibidores de la plasmina humana derivados de dominios kunitz y �?cidos nucleicos que codifican los mismos.
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en) * 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE528014T1 (de) 2002-06-07 2011-10-15 Dyax Corp Polypeptid mit modifizierten kunitz domains
CA2496789C (en) 2002-08-28 2013-12-17 Dyax Corp. Methods for preserving organs and tissues
PT1587907E (pt) * 2003-01-07 2011-04-08 Dyax Corp Biblioteca de domínios de kunitz
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
JP4739207B2 (ja) * 2003-08-29 2011-08-03 ダイアックス コーポレーション ポリペグ化されたプロテアーゼインヒビター
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
PL1830924T3 (pl) * 2004-12-23 2013-08-30 Csl Behring Gmbh Zapobieganie tworzeniu i/lub stabilizacji skrzepu
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
PT3459564T (pt) * 2010-01-06 2022-01-31 Takeda Pharmaceuticals Co Proteínas de ligação à calicreína plasmática
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

Also Published As

Publication number Publication date
FI905275A0 (fi) 1990-10-25
WO1989010374A1 (en) 1989-11-02
AU619553B2 (en) 1992-01-30
AU3560389A (en) 1989-11-24
JPH03504009A (ja) 1991-09-05
ZA893075B (en) 1989-12-27
FI93964C (fi) 1995-06-26
IE64230B1 (en) 1995-07-26
EP0339942A3 (en) 1990-05-30
NO904622L (no) 1990-12-18
DE68914022T2 (de) 1994-07-07
EP0339942B1 (en) 1994-03-23
ATE103295T1 (de) 1994-04-15
ES2061983T3 (es) 1994-12-16
NO904622D0 (no) 1990-10-25
IE891334L (en) 1989-10-26
NO302950B1 (no) 1998-05-11
EP0339942A2 (en) 1989-11-02
NZ228896A (en) 1991-08-27
FI93964B (fi) 1995-03-15
DE68914022D1 (de) 1994-04-28
JP2810743B2 (ja) 1998-10-15
US5373090A (en) 1994-12-13

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