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ZA841981B - Compounds for treating hypertension - Google Patents

Compounds for treating hypertension

Info

Publication number
ZA841981B
ZA841981B ZA841981A ZA841981A ZA841981B ZA 841981 B ZA841981 B ZA 841981B ZA 841981 A ZA841981 A ZA 841981A ZA 841981 A ZA841981 A ZA 841981A ZA 841981 B ZA841981 B ZA 841981B
Authority
ZA
South Africa
Prior art keywords
compounds
treating hypertension
hypertension
treating
Prior art date
Application number
ZA841981A
Other languages
English (en)
Inventor
John J Piwinski
John T Suh
Paul Menard
Howard Jones
Edward S Neiss
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of ZA841981B publication Critical patent/ZA841981B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA841981A 1983-03-16 1984-03-16 Compounds for treating hypertension ZA841981B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47580483A 1983-03-16 1983-03-16

Publications (1)

Publication Number Publication Date
ZA841981B true ZA841981B (en) 1984-10-31

Family

ID=23889224

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA841981A ZA841981B (en) 1983-03-16 1984-03-16 Compounds for treating hypertension

Country Status (11)

Country Link
EP (1) EP0121830A3 (xx)
JP (1) JPS59181247A (xx)
KR (1) KR840009072A (xx)
AU (1) AU2580184A (xx)
DK (1) DK156484A (xx)
ES (2) ES8602631A1 (xx)
FI (1) FI841052A (xx)
IL (1) IL71266A0 (xx)
NO (1) NO841024L (xx)
NZ (1) NZ207531A (xx)
ZA (1) ZA841981B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482544A (en) * 1982-11-29 1984-11-13 Usv Pharmaceutical Corporation Compounds for treating hypertension
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
JPS6034993A (ja) * 1983-05-23 1985-02-22 ユーエスヴイー　フアーマシユーテイカル　コーポレーシヨン 高血圧治療用化合物
AU578489B2 (en) * 1984-09-12 1988-10-27 Rorer Pharmaceutical Corporation Proline derivatives
DE3569368D1 (en) * 1984-11-30 1989-05-18 Fisons Plc Angiotensin converting enzyme inhibitors and their production and use as pharmaceuticals
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FR2578543B1 (fr) * 1985-03-11 1988-06-10 Usv Pharma Corp Composes spiro-amidoamino anti-hypertenseurs
ATE62694T1 (de) * 1985-09-16 1991-05-15 Schering Corp Antihypertensive mittel, deren pharmazeutische zusammensetzungen und verfahren zur herstellung von mitteln und zusammensetzungen.
AR033048A1 (es) 2001-03-19 2003-12-03 Kaneka Corp Metodo para la purificacion de la n-(1(s)-etoxicarbonil-3-fenilpropil) -l-alanina
CN105001139B (zh) * 2015-07-08 2018-03-02 南京葆赫生物技术有限公司 一种抗高血压活性肽、其制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
GR75019B (xx) * 1980-09-17 1984-07-12 Univ Miami
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
IN156096B (xx) * 1981-03-19 1985-05-11 Usv Pharma Corp
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
EP0083923B1 (en) * 1982-01-11 1988-10-19 Merck & Co. Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern

Also Published As

Publication number Publication date
DK156484A (da) 1984-09-17
FI841052A0 (fi) 1984-03-15
ES531077A0 (es) 1985-12-16
EP0121830A3 (en) 1986-02-05
IL71266A0 (en) 1984-06-29
ES8704875A1 (es) 1987-05-01
DK156484D0 (da) 1984-03-15
EP0121830A2 (en) 1984-10-17
JPS59181247A (ja) 1984-10-15
FI841052A (fi) 1984-09-17
AU2580184A (en) 1984-09-20
KR840009072A (ko) 1984-12-24
ES545175A0 (es) 1987-05-01
NZ207531A (en) 1986-12-05
NO841024L (no) 1984-09-17
ES8602631A1 (es) 1985-12-16

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