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ZA200803671B - Pyrazine derivatives as sodium channel modulators for the treatment of pain - Google Patents

Pyrazine derivatives as sodium channel modulators for the treatment of pain

Info

Publication number
ZA200803671B
ZA200803671B ZA200803671A ZA200803671A ZA200803671B ZA 200803671 B ZA200803671 B ZA 200803671B ZA 200803671 A ZA200803671 A ZA 200803671A ZA 200803671 A ZA200803671 A ZA 200803671A ZA 200803671 B ZA200803671 B ZA 200803671B
Authority
ZA
South Africa
Prior art keywords
pain
treatment
sodium channel
channel modulators
pyrazine derivatives
Prior art date
Application number
ZA200803671A
Other languages
English (en)
Inventor
Gibson Karl Richard
Glossop Melanie Susanne
Denton Stepen Martin
Poinsard Cedric
Kemp Mark Ian
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of ZA200803671B publication Critical patent/ZA200803671B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
ZA200803671A 2005-11-04 2008-04-25 Pyrazine derivatives as sodium channel modulators for the treatment of pain ZA200803671B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
ZA200803671B true ZA200803671B (en) 2009-03-25

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200803671A ZA200803671B (en) 2005-11-04 2008-04-25 Pyrazine derivatives as sodium channel modulators for the treatment of pain

Country Status (27)

Country Link
US (1) US7572797B2 (xx)
EP (1) EP1945630B1 (xx)
JP (1) JP2009514937A (xx)
KR (1) KR20080066073A (xx)
CN (1) CN101356169A (xx)
AP (1) AP2008004468A0 (xx)
AR (1) AR057855A1 (xx)
AT (1) ATE525372T1 (xx)
AU (1) AU2006310215A1 (xx)
BR (1) BRPI0618129A2 (xx)
CA (1) CA2624621C (xx)
CR (1) CR9954A (xx)
DO (1) DOP2006000243A (xx)
EA (1) EA200801011A1 (xx)
EC (1) ECSP088412A (xx)
ES (1) ES2371932T3 (xx)
GT (1) GT200600475A (xx)
IL (1) IL191059A0 (xx)
MA (1) MA29926B1 (xx)
NL (1) NL2000284C2 (xx)
NO (1) NO20082496L (xx)
PE (1) PE20070715A1 (xx)
TN (1) TNSN08196A1 (xx)
TW (1) TW200804353A (xx)
UY (1) UY29893A1 (xx)
WO (1) WO2007052123A2 (xx)
ZA (1) ZA200803671B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
EP1741708A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
GEP20125379B (en) 2007-05-03 2012-01-10 Pfizer Ltd 2 -pyridine carboxamide derivatives as sodium channel modulators
CA2685952C (en) * 2007-05-03 2012-03-13 Pfizer Limited N- [6-amino-5- (phenyl) pyrazin-2-yl] -isoxazole-4-carboxamide derivatives and related compounds as nav1.8 channel modulators for the treatment of pain
US8614255B2 (en) * 2007-08-21 2013-12-24 Civitas Therapeutics, Inc. Pulmonary pharmaceutical formulations
AU2008334629B2 (en) 2007-12-10 2012-04-12 Novartis Ag Organic compounds
MX2010008818A (es) 2008-02-13 2010-09-07 Eisai R&D Man Co Ltd Derivado de bicicloamina.
EA019819B1 (ru) 2008-05-23 2014-06-30 ПАНМИРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Кристаллическая полиморфная форма с ингибитора белка, активирующего 5-липоксигеназу, фармацевтическая композиция на ее основе и применение в лечении
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) * 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN104520296B (zh) * 2012-04-25 2016-11-16 拉夸里亚创药株式会社 作为ttx-s阻断剂的吡咯并吡啶酮衍生物
EP2951170B1 (en) 2013-02-04 2018-10-24 Janssen Pharmaceutica NV Flap modulators
TWI644899B (zh) * 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
CA2960274A1 (en) * 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamide compounds
EP4275705A3 (en) 2015-02-27 2024-01-17 Calcimedica, Inc. Pancreatitis treatment
JP6738575B2 (ja) * 2015-08-07 2020-08-12 カルシメディカ，インク． 脳卒中および外傷性脳損傷の処置のためのｃｒａｃチャネル阻害剤の使用
GB201801128D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
AU2002343557A1 (en) * 2001-11-21 2003-06-10 Pharmacia And Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
BRPI0415863A (pt) * 2003-10-27 2007-01-09 Astellas Pharma Inc derivados pirazina e seus usos farmacêuticos
ATE437864T1 (de) * 2004-10-22 2009-08-15 Janssen Pharmaceutica Nv Aromatische amide als hemmer der c-fms-kinase

Also Published As

Publication number Publication date
AU2006310215A1 (en) 2007-05-10
JP2009514937A (ja) 2009-04-09
ECSP088412A (es) 2008-05-30
WO2007052123A3 (en) 2007-07-12
EP1945630B1 (en) 2011-09-21
US7572797B2 (en) 2009-08-11
CA2624621A1 (en) 2007-05-10
CR9954A (es) 2008-05-28
US20070105872A1 (en) 2007-05-10
EP1945630A2 (en) 2008-07-23
AP2008004468A0 (en) 2008-06-30
UY29893A1 (es) 2007-06-29
NO20082496L (no) 2008-07-24
IL191059A0 (en) 2008-12-29
WO2007052123A2 (en) 2007-05-10
TNSN08196A1 (fr) 2009-10-30
MA29926B1 (fr) 2008-11-03
NL2000284A1 (nl) 2007-05-07
CN101356169A (zh) 2009-01-28
ES2371932T3 (es) 2012-01-11
DOP2006000243A (es) 2007-05-31
PE20070715A1 (es) 2007-08-11
TW200804353A (en) 2008-01-16
EA200801011A1 (ru) 2009-02-27
GT200600475A (es) 2007-07-06
BRPI0618129A2 (pt) 2011-08-16
AR057855A1 (es) 2007-12-19
ATE525372T1 (de) 2011-10-15
NL2000284C2 (nl) 2007-09-28
CA2624621C (en) 2010-11-30
KR20080066073A (ko) 2008-07-15

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