ZA200801362B - Solid pharmaceutical dosage form - Google Patents
Solid pharmaceutical dosage form Download PDFInfo
- Publication number
- ZA200801362B ZA200801362B ZA200801362A ZA200801362A ZA200801362B ZA 200801362 B ZA200801362 B ZA 200801362B ZA 200801362 A ZA200801362 A ZA 200801362A ZA 200801362 A ZA200801362 A ZA 200801362A ZA 200801362 B ZA200801362 B ZA 200801362B
- Authority
- ZA
- South Africa
- Prior art keywords
- dosage form
- weight
- solid
- surfactant
- water
- Prior art date
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US10/650,178 US20050048112A1 (en) | 2003-08-28 | 2003-08-28 | Solid pharmaceutical dosage form |
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ZA200601718A ZA200601718B (en) | 2003-08-28 | 2006-02-27 | Solid pharmaceutical dosage form |
ZA2008/01361A ZA200801361B (en) | 2003-08-28 | 2008-02-08 | Solid pharmaceutical dosage form |
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ZA200601718A ZA200601718B (en) | 2003-08-28 | 2006-02-27 | Solid pharmaceutical dosage form |
ZA2008/01361A ZA200801361B (en) | 2003-08-28 | 2008-02-08 | Solid pharmaceutical dosage form |
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US (1) | US20050048112A1 (es) |
EP (6) | EP2942051B1 (es) |
JP (6) | JP4815348B2 (es) |
KR (5) | KR101132602B1 (es) |
CN (5) | CN102764244A (es) |
AT (1) | ATE516017T1 (es) |
AU (3) | AU2004283087C1 (es) |
CA (2) | CA2536638C (es) |
CR (3) | CR8256A (es) |
CY (5) | CY1111981T1 (es) |
DK (5) | DK2258345T3 (es) |
EA (4) | EA020992B1 (es) |
EC (1) | ECSP066397A (es) |
ES (5) | ES2608720T3 (es) |
HK (4) | HK1094766A1 (es) |
HR (1) | HRP20110555T1 (es) |
HU (3) | HUE038792T2 (es) |
IL (3) | IL173939A (es) |
ME (2) | MEP17608A (es) |
MX (2) | MX358033B (es) |
NO (3) | NO330282B1 (es) |
NZ (2) | NZ579622A (es) |
PL (5) | PL1663183T3 (es) |
PT (5) | PT2258344E (es) |
RS (2) | RS59969B1 (es) |
SG (3) | SG145690A1 (es) |
SI (5) | SI2258345T1 (es) |
TW (1) | TWI342221B (es) |
UA (1) | UA85564C2 (es) |
WO (1) | WO2005039551A2 (es) |
ZA (3) | ZA200801362B (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1175205B1 (en) * | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US20050048112A1 (en) | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
AU2012202831B2 (en) * | 2005-02-23 | 2015-01-22 | Abbvie Inc. | A solid pharmaceutical dosage formulation |
KR20070025070A (ko) * | 2005-08-31 | 2007-03-08 | 주식회사 대웅제약 | 시부트라민 및 계면활성제를 함유하는 고체분산체 및 그의제조방법 |
ATE482690T1 (de) * | 2005-12-14 | 2010-10-15 | Hoffmann La Roche | Hcv-prodrug-formulierung |
JP5231242B2 (ja) * | 2005-12-14 | 2013-07-10 | シプラ・リミテッド | ヌクレオチド及びヌクレオシド系逆転写酵素阻害剤(テノホビル及びラミブジン)を剤形の異なる部分に含む医薬組合せ |
WO2007087188A2 (en) * | 2006-01-20 | 2007-08-02 | Merck & Co., Inc. | Taste-masked tablets and granules |
EP1832281A1 (en) * | 2006-03-10 | 2007-09-12 | Abbott GmbH & Co. KG | Process for producing a solid dispersion of an active ingredient |
EP1880715A1 (en) * | 2006-07-19 | 2008-01-23 | Abbott GmbH & Co. KG | Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same |
TW200815033A (en) * | 2006-08-10 | 2008-04-01 | Cipla Ltd | Antiretroviral solid oral composition |
WO2008067164A2 (en) | 2006-11-15 | 2008-06-05 | Abbott Laboratories | Solid pharmaceutical dosage formulations |
CN103435570B (zh) | 2007-02-23 | 2015-06-10 | 吉里德科学公司 | 治疗剂的药代动力学特性调节剂 |
GT200800303A (es) * | 2007-12-24 | 2009-09-18 | Combinacion anti-retroviral | |
EP2257279B1 (en) * | 2008-02-28 | 2016-08-17 | AbbVie Inc. | Preparation of tablets |
WO2009153654A1 (en) * | 2008-06-17 | 2009-12-23 | Aurobindo Pharma Limited | Solid dosage forms of antiretrovirals |
ES2598178T5 (es) * | 2008-10-07 | 2023-12-26 | Kudos Pharm Ltd | Formulación farmacéutica 514 |
EP2391350A1 (en) | 2008-12-18 | 2011-12-07 | Ranbaxy Laboratories Limited | Atazanavir formulations |
TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
TWI540132B (zh) | 2009-06-08 | 2016-07-01 | 亞培公司 | Bcl-2族群抑制劑之口服醫藥劑型 |
WO2011013110A1 (en) | 2009-07-31 | 2011-02-03 | Ranbaxy Laboratories Limited | Unit dosage forms of hiv protease inhibitors |
EP2279728A1 (en) | 2009-07-31 | 2011-02-02 | Ranbaxy Laboratories Limited | Solid dosage forms of HIV protease inhibitors |
CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
CA2829186A1 (en) * | 2011-03-07 | 2012-09-13 | Bandi Parthasaradhi Reddy | Amorphous form of lopinavir and ritonavir mixture |
US9096556B2 (en) | 2011-05-27 | 2015-08-04 | Hetero Research Foundation | Amorphous ritonavir co-precipitated |
CA2844827A1 (en) * | 2011-08-16 | 2013-02-21 | Merck Sharp & Dohme Corp. | Use of inorganic matrix and organic polymer combinations for preparing stable amorphous dispersions |
EP2564832A1 (en) | 2011-08-29 | 2013-03-06 | Hexal AG | Solid dosage form of HIV protease inhibitors |
KR101794032B1 (ko) * | 2011-09-21 | 2017-11-07 | (주)바이오시네틱스 | 나노입자 제조방법 |
WO2013131646A1 (en) | 2012-03-07 | 2013-09-12 | Ratiopharm Gmbh | Dosage form comprising lopinavir and ritonavir |
HUE027829T2 (en) | 2012-03-07 | 2016-11-28 | Ratiopharm Gmbh | Dosage forms containing non-crystalline lopinavir and crystalline ritonavir |
CN103655571B (zh) * | 2012-09-11 | 2016-04-20 | 上海星泰医药科技有限公司 | 一种洛匹那韦和利托那韦复方高均匀度纳米共分散体及其制备方法 |
WO2014048783A1 (en) | 2012-09-27 | 2014-04-03 | Basf Se | A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer |
US9744240B2 (en) | 2012-09-27 | 2017-08-29 | Basf Se | Storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin E-derivative and at least one hydrophilic polymer |
WO2014048782A1 (en) | 2012-09-27 | 2014-04-03 | Basf Se | A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer |
US9789063B2 (en) | 2012-09-27 | 2017-10-17 | Basf Se | Storage-stable dust-free homogeneous particulate formulation |
RU2505286C1 (ru) * | 2012-12-29 | 2014-01-27 | Открытое Акционерное Общество "Фармасинтез" | Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения |
RU2543322C1 (ru) * | 2013-09-19 | 2015-02-27 | Открытое Акционерное Общество "Фармасинтез" | Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения |
RU2619840C1 (ru) * | 2016-09-21 | 2017-05-18 | Общество с ограниченной ответственностью "Изварино Фарма" | Фармацевтическая композиция для лечения ВИЧ-инфекции |
RU2659693C1 (ru) * | 2017-06-30 | 2018-07-03 | Общество с ограниченной ответственностью "Изварино Фарма" | Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции |
US20190038754A1 (en) * | 2017-08-07 | 2019-02-07 | SE Tylose, USA, Inc. | Pharmaceutical composition in solid extruded form |
US20190269662A1 (en) * | 2018-03-02 | 2019-09-05 | The University Of Liverpool | Solid compositions of actives, processes for preparing same and uses of such solid compositions |
CN108186578A (zh) * | 2018-03-27 | 2018-06-22 | 聊城大学 | 一种利托那韦固体分散体的制备方法 |
EP3569225A1 (en) | 2018-05-18 | 2019-11-20 | Pharmaceutical Oriented Services Ltd | Solid dispersion containing ritonavir |
TWI799599B (zh) * | 2019-06-06 | 2023-04-21 | 華納國際生物科技股份有限公司 | 醫藥或保健品自乳化固體分散組成物 |
CN114146061B (zh) * | 2020-09-07 | 2023-06-30 | 歌礼生物科技(杭州)有限公司 | 包含固体分散体的蛋白酶抑制剂增效组合物及其制备方法 |
EP4255495A1 (en) | 2020-12-03 | 2023-10-11 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
CN113318076B (zh) * | 2021-06-02 | 2022-09-23 | 聊城大学 | 一种兼具增溶及抑晶效果的利托那韦固体分散体及其制备方法 |
CN114557967B (zh) * | 2022-03-17 | 2023-06-02 | 乐普制药科技有限公司 | 一种利托那韦固体分散体的制备方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2525108B1 (fr) | 1982-04-19 | 1989-05-12 | Elan Corp Ltd | Medicaments a haut degre de solubilite et procede pour leur obtention |
DE3830353A1 (de) | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5696270A (en) * | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
US5542206A (en) | 1994-10-11 | 1996-08-06 | Lisch; Albert | Lure and tackle stacking container |
US5914332A (en) * | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US6232333B1 (en) * | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
US6027747A (en) * | 1997-11-11 | 2000-02-22 | Terracol; Didier | Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions |
DE19841244A1 (de) * | 1998-09-09 | 2000-03-16 | Knoll Ag | Verfahren und Vorrichtung zum Herstellen von Tabletten |
DE60039379D1 (de) | 1999-02-10 | 2008-08-21 | Pfizer Prod Inc | Pharmazeutische feste Dispersionen |
US20030104048A1 (en) * | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
DE19913606A1 (de) | 1999-03-25 | 2000-09-28 | Basf Ag | Pulverförmige Solubilisationshilfsstoffe für feste pharmazeutische Darreichungsformen |
DE19913692A1 (de) | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
ATE429224T1 (de) | 1999-06-04 | 2009-05-15 | Abbott Lab | Arzneizubereitungen enthaltend mindestens einen hiv preoteaseinhibitor |
ATE286720T1 (de) | 1999-11-12 | 2005-01-15 | Abbott Lab | Pharmazeutische formulierungen auf basis fester dispersionen |
EP1175205B1 (en) * | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
MXPA03011922A (es) | 2001-06-22 | 2004-03-26 | Pfizer Prod Inc | Composiciones farmaceuticas que contienen un dispersion solida de un farmaco ligeramente soluble en una matriz y plimero mejorador de solubilidad. |
DE60320940D1 (de) * | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
DE10213242A1 (de) | 2002-03-25 | 2003-10-16 | Abbott Gmbh & Co Kg | Testsystem zur Evaluierung der Kompatibilität biologisch aktiver Substanzen mit Copolymeren |
DE10247037A1 (de) * | 2002-10-09 | 2004-04-22 | Abbott Gmbh & Co. Kg | Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers |
US20050048112A1 (en) | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
WO2008067164A2 (en) | 2006-11-15 | 2008-06-05 | Abbott Laboratories | Solid pharmaceutical dosage formulations |
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2003
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2012
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2013
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2018
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