ZA200503365B - Novel fluoroglycoside heterocyclic derivatives, pharmaceutical products containing said compounds and the use thereof - Google Patents
Novel fluoroglycoside heterocyclic derivatives, pharmaceutical products containing said compounds and the use thereof Download PDFInfo
- Publication number
- ZA200503365B ZA200503365B ZA200503365A ZA200503365A ZA200503365B ZA 200503365 B ZA200503365 B ZA 200503365B ZA 200503365 A ZA200503365 A ZA 200503365A ZA 200503365 A ZA200503365 A ZA 200503365A ZA 200503365 B ZA200503365 B ZA 200503365B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- replaced
- compounds
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 98
- 125000000623 heterocyclic group Chemical group 0.000 title description 5
- 239000000825 pharmaceutical preparation Substances 0.000 title description 3
- 229940127557 pharmaceutical product Drugs 0.000 title description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 50
- 229910052731 fluorine Inorganic materials 0.000 claims description 39
- 239000001257 hydrogen Substances 0.000 claims description 36
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
- 125000004432 carbon atom Chemical group C* 0.000 claims description 32
- 239000004480 active ingredient Substances 0.000 claims description 31
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 30
- -1 COO-(C1-Cp)-alkyl Chemical group 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
- 229910052801 chlorine Inorganic materials 0.000 claims description 20
- 229910052794 bromium Inorganic materials 0.000 claims description 18
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 13
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 10
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- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 229910052740 iodine Inorganic materials 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 8
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- 239000011737 fluorine Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
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DE10258008A DE10258008B4 (de) | 2002-12-12 | 2002-12-12 | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
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