PT1572708E - Novos derivados de fluoroglicosidos heterociclicos, produtos farmaceuticos que contem estes compostos e sua utilizacao - Google Patents

Novos derivados de fluoroglicosidos heterociclicos, produtos farmaceuticos que contem estes compostos e sua utilizacao

Info

Publication number: PT1572708E
Authority: PT; Portugal
Prior art keywords: fluoroglycosides; heterocyclic; compounds; products containing; pharmaceutical products
Prior art date: 2002-12-12

Application number

PT03782250T

Other languages

English (en)

Inventor

Wendelin Frick

Heiner Glombik

Werner Kramer

Hubert Heuer

Brummerhop Harm

Plettenburg Oliver

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-12

Filing date

2003-11-28

Publication date

2006-07-31

2003-11-28 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2006-07-31 Publication of PT1572708E publication Critical patent/PT1572708E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Neurology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)

PT03782250T 2002-12-12 2003-11-28 Novos derivados de fluoroglicosidos heterociclicos, produtos farmaceuticos que contem estes compostos e sua utilizacao PT1572708E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10258008A DE10258008B4 (de)	2002-12-12	2002-12-12	Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel

Publications (1)

Publication Number	Publication Date
PT1572708E true PT1572708E (pt)	2006-07-31

Family

ID=32477575

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT03782250T PT1572708E (pt)	2002-12-12	2003-11-28	Novos derivados de fluoroglicosidos heterociclicos, produtos farmaceuticos que contem estes compostos e sua utilizacao

Country Status (43)

Country	Link
US (2)	US20040259819A1 (pt)
EP (1)	EP1572708B1 (pt)
JP (1)	JP4806193B2 (pt)
KR (1)	KR101160061B1 (pt)
CN (1)	CN1304406C (pt)
AR (1)	AR042437A1 (pt)
AT (1)	ATE323713T1 (pt)
AU (1)	AU2003289911B2 (pt)
BR (1)	BR0317283A (pt)
CA (1)	CA2508226C (pt)
CR (1)	CR7820A (pt)
CY (1)	CY1105621T1 (pt)
DE (2)	DE10258008B4 (pt)
DK (1)	DK1572708T3 (pt)
EC (1)	ECSP055853A (pt)
ES (1)	ES2261993T3 (pt)
GT (1)	GT200300268A (pt)
HK (1)	HK1084123A1 (pt)
HN (1)	HN2003000408A (pt)
HR (1)	HRP20050532A2 (pt)
IL (1)	IL168876A (pt)
JO (1)	JO2353B1 (pt)
MA (1)	MA27560A1 (pt)
ME (1)	MEP40908A (pt)
MX (1)	MXPA05005821A (pt)
MY (1)	MY139302A (pt)
NO (1)	NO330299B1 (pt)
NZ (1)	NZ540695A (pt)
OA (1)	OA12972A (pt)
PA (1)	PA8592301A1 (pt)
PE (1)	PE20040771A1 (pt)
PL (1)	PL212080B1 (pt)
PT (1)	PT1572708E (pt)
RS (1)	RS50908B (pt)
RU (1)	RU2339641C2 (pt)
SI (1)	SI1572708T1 (pt)
SV (1)	SV2004001690A (pt)
TN (1)	TNSN05160A1 (pt)
TW (1)	TWI320044B (pt)
UA (1)	UA81136C2 (pt)
UY (1)	UY28122A1 (pt)
WO (1)	WO2004052903A1 (pt)
ZA (1)	ZA200503365B (pt)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1020944C (zh)	1990-01-30	1993-05-26	阿图尔-费希尔股份公司费希尔厂	紧固件
DE10308353A1 (de)	2003-02-27	2004-12-02	Aventis Pharma Deutschland Gmbh	Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8785403B2 (en)	2003-08-01	2014-07-22	Mitsubishi Tanabe Pharma Corporation	Glucopyranoside compound
MXPA06001274A (es)	2003-08-01	2006-04-11	Tanabe Seiyaku Co	Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
ME01422B (me)	2004-03-16	2013-12-20	Boehringer Ingelheim Int	Derivati benzola supstituisani glukopiranozilom, ljekovi koji sadrže navedena jedinjenja, njihova primjena i njihov postupak proizvodnje
DE102004028241B4 (de) *	2004-06-11	2007-09-13	Sanofi-Aventis Deutschland Gmbh	Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel
US7393836B2 (en)	2004-07-06	2008-07-01	Boehringer Ingelheim International Gmbh	D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200606129A (en)	2004-07-26	2006-02-16	Chugai Pharmaceutical Co Ltd	Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
JP2008508213A (ja) *	2004-07-27	2008-03-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｄ−グルコピラノシル−フェニル置換環状体、そのような化合物を含有する医薬品、それらの使用及びその製造方法
WO2006054629A1 (ja)	2004-11-18	2006-05-26	Kissei Pharmaceutical Co., Ltd.	１－置換－３－（β－Ｄ－グリコピラノシル）含窒素ヘテロ環化合物、及びそれを含有する医薬
TW200635599A (en)	2004-12-16	2006-10-16	Boehringer Ingelheim Int	Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200637869A (en)	2005-01-28	2006-11-01	Chugai Pharmaceutical Co Ltd	The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
AR053329A1 (es) *	2005-01-31	2007-05-02	Tanabe Seiyaku Co	Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
TWI365186B (en)	2005-01-31	2012-06-01	Mitsubishi Tanabe Pharma Corp	Indole derivatives
JP5073948B2 (ja) *	2005-01-31	2012-11-14	田辺三菱製薬株式会社	医薬組成物
DE602006009772D1 (de)	2005-02-23	2009-11-26	Boehringer Ingelheim Int	Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2)
CA2605245A1 (en)	2005-04-15	2006-10-19	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors
UA91546C2 (uk)	2005-05-03	2010-08-10	Бьорінгер Інгельхайм Інтернаціональ Гмбх	КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
US7723309B2 (en)	2005-05-03	2010-05-25	Boehringer Ingelheim International Gmbh	Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7772191B2 (en)	2005-05-10	2010-08-10	Boehringer Ingelheim International Gmbh	Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
DE102005026762A1 (de)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
ATE468347T1 (de)	2005-07-27	2010-06-15	Boehringer Ingelheim Int	Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)- benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters (sglt)
CA2620566A1 (en)	2005-08-30	2007-03-08	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
KR20080053369A (ko)	2005-09-08	2008-06-12	베링거 인겔하임 인터내셔날 게엠베하	1-클로로-4-(β-Ｄ-글루코피라노스-1-일)-2-(4-에티닐-벤질)-벤젠의 결정형, 이의 제조 방법 및 약제 제조를 위한이의 용도
AR056195A1 (es)	2005-09-15	2007-09-26	Boehringer Ingelheim Int	Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
TW200801029A (en)	2006-02-15	2008-01-01	Boehringer Ingelheim Int	Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
PE20080697A1 (es)	2006-05-03	2008-08-05	Boehringer Ingelheim Int	Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
US7803778B2 (en) *	2006-05-23	2010-09-28	Theracos, Inc.	Glucose transport inhibitors and methods of use
DE102006028862A1 (de)	2006-06-23	2007-12-27	Merck Patent Gmbh	3-Amino-imidazo[1,2-a]pyridinderivate
TWI418556B (zh)	2006-07-27	2013-12-11	Mitsubishi Tanabe Pharma Corp	吲哚衍生物
US20080027014A1 (en) *	2006-07-28	2008-01-31	Tanabe Seiyaku Co., Ltd.	Novel SGLT inhibitors
CA2666193A1 (en)	2006-08-08	2008-02-14	Sanofi-Aventis	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
WO2008020011A1 (en)	2006-08-15	2008-02-21	Boehringer Ingelheim International Gmbh	Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
TWI499414B (zh)	2006-09-29	2015-09-11	Lexicon Pharmaceuticals Inc	鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ２）的抑制物與其應用方法
EP2086991A1 (en)	2006-10-27	2009-08-12	Boehringer Ingelheim International GmbH	CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
DE102006053637B4 (de)	2006-11-14	2011-06-30	Sanofi-Aventis Deutschland GmbH, 65929	Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
UY30730A1 (es)	2006-12-04	2008-07-03	Mitsubishi Tanabe Pharma Corp	Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
EP2099791B1 (en)	2006-12-04	2012-11-21	Janssen Pharmaceutica, N.V.	Thienyl-containing glycopyranosyl derivatives as antidiabetics
US7795228B2 (en) *	2006-12-28	2010-09-14	Theracos, Inc.	Spiroheterocyclic glycosides and methods of use
DE102007008420A1 (de)	2007-02-21	2008-08-28	Merck Patent Gmbh	Benzimidazolderivate
WO2008109591A1 (en) *	2007-03-08	2008-09-12	Lexicon Pharmaceuticals, Inc.	Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20090938A1 (es)	2007-08-16	2009-08-08	Boehringer Ingelheim Int	Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
MY162628A (en)	2007-09-10	2017-06-30	Janssen Pharmaceutica Nv	Process for the preparation of compounds useful as inhibitors of sglt
DE102007048716A1 (de)	2007-10-11	2009-04-23	Merck Patent Gmbh	Imidazo[1,2-a]pyrimidinderivate
JP5272395B2 (ja) *	2007-12-12	2013-08-28	セントラル硝子株式会社	４−デオキシ−４−フルオロ−ｄ−グルコース誘導体の製造方法
UA101004C2 (en)	2007-12-13	2013-02-25	Теракос, Инк.	Derivatives of benzylphenylcyclohexane and use thereof
CL2008003653A1 (es)	2008-01-17	2010-03-05	Mitsubishi Tanabe Pharma Corp	Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
DE102008017590A1 (de)	2008-04-07	2009-10-08	Merck Patent Gmbh	Glucopyranosidderivate
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
RU2530494C2 (ru)	2008-08-22	2014-10-10	Теракос, Инк.	Способ получения ингибиторов sglt2
EP2334687B9 (en) *	2008-08-28	2012-08-08	Pfizer Inc.	Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
US9056850B2 (en)	2008-10-17	2015-06-16	Janssen Pharmaceutica N.V.	Process for the preparation of compounds useful as inhibitors of SGLT
WO2010066643A1 (de) *	2008-12-08	2010-06-17	Sanofi-Aventis	Verfahren zur herstellung von 4-fluoro-4-desoxy-alpha-d-glucopyranoside
WO2010066690A1 (en) *	2008-12-08	2010-06-17	Sanofi-Aventis	A novel crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2010068605A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	Novel polymorphic forms of 4-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)-1h-pyrazole-3-yl]4-deoxy-4-fluoro-beta-d-glucopyranoside including hydrates thereof and the preparations thereof
WO2010068601A1 (en) *	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2010077623A1 (en)	2008-12-08	2010-07-08	Sanofi-Aventis	Intermediates and processes for the preparation of fluoroglycoside derivatives
EA022349B1 (ru)	2009-02-13	2015-12-30	Бёрингер Ингельхайм Интернациональ Гмбх	Фармацевтическая композиция, включающая ингибитор sglt2, ингибитор дпп-iv и другой антидиабетический агент, и ее применение
US20110009347A1 (en)	2009-07-08	2011-01-13	Yin Liang	Combination therapy for the treatment of diabetes
SI2451797T1 (sl)	2009-07-10	2013-07-31	Janssen Pharmaceutica, N.V.	Postopek kristalizacije 1-(beta-d-glukopiranosil)-4-metil-3-(5-(4-fluorofenil)-2-tienilmetil) benzena
EP2298782A1 (en)	2009-08-26	2011-03-23	Sanofi-Aventis	Method for producing pyrazole glycoside derivatives
SG178880A1 (en)	2009-08-26	2012-04-27	Sanofi Sa	Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EA022032B1 (ru)	2009-09-30	2015-10-30	Бёрингер Ингельхайм Интернациональ Гмбх	Способ получения глюкопиранозилзамещенных производных бензилбензола
WO2011039107A1 (en)	2009-09-30	2011-04-07	Boehringer Ingelheim International Gmbh	Method for the preparation of a crystalline form of 1-chloro-4- (beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)benzyl)benzene
UY32919A (es)	2009-10-02	2011-04-29	Boehringer Ingelheim Int	Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
JP2013506635A (ja) *	2009-10-02	2013-02-28	サノフイ	骨疾患を処置するための薬剤を製造するためのｓｇｌｔ−１／ｓｇｌｔ−２阻害剤活性を有する化合物の使用
NZ599306A (en)	2009-10-14	2014-06-27	Janssen Pharmaceutica Nv	Process for the preparation of compounds useful as inhibitors of sglt2
US8163704B2 (en)	2009-10-20	2012-04-24	Novartis Ag	Glycoside derivatives and uses thereof
PL2496583T3 (pl)	2009-11-02	2015-04-30	Pfizer	Pochodne dioksabicyklo[3.2.1]oktano-2,3,4-triolowe
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011143296A1 (en)	2010-05-11	2011-11-17	Janssen Pharmaceutica Nv	Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
WO2011153712A1 (en)	2010-06-12	2011-12-15	Theracos, Inc.	Crystalline form of benzylbenzene sglt2 inhibitor
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
AR085689A1 (es)	2011-03-07	2013-10-23	Boehringer Ingelheim Int	Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2
US8710050B2 (en)	2011-03-08	2014-04-29	Sanofi	Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en)	2011-03-08	2014-10-28	Sanofi	Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809324B2 (en)	2011-03-08	2014-08-19	Sanofi	Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683701B1 (de)	2011-03-08	2014-12-24	Sanofi	Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683703B1 (de)	2011-03-08	2015-05-27	Sanofi	Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683705B1 (de)	2011-03-08	2015-04-22	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de)	2011-03-08	2012-09-13	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8809325B2 (en)	2011-03-08	2014-08-19	Sanofi	Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
PT2697218T (pt)	2011-04-13	2016-07-13	Janssen Pharmaceutica Nv	Processo para preparação de compostos úteis como inibidores da sglt2
US9035044B2 (en)	2011-05-09	2015-05-19	Janssen Pharmaceutica Nv	L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
WO2012176804A1 (ja) *	2011-06-20	2012-12-27	キッセイ薬品工業株式会社	グルコピラノシルオキシピラゾール誘導体
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US9192617B2 (en)	2012-03-20	2015-11-24	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US9193751B2 (en)	2012-04-10	2015-11-24	Theracos, Inc.	Process for the preparation of benzylbenzene SGLT2 inhibitors
EP2774619B1 (de)	2013-03-04	2016-05-18	BioActive Food GmbH	Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
ES2702174T3 (es)	2013-04-05	2019-02-27	Boehringer Ingelheim Int	Usos terapéuticos de empagliflozina
US20140303097A1 (en)	2013-04-05	2014-10-09	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en)	2013-04-05	2023-11-14	Boehringer Ingelheim International Gmbh	Pharmaceutical composition, methods for treating and uses thereof
CN105377266A (zh)	2013-04-18	2016-03-02	勃林格殷格翰国际有限公司	药物组合物、治疗方法及其用途
CN105611920B (zh)	2013-10-12	2021-07-16	泰拉科斯萨普有限责任公司	羟基-二苯甲烷衍生物的制备
EP2944311A1 (de)	2014-05-16	2015-11-18	BioActive Food GmbH	Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
US20170071970A1 (en)	2015-09-15	2017-03-16	Janssen Pharmaceutica Nv	Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2663336B1 (fr) *	1990-06-18	1992-09-04	Adir	Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK0850948T3 (da) *	1996-12-26	2002-07-29	Tanabe Seiyaku Co	Propiophenonderivater og fremgangsmåde til fremstilling deraf
JP3055135B2 (ja) *	1996-12-26	2000-06-26	田辺製薬株式会社	プロピオフェノン誘導体及びその製法
WO1998031392A1 (fr) *	1997-01-17	1998-07-23	Drug Delivery System Institute, Ltd.	Medicaments nephrotropiques
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
JP2000080041A (ja) *	1998-03-09	2000-03-21	Tanabe Seiyaku Co Ltd	医薬組成物
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19845405C2 (de) *	1998-10-02	2000-07-13	Aventis Pharma Gmbh	Arylsubstituierte Propanolaminderivate und deren Verwendung
TR200201082T2 (tr) *	1999-08-31	2002-07-22	Kissei Pharmaceutical Co., Ltd.	Glikopriranoziloksipirazol türevleri
WO2001016094A1 (de) *	1999-09-01	2001-03-08	Aventis Pharma Deutschland Gmbh	Sulfonylcarboxamidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PH12000002657B1 (en) *	1999-10-12	2006-02-21	Bristol Myers Squibb Co	C-aryl glucoside SGLT2 inhibitors
ATE312114T1 (de) *	2000-03-17	2005-12-15	Kissei Pharmaceutical	Glucopyranosyloxy-benzylbenzen-derivate, medizinische zusammensetzung und zwischenprodukte für die herstellung der derivate
US6683056B2 (en) *	2000-03-30	2004-01-27	Bristol-Myers Squibb Company	O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) *	2000-03-30	2003-04-29	Bristol-Myers Squibb Company	O-glucosylated benzamide SGLT2 inhibitors and method
DK1277736T3 (da) *	2000-04-28	2007-10-01	Asahi Kasei Pharma Corp	Hidtil ukendte bicykliske forbindelser
WO2002002539A1 (en) *	2000-06-29	2002-01-10	Abbott Laboratories	Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
JP3798375B2 (ja) *	2000-09-29	2006-07-19	キッセイ薬品工業株式会社	グルコピラノシルオキシベンジルベンゼン誘導体およびそれを含有する医薬組成物
EP2163555A1 (en) *	2000-11-02	2010-03-17	Ajinomoto Co., Inc.	New pyrazole derivatives and diabetic medicine containing them
CA2429833A1 (en) *	2000-11-30	2002-06-06	Kissei Pharmaceutical Co., Ltd.	Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
DE60230591D1 (de) *	2001-02-26	2009-02-12	Kissei Pharmaceutical	Glykopyranosyloxypyrazolderivate und deren medizinische verwendung
WO2002068440A1 (fr) *	2001-02-27	2002-09-06	Kissei Pharmaceutical Co., Ltd.	Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci
US20030045553A1 (en) *	2001-04-04	2003-03-06	Bussolari Jacqueline C.	Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
CN100384430C (zh) *	2001-04-04	2008-04-30	奥索-麦克尼尔药品公司	含有葡萄糖重吸收抑制剂和维生素a类-x受体调节剂的联合治疗
JP4399251B2 (ja) *	2001-05-30	2010-01-13	キッセイ薬品工業株式会社	グルコピラノシルオキシピラゾール誘導体、それを含有する医薬組成物、その医薬用途およびその製造中間体
DK1425014T3 (da) *	2001-08-31	2007-04-10	Sanofi Aventis Deutschland	Diarylcycloalkylderivater, fremgangsmåde til deres fremstilling og deres anvendelse som PPAR-aktivatorer
US6884812B2 (en) *	2001-08-31	2005-04-26	Aventis Pharma Deutschland Gmbh	Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
US7399777B2 (en) *	2001-08-31	2008-07-15	Sanofi-Aventis Deutschland Gmbh	Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals
DE10231370B4 (de) *	2002-07-11	2006-04-06	Sanofi-Aventis Deutschland Gmbh	Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de) *	2002-12-12	2006-02-09	Sanofi-Aventis Deutschland Gmbh	Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel

2002
- 2002-12-12 DE DE10258008A patent/DE10258008B4/de not_active Expired - Fee Related
2003
- 2003-11-28 ES ES03782250T patent/ES2261993T3/es not_active Expired - Lifetime
- 2003-11-28 PT PT03782250T patent/PT1572708E/pt unknown
- 2003-11-28 DE DE50303067T patent/DE50303067D1/de not_active Expired - Lifetime
- 2003-11-28 KR KR1020057010457A patent/KR101160061B1/ko not_active IP Right Cessation
- 2003-11-28 CN CNB2003801057098A patent/CN1304406C/zh not_active Expired - Fee Related
- 2003-11-28 OA OA1200500177A patent/OA12972A/en unknown
- 2003-11-28 UA UAA200506789A patent/UA81136C2/uk unknown
- 2003-11-28 DK DK03782250T patent/DK1572708T3/da active
- 2003-11-28 PL PL375790A patent/PL212080B1/pl unknown
- 2003-11-28 WO PCT/EP2003/013455 patent/WO2004052903A1/de active IP Right Grant
- 2003-11-28 AT AT03782250T patent/ATE323713T1/de active
- 2003-11-28 RU RU2005121893/04A patent/RU2339641C2/ru not_active IP Right Cessation
- 2003-11-28 BR BR0317283-0A patent/BR0317283A/pt not_active IP Right Cessation
- 2003-11-28 ME MEP-409/08A patent/MEP40908A/xx unknown
- 2003-11-28 NZ NZ540695A patent/NZ540695A/en not_active IP Right Cessation
- 2003-11-28 JP JP2004557953A patent/JP4806193B2/ja not_active Expired - Fee Related
- 2003-11-28 AU AU2003289911A patent/AU2003289911B2/en not_active Ceased
- 2003-11-28 CA CA2508226A patent/CA2508226C/en not_active Expired - Fee Related
- 2003-11-28 EP EP03782250A patent/EP1572708B1/de not_active Expired - Lifetime
- 2003-11-28 RS YUP-2005/0432A patent/RS50908B/sr unknown
- 2003-11-28 MX MXPA05005821A patent/MXPA05005821A/es active IP Right Grant
- 2003-11-28 SI SI200330284T patent/SI1572708T1/sl unknown
- 2003-12-03 GT GT200300268A patent/GT200300268A/es unknown
- 2003-12-09 JO JO2003167A patent/JO2353B1/en active
- 2003-12-10 TW TW092134766A patent/TWI320044B/zh not_active IP Right Cessation
- 2003-12-10 HN HN2003000408A patent/HN2003000408A/es unknown
- 2003-12-10 PE PE2003001249A patent/PE20040771A1/es not_active Application Discontinuation
- 2003-12-11 MY MYPI20034745A patent/MY139302A/en unknown
- 2003-12-11 AR ARP030104574A patent/AR042437A1/es unknown
- 2003-12-12 PA PA20038592301A patent/PA8592301A1/es unknown
- 2003-12-12 UY UY28122A patent/UY28122A1/es unknown
- 2003-12-12 SV SV2003001690A patent/SV2004001690A/es active IP Right Grant
- 2003-12-12 US US10/734,573 patent/US20040259819A1/en not_active Abandoned
2005
- 2005-04-26 ZA ZA200503365A patent/ZA200503365B/en unknown
- 2005-05-02 CR CR7820A patent/CR7820A/es unknown
- 2005-05-30 IL IL168876A patent/IL168876A/en not_active IP Right Cessation
- 2005-06-10 EC EC2005005853A patent/ECSP055853A/es unknown
- 2005-06-10 HR HR20050532A patent/HRP20050532A2/xx not_active Application Discontinuation
- 2005-06-10 MA MA28327A patent/MA27560A1/fr unknown
- 2005-06-10 TN TNP2005000160A patent/TNSN05160A1/en unknown
- 2005-06-30 NO NO20053201A patent/NO330299B1/no not_active IP Right Cessation
2006
- 2006-04-07 HK HK06104254A patent/HK1084123A1/xx not_active IP Right Cessation
- 2006-06-21 CY CY20061100833T patent/CY1105621T1/el unknown
2010
- 2010-05-25 US US12/786,943 patent/US20100261664A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2261993T3 (es)	2006-11-16
PL212080B1 (pl)	2012-08-31
PL375790A1 (en)	2005-12-12
UY28122A1 (es)	2004-07-30
JP2006510644A (ja)	2006-03-30
EP1572708B1 (de)	2006-04-19
NO20053201L (no)	2005-08-04
JP4806193B2 (ja)	2011-11-02
RU2005121893A (ru)	2006-01-20
CY1105621T1 (el)	2010-12-22
AU2003289911B2 (en)	2009-09-17
CA2508226C (en)	2011-12-20
CA2508226A1 (en)	2004-06-24
DE10258008A1 (de)	2004-07-08
ZA200503365B (en)	2006-11-29
MXPA05005821A (es)	2005-08-29
DK1572708T3 (da)	2006-08-21
US20100261664A1 (en)	2010-10-14
IL168876A (en)	2010-06-30
ATE323713T1 (de)	2006-05-15
AU2003289911A1 (en)	2004-06-30
TNSN05160A1 (en)	2007-05-14
HK1084123A1 (en)	2006-07-21
NO20053201D0 (no)	2005-06-30
NO330299B1 (no)	2011-03-28
PA8592301A1 (es)	2004-07-26
ECSP055853A (es)	2005-09-20
HRP20050532A2 (en)	2006-09-30
NZ540695A (en)	2007-02-23
MA27560A1 (fr)	2005-10-03
RS20050432A (en)	2007-06-04
MEP40908A (en)	2011-02-10
TW200418870A (en)	2004-10-01
JO2353B1 (en)	2006-12-12
SV2004001690A (es)	2004-03-19
RS50908B (sr)	2010-08-31
DE50303067D1 (de)	2006-05-24
MY139302A (en)	2009-09-30
WO2004052903A1 (de)	2004-06-24
KR101160061B1 (ko)	2012-06-26
BR0317283A (pt)	2005-11-08
KR20050085482A (ko)	2005-08-29
US20040259819A1 (en)	2004-12-23
PE20040771A1 (es)	2005-01-21
GT200300268A (es)	2004-03-03
TWI320044B (en)	2010-02-01
EP1572708A1 (de)	2005-09-14
AR042437A1 (es)	2005-06-22
HN2003000408A (es)	2006-01-07
RU2339641C2 (ru)	2008-11-27
SI1572708T1 (sl)	2006-08-31
DE10258008B4 (de)	2006-02-02
CN1304406C (zh)	2007-03-14
CN1723214A (zh)	2006-01-18
CR7820A (es)	2008-11-25
OA12972A (en)	2006-10-13
UA81136C2 (en)	2007-12-10

Publication	Publication Date	Title
PT1572708E (pt)	2006-07-31	Novos derivados de fluoroglicosidos heterociclicos, produtos farmaceuticos que contem estes compostos e sua utilizacao
NO20043733L (no)	2004-10-20	Aryl-5-tio-Β-D-glukopyranosid-derivater og legemidler for diabetes inneholdende de samme
IL163831A0 (en)	2005-12-18	Derivatives of aminoindazoles, method of preparation and intermediates of the method as drugs pharmaceutical compounds containing
PT1307457E (pt)	2004-08-31	Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos
NO20021689L (no)	2002-05-30	5-leddede heterocykliske derivater, fremstilling derav og anvendelse som medikamenter
NO20043702L (no)	2004-12-03	8-azaprostaglandinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel
NO20052855D0 (no)	2005-06-13	Fosfonoksykinazolinderivater og farmasoytisk anvendelse derav.
NO20054244D0 (no)	2005-09-13	Nitrogeninneholdende heterocykliske derivater og legemidler inneholdende de samme som den aktive bestanddel
CY2017048I1 (el)	2018-09-05	Νεες φαρμακευτικες χρησεις των παραγωγων σταυροσπορινης
EE200200357A (et)	2003-10-15	Ravimaine suurenenud kontsentratsioone andvad farmatseutilised kompositsioonid
NO20051645L (no)	2005-05-19	Nye aminoindozolderivater som medisin og farmakologiske preparater inneholdende disse
DK1498411T3 (da)	2013-04-15	Diketohydrazinderivatforbindelser og medikamenter indeholdende forbindelserne som den aktive bestanddel
NO20053212L (no)	2005-08-04	Nye aromatiske fluorglukosidderivater, farmasoytiske produkter inneholdende disse forbindelser og anvendelse derav.
EE200300077A (et)	2004-12-15	Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks
EE200300311A (et)	2003-10-15	Ftalasinoon-piperidinoderivaadid, nende kasutamine ja ravim
PT1083171E (pt)	2004-09-30	Derivados de pirazolina sua preparacao e aplicacao como medicamentos
EE200300207A (et)	2003-08-15	Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
PT1119557E (pt)	2004-04-30	Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos
EP1513825A4 (en)	2011-01-05	ANTITU-CULINARY MEDICAMENT: COMPOSITIONS AND METHODS
DK1702917T3 (da)	2017-11-13	Amidderivat og medicin
NO20043866L (no)	2004-09-15	Farmasoytisk formulering av IRESSA omfattende et vannopploselig cellulosederivat
PT973763E (pt)	2003-10-31	Novos derivados do 2-(iminometil)amino-fenilo, sua preparacao, sua aplicacao na qualidade de medicamentos e composicoes farmaceuticas que os contem
NO20055652D0 (no)	2005-11-30	Laktatinneholdende farmasoytisk preparat og anvendelse av dette
ATE271036T1 (de)	2004-07-15	Perindoprilsalz und dieses enthaltende arzneimittel
PT1230230E (pt)	2003-12-31	Derivados de indeno-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorexigenico