ZA200409823B - Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof - Google Patents

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof Download PDF

Info

Publication number: ZA200409823B
Authority: ZA; South Africa
Prior art keywords: formula; methyl; compound; pyridyl; trifluoromethyl
Prior art date: 2002-06-07

Application number

ZA200409823A

Other languages

English (en)

Inventor

Francoise Bono

Miachel Bosch

Victor Dos Santos

Jean M Herbert

Dino Nisato

Bernard Tonnerre

Jean Wagnon

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-07

Filing date

2004-12-03

Publication date

2006-07-26

2004-12-03 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2006-07-26 Publication of ZA200409823B publication Critical patent/ZA200409823B/en

Links

238000002360 preparation method Methods 0.000 title claims description 10
230000001225 therapeutic effect Effects 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 155
-1 trifluoromethoxy radical Chemical class 0.000 claims description 94
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 30
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
125000000217 alkyl group Chemical group 0.000 claims description 23
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 22
239000002253 acid Substances 0.000 claims description 22
238000000034 method Methods 0.000 claims description 22
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 22
125000004432 carbon atom Chemical group C* 0.000 claims description 21
229910052801 chlorine Inorganic materials 0.000 claims description 20
125000005843 halogen group Chemical group 0.000 claims description 19
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 18
229910052799 carbon Inorganic materials 0.000 claims description 18
238000007792 addition Methods 0.000 claims description 17
WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 claims description 16
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
239000012453 solvate Substances 0.000 claims description 14
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150000001412 amines Chemical group 0.000 claims description 10
229910052757 nitrogen Inorganic materials 0.000 claims description 10
125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
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HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 5
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DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 claims description 5
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125000004429 atom Chemical group 0.000 claims description 4
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ZA200409823A 2002-06-07 2004-12-03 Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof ZA200409823B (en)

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FR0207001		2002-06-07

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2003
- 2003-05-06 UA UA20041210010A patent/UA77526C2/uk unknown
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- 2003-06-05 DE DE60307632T patent/DE60307632T2/de not_active Expired - Lifetime
- 2003-06-05 US US10/516,808 patent/US7294628B2/en not_active Expired - Lifetime
- 2003-06-05 PT PT03757108T patent/PT1513835E/pt unknown
- 2003-06-05 EA EA200401470A patent/EA007501B1/ru not_active IP Right Cessation
- 2003-06-05 CN CNB038188082A patent/CN100448875C/zh not_active Expired - Fee Related
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- 2003-06-05 AT AT03757108T patent/ATE336491T1/de active
- 2003-06-05 WO PCT/FR2003/001685 patent/WO2003104225A1/fr active IP Right Grant
- 2003-06-05 EP EP03757108A patent/EP1513835B1/fr not_active Expired - Lifetime
- 2003-06-05 DK DK03757109T patent/DK1513836T3/da active
- 2003-06-05 EP EP03757109A patent/EP1513836B1/fr not_active Expired - Lifetime
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2004
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Also Published As

Publication number	Publication date
TW200400185A (en)	2004-01-01
CA2487840C (en)	2011-05-17
US7294628B2 (en)	2007-11-13
RS20050014A (en)	2007-06-04
MEP11508A (en)	2010-06-10
AR040246A1 (es)	2005-03-23
US20060167007A1 (en)	2006-07-27
ES2264001T3 (es)	2006-12-16
KR100970812B1 (ko)	2010-07-16
AU2003255644B2 (en)	2009-02-05
JP4441401B2 (ja)	2010-03-31
PT1513835E (pt)	2006-12-29
BR0311828A (pt)	2005-03-29
IS7579A (is)	2004-12-02
TWI283671B (en)	2007-07-11
CY1107330T1 (el)	2012-11-21
DE60307632D1 (de)	2006-09-28
AU2003255645A1 (en)	2003-12-22
EP1513836B1 (fr)	2006-05-03
JP4437075B2 (ja)	2010-03-24
PT1513836E (pt)	2006-09-29
DE60307632T2 (de)	2007-08-09
PL208711B1 (pl)	2011-05-31
KR20050008802A (ko)	2005-01-21
DE60305037D1 (de)	2006-06-08
US7468368B2 (en)	2008-12-23
NO20045331L (no)	2005-03-07
TWI319400B (en)	2010-01-11
NZ537044A (en)	2006-08-31
DK1513836T3 (da)	2006-09-11
US20050176722A1 (en)	2005-08-11
HRP20041157A2 (en)	2005-06-30
JP2005534661A (ja)	2005-11-17
EP1513835B1 (fr)	2006-08-16
PL374729A1 (pl)	2005-10-31
ATE325122T1 (de)	2006-06-15
EP1513836A1 (fr)	2005-03-16
JP2005533051A (ja)	2005-11-04
NO329669B1 (no)	2010-11-29
EA007501B1 (ru)	2006-10-27
MA27233A1 (fr)	2005-02-01
IS2302B (is)	2007-10-15
CA2487840A1 (en)	2003-12-18
DK1513835T3 (da)	2006-12-27
CY1105784T1 (el)	2011-02-02
ATE336491T1 (de)	2006-09-15
WO2003104225A1 (fr)	2003-12-18
HK1076110A1 (en)	2006-01-06
CN100448875C (zh)	2009-01-07
AU2003255644A1 (en)	2003-12-22
MXPA04012341A (es)	2005-09-30
WO2003104226A1 (fr)	2003-12-18
DE60305037T2 (de)	2006-12-14
CN1675203A (zh)	2005-09-28
EP1513835A1 (fr)	2005-03-16
RS52588B (en)	2013-04-30
ES2271637T3 (es)	2007-04-16
EA200401470A1 (ru)	2005-06-30
UA77526C2 (en)	2006-12-15
HRP20041157B1 (en)	2012-11-30
TW200407321A (en)	2004-05-16
AR040247A1 (es)	2005-03-23

Publication	Publication Date	Title
ZA200409823B (en)	2006-07-26	Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof
AU2004227943A1 (en)	2004-10-21	Novel compounds and compositions as protein kinase inhibitors
AU740360B2 (en)	2001-11-01	Indazole amide compounds as serotoninergic agents
US7423039B2 (en)	2008-09-09	(4-phenylpiperazin-1-yl)acylpiperidine derivatives, preparation thereof and application of same in therapeutics
CN113185452A (zh)	2021-07-30	脲衍生物或其药用盐
US20100240670A1 (en)	2010-09-23	4-[(arylmethyl)aminomethyl]piperidine derivatives, their preparation and their therapeutic application
KR101230851B1 (ko)	2013-02-07	세포사멸 유도 활성을 갖는 이미다조피라진온 유도체
IL165420A (en)	2010-06-30	Piperazinylacylpiperidine and homopiperazinylacylpiperidine derivatives, their preparation and their use in the preparation of medicaments