ZA200209776B - Colchinol derivatives as vascular damaging agents. - Google Patents

Info

Publication number

ZA200209776B

ZA200209776B ZA200209776A ZA200209776A ZA200209776B ZA 200209776 B ZA200209776 B ZA 200209776B ZA 200209776 A ZA200209776 A ZA 200209776A ZA 200209776 A ZA200209776 A ZA 200209776A ZA 200209776 B ZA200209776 B ZA 200209776B

Authority

ZA

South Africa

Prior art keywords

alkyl

salkyl

formula

carbamoyl

group

Prior art date

2000-07-07

Links

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• 230000002792 vascular Effects 0.000 title claims description 20
• 230000000254 damaging effect Effects 0.000 title claims description 18
• HSDSUBIABLFGDX-AWEZNQCLSA-N (7s)-7-amino-1,2,3-trimethoxy-6,7-dihydro-5h-dibenzo[5,3-b:1',2'-e][7]annulen-9-ol Chemical class C1C[C@H](N)C2=CC(O)=CC=C2C2=C1C=C(OC)C(OC)=C2OC HSDSUBIABLFGDX-AWEZNQCLSA-N 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims description 161
• -1 hydroxy, phosphoryloxy Chemical group 0.000 claims description 161
• 125000000217 alkyl group Chemical group 0.000 claims description 119
• 125000001424 substituent group Chemical group 0.000 claims description 92
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 78
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• 229940002612 prodrug Drugs 0.000 claims description 47
• 239000000651 prodrug Substances 0.000 claims description 47
• 239000012453 solvate Substances 0.000 claims description 43
• 229910052757 nitrogen Inorganic materials 0.000 claims description 41
• 238000000034 method Methods 0.000 claims description 38
• 238000011282 treatment Methods 0.000 claims description 35
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 33
• 241001465754 Metazoa Species 0.000 claims description 29
• 125000002757 morpholinyl group Chemical group 0.000 claims description 29
• 125000000623 heterocyclic group Chemical group 0.000 claims description 28
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
• 125000004193 piperazinyl group Chemical group 0.000 claims description 25
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 23
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• 238000004519 manufacturing process Methods 0.000 claims description 21
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 20
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