RO77533A - PROCESS FOR THE PREPARATION OF VINBLASTIN DERIVATIVES, LEUROZIDINE AND LEUROCRISTINA - Google Patents

PROCESS FOR THE PREPARATION OF VINBLASTIN DERIVATIVES, LEUROZIDINE AND LEUROCRISTINA

Info

Publication number: RO77533A
Authority: RO; Romania
Prior art keywords: leurozidine; leurocristina; vinblastin; derivatives; preparation
Prior art date: 1973-04-02

Application number

RO7498695A

Other languages

French (fr)

Romanian (ro)

Inventor

George J Cullinan

Koert Gerzon

Original Assignee

Eli Lilly And Co,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-04-02

Publication date

1982-02-01

1974-04-02 Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us

1982-02-01 Publication of RO77533A publication Critical patent/RO77533A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

RO7498695A 1973-04-02 1974-04-02 PROCESS FOR THE PREPARATION OF VINBLASTIN DERIVATIVES, LEUROZIDINE AND LEUROCRISTINA RO77533A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (1)

Publication Number	Publication Date
RO77533A true RO77533A (en)	1982-02-01

Family

ID=23363051

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RO7498695A RO77533A (en)	1973-04-02	1974-04-02	PROCESS FOR THE PREPARATION OF VINBLASTIN DERIVATIVES, LEUROZIDINE AND LEUROCRISTINA
RO78274A RO73524B (en)	1973-04-02	1974-04-02	Process for the preparation of alkaloid derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
RO78274A RO73524B (en)	1973-04-02	1974-04-02	Process for the preparation of alkaloid derivatives

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (en)
AR (2)	AR204004A1 (en)
AT (1)	AT340605B (en)
BE (1)	BE813168A (en)
BG (3)	BG21235A3 (en)
CA (1)	CA1042428A (en)
CH (1)	CH603669A5 (en)
CS (1)	CS185223B2 (en)
CY (1)	CY1044A (en)
DD (1)	DD113538A5 (en)
DE (1)	DE2415980A1 (en)
DK (1)	DK141511B (en)
ES (2)	ES424882A1 (en)
FR (1)	FR2223044B1 (en)
GB (1)	GB1463575A (en)
HK (1)	HK20180A (en)
HU (1)	HU171572B (en)
IE (1)	IE39071B1 (en)
IL (1)	IL44415A (en)
KE (1)	KE3028A (en)
MY (1)	MY8100025A (en)
NL (1)	NL181079C (en)
PH (1)	PH13623A (en)
RO (2)	RO77533A (en)
SE (1)	SE416206B (en)
SU (4)	SU731900A3 (en)
YU (3)	YU39719B (en)
ZA (1)	ZA741674B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (en) *	1976-09-08	1982-07-07	Lilly Co Eli
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (en) *	1981-12-08	1983-09-01	Omnichem Sa	N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
OA06421A (en) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
FR2623504B1 (en) *	1987-11-25	1990-03-09	Adir	NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
EP1845974A1 (en)	2005-01-21	2007-10-24	Astex Therapeutics Limited	Pharmaceutical compounds
US7405227B2 (en)	2005-07-18	2008-07-29	Bipar Sciences, Inc.	Treatment of cancer
EP2061479A4 (en)	2006-09-05	2010-08-04	Bipar Sciences Inc	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
EP2059498A4 (en)	2006-09-05	2011-01-12	Bipar Sciences Inc	Treatment of cancer
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
JP5528807B2 (en)	2006-10-12	2014-06-25	アステックス、セラピューティックス、リミテッド	Compound drug
EP2217227B1 (en)	2007-11-12	2013-08-21	BiPar Sciences, Inc.	Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
JP6250710B2 (en) *	2013-04-19	2017-12-20	曁南大学	Preparation method of vinblastine derivative
CN113456797B (en) *	2021-06-18	2024-03-08	暨南大学	Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/en active
- 1974-03-13 IE IE532/74A patent/IE39071B1/en unknown
- 1974-03-13 IL IL44415A patent/IL44415A/en unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/en unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/en unknown
- 1974-03-25 CY CY1044A patent/CY1044A/en unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-04-01 SU SU742013753A patent/SU731900A3/en active
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/en unknown
- 1974-04-01 DK DK178774AA patent/DK141511B/en not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/en not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/en unknown
- 1974-04-01 AT AT267974A patent/AT340605B/en not_active IP Right Cessation
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/en not_active IP Right Cessation
- 1974-04-02 BE BE1005847A patent/BE813168A/en not_active IP Right Cessation
- 1974-04-02 RO RO7498695A patent/RO77533A/en unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/en not_active Expired
- 1974-04-02 BG BG028514A patent/BG21235A3/en unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/en unknown
- 1974-04-02 RO RO78274A patent/RO73524B/en unknown
- 1974-04-02 DE DE2415980A patent/DE2415980A1/en active Granted
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/en not_active Expired
- 1974-04-02 BG BG026279A patent/BG22831A3/en unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/en active
- 1975-07-04 SU SU752151512A patent/SU784783A3/en active
- 1975-07-09 SU SU752152020A patent/SU652896A3/en active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/en not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/en active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/en unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/en unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/en unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/en unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/en unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/en not_active Expired

Also Published As

Publication number	Publication date
SU731900A3 (en)	1980-04-30
DE2415980C2 (en)	1989-11-09
IL44415A0 (en)	1974-06-30
IE39071L (en)	1974-10-02
CY1044A (en)	1980-08-01
DK141511B (en)	1980-04-08
NL181079B (en)	1987-01-16
RO73524A (en)	1984-10-31
YU39719B (en)	1985-04-30
JPS49128000A (en)	1974-12-07
BG21612A3 (en)	1976-07-20
SU652896A3 (en)	1979-03-15
YU39876B (en)	1985-04-30
AR203882A1 (en)	1975-10-31
AR204004A1 (en)	1975-11-12
HU171572B (en)	1978-02-28
NL181079C (en)	1987-06-16
DD113538A5 (en)	1975-06-12
BE813168A (en)	1974-10-02
JPS6033837B2 (en)	1985-08-05
PH13623A (en)	1980-08-07
YU81774A (en)	1982-05-31
NL7404423A (en)	1974-10-04
CS185223B2 (en)	1978-09-15
RO73524B (en)	1984-11-30
MY8100025A (en)	1981-12-31
JPS5919117B2 (en)	1984-05-02
ATA267974A (en)	1977-04-15
ES424882A1 (en)	1976-12-16
IL44415A (en)	1978-08-31
BG22831A3 (en)	1977-04-20
JPS59193895A (en)	1984-11-02
HK20180A (en)	1980-04-25
SE416206B (en)	1980-12-08
DK141511C (en)	1980-09-29
FR2223044B1 (en)	1978-06-30
SU623522A3 (en)	1978-09-05
GB1463575A (en)	1977-02-02
YU113880A (en)	1982-05-31
SU784783A3 (en)	1980-11-30
YU39875B (en)	1985-04-30
KE3028A (en)	1980-03-28
DE2415980A1 (en)	1974-10-10
ES446571A1 (en)	1977-06-16
FR2223044A1 (en)	1974-10-25
BG21235A3 (en)	1976-03-20
AU6671974A (en)	1975-09-18
ZA741674B (en)	1975-10-29
CH603669A5 (en)	1978-08-31
IE39071B1 (en)	1978-08-02
YU113980A (en)	1982-05-31
AT340605B (en)	1977-12-27
CA1042428A (en)	1978-11-14

Publication	Publication Date	Title
RO77533A (en)	1982-02-01	PROCESS FOR THE PREPARATION OF VINBLASTIN DERIVATIVES, LEUROZIDINE AND LEUROCRISTINA
RO68468A (en)	1981-06-26	PROCESS FOR THE PREPARATION OF CYCLOHEXAN-1,3-DIONE DERIVATIVES
RO84020A (en)	1984-05-12	PROCESS FOR THE PREPARATION OF ANY SUBSTITUTED ANILINE DERIVATIVES
RO73008A (en)	1981-09-24	PROCESS FOR THE PREPARATION OF DERIVATIVES OF 4-TRIFLUOROMETHYL-4-NITROHALOGENE
RO66907A (en)	1981-06-26	PROCESS FOR PREPARATION OF 2-ACYL-4-OXOPYRAZINOISOCHINOLINE DERIVATIVES
RO69411A (en)	1982-02-01	PROCESS FOR THE PREPARATION OF CHINAZOLON DERIVATIVES
RO74877A (en)	1980-10-30	PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES
RO69617A (en)	1980-08-15	PROCESS FOR THE PREPARATION OF 2-TETRAHYDRO-FURFURYL-6,7-BENZOMORPHANS
NL7414119A (en)	1975-05-02	PROCESS FOR PREPARING 1H-TETRAZOL-5-THIOL DERIVATIVES AND 1-SUBSTITUATED 1H-TETRAZOL-5-THIOLS.
RO73511A (en)	1981-04-30	PROCESS FOR THE PREPARATION OF PIRIMIDONE DERIVATIVES
RO69607A (en)	1980-08-15	PROCESS FOR PREPARATION OF 3-CARBAMOYLOXYETHYLPHALOSPORINE
RO68642A (en)	1980-06-15	PROCESS FOR PREPARING MICOPHENOLIC ACID DERIVATIVES
RO70677A (en)	1981-11-04	PROCESS FOR THE PREPARATION OF DIFENYLAMINE DERIVATIVES
RO70568A (en)	1980-08-15	PROCESS FOR PREPARATION OF 2-ARYL-AMINO-2-IMIDAZOLINE DERIVATIVES
RO71575A (en)	1982-02-26	PROCESS FOR THE PREPARATION OF PIRIDO-BENZODIAZEPINONE DERIVATIVES
RO72980A (en)	1981-08-30	PROCESS FOR PREPARING DERIVATIVES OF 3-TRIAZINYL-TOMOTIL-PHYALOSPORINE
RO69408A (en)	1980-06-15	PROCESS FOR THE PREPARATION OF 5-PYRAZOLONE DERIVATIVES
RO71309A (en)	1981-08-30	PROCESS FOR THE PREPARATION OF BENZO-SULFONIL-URY DERIVATIVES
RO87769A (en)	1985-12-20	PROCEDURE FOR PREPARING TIAZOLIDINE DERIVATIVES
RO70078A (en)	1982-04-12	PROCESS FOR THE PREPARATION OF DIFENYLAMINE DERIVATIVES
RO72458A (en)	1981-02-28	PROCESS FOR PREPARING DERIVATIVES OF MORPHANTRIDINEN, DIBENZODIAZEPINEN, DIBENZOOXEPEPINE, DIBENZOTIAEPINEN, TIENOBENZAZEPINEN, TIENOBENZOTIAZEPINENE
RO69154A (en)	1981-07-30	PROCESS FOR PREPARATION OF 1-PENOXY-3-AMINOPROPAN-2-OL DERIVATIVES
NL7415177A (en)	1975-06-03	PROCESS FOR PREPARING XANTHEEN AND THIOXANTHEEN DERIVATIVES.
RO68703A (en)	1981-09-24	PROCESS FOR THE PREPARATION OF 4-AMINO-3,5-DIHALOGENE-PHENYL-ETANOLAMINE
RO70190A (en)	1982-09-09	PROCEDURE FOR THE PREPARATION OF NERROIMIDAZOL DERIVATIVES