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YU64100A - Postupak za sintetizovanje cox-2 inhibitora - Google Patents

Postupak za sintetizovanje cox-2 inhibitora

Info

Publication number
YU64100A
YU64100A YU64100A YU64100A YU64100A YU 64100 A YU64100 A YU 64100A YU 64100 A YU64100 A YU 64100A YU 64100 A YU64100 A YU 64100A YU 64100 A YU64100 A YU 64100A
Authority
YU
Yugoslavia
Prior art keywords
inhibitors
cox
synthesizing
synthesizing cox
cyclooxygenase
Prior art date
Application number
YU64100A
Other languages
English (en)
Inventor
Edward G. Corley
Ian W. Davies
Robert D. Larsen
Philip J. Pye
Kai Rossen
Original Assignee
Merck & Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co.Inc. filed Critical Merck & Co.Inc.
Publication of YU64100A publication Critical patent/YU64100A/sh
Publication of RS49945B publication Critical patent/RS49945B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/30—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups quaternised

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Pronalazak obuhvata postupak za izradu jedinjenja formule (I), koja su korisna u lečenju bolesti posredovanih ciklooksigenazom-2.[The invention encompasses a process for making compounds of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases.
YUP-641/00A 1998-04-24 1999-04-20 Postupak za sintetizovanje inhibitora cox-2 RS49945B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8288898P 1998-04-24 1998-04-24
US8566898P 1998-05-15 1998-05-15

Publications (2)

Publication Number Publication Date
YU64100A true YU64100A (sh) 2002-11-15
RS49945B RS49945B (sr) 2008-09-29

Family

ID=26767964

Country Status (28)

Country Link
US (2) US6040319A (sh)
EP (1) EP1071745B1 (sh)
JP (2) JP3325264B2 (sh)
KR (1) KR100414998B1 (sh)
CN (1) CN1178658C (sh)
AR (1) AR015279A1 (sh)
AT (1) ATE272613T1 (sh)
AU (1) AU759469B2 (sh)
BR (2) BR9909844B1 (sh)
CA (1) CA2329193C (sh)
CZ (1) CZ292515B6 (sh)
DE (1) DE69919151T2 (sh)
DK (1) DK1071745T3 (sh)
EA (1) EA002975B1 (sh)
ES (1) ES2226378T3 (sh)
HK (1) HK1031399A1 (sh)
HR (1) HRP20000722B1 (sh)
HU (1) HU227627B1 (sh)
IL (2) IL139127A0 (sh)
NZ (1) NZ507597A (sh)
PL (1) PL193248B1 (sh)
PT (1) PT1071745E (sh)
RS (1) RS49945B (sh)
SI (1) SI1071745T1 (sh)
SK (1) SK284805B6 (sh)
TW (1) TW474934B (sh)
UA (1) UA57143C2 (sh)
WO (1) WO1999055830A2 (sh)

Families Citing this family (38)

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US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US7141673B1 (en) 1999-01-14 2006-11-28 Lonza Ag 1-(6-methylpyridine-3-yl)-2-[4-(methylsulphonyl) phenyl] ethanone and method for its preparation
CN1170820C (zh) * 1999-01-14 2004-10-13 隆萨股份公司 1-(6-甲基吡啶-3-基)-2-(4-甲磺酰苯基)乙酮的制备方法
JP2001115963A (ja) 1999-10-13 2001-04-27 Daikin Ind Ltd 圧縮機
US6858631B1 (en) 1999-11-29 2005-02-22 Merck & Co., Inc. Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl
JP4425514B2 (ja) * 1999-11-29 2010-03-03 メルク フロスト カナダ リミテツド ５−クロロ−３−（４−メタンスルホニルフェニル）−６′−メチル−［２，３′］ビピリジニルの多形型、非晶質型および水和型
JP2003523954A (ja) * 1999-12-08 2003-08-12 ファルマシア コーポレイション 治療効果が迅速に開始されるシクロオキシゲナーゼ−２阻害剤組成物
JP2001261653A (ja) * 2000-03-17 2001-09-26 Sankio Chemical Co Ltd ピリジン誘導体の合成法
US6800647B2 (en) 2000-05-26 2004-10-05 Merck & Co., Inc. 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3]bipyridinyl in pure crystalline form and process for synthesis
PH12001001175B1 (en) * 2000-05-26 2006-08-10 Merck Sharp & Dohme 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis
US6521642B2 (en) 2000-05-26 2003-02-18 Merck & Co., Inc. 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
AU5754701A (en) * 2000-07-13 2002-01-30 Pharmacia Corp Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
EP1423114A4 (en) * 2001-05-04 2006-05-17 Merck & Co Inc METHOD AND COMPOSITIONS FOR TREATING MIGRAINE
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
JP4700916B2 (ja) * 2004-02-02 2011-06-15 富士フイルムファインケミカルズ株式会社 ピリジン誘導体の製造方法
US7271383B2 (en) * 2004-08-11 2007-09-18 Lexmark International, Inc. Scanning system with feedback for a MEMS oscillating scanner
EP2494992A1 (en) 2004-08-24 2012-09-05 Merck Sharp & Dohme Corp. Combination therapy for treating cyclooxygenase-2 mediated diseases or conditions in patients at risk of thrombotic cardiovascular events
US20100111858A1 (en) * 2007-01-19 2010-05-06 Howard Carol P Diangostic and Therapeutic Cyclooxygenase-2 Binding Ligands
HUE028730T2 (en) 2009-02-27 2017-01-30 Cadila Healthcare Ltd Process for the preparation of etoricoxib
WO2011158250A1 (en) 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
CA2817939A1 (en) 2010-11-15 2012-05-24 Virdev Intermediates Pvt. Ltd. A process for cyclooxygenase-2 selective inhibitor
ITMI20110362A1 (it) 2011-03-09 2012-09-10 F I S Fabbrica Italiana Sint P A Procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib.
EP2714676B1 (en) 2011-05-27 2019-04-24 Farma GRS, d.o.o. A process for the preparation of polymorphic form i of etoricoxib
ITMI20111455A1 (it) 2011-07-29 2013-01-30 Italiana Sint Spa Nuovo procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib.
CN103204803A (zh) 2012-01-13 2013-07-17 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 用于合成依托考昔的方法
ITMI20120394A1 (it) * 2012-03-14 2013-09-15 Zach System Spa Processo di sintesi di un chetosolfone derivato
EP2831045A2 (en) 2012-03-30 2015-02-04 Mylan Laboratories, Limited An improved process for the preparation of etoricoxib
GR1007973B (el) * 2012-06-26 2013-09-12 Φαρματεν Αβεε, Νεα ν-οξοιμινο παραγωγα ως ενδιαμεσα μιας βελτιωμενης μεθοδου παρασκευης 2,3-διαρυλο-5-υποκατεστημενων πυριδινων
PL2887924T3 (pl) 2012-08-27 2017-09-29 Cadila Healthcare Limited Kompozycje farmaceutyczne etorykoksybu
ITVI20130014A1 (it) 2013-01-22 2014-07-23 Italiana Sint Spa Procedimento molto efficiente per preparare un intermedio di etoricoxib
WO2014114352A1 (en) * 2013-01-25 2014-07-31 Synthon Bv Process for making etoricoxib
CN104418799A (zh) * 2013-09-03 2015-03-18 天津药物研究院 一种依托考昔的晶型及其制备方法和应用
WO2015036550A1 (en) 2013-09-13 2015-03-19 Synthon B.V. Process for making etoricoxib
EP3268085A4 (en) 2015-03-13 2018-10-31 The Board of Trustees of The Leland Stanford Junior University Ltb4 inhibition to prevent and treat human lymphedema
CN104817473A (zh) * 2015-03-27 2015-08-05 南京大学 1-二甲氨基-3-二甲亚胺基-2-氯丙烯高氯酸盐在制备依托考昔中的应用

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CA988522A (en) * 1972-05-05 1976-05-04 Haydn W.R. Williams 1,8-naphthyridine compounds
DE3842062A1 (de) * 1988-12-14 1990-06-28 Hoechst Ag Explosionssichere 1-dimethylamino-3-dimethylimino-2-arylpropen-1-salze, verfahren zu ihrer herstellung und ihre verwendung
TR199900046T2 (xx) * 1996-07-18 1999-04-21 Merck Frosst Canada Inc. Se�ici siklooksijenaz-2 inhibit�rleri olarak ikameli piridinler.
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
ATE272613T1 (de) 2004-08-15
PL193248B1 (pl) 2007-01-31
EA200001102A1 (ru) 2001-04-23
JP3834263B2 (ja) 2006-10-18
CN1306425A (zh) 2001-08-01
EP1071745B1 (en) 2004-08-04
PL344108A1 (en) 2001-09-24
BR9909844B1 (pt) 2010-10-19
HRP20000722B1 (en) 2009-07-31
JP3325264B2 (ja) 2002-09-17
RS49945B (sr) 2008-09-29
IL139127A0 (en) 2001-11-25
HUP0101407A2 (hu) 2001-09-28
PT1071745E (pt) 2004-11-30
EP1071745A4 (en) 2002-05-15
JP2002513035A (ja) 2002-05-08
KR100414998B1 (ko) 2004-01-13
BR9909844A (pt) 2001-04-03
IL139127A (en) 2006-07-05
CN1178658C (zh) 2004-12-08
UA57143C2 (uk) 2003-06-16
US6040319A (en) 2000-03-21
KR20010042941A (ko) 2001-05-25
WO1999055830A2 (en) 1999-11-04
ES2226378T3 (es) 2005-03-16
US6252116B1 (en) 2001-06-26
DE69919151T2 (de) 2005-07-28
HK1031399A1 (en) 2001-06-15
SK284805B6 (sk) 2005-11-03
BRPI9917739B8 (pt) 2021-05-25
HU227627B1 (en) 2011-10-28
CZ20003940A3 (en) 2001-06-13
HRP20000722A2 (en) 2001-06-30
JP2003040852A (ja) 2003-02-13
CZ292515B6 (cs) 2003-10-15
WO1999055830A3 (en) 1999-12-29
SI1071745T1 (en) 2004-10-31
AR015279A1 (es) 2001-04-18
HUP0101407A3 (en) 2002-12-28
TW474934B (en) 2002-02-01
AU3655799A (en) 1999-11-16
BRPI9917739B1 (pt) 2016-05-03
EP1071745A2 (en) 2001-01-31
AU759469B2 (en) 2003-04-17
EA002975B1 (ru) 2002-12-26
SK15892000A3 (sk) 2001-07-10
DK1071745T3 (da) 2004-11-29
NZ507597A (en) 2004-02-27
CA2329193A1 (en) 1999-11-04
DE69919151D1 (de) 2004-09-09
CA2329193C (en) 2007-01-23

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