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YU50302A - Nova heterociklična jedinjenja, njihove soli i njihova primena u medicini - Google Patents

Nova heterociklična jedinjenja, njihove soli i njihova primena u medicini

Info

Publication number
YU50302A
YU50302A YU50302A YUP50302A YU50302A YU 50302 A YU50302 A YU 50302A YU 50302 A YU50302 A YU 50302A YU P50302 A YUP50302 A YU P50302A YU 50302 A YU50302 A YU 50302A
Authority
YU
Yugoslavia
Prior art keywords
agents
remedies
represents hydrogen
ameliorating
lower alkyl
Prior art date
Application number
YU50302A
Other languages
English (en)
Inventor
Hiroshi Matsui
Hideo Kobayashi
Satoru Azukizawa
Masayasu Kasai
Akihisa Yoshimi
Shirahase Hiroaki
Original Assignee
Kyoto Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd. filed Critical Kyoto Pharmaceutical Industries Ltd.
Publication of YU50302A publication Critical patent/YU50302A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Heterociklicno jedinjenje formule (I) gde R1 je atom vodonika ili nizi alkil, R2 je hidrogen atom, alkil koji po potrebi ima supstituent i slicno, R3 je atom vodonika, nizi alkil i slicno, A je jednostruka veza ili >N- R5 gde R5 je atom vodonika ili nizi alkil, B je nizi alkilen, i Y je aril koji po potrebi ima supstituent i slicno, ili njihove farmaceutski prihvatljive soli sa hipoglicemicnim dejstvom, hipolipidemicno dejstvo u krvi, poboljsanje insulinske otpornosti dejstvo i PPAR aktivirajuce dejstvo, a koristi se kao hipoglicemicni agens, hipolipidemicni agens, poboljsivac insulinske rezistencije, terapeutski agens za dijabetes, terapeutski agens za dijabeticne komplikacije, poboljsivac glukozne tolerancije, anti-aterosklerozis agens, agens protiv gojaznosti, antiinflamatorni agens, agens za profilaksis ili tretiranje oboljenja prouzrokovanih PPAR-om i agens za profilaksis ili lecenje sindroma X.
YU50302A 1999-12-03 2000-11-29 Nova heterociklična jedinjenja, njihove soli i njihova primena u medicini YU50302A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34554399 1999-12-03
JP2000295108 2000-09-27

Publications (1)

Publication Number Publication Date
YU50302A true YU50302A (sh) 2006-01-16

Family

ID=26578048

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50302A YU50302A (sh) 1999-12-03 2000-11-29 Nova heterociklična jedinjenja, njihove soli i njihova primena u medicini

Country Status (21)

Country Link
US (1) US6589963B2 (sh)
EP (1) EP1236719A4 (sh)
KR (1) KR100716525B1 (sh)
CN (1) CN1215059C (sh)
AR (1) AR033349A1 (sh)
AU (1) AU782631C (sh)
BR (1) BR0016064A (sh)
CA (1) CA2393265A1 (sh)
CO (1) CO5440230A1 (sh)
CZ (1) CZ20021911A3 (sh)
HK (1) HK1053657A1 (sh)
HU (1) HUP0203431A3 (sh)
IL (2) IL149883A0 (sh)
MX (1) MXPA02005528A (sh)
NO (1) NO323922B1 (sh)
NZ (1) NZ519592A (sh)
PL (1) PL356769A1 (sh)
RU (1) RU2256661C2 (sh)
TW (1) TWI286549B (sh)
WO (1) WO2001040192A1 (sh)
YU (1) YU50302A (sh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
PL367676A1 (en) 2001-05-29 2005-03-07 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic derivatives and medicinal use thereof
KR100898358B1 (ko) * 2001-05-29 2009-05-20 교토 야쿠힝 고교 가부시키가이샤 신규 복소환 화합물 및 그 의약 용도
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
DE10222034A1 (de) * 2002-05-17 2003-11-27 Bayer Ag Tetrahydroisochinolin-Derivate
PA8594401A1 (es) * 2003-02-21 2004-09-16 Pfizer Acidos carboxilicos de heteroarilo condensado como agonista del ppar
CN1300115C (zh) * 2004-03-26 2007-02-14 厦门大学 一种合成1，2，3，4－四氢异喹啉衍生物的方法
EP1805158B1 (en) 2004-10-29 2018-06-27 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
ES2691548T3 (es) 2005-10-25 2018-11-27 Kalypsys, Inc. Sales de moduladores de PPAR y métodos para tratar desórdenes metabólicos
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
WO2009019598A2 (en) * 2007-08-03 2009-02-12 Dr. Reddy's Laboratories Ltd. Inhalation therapy for respiratory disorders
BRPI0910282A2 (pt) * 2008-03-07 2015-09-01 Transtech Pharma Inc Composto oxadiazo-antraceno para o tratamento de diabetes
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2012033195A1 (ja) * 2010-09-10 2012-03-15 京都薬品工業株式会社 複素環化合物
CN102807526B (zh) * 2011-06-21 2015-12-02 寿光富康制药有限公司 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用
CN102702098A (zh) * 2012-05-24 2012-10-03 盛世泰科生物医药技术(苏州)有限公司 6-甲氧基-1,2,3,4四氢喹啉-5羧酸甲酯的合成
AR101196A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
EP0306228B1 (en) 1987-09-04 1999-11-17 Beecham Group Plc Substituted thiazolidinedione derivatives
US5246943A (en) 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
AU3513497A (en) * 1996-07-01 1998-01-21 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
AU3719997A (en) * 1996-07-01 1998-01-21 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds

Also Published As

Publication number Publication date
EP1236719A4 (en) 2003-06-25
TWI286549B (en) 2007-09-11
AU1649501A (en) 2001-06-12
AU782631B2 (en) 2005-08-18
US20030027836A1 (en) 2003-02-06
KR100716525B1 (ko) 2007-05-10
EP1236719A1 (en) 2002-09-04
AU782631C (en) 2006-08-17
WO2001040192A1 (fr) 2001-06-07
RU2256661C2 (ru) 2005-07-20
CN1215059C (zh) 2005-08-17
CZ20021911A3 (cs) 2002-10-16
CO5440230A1 (es) 2004-09-30
CN1402712A (zh) 2003-03-12
NO323922B1 (no) 2007-07-23
NO20022600L (no) 2002-08-05
IL149883A (en) 2007-03-08
KR20020058079A (ko) 2002-07-12
HK1053657A1 (en) 2003-10-31
MXPA02005528A (es) 2002-09-02
BR0016064A (pt) 2004-07-27
IL149883A0 (en) 2002-11-10
US6589963B2 (en) 2003-07-08
HUP0203431A3 (en) 2003-11-28
PL356769A1 (en) 2004-07-12
HUP0203431A2 (hu) 2003-02-28
CA2393265A1 (en) 2001-06-07
NZ519592A (en) 2003-11-28
AR033349A1 (es) 2003-12-17
NO20022600D0 (no) 2002-05-31

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