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YU46987B - Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu - Google Patents

Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu

Info

Publication number
YU46987B
YU46987B YU177388A YU177388A YU46987B YU 46987 B YU46987 B YU 46987B YU 177388 A YU177388 A YU 177388A YU 177388 A YU177388 A YU 177388A YU 46987 B YU46987 B YU 46987B
Authority
YU
Yugoslavia
Prior art keywords
growth factor
human insulin
serum protein
reduced binding
protein carrier
Prior art date
Application number
YU177388A
Other languages
English (en)
Other versions
YU177388A (en
Inventor
J.D. Applebaum
M.L. Bayne
M.A. Cascieri
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of YU177388A publication Critical patent/YU177388A/xx
Publication of YU46987B publication Critical patent/YU46987B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fodder In General (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

ANALOG FAKTORA RASTA SLIČAN HUMANOM INSULINU SA SMANJENIM VEZIVANJEM ZA NOSAČ SERUMSKIH PROTEINA I NJEGOVA PROIZVODNJA U KVASCU, V, ili FV A2 P ili N, A3 E ili Q A4 T,H ili A, A5 A ili S, A6 E ili H, A7 D ili E, A8 Q ili Y, A9 F ili L, i R ostatak hIGF-peptida, pod uslovom da A1 do A9 grupe i druge amino kiseline ne sačinjavaju GPETLCGAELVDALQF-R. Prijava sadrži još 1 nezavisan i 16 zavisnih zahteva.
YU177388A 1987-09-21 1988-09-20 Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu YU46987B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/099,367 US4876242A (en) 1987-09-21 1987-09-21 Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast

Publications (2)

Publication Number Publication Date
YU177388A YU177388A (en) 1990-04-30
YU46987B true YU46987B (sh) 1994-09-09

Family

ID=22274659

Family Applications (2)

Application Number Title Priority Date Filing Date
YU177388A YU46987B (sh) 1987-09-21 1988-09-20 Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu
YU02167/89A YU216789A (en) 1987-09-21 1989-11-14 Process for obtaining polypeptidic analog higf-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU02167/89A YU216789A (en) 1987-09-21 1989-11-14 Process for obtaining polypeptidic analog higf-1

Country Status (16)

Country Link
US (1) US4876242A (sh)
EP (1) EP0309050B1 (sh)
JP (1) JPH01156998A (sh)
KR (1) KR890005150A (sh)
AT (1) ATE100139T1 (sh)
AU (1) AU608364B2 (sh)
DE (1) DE3887052T2 (sh)
DK (1) DK521888A (sh)
FI (1) FI884276A (sh)
HU (1) HU205170B (sh)
IL (1) IL87754A (sh)
NO (1) NO174965C (sh)
NZ (1) NZ226132A (sh)
PT (1) PT88546B (sh)
YU (2) YU46987B (sh)
ZA (1) ZA886966B (sh)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001038A1 (en) * 1985-08-22 1987-02-26 Commonwealth Scientific And Industrial Research Or Peptide analogues of mammalian insulin-like growth factor-1
ATE116335T1 (de) * 1987-12-24 1995-01-15 Gropep Pty Ltd Peptid-analoge vom insulinähnlichen wachstums- faktor 1 (igf-1) oder faktor 2 (igf-2).
US5470828A (en) * 1987-12-24 1995-11-28 Gropep Pty. Ltd. Peptide analogs of insulin-like growth factor II
NZ236618A (en) * 1990-01-03 1997-06-24 Ciba Geigy Ag Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
AU661242B2 (en) * 1991-10-07 1995-07-13 Brigham And Women's Hospital Method for enhancing gut absorption
EP0639981A4 (en) * 1992-05-08 1995-06-28 Univ Jefferson ANALOGS OF THE IGF FACTOR (01/18/94).
WO1993024627A1 (en) * 1992-06-03 1993-12-09 Case Western Reserve University Bandage for continuous application of biologicals
WO1993025226A1 (en) * 1992-06-08 1993-12-23 Kabi Pharmacia Ab Use of growth factor igf-i and/or igf-ii
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
US5401830A (en) * 1992-10-05 1995-03-28 The State University Of New Jersey Insulin receptor-like protein
JPH09507832A (ja) * 1993-09-20 1997-08-12 セルトリックス ファーマシューティカルズ，インコーポレイテッド Ｉｇｆｂｐ単独またはｉｇｆｂｐとｉｇｆとの複合体による免疫疾患および血液疾患の処置
JPH10504971A (ja) * 1994-09-08 1998-05-19 カイロン コーポレイション インスリン様増殖因子の改善された生産方法
US5565428A (en) * 1995-05-22 1996-10-15 Genentech, Inc. Method of administration of IGF-I
US5741776A (en) * 1995-05-22 1998-04-21 Genentech, Inc. Method of administration of IGF-I
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US7700353B2 (en) 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
US6358916B1 (en) 1998-07-22 2002-03-19 Thomas T. Chen Biological activity of IGF-I E domain peptide
US7118752B2 (en) 1998-07-22 2006-10-10 University Of Connecticut Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
US6875741B2 (en) 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
US7173005B2 (en) 1998-09-02 2007-02-06 Antyra Inc. Insulin and IGF-1 receptor agonists and antagonists
EP1141014B1 (en) * 1999-01-06 2004-12-08 Genentech, Inc. Insulin-like growth factor (igf) i mutant variant
AU763039B2 (en) 1999-04-08 2003-07-10 Genentech Inc. Composition based on oppositely-charged polypeptides
US6703040B2 (en) 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
CA2402780A1 (en) * 2000-03-29 2001-10-04 Dgi Biotechnologies, L.L.C. Insulin and igf-1 receptor agonists and antagonists
AU2001263215A1 (en) * 2000-05-16 2001-11-26 Genentech Inc. Method for treating cartilage disorders
WO2002017951A1 (en) 2000-08-29 2002-03-07 Colorado State University Research Foundation Method for treating the central nervous system by administration of igf structural analogs
GB2369572A (en) * 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
JP4489352B2 (ja) * 2001-02-09 2010-06-23 ジェネンテック， インコーポレイテッド Ｉｇｆ−１の結晶化
US7439063B2 (en) * 2002-06-11 2008-10-21 Burnham Institute For Medical Research Neuroprotective synergy of erythropoietin and insulin-like growth factors
NZ545940A (en) 2003-09-12 2009-12-24 Tercica Inc Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency
EP1680073B1 (en) * 2003-10-21 2013-01-02 IGF Oncology, LLC Compounds and method for treating cancer
US9011880B2 (en) * 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
WO2005072292A2 (en) * 2004-01-24 2005-08-11 Hugh Mctavish Methods for enhancing radiation therapy
CA2582552A1 (en) * 2004-10-21 2006-05-04 Igf Oncology, Llc Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
AU2009210570B2 (en) 2008-01-30 2014-11-20 Indiana University Research And Technology Corporation Ester-based insulin prodrugs
JP5789515B2 (ja) 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン類似体
CN102307584A (zh) * 2008-12-19 2012-01-04 印第安纳大学研究及科技有限公司 表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子
CA2744558A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
EP2391630A2 (en) * 2009-01-31 2011-12-07 IGF Oncology, LLC Anti-cancer protein-platinum conjugates
AU2010227419A1 (en) 2009-03-27 2011-10-20 Proyecto De Biomedicina Cima, S.L. Methods and compositions for the treatment of cirrhosis and liver fibrosis
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
US8940860B2 (en) 2010-06-16 2015-01-27 Indiana University Research And Technology Corporation Single-chain insulin agonists exhibiting high activity at the insulin receptor
AU2011270832B2 (en) 2010-06-24 2016-05-12 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
WO2013096386A1 (en) 2011-12-20 2013-06-27 Indiana University Research And Technology Corporation Ctp-based insulin analogs for treatment of diabetes
US9375519B2 (en) 2012-06-25 2016-06-28 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
EP2900255B1 (en) 2012-09-26 2019-01-30 Indiana University Research and Technology Corporation Insulin analog dimers
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
JP6835590B2 (ja) 2014-01-12 2021-02-24 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
CN108271356A (zh) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
ES2947409T3 (es) 2014-09-24 2023-08-08 Univ Indiana Res & Tech Corp Profármacos de insulina a base de amida lipídica
AU2018273370A1 (en) 2017-05-21 2019-10-31 Igf Oncology, Llc An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
WO1987001038A1 (en) * 1985-08-22 1987-02-26 Commonwealth Scientific And Industrial Research Or Peptide analogues of mammalian insulin-like growth factor-1
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
AU607209B2 (en) * 1987-04-23 1991-02-28 Monsanto Technology Llc Secretion of insulin-like growth factor-i in e. coli

Also Published As

Publication number Publication date
EP0309050B1 (en) 1994-01-12
ATE100139T1 (de) 1994-01-15
PT88546A (pt) 1988-10-01
DE3887052D1 (de) 1994-02-24
EP0309050A1 (en) 1989-03-29
NO174965B (no) 1994-05-02
YU216789A (en) 1991-04-30
US4876242A (en) 1989-10-24
ZA886966B (en) 1989-05-30
KR890005150A (ko) 1989-05-13
NO884183L (no) 1989-03-22
AU608364B2 (en) 1991-03-28
AU2245588A (en) 1989-06-01
HU205170B (en) 1992-03-30
DK521888D0 (da) 1988-09-20
NO884183D0 (no) 1988-09-20
NO174965C (no) 1994-08-10
HUT49375A (en) 1989-09-28
IL87754A (en) 1993-08-18
IL87754A0 (en) 1989-02-28
DK521888A (da) 1989-05-03
DE3887052T2 (de) 1994-07-21
YU177388A (en) 1990-04-30
FI884276A0 (fi) 1988-09-16
NZ226132A (en) 1992-02-25
PT88546B (pt) 1992-11-30
JPH01156998A (ja) 1989-06-20
FI884276A (fi) 1989-03-22

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