WO2022189539A1

WO2022189539A1 - Liquid nutritional supplement to be used for stimulating the immune system, method for producing same, and use thereof

Info

Publication number: WO2022189539A1
Application number: PCT/EP2022/056118
Authority: WO
Inventors: Shaban OSMANAJ; Shukri OSMANAJ; Antigone IDRIZAJ
Original assignee: Prosecur Gmbh
Priority date: 2021-03-11
Filing date: 2022-03-10
Publication date: 2022-09-15
Also published as: EP4304619A1; LU102656B1

Abstract

The invention relates to a liquid nutritional supplement to be used for stimulating the immune system, having the following contents: - terpene hydrocarbon of a Cupressaceae plant cooked in water and - gentiobiose and/or bitter components, in particular gentiopicrin and/or amarogentin, from subterranean components of a Gentianaceae plant cooked in water. By conducting a trial on thirty people who have undergone chemotherapy due to a cancer disease, the inventor has ascertained that a drinkable infusion beverage which has the vegetable compounds according to claim 1 advantageously stimulates the immune system, whereby a quick recovery of the patient can be brought about.

Description

Description:

"Liquid food supplement for use in immunostimulation, process for its manufacture and use"

The invention relates to a liquid food supplement for use in immune stimulation, which has the following ingredients:

- terpene hydrocarbons of a cypress plant (Cupressaceae) boiled in water,

- Gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, from subterranean components of a gentian family (Gentianaceae) boiled in water. Furthermore, the invention relates to a method for the production of such a food supplement and its use.

DE 69837474 T2 discloses a composition that can be used to treat viral diseases such as HIV or herpes. The composition includes a nutrient and a botanical extract obtained from Gentiana or Juniperus.

DE 10 2006 006 532 A1 discloses a pharmaceutical composition based on micro-tablets, which is particularly easy to dose and of which at least one micro-tablet may contain juniper (Juniperus) or gentian (Gentiana lutea).

EP 0 621 777 B1 describes a manufacturing process for active substance pellets in which lipophilic substances can be added without the addition of emulsifiers. One of these substances is juniper oil.

EP 1 236466 A1 discloses a bioadhesive, antiviral composition which can adhere to oral mucosal tissue and which has a natural substance such as juniper berry oil or gentian from the Gentianaceae plant family for treating fungal infections.

WO 2018/083115 A1 discloses a herbal antimicrobial composition which has dried Juniperus communis or Gentiana lutea as ingredients. EP 1 228769 A1 discloses a regenerative medicinal product for natural infection-immunological therapy which, in addition to a microorganism component, contains a plant extract from juniper, gentian or pine.

None of the known compositions causes a stimulation of the immune system of a human through purely vegetable substances. In addition, it is not known from any of the known compositions that these can be produced by boiling plant components in water in the manner of an infusion beverage.

AU 2015249035 A1 describes a composition for treating liver diseases. This composition contains, inter alia, an extract from a plant of the genus Juniperus and an extract from a plant of the genus Gentiana.

CN 105456616, CN 104 173965 and CN 104888060 each describe traditional Chinese medicinal compositions containing plants of the genera Gentiana and Juniperus.

The object of the invention is to create a natural and drinkable food supplement whose ingredients stimulate the immune system.

Furthermore, the invention is based on the object of creating a food supplement that can be used as a support, ie as a supplement to drug therapy.

According to the invention, the object is achieved by the features of claim 1.

The inventors found through tests on 30 people who were undergoing chemotherapy for cancer that a drinkable infusion beverage containing the herbal substances according to claim 1 advantageously stimulates the immune system, which means that the patient can recover quickly . In some cases, recovery was twice as fast as predicted by physicians and as would have been expected without the dietary supplement of the present invention. Surprisingly, the effect of this mixture went far beyond the sum of the individual healing effects for which cypress plants such as common juniper (Juniperus commu nis) or yellow gentian (Gentiana lutea) are known. It is assumed that through an interaction of these two components, a chemotherapy-supporting immune reaction is triggered, i.e. the body’s self-healing powers are activated.

Because the plants or at least parts of them are boiled in water, simple production is possible. The inventors have found that it does not matter whether the plants or their parts are dried or freshly cut.

It is conceivable that the plants or parts thereof are chopped up or used in the form of chaff or pellets.

For production, the plants or parts thereof are boiled in water at, for example, 100° C. for 10 to 40 minutes, preferably 30 minutes. After cooling to a temperature of <60° C., the plants or parts thereof are removed by decanting or sieving . The remaining liquid forms the dietary supplement and can be used warm or cold.

Gentiobiose is a disaccharide, while gentianopicrin and/or amarogentin are bitter substances that are found to a particularly high degree in the subterranean components of yellow gentian, i.e. the roots. These bitter substances can stimulate the production of gastric juice, saliva and bile.

The terpene hydrocarbons, in particular terpene alcohols, preferably terpinen-4-ol, α-pinene and/or β-pinene, are expediently obtained from a fruit, needles and/or scale leaves of the cypress plant, in particular common juniper. The essential oil contained in cypress plants, especially their fruits, has a high proportion of a-pinene and/or ß-pinene. a-pinene alone is said to have an anti-inflammatory or in vitro antimicrobial effect. At low doses, a-pinene alone has a bronchospasmolytic effect. Terpinen-4-ol has been shown to have an aquaretic effect on its own.

The cypress plant is preferably the common juniper (Juniperus communis).

In one embodiment of the invention, the gentian plant is yellow gentian (Gentiana Lu tea). This is readily available worldwide.

In a further embodiment of the invention, the dietary supplement contains essential mountain pine (Pinus Mugo) oils, which are preferably obtained by boiling branches, needles and/or cones of the mountain pine in water. The essential oils of the mountain pine, from which mountain pine oil is obtained by steam distillation the can, are known for internal use in catarrhs. Boiling the branches, needles and/or cones ensures that an adequate amount of essential oils is extracted. Needles and/or branches are preferably used, which can be present in particular in the form of chopped chips or pellets.

The food supplement expediently contains linoleic acid, which is obtained in particular by boiling fruits, branches and/or needles of a pine tree, preferably a pine tree, in water. The pine belongs to the pine genus (Pinus) and the pine family (Pinaceae).

Linoleic acid is converted in the human body via the intermediate a-linolenic acid into dihomogammalinolenic acid and arachidonic acid, the former being anti-inflammatory and the latter being pro-inflammatory. The inventors assume that the further components of a food supplement according to the invention result in a shift in the conversion of linoleic acid in favor of arachidonic acid, which triggers a special immune reaction. This is supported by the fact that people complained about nausea after taking the food supplement on the following day, which gave way to a particularly good general physical condition from the second day after taking it.

In one embodiment of the invention, the food supplement is a decoction, for the production of which solid, in particular dried, parts of plants are boiled in the water and removed after cooling. A simple preparation in the manner of a tea is advantageously possible.

Appropriately, the dietary supplement is purely herbal. Synthetically obtained substances are not used, a dietary supplement suitable for vegans is created. Purely plant-based does not rule out that the dietary supplement contains additional water. Rather, purely vegetable means that the composition does not contain any animal substances.

In one embodiment of the invention, the vegetable content is between 0.001% by weight and 5% by weight, preferably between 0.002% by weight and 1.0% by weight. These values relate to the weight fraction in the consumable composition after the solid plant parts have been removed from the water in which they were cooked. It has been found to be particularly effective when the proportions of the individual plant components are the same and total between 0.05 and 0.25% by weight. These vegetable components are also advantageous if they are not present in the same quantity in the dietary supplement.

The food supplement expediently contains terpene hydrocarbons, gentiobiosis and/or bitter substances, essential oils of mountain pine (Pinus Mugo), linoleic acid and a natural resin in the same proportion. The inventors were able to determine the best results in the immune stimulation of chemotherapy patients with these proportions, which were 0.03% by weight per proportion.

In one embodiment of the invention, the food supplement according to the invention consists exclusively of water and the substances from branches, blossoms and/or leaves or needles of yellow gentian (Gentiana Lu tea), common juniper (Juniperus communis), which have passed into the water during cooking. mountain pine (Pinus Mugo), a pine and the resin of a conifer.

In a further embodiment of the invention, the liquid food supplement has the following ingredients:

- terpene hydrocarbons from juniper (Juniperus com munis) boiled in water,

- Gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, of subterranean components of yellow gentian (Geniana Lutea) boiled in water, and essential oils of mountain pine (Pinus Mugo).

The mountain pine extracts also improve the effect of the dietary supplement, i.e. in combination with the other substances they stimulate the immune system particularly well.

The liquid dietary supplement expediently has the following ingredients:

- terpene hydrocarbons from juniper (Juniperus com munis) boiled in water,

- Gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogen tin, of subterranean components of yellow gentian (Geniana Lu tea) cooked in water, the vegetable content being between 0.05 and 0.25% by weight based on the total weight of the dietary supplement. The inventors have found that this plant content, which is low in relation to the prior art, already has a very good immune-stimulating effect.

The invention is explained in more detail below using exemplary embodiments.

600 g of chopped, dried roots of yellow gentian (Gentiana lutea) and 600 g of a chopped mixture of blossoms and branches of common juniper (Juniperus communis) are boiled in 2 l of water at 100° C. for 30 min. After cooking, the liquid is cooled down to 55°C and the botanicals are strained out.

The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks. Subjectively, after 4 days, a good feeling of well-being appeared, which lasted until the end of the chemotherapy.

This liquid contained 0.025% by weight of terpinen-4-ol and 0.03% by weight of Amarogen. In addition, 0.04% by weight of a-pinene.

In 2 I water boiled at 100 °C for 25 min. After cooking, the liquid is cooled down to 55°C and the botanicals are strained out.

This liquid contained 0.022% by weight of terpinen-4-ol, 0.037% by weight of amarogen and 0.029% by weight of mountain pine oil. Also 0.036% by weight of a-pinene.

Example 3:

600 g fresh roots of yellow gentian (Gentiana Lutea), 600 g of a chopped mixture of blossoms and branches of common juniper (Juniperus communis), 600 g crushed fresh needles and pine cones of mountain pine (Pinus Mugo) and 500 g dried fruit and pine needles boiled in 2 l water for 35 min at 100 °C. After boiling, the liquid is cooled down to 55 °C and the plant matter is strained out.

The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks. Subjectively, after 3 days, a good sense of well-being appeared, which lasted until the end of the chemotherapy.

This liquid contained 0.025% by weight of terpinen-4-ol, 0.033% by weight of amarogen, 0.027% by weight of mountain pine oil and 0.031% by weight of linoleic acid.

800 g of a mixture of dried flowers and roots of yellow gentian (Gentiana Lutea), 800 g of a chopped mixture of dried flowers and branches of common juniper (Juniperus communis), 700 g of crushed fresh needles and pine cones of mountain pine (Pinus Mugo) , 600 g of dried fruit and pine needles and 100 g of dried spruce resin are boiled in 3 l of water at 100° C. for 30 min. After boiling, the liquid is cooled down to 60 °C and the solid parts of the plant are sieved off.

The remaining fluid is given to several chemotherapy patients at a dose of 200 ml per week for 5 consecutive weeks. Subjectively, more than half of the users felt well after just 2 days, which lasted until the end of the chemotherapy. Recovery was on average 20% quicker than predicted by treating physicians.

This liquid contained 0.03% by weight of terpinen-4-ol, 0.03% by weight of amarogen, 0.03% by weight of mountain pine oil, 0.03% by weight of linoleic acid and 0.03% by weight of -% resin.

It goes without saying that all combinations of the compositions shown in Examples 1 to 4 are conceivable. For example, the composition of Example 1 can be made with fresh yellow gentian roots.

Claims

1. Liquid food supplement for use in immunostimulation, comprising:

- terpene hydrocarbons of a cypress plant (Cupressaceae) boiled in water,

- Gentiobiosis and/or bitter substances, in particular gentianopicrin and/or amarogentin, from subterranean components of a gentian family (Gentianaceae) boiled in water.

2. Dietary supplement for use according to claim 1, characterized in that the terpene hydrocarbons, in particular terpene alcohols, preferably terpinen-4-ol, α-pinene and/or β-pinene, are from a fruit, leaves and/or scales of the cypress plant , especially the common juniper.

3. Dietary supplement for use according to claim 1 or 2, characterized in that the gentian plant is yellow gentian (Gentiana lutea).

4. Dietary supplement for use according to one of claims 1 to 3, characterized in that the dietary supplement contains essential oils of mountain pine (Pinus Mugo), these being preferably obtained by boiling branches, needles and/or cones of mountain pine in water.

5. Dietary supplement for use according to one of Claims 1 to 4, characterized in that the dietary supplement contains linoleic acid, which is obtained in particular by cooking fruits, branches and/or needles of a pine tree, preferably a pine tree, in water.

6. Dietary supplement for use according to any one of claims 1 to 5, characterized in that that the dietary supplement has a natural resin, in particular the resin of a coniferous tree.

7. Dietary supplement for use according to any one of claims 1 to 6, characterized in that the dietary supplement is a decoction, for the production of which solid, in particular dried, parts of plants are boiled in the water and removed after cooling.

8. Dietary supplement for use according to any one of claims 1 to 7, characterized in that the dietary supplement is purely vegetable.

9. Dietary supplement for use according to any one of claims 1 to 8, characterized in that the vegetable content is between 0.001% by weight and 5% by weight, preferably between 0.002% by weight and 1.0% by weight.

10. Dietary supplement for use according to one of claims 1 to 9, characterized in that the dietary supplement has terpene hydrocarbons, gentiobiosis and/or bitter substances, essential oils of mountain pine (Pinus Mugo), linoleic acid and a natural resin in the same proportion.

11. A process for the preparation of an aqueous food supplement for immunstimulation for use according to any one of claims 1 to 10, in which plant parts are boiled in water and, after cooling, are removed by decantation or sieving.

12. The method according to claim 11, characterized in that an equal amount of a fruit, branches and/or leaves of a cypress plant and a gentian plant are boiled in the water.

13. The method according to claim 11, characterized in that that an equal amount of a fruit, branches and/or leaves of a cypress plant, a gentian plant, a pine tree, preferably a pine tree, and a vegetable resin are boiled in the water.

14. Use of a liquid dietary supplement for use according to ei nem of claims 1 to 10, which can be produced or produced by a method according to any one of claims 11 to 13, for stimulating the immune system of a human, in particular a human suffering from a tumor disease's rule.