DE102005046892A1 - Composition, useful for the treatment of e.g. oliguria, comprises plant extracts of Alismatis Orientale, Plantago asiatica or Plantago depressa and Polygonum multiflorum - Google Patents

Abstract

Composition comprises plant extracts of Alismatis Orientale, Plantago asiatica or Plantago depressa and Polygonum multiflorum. ACTIVITY : Antilipemic; Anorectic; Hypotensive; Immunostimulant; Laxative; Muscular-Gen.; Immunomodulator; Nephrotropic. MECHANISM OF ACTION : None given.

Description

The The present invention relates to a vegetable composition Material containing material from at least three different plant species comprises and the use of this composition for the preparation of a Medicament, food or dietary supplement for the treatment of overweight, Obesity and obesity.

Especially in the western industrial nations there are more and more people their body weight does not correspond to an assumed ideal weight. The ideal weight let yourself in the form of the so-called body mass index (BMI), the next to the body weight also considered the height of the person.

Around the value of the ideal weight lies around the so-called Normal weight. This range extends from a BMI of 18.5 to to a BMI of 24.9. From a BMI of 25 one speaks of already an overweight People, where the subjective well-being of a person also can differ significantly from these values.

Objective overweight occurs in all strata of the population and ages, and especially in children steadily increasing in the western world. According to the Federal Statistical Office the proportion of adults who are overweight is in Germany at about 50%, with about half Of these only moderately overweight is.

There both subjective and objective overweight for many the affected person is not the desired one Ideal condition is and at least for the latter case also negative effects of too high body weight known to health, there are a variety of offers and recommendations that promise effective weight loss to effect. Which includes in addition to targeted sports activities Naturally also nutrition plans and diets. Furthermore Also agents are popular that affect the metabolism to this effect should that one Reduction of body weight promoted becomes. These include beside Drugs with synthetic agents, e.g. also medicinal herbs as well Teas or tea blends thereof.

Examples of known drugs with defined active ingredient are sibutramine and orlistat preparations. Sibutramine (eg Reduc-til ^® ) increases the satiety and the body's metabolic rate. For this agent, however, a whole series of possible unwanted side effects are known, such as increase in heart rate, hypertension, nausea, constipation, nervousness, insomnia, dizziness, depression, headache or bladder emptying disorders. Orlistat (eg Xenical ^® ) affects the fat absorption of the intestine and thus causes a reduction of fat absorption in the body. Unpleasant side effects of orlistat supplements are stool softening, fatty stools, excessive stool urgency and, in rare cases, stomach pain.

As already mentioned are in addition to the aforementioned medicines also teas or tea blends popular to promote the reduction of body weight. These are also referred to as "slimming tea". To include these slenderstees for example, the so-called mate tea, which leaves the leaves of Holly is harvested and said to be hungry brakes and food cravings to protect. In addition, the so-called Pu Erh tea is known, from the leaves of the Dayeh tea tree from the southern Chinese Yunnan Province is produced. This tea will have a promotional effect attributed to fat burning. Also the green tea from the conventional Tea plant Camellia sinensis is said to be beneficial to fat burning act and thus facilitate weight loss. Furthermore, the so-called Lapacho tea is known from the tree bark of the Lapacho tree, the general to stimulate the metabolism.

Next the teas, which consist only of the plant material of a plant species, There are also slimming tea, made from a mixture of plant material best of various plant species. For example, e.g. a tea blend known to promote the reduction of body weight, and those from the components marigolds, chamomile flowers, cornflowers, Sunflowers, rose petals, elderflower as well as Krauseminzenblatt exists.

The known from the prior art slimming products, such as sibutramine and orlistat Prä Prepared masses have proven to be effective in promoting weight loss. However, the tolerance of these preparations is limited in many users, since the intake of such preparations may be associated with a variety of side effects that may affect the quality of life not insignificant. In addition, these agents are synthetic drugs. In the population, however, especially herbal preparations enjoy high acceptance, as the plant ingredients good effect is attributed to good tolerability.

To such herbal supplements counting Naturally the ones mentioned above Slimming teas. These, in fact, have less unpleasant side effects and like also each have a positive effect in the regulation of Body weight, especially of overweight People, exhibit. However, the weight-reducing effect the known slimming tea rather low.

Out The prior art is thus far no effective slimming product known, which does not have unpleasant side effects at the same time. There is therefore a big one Need for an agent, preferably a pure vegetable Material that is used to treat overweight, obesity and Obesity is appropriate, effective in promoting weight loss works and as possible has few side effects.

The It is an object of the present invention to provide an agent from essentially vegetable material intended for Treatment of obesity, Obesity and obesity is appropriate and this more effective acts as the for this use previously known preparations without having unpleasant side effects go hand in hand. Another requirement of this remedy is that it is for the user well tolerated and above In addition, toxicologically harmless.

These Task is achieved by a composition of vegetable material dissolved, wherein this composition material of at least the three plant species Alismatis orientale, Plantago asiatica and Polygonum multiflorum contains or at least the three plant species Alismatis Orientale, Plantago depressa and polygonum multiflorum.

Surprisingly could for the composition of the invention be shown to be at Application by a larger group of people from overweight men and women a reduction in the body weight of each People in a relatively short time (a few weeks to a few months) effect could. For the details of these results, the specifics the composition, the manner of application of the invention and to their specific embodiments will be explained in more detail below.

The Plants whose plant material in the composition according to the invention contained, are medicinal plants that are in traditional Chinese Medicine for various complaints apply. So will Alismatis orientale according to the traditional Chinese medicine for promotion the urine flow and in this context in particular for treatment of edema used. In addition, there are also positive effects in the application in diarrhea and inflammatory Bowel disease known. Also Plantago asiatica and Plantago depressa are original for your In addition, however, diuretic effects are also known as treatment used by diarrhea. Polygonum multitlorum is primarily called Laxans used, but is also used to detoxify the body, as well as to increase the defenses.

The Ingredients of the composition of the invention thus each for a biological activity, i. a specific one Effect on the human organism and therefore also according to their specific action targeted for the treatment of certain symptoms and diseases used. about these different "individual effects" of the components However, the composition surprisingly showed be that the Combination of these ingredients to the composition of the invention has further advantageous effects.

Thus, an appetite-suppressing effect was observed for the composition according to the invention, ie persons who were administered preparations of the composition according to the invention indicated that their previously large appetite had decreased permanently, so that these persons volunteered spontaneously, for example after administration of the composition according to the invention Snacking and larger refills at the main meals renounced or from the outset only small portions close to men. In particular, the use of the composition according to the invention satisfies the feeling of cravings of the patients. Many patients also describe the effect as having the feeling that they are getting fuller faster.

Furthermore the composition of the invention is characterized in that they leads to a reduction in blood lipid levels. This effect may seem like one certain part on the changed eating habits attributed to the test persons. About that but it is assumed that the combination of the active Principles of different plant materials a metabolism-physiological Effect, which promotes the blood lipid metabolism activity and thereby the blood lipid levels lowers.

The Combination of appetite-suppressing Effect and blood lipid lowering effect is essential Advantage of the present invention, since the two effects taken alone probably not enough for a means to promote the reduction of body weight. Only by intervening on two essential points, namely the Fat balance of the body and the absolute energy intake in the body, can be an effective weight-reducing Effect can be achieved.

About the influence In addition to energy intake and household, the composition of the invention even more effects on when applying the composition to promote the weight reduction of overweight People are beneficial. Thus, the composition according to the invention increases to some extent, the defenses of the user. This is especially advantageous because v.a. in severely overweight People frequently only supported through radical change in diet and lifestyle habits Customer order can be achieved. this leads to often to a weakening the overall constitution of the patients, who then respond accordingly vulnerable for easy Become infections. Such infections are by the one who want to lose weight, often as occasion, that To cancel the project as the measures Apparently to increase the susceptibility to losing weight. the occurs the defense force increasing effect of the composition according to the invention advantageous contrary.

One Another effect of the composition of the invention, also for the Acceptance of weight loss therapy is important is that the Composition according to the invention especially in overweight People frequently present increased Lowering blood pressure is possible. Noteworthy here is that the hypotensive Effect does not occur among users whose blood pressure is normal or even a little too low value, but only at those whose blood pressure is elevated, especially in those in whom the blood pressure is slightly elevated. The achieved blood pressure reduction leads the patient usually to a better acceptance of the therapy, since immediately after start of therapy already an improvement of the Well-being is noticeable because of the acute symptoms of hypertension, such as e.g. Headache, dizziness, tiredness and sleep disorders, disappear or be mitigated.

Furthermore was for the composition of the invention as a further effect found that the administration of a preparation of constipation made with this composition prevents, but without laxative to act. In the course of a weight loss therapy will be changed a variety of physiological conditions in the human body. In addition to a change Metabolic physiology, for example, the intestinal activity and the water balance is affected. hereby it can come at times to constipation conditions, on the one hand cause unpleasant discomfort can and on the other the perceptibility prevent the progression of weight reduction. That bows the Composition according to the invention by preventing the development of constipation.

It was also found that the Composition according to the invention the oligurie prevents. So is in patients who have one out of this Composition prepared by the preparation, prevents that the Urine flow under the physiological normal level drops. That in the treated Patients who had low urinary flow promoted the Administration of a preparation of the composition according to the invention the urine flow, until it reached normal levels again. Since already on it was pointed out that at a therapy for weight reduction of the water balance will be affected can, is also the supportive Regulation in the aforementioned sense advantageous, especially too low Urine flow too an excessive collection of liquid in the body leads and thus the result or the intermediate results of the weight loss therapy falsified to the detriment of the patient can be.

Of course, taking advantage of the aforementioned side effects, the composition of the invention can also be used specifically in patients who are not overweight, but have to suffer from complaints that positively influenced by the effects of the composition or even over such as in patients who have slightly elevated blood pressure, who are particularly susceptible to disease or prophylactic to prevent disease and / or tend to constipation or low urine flow.

Of Further, the composition of the invention Also contain material from other plant species. This can be, for example other herbal ingredients that are a weight-reducing Effect on the human body have, or other plant constituents, the intake of preparations make this composition more pleasant, e.g. herbal flavorings and essential oils. Also for the Indications of increased Blood pressure, immune deficiency, Constipation and / or oliguria can also provided additional plant components in the composition be.

Preferably is that for the composition of the invention used herbal material from single or several different Plant organs of the respective plant species contained in the mixture, since the active ingredients (the active substance) the plant species used are not statistically distributed throughout the plant but enriched in certain parts of the plants and in others are significantly smaller or nonexistent. Preferably used plant organs are therefore dependent from the respec gene plant root, rhizome, shoot, leaf, flower and / or Fruit or individual components of these organs.

So is in a specific embodiment of the present invention selected a composition whose vegetable material the herbal drugs with the terms Rhizoma Alismatis, Herba Plantaginis and Radix Polygoni Multiflori comprises for this These special drugs could be shown to be the effective ingredients in the for the composition of the invention have suitable concentrations and in suitable form.

The Herbal material may be present as a whole drug in the composition, but is preferably crushed, so chopped or pulverized before. Of course let yourself Mix the composition in powdered form better homogeneous. Also for further processing into medicines, food or nutritional supplements or for the extraction is as possible high degree of comminution advantageous.

ever after which major and minor complaints occur in a patient and in what combinations, can the proportions of the different compulsory in the composition contained plant materials for patients, for example increased Have blood pressure or develop this in the course of therapy, the especially vulnerable for diseases are or will be in the course of therapy or prophylactic Want to prevent diseases and / or prone to constipation or low urine flow or develop these symptoms in the course of therapy vary.

In a particular embodiment of the present invention, the proportionate composition of the plant material is selected so that the respective herbal drugs are included in the composition with the following proportions: Rhizoma Alismatis 10 to 40% by weight Herba Plantaginis 10 to 40% by weight Radix polygoni multiflori 10 to 40% by weight.

Especially regarding laxative and diuretic drugs those given in this advantageous composition for these ingredients Upper limits not exceeded be as overly funded Urinary or Stuhldrang on the one hand, the acceptance of the slimming agent degrades and on the other hand can also be harmful to health.

In particular, taking into account the previously noted, in a further preferred embodiment of the present invention, the proportions of the respective herbal drugs in the composition are as follows: Rhizoma Alismatis 5 to 30% by weight Herba Plantaginis 15 to 35% by weight Radix polygoni multiflori From 20 to 45% by weight.

This composition has proven to be particularly advantageous for the previously treated with appropriate agents and leads to the best results. Compositions with the previously However, given broader areas, in comparison to prior art agents, improved results have already been obtained and may also be used with particular advantage when used by a slightly different group of persons (eg children, senior citizens).

at alternative embodiments In the present invention, the vegetable material is the composition from extracts of the respective plant species. Preferably, these are Extracts of single or multiple plant organs of the respective plant species, such as. Extracts of root, rhizome, sprout, leaf, flower and / or Fruit or a component of these organs. Especially preferred comprises the composition the extracts of the vegetable drug with the Names Rhizoma alismatis, Herba Plantaginis and Radix polygoni Multi Flori.

at The extracts are preferably aqueous extracts or extracts with organic solvents from the respective plant species. These are especially alcoholic as well as aqueous-alcoholic excerpts preferred because it has been found that the compositions are particularly Well, the extracts contained with these solvents or solvent mixtures had been made.

In a particular embodiment of an extract-based composition, the extracts of the respective herbal drugs are contained in the composition with the following proportions, the data in percent by weight being based on the proportion of dry extract of the respective drug in the total composition: Rhizoma Alismatis 5 to 20% by weight Herba Plantaginis 20 to 35% by weight Radix polygoni multiflori From 25 to 45% by weight.

These Values give way naturally clearly from the unit values for Compositions from, for example, powdered drugs, since depending on the drug per gram different amounts of dry extract obtained, the amount of dry extract obtained for a drug in turn dependent from the solvent used is what makes the broad share areas.

at particular embodiments comprises the composition of the invention in addition also Shares of Cassia obtusifolia, whose plant material for its mild laxative and thus weak laxative effect is known. Particularly preferred is a Cassia obtusifolia portion of the total composition from 1 to 5% by weight. Preferably, the Cassia obtusifolia portion of the drug Semen Cassiae.

Of the Proportion of Cassia obtusifolia plant material may be fresh or dried plant material or else from aqueous, alcoholic or watery-alcoholic Extracts consist of extracts as well as other organic solvents wherein the extracts are preferably as dry extracts are incorporated in the mixture.

A preferred composition according to the present invention with a content of plant material of Cassia obtusifolia contains proportionally the following constituents: Rhizoma Alismatis 5 to 20% by weight Semen Cassiae 1 to 5% by weight Herba Plantaginis 15 to 30% by weight Radix polygoni multiflori From 20 to 45% by weight.

at particularly preferred embodiments comprises the composition according to the invention additionally Proportions of the algae Sargassum pallidum and / or Sargassum fusiforme. Particularly preferred is a sargassum portion of the total composition from 5 to 30% by weight. Preferably, for this component of the composition used the drug Herba Sargassi.

Of the Sargassum content can be fresh or dried algae material or also from aqueous, alcoholic or aqueous-alcoholic Extracts consist of extracts as well as other organic solvents wherein the extracts are preferably as dry extracts are incorporated in the mixture.

A preferred composition according to the present invention with an algal content proportionately contains the following constituents: Rhizoma Alismatis 5 to 25% by weight Herba Sargassi 5 to 30% by weight Herba Plantaginis 5 to 35% by weight Radix polygoni multiflori 5 to 30 wt .-%.

As already explained at the beginning, has the composition according to the invention an excellent weight-reducing effect especially in overweight People up. Therefore, compositions according to this invention are preferred for the manufacture of a medicament, food or dietary supplement for treatment or support the treatment of obesity, Obesity and obesity used.

Of Further are compositions according to the invention preferably also for the manufacture of a medicament, foodstuff or dietary supplement for treatment or support treatment or prevention of slightly elevated blood pressure and / or used for the prevention of hyperlipidemia. Furthermore Compositions according to this Invention also preferred for the preparation of a medicament, foodstuff or dietary supplement to strengthen of the defenses used, preferably for the manufacture of a medicament, foodstuff or dietary supplement to strengthen used the immune system. Furthermore are compositions of the invention preferred for the manufacture of a medicament, foodstuff or Dietary supplement for treatment or support used for the treatment or prevention of constipation. And Furthermore, compositions according to this invention are preferably also for the manufacture of a medicament, foodstuff or nutritional supplement for treatment or support used for the treatment or prevention of oliguria. In a another embodiment These inventions are the compositions for the preparation a drug, food or dietary supplement for treatment or support the treatment of tiredness symptoms used.

These Use is preferably for the manufacture of a medicament, Food or dietary supplement for oral administration. This drug, food or dietary supplements is in preferred embodiments in "dry" form, e.g., in shape of powders, capsules, pills and dragees. On the other hand is also the use for the manufacture of a medicament, food or dietary supplement in "liquid" form preferred, such as. in the form of suspensions, syrups, emulsions, elixirs as well as in the form of hot or cold aqueous or aqueous-alcoholic Statements.

at a group of embodiments is for the preparations to be made from shredded plant material, while alternatively for the crushed plant material in another group of embodiments Plant extracts are used. In specific embodiments comprises the plant material used both extract and unextracted vegetable material.

The Plant material is preferably made with plant and / or non-herbal adjuvants (e.g., carriers) to a drug, Food or dietary supplements processed and / or processed into a drug, food or dietary supplements with vegetable and / or non-herbal active substances of a suitable Active complex (e.g., anti-fulgurant agents) and / or with nutritional supplements (e.g., vitamins, trace elements). Other herbal and / or non-herbal active ingredients, preferably in a medicament, Food or supplements, that is the composition of the invention comprises are appetizing, defense force increasing, hypotensive, Blutfettsenkende, obstipationsvorbeugende and / or diuretic agents.

Further Features and advantages of this invention will be apparent from the following Application example and the results achieved by the application out.

In one application example of the present invention, a tea mixture was used, which was proportionately composed of vegetable matter as follows: Rhizoma Alismatis 8 g (22% by weight) Sargassum pallidum 9 g (28% by weight) Herba Plantaginis 10 g (25% by weight) Radix polygoni multiflori 9 g (25% by weight)

For the preparation of the tea, the material was crushed and mixed. For preparation One day ration was 40 g of the mixed material with 2000 ml of cold to lukewarm water and subsequently Soaked for 30 minutes. After expiration of the soaking time the extract was brought to a boil and for Cooked for 5 minutes.

Subsequently was the tea is poured through a sieve and as soon as it reaches the appropriate temperature (drink-warm) had drunk. about the day became 1-2 l of the tea, what about a period of several weeks has been carried out. This treatment led in different subjects to the reproduced below Results.

Results

In Table 1 shows the patients treated with a tea preparation from a composition according to the invention from vegetable material.

Table 1:

in the Treatment period of several weeks were at the in table 1 presented the results shown in Table 2 achieved.

Table 2:

• *: based on the starting weight (see Tab. 1)

Out the results of treatment of overweight shown in Table 2 Patients with a tea preparation according to the example over several Weeks can be read that already after three weeks for all ten treated persons a reduction of body weight based on the starting body weight average of 8%. The weight reduction increased among those who continued treatment for another week on average 10%. In the patients receiving treatment over a total could last at least 5 weeks, could reduce weight average of 12%. The two patients who even over Treated for 6 weeks, their weight overall increased by 13% or even reduce by 17%.

Parallel to determine the weight change Surveys of patients were also conducted on their condition and compared with the data of the subjects before starting the treatment. Before the start of treatment, 8 of the 10 subjects had indicated, under a lot of appetite and regular cravings to suffer (patients 1, 2 and 5-10). All of these patients stated that their appetite was in the first 1-3 weeks have significantly reduced and that they no more cravings suffered.

at Two patients had mild hypertension before treatment been detected (patients 3 and 4). In both patients could after 3 to 4 weeks, it can be established that the blood pressure normalizes would have.

Two Patients had constipation before starting treatment complained (patients 3 and 8). In both patients could by the Treatment of this discomfort complex can be significantly alleviated.

Out The test results clearly show that the composition of the invention a has excellent weight-reducing effect in overweight people. About that In addition, these results also indicate that compositions according to the invention for the preparation of preparations for treatment or support the treatment of constipation, mild hypertension and food cravings can be used with advantage.

Claims (21)

Composition of plant material, the composition comprising material from at least the three plant species a) Alismatis Orientale, b) Plantago asiatica or Plantago depressa and c) Polygonum multiflorum contains. Composition according to Claim 1, characterized that this Plant material from the plant organs of the respective plant species consists, preferably of root, rhizome, shoot, leaf, flower and / or Fruit and / or a component of these organs. Composition according to Claim 2, characterized that this herbal material the herbal drugs with the terms a) Rhizoma Alismatis, b) Herba Plantaginis and c) Radix Polygoni Multi Flori includes. Composition according to Claim 3, characterized that this vegetable material is crushed and / or powdered. Composition according to any one of Claims 3 and 4, characterized in that the respective herbal drugs are present in the composition in proportions of: Rhizoma Alismatis 10 to 40% by weight Herba Plantaginis 10 to 40% by weight Radix polygoni multiflori 10 to 40% by weight. Composition according to any one of Claims 3 and 4, characterized in that the respective herbal drugs are present in the composition in proportions of: Rhizoma Alismatis 5 to 30% by weight Herba Plantaginis 15 to 35% by weight Radix polygoni multiflori From 20 to 45% by weight. Composition according to Claim 1, characterized that this plant material consists of extracts of the respective plant species, preferably from extracts of individual plant organs of the respective plant species and most preferably from extracts of root, rhizome, sprout, leaf, Blossom and / or Fruit and / or a component of these organs of the respective plant species. Composition according to Claim 7, characterized that this herbal material containing the extracts of herbal drugs designations a) Rhizoma Alismatis, b) Herba Plantaginis and c) Radix Polygoni Multiflori includes. A composition according to any one of claims 7 and 8, characterized in that the Extracts of water excerpts and / or extracts with organic solvents from the respective plant species are, preferably alcoholic and / or aqueous-alcoholic excerpts are. Composition according to any one of Claims 7 to 9, characterized in that the extracts of the respective herbal medicaments are present in the composition with the following dry extract contents: Rhizoma Alismatis 5 to 25% by weight Herba Plantaginis 20 to 35% by weight Radix polygoni multiflori From 25 to 45% by weight. A composition according to any one of claims 1 to 10, characterized in that in addition also Contains plant material parts of Cassia obtusifolia. A composition according to any one of claims 1 to 11, characterized in that in addition also Contains proportions of Sargassum pallidum and / or Sargassum fusiforme. Use of a composition according to any one of claims 1 to 12 for the preparation of a medicament, food or dietary supplement for controlling blood lipid levels, preferably for the manufacture of a medicament for lowering blood lipid levels. Use of a composition according to one of claims 1 to 12 for making an appetite suppressant. Use of a composition according to one of claims 1 to 12 for the manufacture of a medicament, food or Dietary supplement for treatment or support the treatment of obesity, Obesity and obesity. Use of a composition according to one of claims 1 to 12 for the manufacture of a medicament, food or Dietary supplement for treatment or support the treatment or the prevention of slightly elevated blood pressure, preferably for the manufacture of a medicament, foodstuff or dietary supplement for lowering slightly increased Blood pressure. Use of a composition according to one of claims 1 to 12 for the manufacture of a medicament, food or Dietary supplement to strengthen the defenses, preferably for the manufacture of a medicament, foodstuff or dietary supplement to stimulate the immune system and / or the immune system. Use of a composition according to one of claims 1 to 12 for the manufacture of a medicament, food or Dietary supplement for treatment or support the treatment or the prevention of constipation or treatment or for support the treatment of tiredness or states of exhaustion. Use of a composition according to one of claims 1 to 12 for the manufacture of a medicament, food or Dietary supplement for treatment or support the treatment or the prevention of oliguria. Use according to any one of claims 13 to 19 wherein the medicament, Food or dietary supplements in the form of powders, granules, capsules, tablets, dragees, suspensions, Syrups, emulsions, elixirs or hot or cold aqueous or aqueous-alcoholic Statements. Use according to any one of claims 13 to 20 wherein the medicament, Food or dietary supplements additionally herbal and / or non-vegetable adjuvants, preferably Carriers, herbal and / or non-herbal active substances, preferably fatty acid-promoting, appetite suppressing, defensive strength enhancing, antihypertensive, constipation preventive and / or diuretic Active ingredients and / or nutritional supplements, preferably contains vitamins and / or trace elements.