WO2018124572A1

WO2018124572A1 - Silicon resin composition, preparation method therefor, and scar treatment agent including same

Info

Publication number: WO2018124572A1
Application number: PCT/KR2017/014888
Authority: WO
Inventors: 박일규; 김현정; 강휘주
Original assignee: 주식회사 제네웰
Priority date: 2016-12-28
Filing date: 2017-12-15
Publication date: 2018-07-05
Also published as: KR101921727B1; JP6821054B2; JP2020501868A; CN110121368A; KR20180076871A

Abstract

The present invention relates to a silicon resin composition, a preparation method therefor, and a scar treatment agent including the same and, more specifically, to a silicon resin composition, a preparation method therefor, and a scar treatment agent including the same, the composition comprising: a) 5-70 wt% of a silicon resin; b) 0-40 wt% of wax; c) 1-15 wt% of an emulsifier; d) 0.01-10 wt% of a drug; e) 0.01-10 wt% of an activator; f) 0-30 wt% of a sunscreen; g) 0-5 wt% of an antioxidant; h) 0-80 wt% of water; and i) 0.1-5 wt% of a preservative. The present invention has an effect of providing the silicon resin composition, the preparation method therefor, and the scar treatment agent including the same, the agent being safe by using biocompatible raw materials that are harmless to the human body, being convenient by lacking stickiness while being smoothly applied, and forming a thin silicon film while quickly drying so as to protect a scar and create a moist environment, having a special efficacy for the prevention and the alleviation of redness or pigmentation of a scar by means of ultraviolet ray blocking and antioxidant effects, and softening and flattening a scar better than a conventional agent by having improved absorption of a drug and an activator, that is, an active ingredient, through a high occlusive property and skin softening, thereby generating a synergic effect for the prevention, treatment, and alleviation of a scar, and additionally, having excellent flexibility, waterproof, and moisturizing properties.

Description

Silicone resin composition, preparation method thereof and scar healing agent comprising same

The present invention relates to a silicone resin composition, a method for preparing the same, and a scar treatment agent including the same. More particularly, the use of a biocompatible raw material harmless to the human body is safe, smooth, and non-sticky, and is quick and dry. It forms a film to protect scars and creates a moisture environment, and is effective in preventing and improving scar erythema and pigmentation due to UV protection and anti-oxidant effect.The drug and the activator In addition, the absorption of the active ingredient is improved, thereby making the scar softer and flatter than the prior art, thereby producing a synergistic effect on the prevention, treatment, and improvement of the scar. It relates to a scar treatment comprising.

Scar tissue usually causes the body's body to initiate an accurate and rapid wound healing response when the skin or dermis is cut or burned, causing damaged tissue to be part of the reconstruction or repair process. However, if the reconstruction or repair process is poorly controlled, even the normal healing process may cause excessive scarring and pain.

Scars are different from the surrounding skin in the color, roughness or softness of the skin, causing severe mental stress when they appear in the appearance area, and the scars in the areas where stretching is caused to damage the skin tissue again. This results in treatment time, and consequent shrinkage of surrounding tissues causes great inconvenience in life.

Conventionally, a method for preventing or improving scars using a silicone gel sheet or a silicone ointment has been disclosed, but it is inconvenient to use due to stickiness, the scar healing effect is not larger than expected, and there is a problem in that pigmentation or erythema prevention effects are insignificant.

[Preceding technical literature

[Patent Documents]

Korean Patent Publication No. 2013-0120537

In order to solve the problems of the prior art as described above, the present invention is safe, smooth, and non-sticky with the use of biocompatible raw materials harmless to the human body, and convenient to dry quickly, forming a thin silicone film to form a scar protection and moisture environment In addition, it is effective in preventing and improving erythema and pigmentation of scars by sun protection and anti-oxidation effect, and the absorption of drugs and activators, that is, active ingredients, is improved due to high occlusive property and skin softening. The purpose of the present invention is to provide a silicone resin composition having excellent flexibility, waterproofness, and moisturizing property, a method of manufacturing the same, and a scar treating agent including the same, in which a synergistic effect is generated in the prevention, treatment, and improvement of the scar by softening and flattening the contrast scar. do.

The above and other objects of the present invention can be achieved by the present invention described below.

In order to achieve the above object, the present invention is a) 5 to 70% by weight of silicone resin, b) 0 to 40% by weight of wax, c) 1 to 15% by weight of emulsifier, d) 0.01 to 10% by weight of drug, e) 0.01 to 10% by weight of activator, f) 0 to 30% by weight of sunscreen, g) 0 to 5% by weight of antioxidant, h) 0 to 80% by weight of water and i) 0.1 to 5% by weight of preservative A silicone resin composition is provided.

In addition, the present invention is A) 5 to 70% by weight of the silicone resin, 0 to 40% by weight of the wax, 1 to 15% by weight of the emulsifier and 0 to 30% by weight of the sunscreen under stirring at 60 to 80 ℃ mixing; And B) 0.01 to 10% by weight of drug, 0.01 to 10% by weight of activator, 0 to 5% by weight of antioxidant, 0 to 80% by weight of water and 0.1 to 5% by weight of preservative, and 45 to It provides a method for producing a silicone resin composition comprising a; mixing by stirring under 70 ℃.

In addition, the present invention provides a scar treatment agent comprising the silicone resin composition.

According to the present invention, the use of biocompatible raw materials that are harmless to the human body is safe, smooth, and non-sticky, convenient, and quickly dried to form a thin silicon film to protect scars and create a moisture environment, and to protect the scars by UV protection and antioxidant efficacy. It is effective in preventing and improving erythema and pigmentation, and the high occlusive property and skin softening improve the absorption of drugs and activators, i.e. active ingredients, making the scars softer and flatter than the prior art. Synergistic effect is generated in the treatment and improvement, and in addition, there is an effect of providing a silicone resin composition having excellent flexibility, waterproofness, and moisturizing property, a method for preparing the same, and a scar treatment agent including the same.

1 is a step of preparing to confirm the effect of the scar treatment, the same wound on the four parts of the rabbit ears and left for 3 weeks after the scar was confirmed, a series of treatment of the scar treatment on each of the sites This is a test flow diagram that outlines the process.

FIG. 2 is applied to the four scars of the test subjects prepared in FIG. 1 for histology analysis, respectively, twice a day for 4 weeks with a silicone resin composition prepared in Example 4 and a commercially available scar drug. Next, Masson's trichrome staining method was used for microscopic examination.

Hereinafter, the silicone resin composition of the present disclosure, a preparation method thereof, and a scar treatment agent including the same will be described in detail.

The present inventors add drugs and activators to a silicone resin mixture consisting of silicone resins, waxes and emulsifiers of a predetermined composition ratio, and optionally apply a silicone resin composition containing a sunscreen, antioxidant, water, and / or a preservative to the scar. When applied, it rapidly dries to form a thin silicon film (high occlusive property) to provide adequate light pressure while creating scar protection and rehydration, which results in capillary permeability and collagen deposition. (collagen deposition) is greatly reduced, the scar is greatly improved, and even smooth and smooth, non-sticky, easy to use, in particular, the synergistic effect compared to the prior art in terms of UV protection and antioxidant efficacy, it is confirmed that further research As a result, the present invention has been completed.

The silicone resin composition of the present invention comprises a) 5 to 70% by weight of silicone resin, b) 0 to 40% by weight of wax, c) 1 to 15% by weight of emulsifier, d) 0.01 to 10% by weight of drug, e) 0.01 to activator. 10 weight percent, f) 0-30 weight percent sunscreen, g) 0-5 weight percent antioxidant, h) 0-80 weight percent water and i) 0.1-5 weight percent preservative.

In another example, the silicone resin composition of the present invention comprises a) 5 to 70 weight percent of silicone resin, b) 1 to 40 weight percent of wax, c) 1 to 15 weight percent of emulsifier, d) 0.01 to 10 weight percent of drug, e A) 0.01 to 10% by weight of activator, f) 0 to 30% by weight of sunscreen, g) 0 to 5% by weight of antioxidant, h) 0 to 80% by weight of water and i) 0.1 to 5% by weight of preservative It is characterized by.

In another example, the silicone resin composition of the present invention comprises a) 15 to 70 weight percent of silicone resin, b) 1 to 40 weight percent of wax, c) 1 to 15 weight percent of emulsifier, d) 0.1 to 10 weight percent of drug, e A) 0.5 to 10 weight percent activator, f) 0 to 30 weight percent sunscreen, g) 0 to 5 weight percent antioxidant, h) 0 to 80 weight percent water and i) 0.1 to 5 weight percent preservative. It is characterized by.

The a) the silicone resin may be at least three kinds selected from the group consisting of silicone elastomers, film formers, silicone fluids and cyclic siloxanes, for example, in this case is a biocompatible raw material that is harmless to the human body and is safe and smooth without stickiness. In addition, it forms a thin silicon film as it dries quickly, thereby protecting scars and creating a moisture environment.

The a) silicone resin is, for example, a mixture of 2 to 75 wt% of silicone elastomer, 0.5 to 20 wt% of film former, 0.5 to 45 wt% of silicone fluid, and 0 to 80 wt% of cyclic siloxane, based on 100 wt% of the silicone resin. It can be, within this range is a biocompatible raw material harmless to the human body, safe, smooth and non-sticky, convenient, fast drying thin silicone film to form a scar protection and moisture effect is effective.

As another example, the a) the silicone resin is 5 to 50% by weight of the silicone elastomer, 2 to 10% by weight of the film former, 2 to 40% by weight of the silicone fluid and 0.1 to 65% by weight of the cyclic siloxane based on 100% by weight of the silicone resin It can be a blend of%, within this range is a biocompatible raw material harmless to the human body, safe, smooth and non-sticky, convenient, fast drying, thin silicone film to form a scar protection and moisture effect.

As another example, the a) the silicone resin is 10 to 50% by weight of the silicone elastomer, 2 to 10% by weight of the film former, 2 to 40% by weight of the silicone fluid and 5 to 65% by weight of the cyclic siloxane relative to 100% by weight of the silicone resin It can be a blend of%, within this range is a biocompatible raw material harmless to the human body, safe, smooth and non-sticky, convenient, fast drying, thin silicone film to form a scar protection and moisture effect.

The silicone elastomer may be, for example, a crosslinked silicone polymer having a weight average molecular weight of 100,000 g / mol or more, or 100,000 to 10,000,000 g / mol.

As another example, the silicone elastomer may be a crosslinked dimethicone or dimethicone derivative, stearyl methyl-dimethyl siloxane copolymer, polysilicon-11, cetearyl dimethicone-vinyl dimethicone crosspolymer, dimethicone-phenyl vinyl dimethicone It may be at least one selected from the group consisting of a crosspolymer and a dimethicone-vinyl dimethicone crosspolymer.

In the present description, the weight average molecular weight may be measured by gel permeation chromatography.

The silicone fluid may be, for example, a nonvolatile silicone fluid, preferably a nonvolatile silicone oil, and specifically using Ubelode (manufactured by Fisher Scientific Co.), a glass capillary viscometer according to ASTM D445, IP71. It may be a volatile silicone oil having a measured viscosity at 25 ° C. of 2 to 105,000 cts, 4 to 95,000 cts, 1,000 to 14,000 cts, or 11,000 to 14,000 cts, and has excellent effects in durability and ease of application within this range.

As another example, the silicone fluid may be a silicone fluid 1 having a viscosity of 1 to 20 cst or 1 to 10 cst, a silicone fluid 2 of 10,000 to 15,000 cst or 11,000 to 14,000 cst, and 80,000 to 120,000 cst or 90,000 to It may be at least one selected from the group consisting of 110,000 cst of silicone fluid (3), preferably 10,000 to 15,000 cst or 11,000 to 14,000 cst of silicone fluid (2), and 80,000 to 120,000 cst or 90,000 to 110,000 cst of silicone A mixture of the fluid 3, most preferably a mixture of the silicone fluid 1 having a viscosity of 1 to 20 cst or 1 to 10 cst and a silicone fluid 3 of 80,000 to 120,000 cst or 90,000 to 110,000 cst In this case, the touch is good, and there is an effect excellent in durability and ease of application.

The weight ratio of the silicone fluid 1 and the silicone fluid 3 may be, for example, 1: 0.1 to 0.9, 1: 0.1 to 0.5, or 1: 0.15 to 0.4, the feel is good within this range, durability and application Ease of excellence has an effect.

The weight ratio of the silicone fluid 2 and the silicone fluid 3 may be, for example, 1: 1 to 5 or 1: 1.5 to 2.5, and a good feel within this range, and excellent durability and ease of application. .

As another example, the silicone fluid may be a linear silicone polymer, and in particular, at least one selected from the group consisting of a linear dimethicone polymer, a linear polydimethylsiloxane polymer, a polymethylethylsiloxane, and a polymethiphenylsiloxane, in which case It is effective in durability and ease of application.

The film forming agent may be, for example, one of various film forming silicone resins known in the art, and may be, for example, an MQ type silicone resin, a T type silicone resin, or a mixture thereof, and specific examples include trimethylsiloxysilicate, Cyclopentasiloxane, propyl silsesquioxane resin, and silsesquioxane may be one or more selected from the group consisting of, in this case, to improve the fluidity and feel of the silicone resin composition, and improve the dispersion of other additives such as drugs It works.

The film-forming agent has a viscosity at 25 ° C. measured using Ubelode (manufactured by Fisher Scientific Co., Ltd.) which is a glass capillary viscometer according to ASTM D445, IP71, for example, 200 to 2,000 cst, 300 to 1,500 cst, Or 400 to 1,000 cst, the flowability and feel of the silicone resin composition is good within this range, and there is an effect of improving the dispersion of other additives such as drugs.

The cyclic siloxane is not particularly limited in the case of cyclic siloxanes commonly used in the art, and may be, for example, a hypermethylated cyclic siloxane, and specific examples include cyclotetrasiloxane, decamethylcyclopentasiloxane, etc., such as octamethylcyclotetrasiloxane. It may be one or more selected from the group consisting of cyclohexasiloxane, such as cyclopentasiloxane and dodecamethylcyclohexasiloxane.

The a) the silicone resin may be, for example, 15 to 65% by weight, 20 to 65% by weight, 15 to 40% by weight, 15 to 30% by weight, or 15 to 25% by weight, the living body harmless to the human body within this range It is safe, smooth, and non-sticky as a suitable raw material. It is convenient to dry and forms a thin silicon film that dries quickly, protecting scars and creating a moisture environment.

B) the wax may be, for example, at least one selected from the group consisting of bees wax, paraffin, sorbitan olivate, and silicone wax, in which case it is effective to improve the stability and spreadability of the formulation.

B) the wax may be, for example, 1 to 30% by weight, 1 to 25% by weight, 1 to 15% by weight, 3 to 10% by weight, 4 to 8% by weight, or 5 to 7% by weight, within this range. It has the effect of improving the stability and spreadability of the formulation.

C) The emulsifier may be at least one selected from the group consisting of fatty alcohols having 15 to 26 carbon atoms and silicone emulsifiers, in which case the natural emulsification effect is excellent, but the biocompatible raw materials are harmless to the human body. It is safe, smooth and has no stickiness and has a convenient effect.

C) the emulsifier may be, for example, 1 to 10% by weight, 2 to 8% by weight, 2 to 7% by weight, or 2 to 5% by weight. It is not sticky and has a convenient effect.

The fatty alcohols having 15 to 26 carbon atoms may be, for example, fatty alcohols having 15 to 23 carbon atoms, or fatty alcohols having 16 to 20 carbon atoms, and preferably cetyl alcohol.

The silicone emulsifier is not particularly limited in the case of a silicone emulsifier commonly used in the art, for example, selected from the group consisting of a PEG-based silicone emulsifier, a branched polyglycerin-based silicone emulsifier and a crosslinked polyglycerol-based silicone emulsifier It can be 1 or more types, and in this case, the effect of keeping a silicone resin composition uniform is large.

For example, the silicone emulsifier may have a viscosity of 1,000 to 5,000 cst, 1,500 to 2,500 cst, or 1,600 to 2,000 cst, and has a great effect of keeping the silicone resin composition uniform in this range.

The polyglycerol-based silicone emulsifier may be a cross-linked polyglycerol modified dimethicone, for example, polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethyldisiloxyethyl dimethicone, lauryl polyglycerol Reel-3 Polydimethyldisiloxyethyl Dimethicone, Dimethicone-Polyglycerin-3 Crosspolymer, Lauryl Dimethicone / Polyglycerin-3 Crosspolymer, Polyethyleneglycol-9 Polydimethylsiloxyethyldimethicone, Dimethicone Copolyol It may be at least one selected from the group consisting of, cetyl dimethicone copolyol, PG-10 dimethicone and polyethylene glycol-7 dimethicone.

For example, the emulsifier may have a hydrophile-lipophile balance (HLB) of 1 to 14, and preferably 2 to 11, as measured by Griffin's method, and has a great effect of maintaining the silicone resin composition in a uniform state within this range.

The drug d) may be at least one selected from the group consisting of, for example, antioxidants, anticancer agents, anti-inflammatory agents, hormones, and calcium channel blockers, and in this case, it is particularly effective for preventing and improving erythema or pigmentation of scars due to antioxidant effects. Its rapid absorption has a synergistic effect on scar prevention, treatment and improvement.

D) the drug may be, for example, 0.1 to 5% by weight, 0.1 to 3% by weight, 0.1 to 2% by weight, 0.5 to 2% by weight, 1 to 2% by weight, or 1.5 to 2% by weight, within this range It is effective in the prevention and improvement of scar erythema and pigmentation due to the antioxidant effect, and has a synergistic effect on the scar prevention, treatment and improvement by rapid absorption.

The antioxidant may be, for example, an ascorbic acid derivative, in which case the antioxidant and scar healing effects are excellent.

The ascorbic acid derivatives are not particularly limited in the case of ascorbic acid derivatives commonly used in the art or commercially available, but may be, for example, ascorbic acid and ascorbic acid fatty acid esters thereof, acylated with single or multiple fatty acid groups, and salts thereof. Specific examples include ascorbyl laurate, ascorbyl myristate, ascorbyl palmitate, ascorbyl isopalmitate, ascorbyl-6-palmitate, ascorbyl stearate, ascorbyl behenate and their It may be at least one selected from the group consisting of metal salts, preferably ascorbyl tetraisopalmitate.

The anticancer agent may be, for example, 5-fluorouracil, bleomycin, or the like.

The anti-inflammatory agent may be, for example, dipotassium glytilytinate, allantoin, or a mixture thereof, preferably allantoin, and when used with water, may be used with a chelating agent such as disodium ethane, and in this case, anti-inflammatory Excellent effect and soothing effect.

The allantoin and disodium idieti may be, for example, a weight ratio of 1: 0.01 to 1: 0.5, 1: 0.05 to 1: 0.2, or 1: 0.08 to 1: 0.12, and have an anti-inflammatory effect and a soothing effect in this range. Is excellent.

The hormonal agent may be, for example, triamcinolone, which is effective in improving and treating scars.

The calcium channel blocker may be, for example, verapamil, in which case the scar healing effect is excellent.

The e) activator may be at least one selected from the group consisting of vitamin derivatives and onion extracts (Allium Cepa), for example, in this case, the absorption into the scar with the drug is improved, preventing, treating and improving the scars compared to the prior art. A synergy effect occurs.

The e) activator is for example 1 to 5% by weight, 1 to 5% by weight. It may be from 2 to 5% by weight, or from 2 to 3% by weight and within this range the absorption into the scar with the drug is improved resulting in a synergistic effect on scar prevention, treatment and improvement over the prior art.

Vitamin derivatives and onion extracts herein are not particularly limited in the case of vitamin derivatives that may be used in the art or are commercially available.

The vitamin derivative may be at least one selected from the group consisting of derivatives of vitamins A, C, D and E, for example, in this case, the absorption into the scar with the drug is improved to prevent, treat and improve the scar compared with the prior art. Synergies occur.

The onion extract may be, for example, an extract of dried onions containing water, alcohol or water-alcohol, and specifically, dried onions known as dried onion chips obtained from a stock plant onion at 40-90 ° C. After extracting the components with the extraction solvent, the extract solution (leach) is evaporated at an elevated temperature of 30 ℃ or more under reduced pressure to obtain an onion extract, and subsequently dissolved in water, alcohol or water-alcohol onion extract in liquid form Can be obtained.

The liquid onion extract may be, for example, 5 to 60% by weight, 10 to 50% by weight, 10 to 40% by weight, or 10 to 15% by weight of the solvent.

The alcohol may be at least one selected from the group consisting of ethanol, isopropanol, propanol, butylene glycol and propylene glycol, for example.

In the present description, the weight of the onion extract is based on solids.

As a specific example, the onion extract may be prepared as follows:

The dried onion may be extracted with purified water, for example, at a ratio of 1:16 of the drug (dried onion) to the extraction solvent (water). The ratio of dry agent to natural extract corresponds to 1.8: 1 or 1.5-2.2: 1. The dry drug to liquid extract ratio is 0.16: 1. Drugs (eg 16 kg onion chips) are leached exclusively with hot water (80-90 ° C.). Thereafter, the leachate is evaporated at 55 ° C. or higher under reduced pressure to obtain onion extract (concentrated extract). The heating is performed briefly here (3 seconds at 141 ° C). The resulting onion extract is a concentrated liquid, which is dissolved in water, alcohol or a water-alcohol mixture to obtain a liquid extract of the aforementioned ratio. Here a reddish brown to brown liquid with characteristic flavor is made. The extract is admixable with water in any ratio and has a relative density of 1.00 to 1.03 g / ml at 20 ° C. If water / alcohol (particularly ethanol) is used for the processing, approximately 13-20% (v / v) of alcohol (eg ethanol) may be present. The dry residue (after 2 hours at 105 ° C.) is at least 7.0% (m / m). With regard to microbiological purity, the product meets the requirements of category 3 of German Pharmacopeia 10.

The f) sunscreen may be, for example, an inorganic sunscreen, an organic sunscreen, and a mixture thereof, and in this case, it is effective in preventing and improving erythema and pigmentation of scars.

The f) sunscreen may be, for example, 0.1 to 30% by weight, 0 to 20% by weight, 0.1 to 20% by weight, 0 to 15% by weight, or 0.1 to 15% by weight, within this range the scar erythema or It is effective in preventing and improving pigmentation.

The inorganic sunscreen is not particularly limited as long as it is an inorganic sunscreen commonly available in the art, but may preferably be zinc oxide, titanium oxide or a mixture thereof, preferably zinc oxide, in which case of scar It is effective in preventing and improving erythema and pigmentation.

The organic sunscreen is not particularly limited in the case of an organic sunscreen commonly used in the art, but preferably at least one selected from the group consisting of octinoate, octysalate, octocrylene and avobenzone, It is preferably octinoate, in which case it is effective in preventing and improving erythema and pigmentation of scars.

In another example, the sunscreen agent is benzophenones such as dihydroxy benzophenone, melanin, ethyl paraaminobenzoic acid, 2-dimethylhexyl ester of paradimethylaminobenzoic acid, synoxite, 2-ethylhexyl ester of paramethoxy cinnamic acid, 2 -(2-hydroxy-5-methylphenyl) benzotriazole, urokanoic acid, anthranilate, cinnamate, salicylate, derivative of dibenzoylmethane, derivative of camphor, derivative of triazine, derivative of benzophenone, derivatives of β, β'-diphenylacrylate, derivatives of benzotriazole, derivatives of benzyl malonate, derivatives of benzimidazole, imidazolines, derivatives of benzoallyl, derivatives of p-aminobenzoic acid, titanium oxide and oxidation It may be at least one selected from the group consisting of zinc and the like.

The h) water may be, for example, 0.1 to 80% by weight, 30 to 80% by weight, 45 to 70% by weight, or 50 to 65% by weight, and sufficiently dissolve drugs, activators, antioxidants, etc. within this range. It is easy to apply, smooth and has no stickiness, and helps to form a thin silicone film that dries quickly.

The h) water may be, for example, purified water or distilled water.

The g) antioxidant may be, for example, 0.1 to 5% by weight, 0.5 to 3% by weight or 0.5 to 2% by weight, it is effective in preventing and improving erythema or pigmentation of scars within this range.

The antioxidant in the present disclosure is not particularly limited when the antioxidant is commonly used in the art, but may be, for example, one or more selected from the group consisting of butylhydroxyanisole, molded asset, molded asset propyl and erythorbic acid.

F) The preservative is, for example, imidazolidinyl urea (Imidazolidinyl Urea), methylparaben (Methylparaben), salicylic acid (Salicylic acid), methylchloroisothiazolinone (Methylchloroisothiazolinone), methylisodiazolinone (Methylisothiazolinone), ethyl paraben (Ethylparaben), Butylparaben, Propylparaben, Isopropylparaben, Isopropylparaben, Phenoxyethanol, DMDM Hydantoin, 1,2-hexanediol (1,2 Hexanediol), capryloylglycine, glyceryl caprylate, sodium levulinate, zinc gluconate, copper gluconate, zinc pyrrolidone carboxylic acid, copper pyrrolidone carboxylic acid, phytosphingosine Selected from the group consisting of phytosphingosine derivatives, benzoyl peroxides, pyroxtonolamines, zinc pyrithiones, selenium sulfides, econazoles, ketoconazoles, erythromycin and clindamycin It is at least one, and preferably 1,2-hexanediol, and in this case is excellent in preserving effects of the silicone resin composition.

Method for producing a silicone resin composition of the present invention is A) 5 to 70% by weight of silicone resin, 1 to 40% by weight of wax, 1 to 15% by weight of emulsifier and 0 to 30% by weight of sunscreen under stirring at 60 to 80 ℃ mixed Doing; And B) 0.01 to 10% by weight of drug, 0.01 to 10% by weight of activator, 0 to 5% by weight of antioxidant, 0 to 80% by weight of water and 0.1 to 5% by weight of preservative, and 45 to Mixing by stirring under 70 ℃; characterized in that it comprises a.

The components used in steps A) and B) include all of the foregoing.

Mixing in the step A) may be carried out at 60 to 75 ℃, 65 to 70 ℃, or 63 to 67 ℃.

In the step B), for example, the drug or a part thereof and a mixed solution made by mixing water under 50 to 75 ° C. are first introduced into the mixture made in the step A) and mixed, and then the activator, antioxidant, and Preservatives can be added, in this case, the dispersion is uniform, there is no stickiness while the silicone resin composition is gently applied to the skin is convenient to use and has the effect of improving the absorption of the active ingredient.

The mixed solution of step B) may be prepared by mixing the drug or part thereof with water at 60 to 70 ° C., or 63 to 67 ° C., for example.

When the mixed solution is added to the mixture made in step A), for example, it can be maintained at 50 to 75 ℃, the dispersion is uniform within this range, the silicone resin composition prepared is smoothly applied to the skin without stickiness It is convenient to use and has the effect of improving the absorption of the active ingredient.

When the mixed solution is added to the mixture in step B), for example, it may be maintained at 60 to 70 ℃, or 63 to 67 ℃.

The activator, antioxidant and preservative may be added to the mixture made in the step A) after the mixture is cooled to 45 to 55 ℃, for example, the dispersion becomes uniform within this range, While the silicone resin composition is gently applied to the skin, there is no stickiness, so it is convenient to use and the absorption of the active ingredient is improved.

As another example, the activator, antioxidant and preservative may be added when the mixed solution is added to the mixture made in step A) and then cooled to 48 to 52 ℃.

The scar treatment agent of the present invention is characterized in that it comprises the silicone resin composition.

The scar treatment agent herein is not limited to its name, and may include any case of a drug for preventing, ameliorating or treating scars, and examples thereof include scar improvers, scar inhibitors, scar drugs, and the like.

The scar treatment agent may be, for example, a sheet type, a cream type or a gel type, preferably a cream type or a gel type, and in this case, it is easy to apply smoothly and is non-sticky, and thus, the treatment area can be arbitrarily adjusted. Simple and economical effect is excellent.

The scar treatment agent may have a sun protection index (SPE) according to ISO 24444 standard, for example, 25 or more, 30 or more, or 30 to 50, without adversely affecting other physical properties of the silicone resin composition within this range. It is effective in preventing and improving erythema and pigmentation of scars by UV protection.

The scar treatment agent may be, for example, at least 40%, at least 45%, at least 50%, or at least 50% of an antioxidant effect by the DPPH method, and if it does not adversely affect other physical properties of the silicone resin composition within this range. It is also effective in preventing and improving erythema and pigmentation of scars due to the antioxidant effect.

Hereinafter, preferred examples are provided to aid the understanding of the present invention, but the following examples are merely for exemplifying the present invention, and it will be apparent to those skilled in the art that various changes and modifications can be made within the scope and spirit of the present invention. It is natural that such variations and modifications fall within the scope of the appended claims.

EXAMPLE

In the following Examples and Comparative Examples, the components included in the silicone resin mixture are manufactured by Dow corning Co., Ltd. as follows.

1) silicone elastomer

1-1) ST-Elastomer 10

1-2) TI-3021

2) silicone resin ( Film forming agent )

2-1) TI-7021 (400 ~ 1,000 cst):

3) silicone fluid

3-1) TI-2021 (2 ~ 4 cst) used to improve the feel)

3-2) TI-1050 (Various viscosity range, 95,000 ~ 105,000 cst product used for viscosity control)

3-3) Q7-9120 (11,875-13,125 cst)

4) annular Siloxane

4-1) ST-Cyclomethicone 5-NF

Example 1 (stick type)

64.5 g of the silicone resin mixture (Q7-9120: TI-3021: TI-1050: Elastomer 10: TI-7021: 5-NF = 1: 6: 2: 8: 3: 80 weight ratio) is stirred while heating to 70. 25 g of beeswax and 7 g of cetyl alcohol as an emulsifier are added with stirring at 70 ° C. and when thoroughly mixed, the temperature is reduced to 55, 2 g of onion extract, 0.5 g of ascorbyl tetraisopalmitate and 1,2-hexanediol 1 as preservatives. add g. Place in a container before fully cooled.

Example 2 (cream or gel type)

Silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: 10: 30 weight ratio) in 20 g of silicone emulsifier (Dow corning ES-5300, viscosity 1800 mm ² / s) 4 g and 7 g of sorbitan oleate are added and heated to 65 and stirred. 0.5 g of allantoin, 0.05 g of disodium ethane and 64.45 g of purified water were added to another reactor, and the mixture was heated and stirred to 65 ° C. Slowly pour the contents of the reactor containing purified water into the reactor containing the silicone resin at 65 and stir. When the phases are thoroughly mixed, stop heating and add 50 g of onion extract, 1 g of tocopheryl acetate, and 1 g of 1,2-hexanediol as preservative. Continue to stir until cooled.

Example 3 (cream or gel type)

20 g of a silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: 10: 30 weight ratio) 10 g of zinc oxide, 5 g of octinoate, silicone emulsifier (Dow corning ES-5300, viscosity 1800 mm ² / s) 4 g, sorbitan oleate 5 g is added and heated to 65 and stirred. 0.5 g of allantoin, 0.05 g of disodium ethane, and 51.45 g of purified water were added to another reactor, and the mixture was heated to 65 and stirred. Slowly pour the contents of the reactor containing purified water into the reactor containing the silicone resin at 65 and stir. When the phases are completely mixed, stop heating and add 50 g of onion extract, 1 g of tocopheryl acetate, and 1 g of 1,2-hexanediol as preservative. Continue to stir until cooled.

Example 4 (cream or gel type)

Silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: 10: 30 weight ratio) in 20 g of silicone emulsifier (Dow corning ES-5300, viscosity 1800 mm ² / s) 4 g and 7 g of sorbitan oleate are added and heated to 65 and stirred. In another reactor, 0.1 g of verapamil, 0.5 g of allantoin, 0.05 g of disodium ethane, and 64.35 g of purified water were added thereto, and the mixture was heated and stirred to 65 ° C. Slowly pour the contents of the reactor containing purified water into the reactor containing the silicone resin at 65 and stir. When the phases are completely mixed, stop heating and add 50 g of onion extract, 1 g of tocopheryl acetate, and 1 g of 1,2-hexanediol as preservative. Continue to stir until cooled.

Example 5 (cream or gel type)

Silicone emulsifier (Dow corning ES-) in 20 g of silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10: 5-NF = 5: 30: 25: 10: 25: 5 weight ratio) 5300, viscosity 1800 mm ² / s) 4 g and 7 g of sorbitan oleate were added thereto, heated to 65 and stirred. In another reactor, 0.1 g of verapamil, 0.5 g of allantoin, 0.05 g of disodium ethane, and 64.35 g of purified water were added thereto, and the mixture was heated and stirred to 65 ° C. Slowly pour the contents of the reactor containing purified water into the reactor containing the silicone resin at 65 and stir. When the phases are completely mixed, stop heating and add 50 g of onion extract, 1 g of tocopheryl acetate, and 1 g of 1,2-hexanediol as preservative. Continue to stir until cooled.

Example 6 (wax free type)

Silicone resin mixture (Q7-9120: TI-1050: TI-3021: TI-7021: Elastomer 10 = 1: 6: 13: 5: 75 weight ratio) in 40 g of silicone emulsifier (Dow corning Emulsifier 10, HLB ratio 2.2%, Viscosity 1100-3500 cps or cst) 4 g is added and stirred at room temperature. Into another reactor, 0.5 g of allantoin, 0.05 g of disodium ethane and 55.45 g of purified water were added, and the mixture was heated to 60 and stirred. After cooling the reactor containing the purified water completely, slowly pour the contents into the reactor containing the silicone resin and stir. When the phases are completely mixed, use a homogenizer to perform high speed agitation.

Comparative example 1 to 4 (commercially available scar treatment)

Kelo-cote Topical Gel (manufactured by Formulated Solution LLC), Kelo-cote Solaire (manufactured by Formulated Solutions LLC), Dermatix Ultra gel (manufactured by Toshiki International Singapore Pte Ltd.), and Bentlax gel (Taeguk Pharm) by Comparative Examples 1 to 4, respectively. Used.

[Test Example]

The properties of the silicone resin composition prepared in Examples 4 to 5 and the scar treatment agent of Comparative Examples 1 to 4 were measured by the following method, and the results are shown in Table 1 and FIG. 2 below.

* Antioxidant effect: Measured by DPPH method, the higher the value, the better the antioxidant effect.

* UV protection performance (SPF): measured by human patch test according to ISO 2444.

* Stickiness degree: The sample was measured based on the touch when applied to the skin, and if there is no stickiness, +++, the normal case ++, it is marked as + if very sticky.

구분division	실시예 4Example 4	실시예 5Example 5	비교예 1Comparative Example 1	비교예 2Comparative Example 2	비교예 3Comparative Example 3	비교예 4Comparative Example 4
산화방지성능Antioxidant Performance	5252	5353	1One	1010	22	3838
자외선차단성능UV protection performance	3232	3030	00	3030	00	00
끈적임Sticky	++++++	++++++	++	++	++++++	++++

As shown in Table 1, the silicone resin compositions (Examples 4 and 5) of the present invention are excellent in anti-oxidation and UV blocking performance, and smoothly applied while being sticky compared to Comparative Examples 1 to 4 corresponding to the prior art. None could be confirmed.

In addition, as shown in Figure 2, the silicone resin composition (Example 4) of the present invention significantly reduces the abnormal collagen (disorganized collagen) compared to the comparative examples 3 and 4 of the prior art, the normal collagen (normal pattern collagen) is increased Could confirm.

Claims

a) 5 to 70 weight percent of silicone resin, b) 0 to 40 weight percent of wax, c) 1 to 15 weight percent of emulsifier, d) 0.01 to 10 weight percent of drug, e) 0.01 to 10 weight percent of activator, f) ultraviolet light 0 to 30 wt% of a blocking agent, g) 0 to 5 wt% of an antioxidant, h) 0 to 80 wt% of water, and i) 0.1 to 5 wt% of a preservative.

Silicone resin composition.
The method of claim 1,

A) the silicone resin is at least three selected from the group consisting of silicone elastomers, film formers, silicone fluids and cyclic siloxanes

Silicone resin composition.
The method of claim 2,

The a) silicone resin is a mixture of 2 to 75% by weight of the silicone elastomer, 0.5 to 20% by weight of the film former, 0.5 to 45% by weight of the silicone fluid and 0 to 80% by weight of the cyclic siloxane relative to the total 100% by weight of the silicone resin Characterized

Silicone resin composition.
The method of claim 1,

B) the wax is at least one selected from the group consisting of bees wax, paraffin, sorbitan oleate and silicone wax

Silicone resin composition.
The method of claim 1,

B) the wax is characterized in that it comprises 1 to 40% by weight

Silicone resin composition.
The method of claim 1,

C) the emulsifier is at least one selected from the group consisting of fatty alcohols having 15 to 26 carbon atoms and silicone emulsifiers

Silicone resin composition.
The method of claim 1,

The d) the drug is at least one member selected from the group consisting of antioxidants, anti-inflammatory agents and calcium channel blockers

Silicone resin composition.
The method of claim 1,

The e) activator is characterized in that at least one selected from the group consisting of vitamin derivatives and onion extract (Allium Cepa)

Silicone resin composition.
The method of claim 1,

F) the sunscreen is an inorganic sunscreen, an organic sunscreen and a mixture thereof

Silicone resin composition.
The method of claim 1,

F) the sunscreen is characterized in that it comprises 0.1 to 30% by weight

Silicone resin composition.
The method of claim 1,

G) antioxidant is characterized in that it comprises 0.1 to 5% by weight

Silicone resin composition.
The method of claim 1,

H) the water is characterized in that it comprises 0.1 to 80% by weight

Silicone resin composition.
The method of claim 1,

F) Preservatives imidazolidinyl urea (Imidazolidinyl Urea), methylparaben (Methylparaben), salicylic acid (Salicylic acid), methylchloroisothiazolinone, methylisodiazolinone (Methylisothiazolinone), ethyl paraben (Ethylparaben) ), Butylparaben, Propylparaben, Isopropylparaben, Isopropylparaben, Phenoxyethanol, DMDM Hydantoin, 1,2-hexanediol (1,2-Hexanediol) ), Capryloylglycine, glyceryl caprylate, sodium levulinate, zinc gluconate, copper gluconate, zinc pyrrolidone carboxylic acid, copper pyrrolidone carboxylic acid, phytosphingosine, phi 1 type selected from the group consisting of tosphingosine derivatives, benzoyl peroxide, pyroxtonolamine, zinc pyrithione, selenium sulfide, echoazole, ketoconazole, erythromycin and clindamycin Characterized in that the dealer

Silicone resin composition.
A) mixing 5 to 70% by weight of silicone resin, 1 to 40% by weight of wax, 1 to 15% by weight of emulsifier and 0 to 30% by weight of sunscreen by stirring under 60 to 80 ° C; And

B) 0.01 to 10% by weight of drug, 0.01 to 10% by weight of activator, 0 to 5% by weight of antioxidant, 0 to 80% by weight of water and 0.1 to 5% by weight of preservative are added to the mixed mixture and 45 to 70%. Mixing by stirring under ℃; characterized in that it comprises a

Method for producing a silicone resin composition.
The method of claim 14,

Step B) is a mixture of the drug or a portion thereof and water at 50 to 75 ℃ mixed solution, first put into the mixture made in step A) and mixed, and then the activator, antioxidant and preservative Characterized in

Method for producing a silicone resin composition.
The method of claim 15,

When the mixed solution is added to the mixture made in step A) is maintained at 50 to 75 ℃

Method for producing a silicone resin composition.
The method of claim 15,

The activator, antioxidant and preservative are added to the mixture when it is cooled to 45 to 55 ℃ after the mixture is added to the mixture made in step A)

Method for producing a silicone resin composition.
A silicone resin composition according to any one of claims 1 to 13, characterized by comprising

Scar remedy.
The method of claim 18,

The scar treatment agent is characterized in that the sheet (sheet) type, cream type or gel type

Scar remedy.
The method of claim 18,

The scar treatment agent is characterized in that the UV protection index (SPE) of 25 or more according to the ISO 24444 standard

Scar remedy.
The method of claim 17,

The scar treatment agent has an antioxidant effect of at least 40% by DPPH method

Scar remedy.