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WO2015149392A1 - Préparation d'un médicament traditionnel chinois destiné à traiter une colite chronique et son procédé de préparation - Google Patents

Préparation d'un médicament traditionnel chinois destiné à traiter une colite chronique et son procédé de préparation Download PDF

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Publication number
WO2015149392A1
WO2015149392A1 PCT/CN2014/075339 CN2014075339W WO2015149392A1 WO 2015149392 A1 WO2015149392 A1 WO 2015149392A1 CN 2014075339 W CN2014075339 W CN 2014075339W WO 2015149392 A1 WO2015149392 A1 WO 2015149392A1
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WO
WIPO (PCT)
Prior art keywords
preparation
asparagus
chinese medicine
licorice
traditional chinese
Prior art date
Application number
PCT/CN2014/075339
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English (en)
Chinese (zh)
Inventor
袁志贤
Original Assignee
袁志贤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 袁志贤 filed Critical 袁志贤
Publication of WO2015149392A1 publication Critical patent/WO2015149392A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Definitions

  • the invention relates to a traditional Chinese medicine preparation for treating colitis, in particular to a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof.
  • the intestine refers to the digestive tract from the pylorus of the stomach to the anus.
  • the intestine is the longest part of the digestive tract and the most important part of the function.
  • the intestine is the largest digestive organ of the human body and the largest detoxification organ in the human body. From the perspective of physiology, anatomy, and cytology, large intestine detoxification accounts for more than 85 % of human detoxification; 80% of the human body's immune structure is around the intestine, and endotoxin accumulation is the killer of autoimmune immunity.
  • Chronic colitis is a common disease. Clinical manifestations include increased frequency of stools, no grain, or watery or sticky, accompanied by bowel, abdominal pain, and even spleen and kidney.
  • the general disease is in the intestine, but it involves the spleen, stomach, liver, kidney and other organs. It will be thin and burnout for a long time.
  • This card is one of the common spleen and stomach diseases in the clinic. It has a high incidence rate, easy recurrence, and lingering, which seriously affects people's normal life, and the cancer rate is about 5%.
  • the object of the present invention is to provide a traditional Chinese medicine preparation for treating chronic colitis based on the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof, the present invention
  • the treatment of colitis is obvious, and it is non-toxic, has no side effects, and has stable effects.
  • the preparation process is simple and easy.
  • the preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And a preparation of a composition prepared from red dates, wherein the mass ratio of each component is: Magnolia 12-20g ⁇ 10-22g Wu Wei
  • the preferred raw materials of the present invention is: Magnolia 12-18g ⁇ 10-18g Wujing 8-12g Astragalus 12-18g Licorice 8-12g Sanqi 10-15g Rhubarb 8-12g White peony 12-16g bergamot 8-12g yam 10-15g medlar 10-14g 10-15g
  • the present invention is also preferable to the raw material of Magnolia 15g ⁇ 12g Wujing 9g Astragalus 15g Licorice 10g Sanqi 12g Rhubarb 12g White peony 10g Bergamot 8g Yam 12g Chuanxiong 14g Fragrance 12g Iris 8g asparagus 8g thief bone 12g pinellia 10g yanhusuo 8g habitat 10g jujube 15g c
  • the above preparation method for treating a chronic colitis traditional Chinese medicine preparation comprises the following steps:
  • step 3 mix the powders of each component in step 1) and 2), add boiling water twice, add 10 times pure water for 1 hour, extract the filtrate for use; 6 times pure water decoction for half an hour, then combine the decoction and filter, spare; 4), the remaining Sanqi, Yam, Chuanxiongzi, Jiangxiang, Iris, asparagus, ribs, and raw land are proportioned well, crushed into powder by a pulverizer and passed through a 80 mesh sieve, and dried naturally. spare;
  • step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
  • the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to 3) the combined decoction in the step, and the mixture is shaken to obtain.
  • the prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening, and it is used for a long time, the effect is better.
  • the theoretical basis of the present invention is: Magnolia, a medicinal plant belonging to the family Magnoliaceae, and the growth region is mainly in Sichuan, Hubei and the like. Indications of food stagnation, abdominal distension constipation, wet resistance in the coke, vomiting and diarrhea, suffocating, chest full of asthma and cough and other symptoms. It has the effects of stagnation of phlegm and blood stasis, qi and asthma, phlegm and phlegm, and dispelling wind and analgesia.
  • Decoction has a broad-spectrum antibacterial effect, inhibiting Staphylococcus aureus, hemolytic streptococcus, diphtheria bacilli in vitro; in addition, Magnolia also regulates smooth muscle, anti-ulcer, central inhibition, blood pressure lowering, anti-pathogenic microorganisms , anti-tumor and other effects.
  • ⁇ sweet, light, flat, medicine has the benefit of water and moisture, spleen and stomach, Ningxin and soothe the nerves, attending urinary unfavorable, edema full, sputum cough, vomiting, modern medical research: ⁇ can enhance the body The immune function, ⁇ polysaccharide has obvious anti-tumor and liver-preserving effects.
  • Wu Hao hot taste, bitter taste, Xin
  • the Scriptures records Wu Hao: “Main temperature in the air, pain, cough, cold, heat, dehumidification, blood stasis, wind and evil, Kai Lili.”
  • Compendium of Materia Medica records Wu Hao: “Open stagnation, cure phlegm, phlegm and phlegm, headache, yin and stomach pain, phlegm and blood stasis, mouth sore mouth. "There are cold and pain relief, lowering vomiting, used to treat liver and stomach deficiency, yin Headache or stomach cramps caused by turbidity.
  • Astragalus membranaceus has the benefits of qi and sun, solid table antiperspirant, diuretic swelling, detoxification and myogenic effects. Indications for all qi deficiency and blood loss, such as spleen deficiency diarrhea, lung deficiency cough, rectal prolapse, uterine ptosis, spontaneous sweating, night sweats, edema, blood stasis, sputum is difficult to collapse or long-term collapse.
  • Licorice a kind of tonic Chinese herbal medicine, the medicinal parts are roots and rhizomes.
  • the roots of the medicinal properties are cylindrical, with spleen and qi, clearing away heat and detoxification, relieving cough, relieving pain, reconciling the effects of various medicines; Weary fatigue, palpitations, shortness of breath, coughing, abdominal pain, sudden pain in the limbs, swollen sores, relieve drug toxicity, potency and so on. Sanqi, used to stop bleeding and dilated blood, reduce swelling and pain.
  • yin deficiency fever dry lung cough, fatigue cough, Tianjin wound thirst, upset insomnia, internal heat and thirst, intestinal dry constipation, lung sputum, lung sputum, diphtheria and other symptoms; inhibition of a variety of bacteria, anti- Tumor activity, can nourish yin and spleen, moisten the lungs and clear the heart, remove dryness and reduce fire.
  • Cuttlefish bone containing calcium carbonate, can neutralize stomach acid, relieve symptoms of vomiting and heartburn, promote inflammation of the ulcer surface, prevent bleeding, relieve local pain. It can be used as an antacid.
  • Corydalis, temperature, taste, bitterness, liver, spleen, stomach, is a wonderful product of promoting blood circulation, relieving pain and relieving pain, especially known for its anti-pain effect.
  • the curative effect is remarkable.
  • Jujube, jujube is warm and sweet, contains protein, fat, sugar, calcium, phosphorus, iron, magnesium and rich vitamins.
  • the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses of treatment as therapeutic effects.
  • the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
  • the beneficial effects of the present invention are that the preparation prepared by the present invention is for treatment Chronic colitis has good effects, and it is non-toxic, has no side effects, and has a stable effect.
  • the preparation process is simple and easy. Concrete real
  • the preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And the preparation of the composition prepared by the red jujube, wherein the mass ratio of each component is: Magnolia 12g ⁇ 10g Wujing 10g Astragalus 12g Licorice 12g Sanqi 15g Rhubarb 10g White Pelican 12g Bergamot 8g Yam 15g Chuanxiong 15g Fragrance 13g Festival Iris 12g asparagus 8g thief bone 10g Pinellia 12g Yanhusuo 13g soil 10g jujube 16g.
  • the preparation method of the traditional Chinese medicine preparation for treating chronic colitis includes the following steps: 1) placing the cockroach into a small pot for small frying until the surface is slightly coke, and then pulverizing through a pulverizer and passing through a 80 mesh sieve for use; 2), the magnolia, Wujing, Astragalus, licorice, rhubarb, white peony, bergamot, red dates, pinellia, yanhusuo are proportioned well, pulverized into powder after crushing machine and passed through a 90 mesh sieve, naturally dried, ready for use;
  • step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
  • the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to the combined decoction in the step 3), and mixed and shaken to obtain.
  • the preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une préparation d'un médicament traditionnel chinois destiné à traiter une colite chronique et son procédé de préparation, comprenant du magnolia officinalis, du Wolfiporia extensa, du Tetradium ruticarpum, du Astragalus propinquus, de la réglisse, du Panax notoginseng, de la rhubarbe de grande culture, de la pivoine de Chine, de la main de Bouddha, du Dioscorea opposita, du Melia toosendan, du Dalbergia odorifera, du rhizome d'anémone Altaicae, de l'asparage de Cochinchine, de l'os de seiche, de la pinellie ternée, du Corydalis yanhusuo, du Radix Rehmanniae, et du jujube, lesdits ingrédients étant soumis à des processus de farinage, de décoction, d'extraction à l'éthanol et de mélange en une composition pour préparations liquides.
PCT/CN2014/075339 2014-03-31 2014-04-15 Préparation d'un médicament traditionnel chinois destiné à traiter une colite chronique et son procédé de préparation WO2015149392A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410124716.2A CN103860844B (zh) 2014-03-31 2014-03-31 一种治疗慢性结肠炎的中药制剂及其制备方法
CN201410124716.2 2014-03-31

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WO2015149392A1 true WO2015149392A1 (fr) 2015-10-08

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104623254A (zh) * 2015-02-26 2015-05-20 王燕 治疗慢性肠炎的中药组合物及制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139980A (ja) * 1997-11-04 1999-05-25 Teikoku Seiyaku Co Ltd 潰瘍性大腸炎治療剤
CN102920820A (zh) * 2012-11-21 2013-02-13 杨文琳 一种治疗慢性结肠炎的中药组合物
CN102988870A (zh) * 2012-11-30 2013-03-27 北京中融阳光投资管理有限公司 一种治疗肝胆胃肠道疾病的口服液

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101422557A (zh) * 2007-10-29 2009-05-06 刘芳 治疗结肠炎的药物
CN101391088B (zh) * 2008-10-22 2010-12-22 付道成 肠胃炎口服药物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139980A (ja) * 1997-11-04 1999-05-25 Teikoku Seiyaku Co Ltd 潰瘍性大腸炎治療剤
CN102920820A (zh) * 2012-11-21 2013-02-13 杨文琳 一种治疗慢性结肠炎的中药组合物
CN102988870A (zh) * 2012-11-30 2013-03-27 北京中融阳光投资管理有限公司 一种治疗肝胆胃肠道疾病的口服液

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QIAN, JINDONG;: "The Study Development of Ulcerative Colitis Treated with TCM", JOURNAL OF PRACTICAL TRADITIONAL CHINESE INTERNAL MEDICINE, vol. 21, no. 1, 28 February 2007 (2007-02-28), pages 21 - 22 *

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CN103860844A (zh) 2014-06-18
CN103860844B (zh) 2016-03-02

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