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WO2014169845A3 - 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof - Google Patents

4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof Download PDF

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Publication number
WO2014169845A3
WO2014169845A3 PCT/CN2014/075683 CN2014075683W WO2014169845A3 WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3 CN 2014075683 W CN2014075683 W CN 2014075683W WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrid
pyrazolo
dihydro
ones
preparation
Prior art date
Application number
PCT/CN2014/075683
Other languages
French (fr)
Chinese (zh)
Other versions
WO2014169845A2 (en
Inventor
魏用刚
邱关鹏
卢泳华
余彦
雷柏林
王松
黄清平
高秋
楚洪柱
祝国智
罗新峰
倪丽军
陈娅姝
邓炳初
Original Assignee
四川海思科制药有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 四川海思科制药有限公司 filed Critical 四川海思科制药有限公司
Priority to CN201480003262.1A priority Critical patent/CN105026392B/en
Publication of WO2014169845A2 publication Critical patent/WO2014169845A2/en
Publication of WO2014169845A3 publication Critical patent/WO2014169845A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, as shown in Formula (I), and to a preparation method and an application thereof; the definition of each substituent in the Formula (I) compound is the same as the definition found in the description.
PCT/CN2014/075683 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof WO2014169845A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480003262.1A CN105026392B (en) 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201310138026.8 2013-04-19
CN201310138026 2013-04-19
CN201310372920 2013-08-23
CN201310372920.1 2013-08-23
CN201310428690.6A CN104109165A (en) 2013-04-19 2013-09-18 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives, and preparation method and application thereof
CN201310428690.6 2013-09-18

Publications (2)

Publication Number Publication Date
WO2014169845A2 WO2014169845A2 (en) 2014-10-23
WO2014169845A3 true WO2014169845A3 (en) 2014-12-11

Family

ID=51706170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/075683 WO2014169845A2 (en) 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof

Country Status (2)

Country Link
CN (2) CN104109165A (en)
WO (1) WO2014169845A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3064497A1 (en) * 2015-07-20 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Dimer impurities of apixaban and method to remove them
MA43706B1 (en) 2016-03-17 2020-09-30 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as a taar agonist
CN107474030B (en) * 2016-06-08 2021-03-30 首都医科大学 Warfarin-aspirin conjugates, their synthesis, antithrombotic activity and uses
CN109232596B (en) * 2018-09-05 2020-03-17 大连九信精细化工有限公司 Synthetic method of dibenzofuran carbazole
CN110143914B (en) * 2019-06-21 2022-03-29 常州恒邦药业有限公司 Preparation method of apixaban intermediate
BR112023024741A2 (en) 2021-05-27 2024-02-15 Jiangsu Hengrui Pharmaceuticals Co Ltd QUINOLINAMINE COMPOUND, PREPARATION METHOD FOR THE SAME AND APPLICATION OF THE SAME IN PHARMACEUTICAL PRODUCTS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391575A (en) * 1998-12-23 2003-01-15 杜邦药品公司 Nitrogen containing heterobicycles as factor XA inhibitors
US20100048611A1 (en) * 2006-05-31 2010-02-25 Bayer Healthcare Ag Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012895A (en) * 2000-06-23 2003-05-14 Bristol Myers Squibb Pharma Co 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors.
KR100909141B1 (en) * 2001-09-21 2009-07-23 브리스톨-마이어스스퀴브컴파니 Lactam-Containing Compounds and Derivatives thereof as Factor Xa Inhibitors
TW200738672A (en) * 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
CN101065379B (en) * 2004-09-28 2011-05-11 布里斯托尔-迈尔斯斯奎布公司 Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391575A (en) * 1998-12-23 2003-01-15 杜邦药品公司 Nitrogen containing heterobicycles as factor XA inhibitors
US20100048611A1 (en) * 2006-05-31 2010-02-25 Bayer Healthcare Ag Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof

Also Published As

Publication number Publication date
WO2014169845A2 (en) 2014-10-23
CN105026392B (en) 2017-05-10
CN105026392A (en) 2015-11-04
CN104109165A (en) 2014-10-22

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