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WO2014024203A8 - Procédé perfectionné pour la préparation de chlorhydrate de dexméthylphénidate - Google Patents

Procédé perfectionné pour la préparation de chlorhydrate de dexméthylphénidate Download PDF

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Publication number
WO2014024203A8
WO2014024203A8 PCT/IN2012/000710 IN2012000710W WO2014024203A8 WO 2014024203 A8 WO2014024203 A8 WO 2014024203A8 IN 2012000710 W IN2012000710 W IN 2012000710W WO 2014024203 A8 WO2014024203 A8 WO 2014024203A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
dexmethylphenidate hydrochloride
hydrochloride
dexmethylphenidate
Prior art date
Application number
PCT/IN2012/000710
Other languages
English (en)
Other versions
WO2014024203A1 (fr
Inventor
Nand Lal AGARWAL
Rahul Arunbhai BHAVSAR
Kunal Kamleshbhai PATHAK
Original Assignee
Zcl Chemicals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zcl Chemicals Limited filed Critical Zcl Chemicals Limited
Publication of WO2014024203A1 publication Critical patent/WO2014024203A1/fr
Publication of WO2014024203A8 publication Critical patent/WO2014024203A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un procédé perfectionné pour la préparation de chlorhydrate de Dexméthylphénidate de formule (A). Plus particulièrement, la présente invention concerne un procédé perfectionné pour la préparation de chlorhydrate de Dexméthylphénidate de formule (A) et de son intermédiaire de chlorhydrate d'acide d-thréo ritalinique de formule (III).
PCT/IN2012/000710 2012-08-07 2012-10-29 Procédé perfectionné pour la préparation de chlorhydrate de dexméthylphénidate WO2014024203A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN228/MUM/2012 2012-08-07
IN2258MU2012 2012-08-07
IN2258/MUM/2012 2012-08-07

Publications (2)

Publication Number Publication Date
WO2014024203A1 WO2014024203A1 (fr) 2014-02-13
WO2014024203A8 true WO2014024203A8 (fr) 2014-03-13

Family

ID=50067503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000710 WO2014024203A1 (fr) 2012-08-07 2012-10-29 Procédé perfectionné pour la préparation de chlorhydrate de dexméthylphénidate

Country Status (1)

Country Link
WO (1) WO2014024203A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744342A (zh) * 2015-02-11 2015-07-01 河南中帅医药科技股份有限公司 盐酸右哌甲酯晶型及其制备方法
CN107325039B (zh) * 2016-04-29 2022-12-16 国药集团国瑞药业有限公司 一种盐酸右哌甲酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
CH712083B1 (de) * 2003-02-05 2017-07-31 Siegfried Ag Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern.
WO2004080959A2 (fr) * 2003-03-07 2004-09-23 Isp Investments Inc. Procede de preparation de dexmethylphenidate hydrochlorure
WO2010128517A1 (fr) * 2009-05-07 2010-11-11 Malladi Drugs & Pharmaceuticals Ltd. Procédé amélioré pour la préparation de chlorhydrate d'acide d-thréo-ritalinique par la résolution de l'acide dl-thréo-ritalinique au moyen d'un acide carboxylique chiral
ES2465219T3 (es) * 2009-12-01 2014-06-05 Harman Finochem Limited Proceso para la preparación de clorhidrato de metilfenidato
KR20150029769A (ko) * 2010-12-17 2015-03-18 로드스 테크놀로지즈 메틸페니데이트 염산염의 저온합성

Also Published As

Publication number Publication date
WO2014024203A1 (fr) 2014-02-13

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