[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2013059530A3 - Peptidomimetic macrocycles - Google Patents

Peptidomimetic macrocycles Download PDF

Info

Publication number
WO2013059530A3
WO2013059530A3 PCT/US2012/060919 US2012060919W WO2013059530A3 WO 2013059530 A3 WO2013059530 A3 WO 2013059530A3 US 2012060919 W US2012060919 W US 2012060919W WO 2013059530 A3 WO2013059530 A3 WO 2013059530A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
peptidomimetic
disease
treatment
Prior art date
Application number
PCT/US2012/060919
Other languages
French (fr)
Other versions
WO2013059530A2 (en
Inventor
Noriyuki Kawahata
Carl Elkin
Original Assignee
Aileron Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics, Inc. filed Critical Aileron Therapeutics, Inc.
Publication of WO2013059530A2 publication Critical patent/WO2013059530A2/en
Publication of WO2013059530A3 publication Critical patent/WO2013059530A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided are novel peptidomimetic macrocycles and methods of using the macrocycles for the treatment of disease.
PCT/US2012/060919 2011-10-18 2012-10-18 Peptidomimetic macrocycles WO2013059530A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161548695P 2011-10-18 2011-10-18
US61/548,695 2011-10-18

Publications (2)

Publication Number Publication Date
WO2013059530A2 WO2013059530A2 (en) 2013-04-25
WO2013059530A3 true WO2013059530A3 (en) 2015-06-11

Family

ID=48141627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/060919 WO2013059530A2 (en) 2011-10-18 2012-10-18 Peptidomimetic macrocycles

Country Status (1)

Country Link
WO (1) WO2013059530A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061577A (en) 2006-12-14 2015-11-18 爱勒让治疗公司 Bis-sulfhydryl macrocyclization systems
JP4997293B2 (en) 2007-02-23 2012-08-08 エイルロン セラピューティクス，インコーポレイテッド Triazole macrocycle
EP2142562B1 (en) 2007-03-28 2013-07-03 President and Fellows of Harvard College Stitched polypeptides
BRPI0918948A2 (en) 2008-09-22 2015-12-15 Aileron Therapeutics Inc peptidomimetic macrocycles
US9458202B2 (en) 2008-11-24 2016-10-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR20130099938A (en) 2010-08-13 2013-09-06 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
BR112014009418A2 (en) 2011-10-18 2017-04-18 Aileron Therapeutics Inc peptidomimetic macrocycles
ES2817877T3 (en) 2012-02-15 2021-04-08 Aileron Therapeutics Inc Peptidomimetic macrocycles
JP6450192B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド Triazole-bridged and thioether-bridged peptidomimetic macrocycles
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN112245565A (en) 2014-09-24 2021-01-22 艾瑞朗医疗公司 Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108368161A (en) 2015-09-10 2018-08-03 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound as MCL-1 conditioning agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010317A1 (en) * 2000-03-17 2002-01-24 Wild Carl T. Method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins
US20080242598A1 (en) * 2004-03-19 2008-10-02 The University Of Queensland Alpha Helical Mimics, Their Uses and Methods For Their Production
US20110046043A1 (en) * 2007-12-31 2011-02-24 Deyun Wang Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010317A1 (en) * 2000-03-17 2002-01-24 Wild Carl T. Method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins
US20080242598A1 (en) * 2004-03-19 2008-10-02 The University Of Queensland Alpha Helical Mimics, Their Uses and Methods For Their Production
US20110046043A1 (en) * 2007-12-31 2011-02-24 Deyun Wang Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 27 September 1995 (1995-09-27), accession no. AA7668.1. *
XIE, D. ET AL.: "An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, no. 1, January 2010 (2010-01-01), pages 191 - 196 *

Also Published As

Publication number Publication date
WO2013059530A2 (en) 2013-04-25

Similar Documents

Publication Publication Date Title
WO2013059530A3 (en) Peptidomimetic macrocycles
PH12014501844A1 (en) Peptidomimetic macrocycles
WO2012173846A3 (en) Peptidomimetic macrocycles
MX355543B (en) Peptidomimetic macrocycles.
WO2010083347A3 (en) Peptidomimetic macrocycles
WO2012048099A3 (en) Nanoparticle-loaded cells
MY158992A (en) Forms of rifaximin and uses thereof
EP2558493A4 (en) Antibodies for the treatment of clostridium difficile-associated infection and disease
HK1202313A1 (en) Methods and compositions for the treatment and diagnosis of bladder cancer
PL2651313T3 (en) Instrument for stretching the skin
WO2012166626A8 (en) Reagents and methods for treating dental disease
PT2739615T (en) Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
HK1197276A1 (en) Methods and compositions for the treatment and diagnosis of bladder cancer
IL228446A0 (en) Diagnostic methods based on the kras variant
ZA201208172B (en) Methods for the treatment of il-1b related conditions
AU2012265069A1 (en) Compression bandage for placing on the human or animal body
HK1192726A1 (en) 1,2,4-thiadiazol-5-ylpiperazine derivatives useful in the treatment of neurodegenerative diseases 124--5-
EP2785335B8 (en) Methods and pharmaceutical compositions for the treatment of darier disease
EP3406242B8 (en) Tlr4 antagonist for use in the treatment of increased ammonia plasma levels
WO2011088020A9 (en) Modified saponins for the treatment of fungal infections
HK1203190A1 (en) Compounds for use in imaging, diagnosing and or treatment of diseases of the central nervous system
WO2015073788A3 (en) Methods and compositions for the treatment of hcmv
SG194235A1 (en) Methods of predicting the development of complement-mediated disease
ZA201306759B (en) Compounds for use in imaging,diagnosing and/or treatment of diseases of the central nervous system
AU2011900677A0 (en) Therapeutic and diagnostic agents

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12842476

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12842476

Country of ref document: EP

Kind code of ref document: A2