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WO2012008809A3 - Microorganism having improved l-ornithine productivity, and method for producing l-ornithine using same - Google Patents

Microorganism having improved l-ornithine productivity, and method for producing l-ornithine using same Download PDF

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Publication number
WO2012008809A3
WO2012008809A3 PCT/KR2011/005251 KR2011005251W WO2012008809A3 WO 2012008809 A3 WO2012008809 A3 WO 2012008809A3 KR 2011005251 W KR2011005251 W KR 2011005251W WO 2012008809 A3 WO2012008809 A3 WO 2012008809A3
Authority
WO
WIPO (PCT)
Prior art keywords
ornithine
producing
microorganism
improved
same
Prior art date
Application number
PCT/KR2011/005251
Other languages
French (fr)
Korean (ko)
Other versions
WO2012008809A2 (en
Inventor
조재용
Original Assignee
상지대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 상지대학교산학협력단 filed Critical 상지대학교산학협력단
Publication of WO2012008809A2 publication Critical patent/WO2012008809A2/en
Publication of WO2012008809A3 publication Critical patent/WO2012008809A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to an L-ornithine-producing microorganism, in which the gluconate kinase (GntK) activity is weakened relative to an intrinsic activity thereof, and to a method for producing L-ornithine from the L-ornithine-producing microorganism. According to the present invention, L-ornithine can be produced at a high yield rate and with high efficiency, and the thus-produced L-ornithine can be effectively used in the medical and pharmaceutical industry, the food industry, the feed industry, the chemical industry, etc.
PCT/KR2011/005251 2010-07-15 2011-07-15 Microorganism having improved l-ornithine productivity, and method for producing l-ornithine using same WO2012008809A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100068619A KR101300185B1 (en) 2010-07-15 2010-07-15 A microorganism having enhanced L-ornithine productivity and a method of producing L-ornithine using the same
KR10-2010-0068619 2010-07-15

Publications (2)

Publication Number Publication Date
WO2012008809A2 WO2012008809A2 (en) 2012-01-19
WO2012008809A3 true WO2012008809A3 (en) 2012-05-18

Family

ID=45469966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/005251 WO2012008809A2 (en) 2010-07-15 2011-07-15 Microorganism having improved l-ornithine productivity, and method for producing l-ornithine using same

Country Status (2)

Country Link
KR (1) KR101300185B1 (en)
WO (1) WO2012008809A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2430152B1 (en) * 2010-07-15 2016-08-24 CJ CheilJedang Corporation Microorganism with enhanced l-lysine productivity and method for producing l-lysine using the same
WO2014036528A2 (en) 2012-08-31 2014-03-06 Ixchel Pharma, Llc Agents useful for treating obesity, diabetes and related disorders
KR101429815B1 (en) * 2012-10-05 2014-08-12 상지대학교산학협력단 Corynebacterium sp. microorganism having enhanced L-threonine productivity by regulation of GntK activity and a method of producing L-threonine using the same
CN103794988B (en) 2012-10-26 2017-07-28 施耐德电器工业公司 Supply gas component
CN103014086B (en) * 2012-12-12 2015-02-11 武汉圣佳化工有限公司 Method for continuously producing L-ornithine composite salt by enzyme immobilization
KR101526047B1 (en) * 2013-04-26 2015-06-04 상지대학교산학협력단 Microorganism having improved L-ornithin production by increasing the aminotransferase activity and process for preparing the L-ornithin employing the same
EP3268468A1 (en) 2015-03-12 2018-01-17 Biopetrolia AB L-ornithine production in eukaryotic cells
CN113604390B (en) * 2021-08-16 2023-04-25 江苏澳创生物科技有限公司 Corynebacterium glutamicum and application thereof in fermentation production of L-ornithine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 27 April 2009 (2009-04-27), "Gluconate Kinase[Corynebacterium glutamicum ATCC 13032].", accession no. 01686 *
DATABASE GENBANK 27 April 2009 (2009-04-27), "Sugar Kinase[Corynebacterium glutamicum ATCC 13032].", accession no. 02203 *
HWANG, GWI HYE.: "Modulation of pentose phosphate pathway activity for overproduction of L-omithine in Corynebacterium glutamicum.", GRADUATE SCHOOL OF SANGJI UNIVERSITY, MASTER'S THESIS., August 2009 (2009-08-01) *
HWANG,J.H. ET AL.: "Effect of Increased Glutamate Avilability on L-Ornithine Production in Corynebacterium glutamicum.", J.MICROBIOL.BIOTECHNOL., vol. 18, April 2008 (2008-04-01), pages 704 - 710, XP002739707 *

Also Published As

Publication number Publication date
KR20120007855A (en) 2012-01-25
WO2012008809A2 (en) 2012-01-19
KR101300185B1 (en) 2013-08-26

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