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WO2011139595A3 - Elongated biodegradable depot for sustained drug release to treat chronic pelvic pain - Google Patents

Elongated biodegradable depot for sustained drug release to treat chronic pelvic pain Download PDF

Info

Publication number
WO2011139595A3
WO2011139595A3 PCT/US2011/033545 US2011033545W WO2011139595A3 WO 2011139595 A3 WO2011139595 A3 WO 2011139595A3 US 2011033545 W US2011033545 W US 2011033545W WO 2011139595 A3 WO2011139595 A3 WO 2011139595A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric substrate
drug release
elongated
pelvic pain
treat chronic
Prior art date
Application number
PCT/US2011/033545
Other languages
French (fr)
Other versions
WO2011139595A2 (en
WO2011139595A4 (en
Inventor
Thomas C. Bischoff
Keith R. Hildebrand
Christopher M. Hobot
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Publication of WO2011139595A2 publication Critical patent/WO2011139595A2/en
Publication of WO2011139595A3 publication Critical patent/WO2011139595A3/en
Publication of WO2011139595A4 publication Critical patent/WO2011139595A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3401—Puncturing needles for the peridural or subarachnoid space or the plexus, e.g. for anaesthesia

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention describes a device for administering a therapeutic agent to a subject at a sustained rate over a period of time, the device being shaped, sized and adapted for administering the therapeutic agent into the region of the spinal column of the subject, the device comprising: an elongated first polymeric substrate having a proximal end, a distal end and diameter or width of about 1 mm to about 10 mm and a length of about 4 cm to about 35 cm; optionally, an elongated second polymeric substrate positioned within the first polymeric substrate; and at least one therapeutic agent, loaded into or onto the first polymeric substrate or second polymeric substrate or both, wherein the therapeutic agent is available for diffusion into the region of the spinal column of the subject.
PCT/US2011/033545 2010-04-27 2011-04-22 Elongated biodegradable depot for sustained drug release to treat chronic pelvic pain WO2011139595A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32843610P 2010-04-27 2010-04-27
US61/328,436 2010-04-27

Publications (3)

Publication Number Publication Date
WO2011139595A2 WO2011139595A2 (en) 2011-11-10
WO2011139595A3 true WO2011139595A3 (en) 2012-05-31
WO2011139595A4 WO2011139595A4 (en) 2012-08-16

Family

ID=44904311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/033545 WO2011139595A2 (en) 2010-04-27 2011-04-22 Elongated biodegradable depot for sustained drug release to treat chronic pelvic pain

Country Status (1)

Country Link
WO (1) WO2011139595A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
JP6360488B2 (en) * 2012-11-01 2018-07-18 トレント・ファーマシューティカルズ・リミテッドＴｏｒｒｅｎｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｉｍｉｔｅｄ Pharmaceutical composition of tapentadol for parenteral administration
WO2015023675A2 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
ITMI20131453A1 (en) * 2013-09-05 2015-03-06 Francesco Ugo Prada ULTRA-COMPATIBLE ARTIFICIAL CRANIOTOMIC OPERCOLO
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
EP3209282A4 (en) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
CN107789628B (en) * 2016-12-29 2021-07-23 天津键凯科技有限公司 Application of conjugate of polyethylene glycol and local anesthetic in non-anesthesia analgesia
BR102020010923A2 (en) * 2020-05-29 2021-12-14 Luiz Peracchi Edson Long-lasting resorbable subcutaneous implant with prolonged release of pre-concentrated pharmacologically active substance in polymer for the treatment of chronic adrenal insufficiency or hypocortisolism
EP4188322A1 (en) 2020-07-25 2023-06-07 Pharmafina Ilac Satis ve Pazarlama Anonim Sirketi Combination of medications in a parenteral dosage form for long-term anaesthesia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033295A1 (en) * 2003-08-08 2005-02-10 Paul Wisnewski Implants formed of shape memory polymeric material for spinal fixation
US20090123508A1 (en) * 2007-10-04 2009-05-14 Boston Scientific Scimed, Inc. Implantable Drug Depot for Intrathecal Drug Delivery System for Pain Management

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4917686A (en) 1985-12-16 1990-04-17 Colorado Biomedical, Inc. Antimicrobial device and method
US5245098A (en) 1992-01-21 1993-09-14 The University Of Akron Process for preparation of non-conjugated diolefins
BR9908339A (en) 1998-02-23 2001-10-02 Mnemoscience Gmbh Method for the manufacture of an article with format memory, polymer composition with format memory and respective method of forming the field
KR100874602B1 (en) 2001-01-24 2008-12-19 존슨 앤드 존슨 비젼 케어, 인코포레이티드 Shape memory styrene copolymer
DE10217350C1 (en) 2002-04-18 2003-12-18 Mnemoscience Gmbh polyesterurethanes
US7557167B2 (en) 2006-09-28 2009-07-07 Gore Enterprise Holdings, Inc. Polyester compositions, methods of manufacturing said compositions, and articles made therefrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050033295A1 (en) * 2003-08-08 2005-02-10 Paul Wisnewski Implants formed of shape memory polymeric material for spinal fixation
US20090123508A1 (en) * 2007-10-04 2009-05-14 Boston Scientific Scimed, Inc. Implantable Drug Depot for Intrathecal Drug Delivery System for Pain Management

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BEHL M., LENDLEIN A.: "Shape-memory polymers", MATERIALS TODAY, vol. 10, no. 4, 30 April 2007 (2007-04-30), pages 20 - 28, XP002672786 *

Also Published As

Publication number Publication date
WO2011139595A2 (en) 2011-11-10
WO2011139595A4 (en) 2012-08-16

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