WO2011161544A8 - Biomarker for fatigue, and use thereof - Google Patents
Biomarker for fatigue, and use thereof Download PDFInfo
- Publication number
- WO2011161544A8 WO2011161544A8 PCT/IB2011/001917 IB2011001917W WO2011161544A8 WO 2011161544 A8 WO2011161544 A8 WO 2011161544A8 IB 2011001917 W IB2011001917 W IB 2011001917W WO 2011161544 A8 WO2011161544 A8 WO 2011161544A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ratio
- fatigue
- acid ratio
- acid
- cis
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- GTZCVFVGUGFEME-HNQUOIGGSA-N cis-Aconitic acid Natural products OC(=O)C\C(C(O)=O)=C/C(O)=O GTZCVFVGUGFEME-HNQUOIGGSA-N 0.000 abstract 2
- GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- ODBLHEXUDAPZAU-ZAFYKAAXSA-N D-threo-isocitric acid Chemical compound OC(=O)[C@H](O)[C@@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-ZAFYKAAXSA-N 0.000 abstract 1
- ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The ratio of measurement values of glucose, citric acid, and cis-aconitic acid in a biological sample of a subject to the measurement values of healthy subjects is calculated, and the glucose ratio, citric acid ratio, and cis-aconitic acid ratio are used to assess and/or determine fatigue. In the same way, the isocitric acid ratio, succinic acid ratio, malic acid ratio, and lactic acid ratio are calculated, combined with the three abovementioned ratios, and used to assess and/or determine fatigue. Thus enabled is the objective and simple diagnosis and assessment of fatigue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/805,449 US20130210045A1 (en) | 2011-02-21 | 2011-08-22 | Biomarker for fatigue, and use thereof |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-144128 | 2010-06-24 | ||
| JP2010144128 | 2010-06-24 | ||
| JP2011-034875 | 2011-02-21 | ||
| JP2011034875A JP5811545B2 (en) | 2010-06-24 | 2011-02-21 | Fatigue biomarkers and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2011161544A2 WO2011161544A2 (en) | 2011-12-29 |
| WO2011161544A3 WO2011161544A3 (en) | 2012-03-01 |
| WO2011161544A8 true WO2011161544A8 (en) | 2012-04-19 |
Family
ID=45371880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2011/001917 WO2011161544A2 (en) | 2010-06-24 | 2011-08-22 | Biomarker for fatigue, and use thereof |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP5811545B2 (en) |
| WO (1) | WO2011161544A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9040082B2 (en) * | 2011-06-24 | 2015-05-26 | K-Pax Pharmaceuticals, Inc. | Compositions and methods for treatment of chronic fatigue |
| JP6521321B2 (en) * | 2013-08-30 | 2019-05-29 | 国立研究開発法人理化学研究所 | Biomarkers of fatigue and their use |
| WO2017218999A1 (en) | 2016-06-17 | 2017-12-21 | Predictive Safety Srp, Inc. | Impairment detection system and method |
| JPWO2018147472A1 (en) * | 2017-02-09 | 2020-01-16 | 学校法人慶應義塾 | Blood biomarkers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3861300B2 (en) * | 1995-09-14 | 2006-12-20 | 大正製薬株式会社 | How to measure fatigue |
| GB9724813D0 (en) * | 1997-11-25 | 1998-01-21 | Univ Nottingham | Reducing muscle fatigue |
| JP2010085369A (en) * | 2008-10-02 | 2010-04-15 | Ttc:Kk | Method and kit for evaluation fatigue |
-
2011
- 2011-02-21 JP JP2011034875A patent/JP5811545B2/en active Active
- 2011-08-22 WO PCT/IB2011/001917 patent/WO2011161544A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011161544A3 (en) | 2012-03-01 |
| WO2011161544A2 (en) | 2011-12-29 |
| JP2012024555A (en) | 2012-02-09 |
| JP5811545B2 (en) | 2015-11-11 |
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