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WO2010018836A3 - ポリグルタミン凝集阻害剤 - Google Patents

ポリグルタミン凝集阻害剤 Download PDF

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Publication number
WO2010018836A3
WO2010018836A3 PCT/JP2009/064205 JP2009064205W WO2010018836A3 WO 2010018836 A3 WO2010018836 A3 WO 2010018836A3 JP 2009064205 W JP2009064205 W JP 2009064205W WO 2010018836 A3 WO2010018836 A3 WO 2010018836A3
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WO
WIPO (PCT)
Prior art keywords
aggregation inhibitor
polyglutamine aggregation
polyglutamine
symbols
pharmaceutically acceptable
Prior art date
Application number
PCT/JP2009/064205
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English (en)
French (fr)
Other versions
WO2010018836A2 (ja
Inventor
御子柴　克彦
信行 貫名
庄一郎 尾崎
耕造 濱田
純一 後藤
商信 鈴木
悦子 戎井
明子 寺内
Original Assignee
独立行政法人科学技術振興機構
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Filing date
Publication date
Application filed by 独立行政法人科学技術振興機構 filed Critical 独立行政法人科学技術振興機構
Publication of WO2010018836A2 publication Critical patent/WO2010018836A2/ja
Publication of WO2010018836A3 publication Critical patent/WO2010018836A3/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明は、下記の一般式（１）～（１３）のいずれかの式によって表される化合物又はその薬学的に許容可能な塩を含む、ポリグルタミン凝集阻害剤を提供する。 （１）Ｒ３－［－Ｘ－Ｂ（ＺＲ１）－Ｙ－Ｂ（ＺＲ２）－Ｗ－］ｎ－Ｒ４、 （２）Ｒ３－［－Ｘ－Ｂ（ＺＲ１）－Ｙ－］ｎ－Ｒ４、 （３）Ｒ３－［－Ｂ（ＺＲ１）－Ｙ－Ｂ（ＺＲ２）－Ｗ－］ｎ－Ｒ４、 （４）Ｒ３－［－Ｘ－Ｂ（ＺＲ１）－］ｎ－Ｒ４、 （５）Ｒ３－［－Ｂ（ＺＲ２）－Ｗ－］ｎ－Ｒ４、 （６）Ｒ３－Ｘ－Ｂ（ＺＲ１）－Ｔ［Ｂ（ＺＲ２）－Ｗ－Ｒ４］２、 （７）Ｒ３－Ｂ（ＯＨ）２、 （８）Ｒ３－Ｂ（ＺＲ１）－Ｘ－Ｂ（ＺＲ２）－Ｒ４、 （９）Ｒ３－Ｂ(Ｒ１)－Ｏ－Ｂ（Ｒ２）－Ｒ４、 （１０）Ｒ３－［－Ｘ－Ｂ（ＺＲ１）－Ｙ－Ｂ（ＺＲ２）－］ｎ－Ｒ４、 （１１）Ｒ３－［－Ｘ－Ｂ（ＺＲ１）－Ｙ－Ｂ（ＺＲ２）－Ｗ－Ｑ－］ｎ－Ｒ４、 （１２）Ｒ３－［－Ｐ－Ｘ－Ｂ（ＺＲ１）－Ｙ－Ｂ（ＺＲ２）－Ｗ－］ｎ－Ｒ４、 （１３）[Ｒ３－Ｘ－Ｂ（ＺＲ１）－Ｙ]２Ｂ（ＺＲ２）、 〔式中、各記号は明細書中の定義と同義である。〕
PCT/JP2009/064205 2008-08-11 2009-08-11 ポリグルタミン凝集阻害剤 WO2010018836A2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008207315 2008-08-11
JP2008-207315 2008-08-11

Publications (2)

Publication Number Publication Date
WO2010018836A2 WO2010018836A2 (ja) 2010-02-18
WO2010018836A3 true WO2010018836A3 (ja) 2010-04-15

Family

ID=41669420

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2009/064206 WO2010018837A2 (ja) 2008-08-11 2009-08-11 蛋白質架橋阻害剤
PCT/JP2009/064205 WO2010018836A2 (ja) 2008-08-11 2009-08-11 ポリグルタミン凝集阻害剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/064206 WO2010018837A2 (ja) 2008-08-11 2009-08-11 蛋白質架橋阻害剤

Country Status (3)

Country Link
US (1) US8853424B2 (ja)
JP (1) JP5606913B2 (ja)
WO (2) WO2010018837A2 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018164959A1 (en) * 2017-03-09 2018-09-13 The Penn State Research Foundation Boron-containing small molecules for inhibiting activity of a receptor-like protein tyrosine phosphatase
CN112011090A (zh) * 2020-09-09 2020-12-01 烟台融晟新材料有限公司 一种po膜用硼酸酯类内添界面接合剂及外涂液的改性剂

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040859A1 (en) * 1996-04-26 1997-11-06 President And Fellows Of Harvard College Bridge-substituted tropanes and uses
WO2003033002A1 (fr) * 2001-10-11 2003-04-24 Ono Pharmaceutical Co Inhibiteurs de l'augmentation de la concentration du calcium intracellulaire
JP2004524281A (ja) * 2000-11-30 2004-08-12 ザ ペン ステート リサーチ ファウンデイション Ｄｎａメチルトランスフェラーゼ阻害剤
WO2006074419A2 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
WO2007056341A1 (en) * 2005-11-08 2007-05-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
WO2007061074A1 (ja) * 2005-11-25 2007-05-31 Japan Science And Technology Agency 新規ビスホウ素化合物
WO2007098418A1 (en) * 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
WO2007125351A1 (en) * 2006-04-27 2007-11-08 Senexis Limited Pyrimidine derivatives for the treatment of amyloid-related diseases
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
JP2008502702A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ボリン酸複合体の抗寄生虫的使用
JP2008502694A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ボリン酸錯体の抗ウイルス使用
JP2008502696A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ホウ素含有化合物およびその使用方法
WO2008055068A2 (en) * 2006-10-28 2008-05-08 Methylgene Inc. Inhibitors of histone deacetylase
JP2009184988A (ja) * 2008-02-07 2009-08-20 Institute Of Physical & Chemical Research 新規ホウ素化合物及びそれを含む細胞内カルシウム濃度調節剤又は医薬組成物

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040859A1 (en) * 1996-04-26 1997-11-06 President And Fellows Of Harvard College Bridge-substituted tropanes and uses
JP2004524281A (ja) * 2000-11-30 2004-08-12 ザ ペン ステート リサーチ ファウンデイション Ｄｎａメチルトランスフェラーゼ阻害剤
WO2003033002A1 (fr) * 2001-10-11 2003-04-24 Ono Pharmaceutical Co Inhibiteurs de l'augmentation de la concentration du calcium intracellulaire
JP2008502702A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ボリン酸複合体の抗寄生虫的使用
JP2008502696A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ホウ素含有化合物およびその使用方法
JP2008502694A (ja) * 2004-06-14 2008-01-31 アナコール ファーマシューティカルズ，インコーポレイテッド ボリン酸錯体の抗ウイルス使用
WO2006074419A2 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
WO2007056341A1 (en) * 2005-11-08 2007-05-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
WO2007061074A1 (ja) * 2005-11-25 2007-05-31 Japan Science And Technology Agency 新規ビスホウ素化合物
WO2007098418A1 (en) * 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
WO2007125351A1 (en) * 2006-04-27 2007-11-08 Senexis Limited Pyrimidine derivatives for the treatment of amyloid-related diseases
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
WO2008055068A2 (en) * 2006-10-28 2008-05-08 Methylgene Inc. Inhibitors of histone deacetylase
JP2009184988A (ja) * 2008-02-07 2009-08-20 Institute Of Physical & Chemical Research 新規ホウ素化合物及びそれを含む細胞内カルシウム濃度調節剤又は医薬組成物

Also Published As

Publication number Publication date
JPWO2010018837A1 (ja) 2012-01-26
JP5606913B2 (ja) 2014-10-15
US8853424B2 (en) 2014-10-07
WO2010018837A2 (ja) 2010-02-18
WO2010018836A2 (ja) 2010-02-18
US20110212919A1 (en) 2011-09-01
WO2010018837A3 (ja) 2010-04-15

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