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WO2009027736A3 - Composés chimiques 000-1 - Google Patents

Composés chimiques 000-1 Download PDF

Info

Publication number
WO2009027736A3
WO2009027736A3 PCT/GB2008/050739 GB2008050739W WO2009027736A3 WO 2009027736 A3 WO2009027736 A3 WO 2009027736A3 GB 2008050739 W GB2008050739 W GB 2008050739W WO 2009027736 A3 WO2009027736 A3 WO 2009027736A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
treatment
diaminopyrimid
lnes
myeloproliferative disorders
Prior art date
Application number
PCT/GB2008/050739
Other languages
English (en)
Other versions
WO2009027736A2 (fr
Inventor
Stephanos Ioannidis
Michelle Lamb
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Stephanos Ioannidis
Michelle Lamb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Stephanos Ioannidis, Michelle Lamb filed Critical Astrazeneca Ab
Publication of WO2009027736A2 publication Critical patent/WO2009027736A2/fr
Publication of WO2009027736A3 publication Critical patent/WO2009027736A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I) et leurs sels, des compositions pharmaceutiques de ceux-ci ainsi que leurs procédés d'utilisation et de préparation. Ces composés permettent de traiter des troubles myéloprolifératifs et le cancer.
PCT/GB2008/050739 2007-08-27 2008-08-27 Composés chimiques 000-1 WO2009027736A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96828207P 2007-08-27 2007-08-27
US60/968,282 2007-08-27

Publications (2)

Publication Number Publication Date
WO2009027736A2 WO2009027736A2 (fr) 2009-03-05
WO2009027736A3 true WO2009027736A3 (fr) 2009-04-23

Family

ID=40303514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/050739 WO2009027736A2 (fr) 2007-08-27 2008-08-27 Composés chimiques 000-1

Country Status (1)

Country Link
WO (1) WO2009027736A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2763900A1 (fr) 2009-06-05 2010-12-09 Cephalon, Inc. Preparation et utilisation de derives de 1,2,4-triazolo[1,5a]pyridine
PL2624696T3 (pl) 2010-10-06 2017-07-31 Glaxosmithkline Llc Pochodne benzimidazolu jako inhibitory kinazy PI3
EP2729459B1 (fr) * 2011-07-07 2018-08-22 Merck Patent GmbH Azaheterocycles substitues pour le traitement du cancer
EP2554544A1 (fr) * 2011-08-01 2013-02-06 Almirall, S.A. Dérivés de pyridin-2(1h)-one en tant qu'inhibiteurs de JAK
KR101893112B1 (ko) * 2012-01-06 2018-08-30 아지오스 파마슈티컬스 아이엔씨. 치료학적으로 활성인 화합물 및 이의 이용 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214814A1 (en) * 2000-12-21 2004-10-28 David Bebbington Pyrazole compounds useful as protein kinase inhibitors
WO2006074057A2 (fr) * 2004-12-30 2006-07-13 Exelixis, Inc. Modulateurs de kinase et procedes d'utilisation
WO2006115452A1 (fr) * 2005-04-27 2006-11-02 Astrazeneca Ab Utilisation des derives de la pyrazolyl-pyrimidine dans le traitement de la douleur
WO2006123113A2 (fr) * 2005-05-16 2006-11-23 Astrazeneca Ab Composes chimiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214814A1 (en) * 2000-12-21 2004-10-28 David Bebbington Pyrazole compounds useful as protein kinase inhibitors
WO2006074057A2 (fr) * 2004-12-30 2006-07-13 Exelixis, Inc. Modulateurs de kinase et procedes d'utilisation
WO2006115452A1 (fr) * 2005-04-27 2006-11-02 Astrazeneca Ab Utilisation des derives de la pyrazolyl-pyrimidine dans le traitement de la douleur
WO2006123113A2 (fr) * 2005-05-16 2006-11-23 Astrazeneca Ab Composes chimiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG TAO ET AL: "Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.", JOURNAL OF MEDICINAL CHEMISTRY 14 AUG 2008, vol. 51, no. 15, 14 August 2008 (2008-08-14), pages 4672 - 4684, XP002514102, ISSN: 1520-4804 *

Also Published As

Publication number Publication date
WO2009027736A2 (fr) 2009-03-05

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