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WO2008027241A3 - Non-human embryonic stem cell lines and transgenic animals derived from them - Google Patents

Non-human embryonic stem cell lines and transgenic animals derived from them Download PDF

Info

Publication number
WO2008027241A3
WO2008027241A3 PCT/US2007/018402 US2007018402W WO2008027241A3 WO 2008027241 A3 WO2008027241 A3 WO 2008027241A3 US 2007018402 W US2007018402 W US 2007018402W WO 2008027241 A3 WO2008027241 A3 WO 2008027241A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell lines
cells
transgenic animals
derived
stem cell
Prior art date
Application number
PCT/US2007/018402
Other languages
French (fr)
Other versions
WO2008027241A2 (en
Inventor
Esmail Behboodi
Isabelle Begin
Khalid M Rao
Hernan Baldassarre
Original Assignee
Pharmathene Inc
Esmail Behboodi
Isabelle Begin
Khalid M Rao
Hernan Baldassarre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathene Inc, Esmail Behboodi, Isabelle Begin, Khalid M Rao, Hernan Baldassarre filed Critical Pharmathene Inc
Publication of WO2008027241A2 publication Critical patent/WO2008027241A2/en
Publication of WO2008027241A3 publication Critical patent/WO2008027241A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/102—Caprine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Stem cells and stem cell lines, derived from animal embryos, such as from goat, are disclosed along with methods of producing such cells and cell lines. Also described are methods of using such cells, and cell lines, for the generation of transgenic animals, such as transgenic goats. Further disclosed are transgenic animals derived from such cells, and cell lines, wherein said animals comprise a heterologous transgene that expresses a selected protein, especially where said protein is produced in the milk or urine of the transgenic animal. An animal model for studying disease or for insertion of stems cells or cells derived from stem cells is also presented.
PCT/US2007/018402 2006-08-30 2007-08-20 Non-human embryonic stem cell lines and transgenic animals derived from them WO2008027241A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84112606P 2006-08-30 2006-08-30
US60/841,126 2006-08-30

Publications (2)

Publication Number Publication Date
WO2008027241A2 WO2008027241A2 (en) 2008-03-06
WO2008027241A3 true WO2008027241A3 (en) 2008-11-20

Family

ID=39136474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018402 WO2008027241A2 (en) 2006-08-30 2007-08-20 Non-human embryonic stem cell lines and transgenic animals derived from them

Country Status (1)

Country Link
WO (1) WO2008027241A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0903975A2 (en) * 2009-03-06 2011-01-11 Sharon Lisauskas Ferraz De Campos process of modification of bovine embryonic stem cells and process of purification of proteins generated by modified bovine embryonic stem cells
CN104026076B (en) * 2013-09-04 2016-04-13 江口县梵态畜牧养殖有限责任公司 The method of special wild boar is cultivated in a kind of pig and wild boar hybridization

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907080A (en) * 1995-11-30 1999-05-25 Nexia Biotechnologies, Inc. Method for development of transgenic dwarf goats
WO2003054182A2 (en) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production of butyrylcholinesterases in transgenic mammals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907080A (en) * 1995-11-30 1999-05-25 Nexia Biotechnologies, Inc. Method for development of transgenic dwarf goats
WO2003054182A2 (en) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production of butyrylcholinesterases in transgenic mammals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YONG, Z. ET AL.: "Nuclear Transplantation in Goats.", THERIOGENOLOGY, vol. 35, no. 1, January 1991 (1991-01-01), pages 229 *

Also Published As

Publication number Publication date
WO2008027241A2 (en) 2008-03-06

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