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WO2007084895A3 - Peptide-based regulation of gap junctions - Google Patents

Peptide-based regulation of gap junctions Download PDF

Info

Publication number
WO2007084895A3
WO2007084895A3 PCT/US2007/060584 US2007060584W WO2007084895A3 WO 2007084895 A3 WO2007084895 A3 WO 2007084895A3 US 2007060584 W US2007060584 W US 2007060584W WO 2007084895 A3 WO2007084895 A3 WO 2007084895A3
Authority
WO
WIPO (PCT)
Prior art keywords
cx43ct
peptide
fifteen
formula
gap junctions
Prior art date
Application number
PCT/US2007/060584
Other languages
French (fr)
Other versions
WO2007084895A2 (en
Inventor
Mario Delmar
Steven M Taffet
Original Assignee
Univ New York State Res Found
Mario Delmar
Steven M Taffet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Mario Delmar, Steven M Taffet filed Critical Univ New York State Res Found
Priority to EP07718080A priority Critical patent/EP1978988A4/en
Publication of WO2007084895A2 publication Critical patent/WO2007084895A2/en
Priority to US12/172,355 priority patent/US20090075291A1/en
Publication of WO2007084895A3 publication Critical patent/WO2007084895A3/en
Priority to US13/279,703 priority patent/US20120101255A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A]n where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula XnRXPX3n where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed.
PCT/US2007/060584 2006-01-13 2007-01-16 Peptide-based regulation of gap junctions WO2007084895A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07718080A EP1978988A4 (en) 2006-01-13 2007-01-16 Peptide-based regulation of gap junctions
US12/172,355 US20090075291A1 (en) 2006-01-13 2008-07-14 Peptide-based regulation of gap junctions
US13/279,703 US20120101255A1 (en) 2006-01-13 2011-10-24 Peptide-based regulation of gap junctions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75888606P 2006-01-13 2006-01-13
US60/758,886 2006-01-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/172,355 Continuation-In-Part US20090075291A1 (en) 2006-01-13 2008-07-14 Peptide-based regulation of gap junctions

Publications (2)

Publication Number Publication Date
WO2007084895A2 WO2007084895A2 (en) 2007-07-26
WO2007084895A3 true WO2007084895A3 (en) 2008-08-14

Family

ID=38288369

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/060584 WO2007084895A2 (en) 2006-01-13 2007-01-16 Peptide-based regulation of gap junctions

Country Status (2)

Country Link
EP (1) EP1978988A4 (en)
WO (1) WO2007084895A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090075291A1 (en) * 2006-01-13 2009-03-19 The Research Foundation Of State University Of New York Peptide-based regulation of gap junctions
WO2009029991A1 (en) 2007-09-07 2009-03-12 Meat & Livestock Australia Limited Agents with angiogenic and wound healing activity
EP2260859A1 (en) * 2009-06-12 2010-12-15 Zealand Pharma A/S Compounds acting as peptide gap junction modulators and their uses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000026315A (en) * 1998-07-09 2000-01-25 Dai Ichi Seiyaku Co Ltd Evaluation of calcium channel activator
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
WO2005079849A2 (en) * 2004-02-25 2005-09-01 Zgene A/S Compounds for enhanced cancer therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009012224A2 (en) * 2007-07-13 2009-01-22 The Research Foundation Of State University Of New York Peptide-based regulation of gap junctions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
JP2000026315A (en) * 1998-07-09 2000-01-25 Dai Ichi Seiyaku Co Ltd Evaluation of calcium channel activator
WO2005079849A2 (en) * 2004-02-25 2005-09-01 Zgene A/S Compounds for enhanced cancer therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE PIR [online] MORI ET AL., XP008120453, Database accession no. (I46480) *
DATABASE PIR [online] MORI ET AL., XP008120454, Database accession no. (T18630) *
DUFFY ET AL.: "Regulation of connexin43 protein complexes by intracellular acidification", CIRCULATION RESEARCH, vol. 94, February 2004 (2004-02-01), pages 215 - 222, XP008128904 *
See also references of EP1978988A4 *

Also Published As

Publication number Publication date
EP1978988A2 (en) 2008-10-15
WO2007084895A2 (en) 2007-07-26
EP1978988A4 (en) 2009-11-04

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