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WO2006075655A1 - Systeme et procede destines a la conception assistee par ordinateur d'une usine - Google Patents

Systeme et procede destines a la conception assistee par ordinateur d'une usine Download PDF

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Publication number
WO2006075655A1
WO2006075655A1 PCT/JP2006/300280 JP2006300280W WO2006075655A1 WO 2006075655 A1 WO2006075655 A1 WO 2006075655A1 JP 2006300280 W JP2006300280 W JP 2006300280W WO 2006075655 A1 WO2006075655 A1 WO 2006075655A1
Authority
WO
WIPO (PCT)
Prior art keywords
module
plant
design
equipment
modules
Prior art date
Application number
PCT/JP2006/300280
Other languages
English (en)
Japanese (ja)
Inventor
Satoshi Ishiura
Yuji Fujita
Naoko Nishida
Mikio Fujimori
Nobuo Kimura
Original Assignee
Chiyoda Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiyoda Corporation filed Critical Chiyoda Corporation
Priority to CN2006800022964A priority Critical patent/CN101142577B/zh
Publication of WO2006075655A1 publication Critical patent/WO2006075655A1/fr

Links

Classifications

    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
    • G05B19/41885—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by modeling, simulation of the manufacturing system
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/10—Geometric CAD
    • G06F30/13—Architectural design, e.g. computer-aided architectural design [CAAD] related to design of buildings, bridges, landscapes, production plants or roads
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/31—From computer integrated manufacturing till monitoring
    • G05B2219/31334—Database with devices, configuration, of plant
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/31—From computer integrated manufacturing till monitoring
    • G05B2219/31343—Design of factory, manufacturing system control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
    • Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]

Definitions

  • the present invention relates to a system and method for assisting in the design of a plant for producing pharmaceuticals, chemical products, food and the like.
  • GMP Good Manufacturing Practice: quality control of pharmaceutical products' quality control It is specified in.
  • GMP has been adopted in the United States since the 1960s, and has established management and compliance matters for producing safe, superior quality and sound pharmaceutical products such as food.
  • GMP for pharmaceuticals is incorporated into the Pharmaceutical Affairs Law, and manufacturers of pharmaceuticals must comply with the standards set forth in GMP.
  • a pharmaceutical manufacturing plant needs to be designed to satisfy the GMP standard.
  • the same is true for food and health care plants, and certainty must be given to the certainty and safety of production control and quality control.
  • awareness of safety has been rising around the world.
  • precise standards are legally established, and even in the industry, a design is made in consideration of appropriate manufacturing control and quality control in order to supply products to the global market, and the plant is constructed according to the design drawings. It must be.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 10-269269
  • the present invention has been made in view of these circumstances, and an object thereof is to provide a technology capable of efficiently supporting plant design.
  • an aspect of the present invention provides a system that supports plant design.
  • This plant design support system includes module storage means for holding the equipment installed in the plant as a module designed to satisfy the design criteria required for the plant design alone, and the module storage means. And placement means for placing the object in a two-dimensional or three-dimensional virtual space.
  • the module storage means holds a group of modules which also have a plurality of module forces for each type of equipment, and the plant design support system may further comprise selection means for selecting a module group force module. Multiple modules per device type It is possible to realize a highly versatile plant design support system by preparing
  • the module storage means holds a module having a joint at a common position for each type of device. It is possible to unambiguously identify the joint position by sharing the position of the joint having the function of joining to other modules for each type of equipment.
  • the position of the joint needs to be at least the same height from the bottom of the module.
  • the joint elements included in the joint for example, the arrangement of pipes and ducts, are also standardized. This eliminates the need to adjust the position of piping and ducts in one or both modules when bonding the modules together, and enables efficient design support of the plant.
  • Another aspect of the present invention is to prepare equipment to be installed in a plant in advance as a module designed to satisfy the design criteria required for plant design alone, and to combine the modules in two dimensions. Or Provides a plant design support method for plant design by joining in a three-dimensional virtual space.
  • FIG. 1 is a diagram showing a step of lithography in plant design.
  • FIG. 2 is a diagram showing the configuration of a plant design support system according to an embodiment of the present invention.
  • FIG. 3 A conceptual view of the top of the equipment module.
  • FIG. 4 is a view showing an example of a selection screen on which each step in the drug substance manufacturing process is shown.
  • FIG. 5 is a view showing a screen for selecting an equipment module in a reaction process.
  • FIG. 6 is a view showing an example of a front view of a three-dimensional design drawing.
  • FIG. 7 is a view showing a right side view of the three-dimensional design drawing.
  • FIG. 8 is a perspective view of a three-dimensional design drawing.
  • FIG. 1 shows validadene steps in plant design. The following shows the design of pharmaceutical plants, but the same applies to manufacturing plants for food and medicine products. Validation steps include: Design Qualification (DQ), Installation Qualification (IQ) at Installation, Operation Qualification (OQ), Operation Qualification (PQ) It consists of 4 processes of Performance Qualification, and the process validation (PV: Process Validation) performed at the end.
  • DQ Design Qualification
  • IQ Installation Qualification
  • OQ Operation Qualification
  • PQ Operation Qualification
  • It consists of 4 processes of Performance Qualification
  • PV Process Validation
  • DQ it is determined whether the design is suitable for required specifications or functional specifications. Specifically, it is determined whether the plant design satisfies the GMP standard as well as the requirements of the ordering company pharmaceutical company. IQ confirms the qualification when arranging various facilities according to the design drawings, and OQ tests the important functions and performance of the installed facilities. This DQ, IQ, OQ is generally performed by the plant manufacturer. The plant will be delivered to a pharmaceutical company when validation to OQ is completed. In PQ, pharmaceutical companies perform a wide variety of performance checks in their plants. For example, in the case of a multi-purpose type of brush, it is confirmed whether various types of drugs can be manufactured. Lastly, PV is implemented by clarifying, in a written form, the assurance that products consistent with the determined characteristics and qualities are consistently produced.
  • FIG. 2 shows the configuration of a plant design support system 10 according to an embodiment of the present invention.
  • the plant design support system 10 is used by a plant manufacturing company and has a function to support plant design.
  • the plant design support system 10 includes a receiving unit 12 for receiving input instructions from the user, a processing unit 20 for creating a plant design drawing, a module storage unit 30 for holding facility modules installed in the plant, and a processing unit 20. And a design drawing storage unit 40 for storing the design drawing created in the above.
  • the above configuration can be realized by the CPU, memory, and other LSIs of an arbitrary computer, and software can be realized by a program loaded into the memory, etc. Depicts the functional blocks realized by Therefore, it is understood by those skilled in the art that these functional blocks can be realized in various forms by hardware only, software only, or a combination thereof.
  • the input interface 2 is configured by tools that can be operated by the user, such as a mouse and a keyboard.
  • the user operates the input interface 2 to create a design drawing while viewing the screen displayed on the display 4.
  • the display 4 is configured by a motor such as a liquid crystal panel or a CRT.
  • the module storage unit 30 holds the equipment installed in the plant as an equipment module designed to satisfy the design criteria required for the plant design alone.
  • This design standard may be a legal standard such as, for example, GMP, or may be derived from know-how to satisfy the legal standard of GMP.
  • the module storage unit 30 holds a group of modules which also become a plurality of facility module forces for each type of device.
  • the equipment module main body is configured as a three-dimensional drawing that three-dimensionally represents the equipment main body and surrounding piping and ducts.
  • the facility module body can be formed by CAD data or the like.
  • An equipment module contains equipment of the type expected to be required in a multipurpose plant.
  • a plurality of equipment modules be prepared in advance for all the processes required for manufacturing various types of medicines.
  • pharmaceuticals, reaction process, solid-liquid separation process, drying process When manufactured by executing the crystallization step, the solid-liquid separation step, and the drying step, the module storage unit 30 needs to store the equipment module in each step in advance.
  • equipment modules comprising a plurality of types of reactors are provided for the reaction process, and each equipment module includes an inlet for the pharmaceutical raw material to the reactors and a pipe or duct extending along the reactor.
  • Etc. Force is created in a form that meets the GMP standard.
  • a single installation module is preset to meet the required design criteria, and a closed system module that satisfies the design criteria alone, excluding the inlets and outlets for the other installation modules. It becomes.
  • an equipment module is prepared for a solid-liquid separation / drying process in which the solid-liquid separation process and the drying process are integrally performed. , Even!
  • unit operations In operations performed in the reaction step (hereinafter referred to as “unit operations”), raw material input “reception operation”, purified water input operation, temperature increase “temperature decrease operation, pressure reduction” pressurization operation, plant nitrogen purge operation , Stirring operation, transfer operation etc. Design criteria exist for each unit operation, and this design criteria is derived from GMP and the accumulated power of past experiences as described above.
  • Examples of typical design criteria include the following.
  • the installation module is provided with a block made of steel frame so as to satisfy these design criteria, and piping, ducts, equipment body, etc. routed around in the block are arranged at appropriate positions. It is designed in advance. For example, dust tends to be accumulated on pipes and ducts, but if accumulated dust gets into the inside of the device body, it is not possible to execute an appropriate process. for that reason, Even if dust accumulates on the piping or duct, foreign matter contamination can be prevented by providing the piping or duct outside at a position where the dust does not enter the main body of the device.
  • the material which is the same as that of the block, piping, duct, etc. is defined.
  • FIG. 3 is a conceptual view of the top of the equipment module.
  • the equipment module 50 includes an equipment main body 60 and a first joint 54 for receiving the product of another equipment module power placed in the front stage of the equipment module 50, another placed in the back stage of the equipment module 50.
  • a second joint unit 56 for delivering the product to the equipment module, a piping rack 52 having a plurality of pipings, and a sub piping unit 58 for connecting the piping of the piping rack 52 and the device body 60 are provided.
  • the piping rack 52 is provided at a position away from the device main body 60 so that dust on the piping does not enter the inside of the device main body 60.
  • the direction of the arrow of each sub piping in the sub piping portion 58 indicates whether it is a force supplied to the device main body 60 or whether it is taken out from the device main body 60.
  • the instrument body 60 shows a reactor.
  • the facility module 50 has a joint at a common position for each type of device! That is, in the same equipment module group, the positions of joints of all the equipment modules 50 are made common.
  • the distance dl from one side (the upper side in FIG. 3) of the facility module 50 to the end of the second joint 56 and the length of the second joint 56 when viewed two-dimensionally with respect to the second joint 56 The d2 is the same for all the equipment modules 50 in the same equipment module group.
  • the height from the bottom of the equipment module 50 is also the same.
  • the number and arrangement of pipes and ducts at the second joint 56 are also the same. The same applies to the first joint 54. It is not necessary to carry out the commonality between the first joint 54 and the second joint 56.
  • the position and the internal arrangement of the first joint 54 in the same facility module group are commonality. Also, the position and internal arrangement of the second joint 56 may be made common. According to the plant design support system 10 of the present embodiment, it is possible to easily join other equipment modules to one equipment module 50.
  • the distance dl does not necessarily have to be common.
  • the distance dl is common
  • the positions of the joints are made common.
  • the process often proceeds in a fixed order. Therefore, the joint between the other equipment module and the second joint 56, which are arranged on the second floor, are joined so that the joint of the other equipment module arranged in the previous stage and the first joint 54 are joined.
  • the joining of the installation modules can be easily realized simply by arranging the installation modules next to each other.
  • the position of the joint is a concept including the position of pipes and ducts that abut, and by bringing the joints of two equipment modules into contact, the pipes included in each will be connected. Become.
  • connection between the installation modules can be realized simply by arranging the installation modules adjacent to each other, which is used as a highly convenient design support tool. It will be possible to
  • the selection unit 24 displays a selection screen of the facility module 50 on the display 4. This selection screen may be displayed on the display 4 when the user designs a plant, and may be displayed when the plant design support system 10 is started.
  • FIG. 4 shows an example of a selection screen in which each step in the drug substance manufacturing process is shown.
  • a check box is provided on the left side of the process name, and when the user checks the check box using the input interface 2, the specification of the facility module in the process is displayed.
  • the module storage unit 30 includes, for example, facility module groups in each step necessary for drug substance production such as weighing step and filling step. Is prepared.
  • FIG. 5 shows an equipment module selection screen of the reaction process displayed when the reaction process is selected on the selection screen of FIG.
  • This selection screen displays specifications such as reactor volume, manufacturer, and equipment module price.
  • a check box is provided on the left side of each specification, and when the user checks the check box using input interface 2, the facility module is selected.
  • Users are provided by the pharmaceutical company (client) Select the equipment module by operating the input interface 2 by selecting the indicated requirements and budget.
  • the selection unit 24 has a function of causing the user to select an arbitrary equipment module from among a plurality of equipment module groups.
  • the selection unit 24 reads the equipment module selected by the user from the module storage unit 30 and supplies the same to the arrangement unit 22.
  • the placement unit 22 places the equipment module read from the module storage unit 30 in a two-dimensional or three-dimensional virtual space.
  • the placement unit 22 forms a three-dimensional virtual space on the display 4 and the equipment module is arranged on the space. Arrange it.
  • the installation module 50 is provided with joints on the top and bottom surfaces.
  • the facility module 50 is three-dimensionally configured, and by arranging the facility module on a three-dimensional virtual space, it is possible to create a CAD design drawing that is easy to understand intuitively. .
  • the screen provided to the user on display 4 may be only the selection screen shown in FIG. 4, FIG. 5, etc. OK.
  • the function of the selection unit 24 allows the user to set up each process.
  • the modules may be selected, and when all of the equipment modules have been selected, the placement unit 22 may automatically arrange each of the equipment modules within a limited plant space. In this case, the user can omit the time and effort of arranging each of the equipment modules, so that the plant design support system 10 can be realized with high convenience.
  • the arrangement unit 22 may form a two-dimensional virtual space and arrange the facility module 50.
  • the equipment module itself is configured as a three-dimensional object, but in the case of simply showing the arrangement relationship of the equipment to the user, it is not necessary to represent the three-dimensional structure of each equipment on the display 4.
  • a plurality of equipment modules arranged in an appropriate order may be displayed on the display 4.
  • arrangement unit 22 has a function to automatically arrange an installation module.
  • an installation module may be It may be placed in a three-dimensional or three-dimensional virtual space.
  • the automatic placement function when the equipment module can not be placed successfully, the user adjusts the positional relationship of each. If the placement unit 22 does not have the automatic placement function, the user may operate the input interface 2 to place the equipment module at any position.
  • the placement unit 22 may have an automatic placement function, or may have a function of placing a facility module by an operation from the user.
  • arrangement part 22 can realize plant design support system 10 which is highly convenient for the user by having both functions.
  • the design drawing is completed.
  • the completed design drawing is stored in the design drawing storage unit 40.
  • the single module of the facility module 50 is configured to conform to GMP, and the facility module 50 can be easily joined together, so that the entire design can be easily conformed to the GMP. It will be beautiful to do it.
  • FIG. 6 shows an example of a front view of a three-dimensional design drawing.
  • a reactor module 50a a solid-liquid separation 'dryer module 50b, a crystallizer module 50c, a solid-liquid separator module 50d, and a dryer module 50e are shown.
  • the reaction process in the reactor module 50a, the solid-liquid separation 'solid-liquid separation' drying process in the dryer module 50b, the crystallization process in the crystallizer module 50c, the solid-liquid separator module 50d The liquid separation step and the drying step in the dryer module 50e are performed in this order. Placing them from top to bottom in order of process has the advantage of facilitating the transfer of products in each process.
  • the junctions are provided in the horizontal direction.
  • the junctions are in the vertical direction of the installation modules 50. It is provided in the direction of connecting to The transfer of product from the solid-liquid separation 'dryer module 50b to the crystallizer module 50c utilizes an elevator.
  • FIG. 7 shows a right side view of the three-dimensional design drawing
  • FIG. 8 shows a perspective view of the three-dimensional design drawing.
  • the joints of all the equipment modules 50 are provided at a common position, and the joints of the other adjacent equipment modules are adjacent to each other. Being formed in accordance with the position of the joint facilitates joining of the equipment modules.
  • the present invention can be used in a system that supports plant design.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Computer Hardware Design (AREA)
  • General Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Theoretical Computer Science (AREA)
  • Architecture (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Pure & Applied Mathematics (AREA)
  • Evolutionary Computation (AREA)
  • Civil Engineering (AREA)
  • Computational Mathematics (AREA)
  • Structural Engineering (AREA)
  • Quality & Reliability (AREA)
  • Automation & Control Theory (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

L'invention concerne une technologie destinée à la conception d'une usine. Ce système de conception assistée par ordinateur d'une usine (10) comprend une section de stockage de modules (30) contenant un modèle de dispositif destiné à être installé dans une usine sous forme de module répondant à des critères de conception requis pour la conception d'une usine. Cette section de stockage de modules (30) contient un groupe de modules constitué d'une pluralité de modules pour chaque type de dispositif. Dans ce groupe de modules, la position des raccords est adaptée de façon à faciliter les joints avec un module d'un autre groupe de modules. Le système comprend également une section d'agencement (22) permettant d'extraire les données sur les modules de la section de stockage de modules (30) et de les afficher dans un espace virtuel bi- ou tridimensionnel et, ainsi, de compléter le plan d'une usine.
PCT/JP2006/300280 2005-01-13 2006-01-12 Systeme et procede destines a la conception assistee par ordinateur d'une usine WO2006075655A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2006800022964A CN101142577B (zh) 2005-01-13 2006-01-12 工厂设计辅助系统和方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-006649 2005-01-13
JP2005006649A JP2006195735A (ja) 2005-01-13 2005-01-13 プラント設計支援システム及び方法

Publications (1)

Publication Number Publication Date
WO2006075655A1 true WO2006075655A1 (fr) 2006-07-20

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Family Applications (1)

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PCT/JP2006/300280 WO2006075655A1 (fr) 2005-01-13 2006-01-12 Systeme et procede destines a la conception assistee par ordinateur d'une usine

Country Status (3)

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JP (1) JP2006195735A (fr)
CN (1) CN101142577B (fr)
WO (1) WO2006075655A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016074730A1 (fr) * 2014-11-13 2016-05-19 Siemens Aktiengesellschaft Procédé de planification pour la fabrication d'un produit et module de production avec information d'autodescription

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JP5074328B2 (ja) * 2008-08-25 2012-11-14 高砂熱学工業株式会社 設備要素を積み重ねる設備の設計支援装置、設計支援方法、およびプログラム
WO2012058604A2 (fr) * 2010-10-28 2012-05-03 Parametric Technology Corporation Procédés et systèmes de conception assistée par ordinateur
CN102609562A (zh) * 2012-01-10 2012-07-25 中联重科股份有限公司 布料机设计选型系统及方法
EP2874029A1 (fr) 2013-11-15 2015-05-20 Bayer Technology Services GmbH Procédé de fonctionnement d'une installation conçue pour réaliser au moins une réaction chimique
US10998086B2 (en) * 2014-11-24 2021-05-04 Bayer Aktiengesellschaft Method for configuring a production plant designed for performing at least one chemical reaction
CN107895065A (zh) * 2017-10-23 2018-04-10 中材建设有限公司 一种基于三维技术的工厂设计方法
CN113927213A (zh) * 2020-07-13 2022-01-14 一汽-大众汽车有限公司 用于提供三维安全组合模块的方法和装置

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JP2002251426A (ja) * 2001-02-21 2002-09-06 Mitsubishi Heavy Ind Ltd プラントデザイン装置、プラントデザイン方法、および、プログラム

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JPH01318890A (ja) * 1989-05-09 1989-12-25 Fuji Electric Co Ltd ユニット式熱交換器
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JPH0521084A (ja) * 1991-07-17 1993-01-29 Fuji Electric Co Ltd ユニツト組立型燃料電池発電システム
US20020046918A1 (en) * 2000-07-28 2002-04-25 Yasuhiko Yamazaki Production system
JP2002251426A (ja) * 2001-02-21 2002-09-06 Mitsubishi Heavy Ind Ltd プラントデザイン装置、プラントデザイン方法、および、プログラム

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016074730A1 (fr) * 2014-11-13 2016-05-19 Siemens Aktiengesellschaft Procédé de planification pour la fabrication d'un produit et module de production avec information d'autodescription
US11003174B2 (en) 2014-11-13 2021-05-11 Siemens Aktiengesellschaft Method for planning the manufacture of a product and production module having self-description information

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Publication number Publication date
JP2006195735A (ja) 2006-07-27
CN101142577B (zh) 2012-10-10
CN101142577A (zh) 2008-03-12

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