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WO2005100373A3 - Derives du monosaccharide - Google Patents

Derives du monosaccharide Download PDF

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Publication number
WO2005100373A3
WO2005100373A3 PCT/IB2005/000974 IB2005000974W WO2005100373A3 WO 2005100373 A3 WO2005100373 A3 WO 2005100373A3 IB 2005000974 W IB2005000974 W IB 2005000974W WO 2005100373 A3 WO2005100373 A3 WO 2005100373A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
inflammatory
compounds
inflammatory agents
monosaccharide derivatives
Prior art date
Application number
PCT/IB2005/000974
Other languages
English (en)
Other versions
WO2005100373A2 (fr
Inventor
Viswajanani Jitendra Sattigeri
Sudershan K Arora
Mohammad Salman
Venkata P Palle
Abhijit Ray
Raj Kumar Shirumalla
Original Assignee
Ranbaxy Lab Ltd
Viswajanani Jitendra Sattigeri
Sudershan K Arora
Mohammad Salman
Venkata P Palle
Abhijit Ray
Raj Kumar Shirumalla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Viswajanani Jitendra Sattigeri, Sudershan K Arora, Mohammad Salman, Venkata P Palle, Abhijit Ray, Raj Kumar Shirumalla filed Critical Ranbaxy Lab Ltd
Publication of WO2005100373A2 publication Critical patent/WO2005100373A2/fr
Publication of WO2005100373A3 publication Critical patent/WO2005100373A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés du monosaccharide en tant qu'agents anti-inflammatoires. Les composés de l'invention peuvent servir à inhiber et à prévenir une inflammation et des pathologies associées, y compris des maladies inflammatoires et auto-immunes telles que l'asthme, la polyarthrite rhumatoïde, le diabète de type I, la sclérose en plaques, le rejet de greffe allogénique, le psoriasis, les maladies entériques inflammatoires, la colite ulcéreuse, l'acné, l'athérosclérose, le cancer, la prurit ou la rhinite allergique. La présente invention porte également sur des compositions pharmaceutiques contenant les composés de l'invention et sur des méthodes pour traiter l'asthme, les maladies respiratoires obstructives, la polyarthrite rhumatoïde, le diabète de type I, la sclérose en plaques, le rejet de greffe allogénique, le psoriasis, les maladies entériques inflammatoires, la colite ulcéreuse, l'acné, l'athérosclérose, le cancer, la prurit ou la rhinite allergique, ainsi que d'autres troubles inflammatoires et/ou auto-immunes, au moyen des composés de l'invention.
PCT/IB2005/000974 2004-04-13 2005-04-13 Derives du monosaccharide WO2005100373A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56179104P 2004-04-13 2004-04-13
US60/561,791 2004-04-13

Publications (2)

Publication Number Publication Date
WO2005100373A2 WO2005100373A2 (fr) 2005-10-27
WO2005100373A3 true WO2005100373A3 (fr) 2006-04-06

Family

ID=34965503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000974 WO2005100373A2 (fr) 2004-04-13 2005-04-13 Derives du monosaccharide

Country Status (1)

Country Link
WO (1) WO2005100373A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104066730B (zh) * 2011-10-14 2017-03-08 埃姆比特生物科学公司 杂环化合物及其作为iii型受体酪氨酸激酶调节剂的用途
KR102449266B1 (ko) * 2020-06-23 2022-09-30 (주)바이오메트릭스 테크놀로지 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법
JP7376108B2 (ja) 2020-06-23 2023-11-08 バイオメトリックス テクノロジーズ インコーポレイテッド 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013117A2 (fr) * 1991-12-20 1993-07-08 Greenwich Pharmaceuticals Incorporated DERIVES 5- ou 6-AMINODESOXYFURANOSIDE A ACTIVITE ANTI-INFLAMMATOIRE ET ANTI-PROLIFERATIVE
US5298494A (en) * 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
WO1994011381A1 (fr) * 1992-11-13 1994-05-26 Greenwich Pharmaceuticals Incorporated Composes antiproliferatifs et anti-inflammatoires: derives de monosaccharides de pentose
WO1994028910A1 (fr) * 1993-06-11 1994-12-22 Boston Life Sciences, Inc. Composes immunomodulateurs, anti-inflammatoires, et anti-proliferatifs: derives 5,6-didesoxy, 5-amino de l'idose et derives 6-desoxy, 6-amino du glucose
WO1996035431A1 (fr) * 1995-05-09 1996-11-14 Chemora Pharmochem Derives de l'acide 2,3:4,6-di-o-isopropylidene-alpha-l-xylo-2-hexulofluranosonique
WO2000042053A1 (fr) * 1999-01-12 2000-07-20 Ranbaxy Laboratories Limited Derives de monosaccharides en tant qu'inhibiteurs de l'adhesion cellulaire
WO2004071515A1 (fr) * 2003-02-12 2004-08-26 Ranbaxy Laboratories Limited Preparation de derives de monosaccharide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298494A (en) * 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
WO1993013117A2 (fr) * 1991-12-20 1993-07-08 Greenwich Pharmaceuticals Incorporated DERIVES 5- ou 6-AMINODESOXYFURANOSIDE A ACTIVITE ANTI-INFLAMMATOIRE ET ANTI-PROLIFERATIVE
WO1994011381A1 (fr) * 1992-11-13 1994-05-26 Greenwich Pharmaceuticals Incorporated Composes antiproliferatifs et anti-inflammatoires: derives de monosaccharides de pentose
WO1994028910A1 (fr) * 1993-06-11 1994-12-22 Boston Life Sciences, Inc. Composes immunomodulateurs, anti-inflammatoires, et anti-proliferatifs: derives 5,6-didesoxy, 5-amino de l'idose et derives 6-desoxy, 6-amino du glucose
WO1996035431A1 (fr) * 1995-05-09 1996-11-14 Chemora Pharmochem Derives de l'acide 2,3:4,6-di-o-isopropylidene-alpha-l-xylo-2-hexulofluranosonique
WO2000042053A1 (fr) * 1999-01-12 2000-07-20 Ranbaxy Laboratories Limited Derives de monosaccharides en tant qu'inhibiteurs de l'adhesion cellulaire
WO2004071515A1 (fr) * 2003-02-12 2004-08-26 Ranbaxy Laboratories Limited Preparation de derives de monosaccharide

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
COAT J.P. ET AL.: "Préparation et couplage sur des polypeptides de 5'-O-carboxyméthyl-ribonucléosides", CARBOHYDRATE RESEARCH, vol. 12, 1970, Belgium, pages 335 - 346, XP002360609 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1985, PAULSEN, HANS ET AL: "Branched and chain-extended sugars, XXVIII. Synthesis of 6-amino-6-deoxyhepturonic acids", XP002360612, retrieved from STN Database accession no. 102:149685 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1998, TOIKKA, MERJA ET AL: "Lignin-carbohydrate model compounds. Formation of lignin-methyl arabinoside and lignin-methyl galactoside benzyl ethers via quinone methide intermediates", XP002344213, retrieved from STN Database accession no. 130:139518 *
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY , (22), 3813-3818 CODEN: JCPRB4; ISSN: 0300-922X, 1998 *
KATIYAR D ET AL: "Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 40, no. 4, April 2005 (2005-04-01), pages 351 - 360, XP004814470, ISSN: 0223-5234 *
LIEBIGS ANNALEN DER CHEMIE , (1), 113-28 CODEN: LACHDL; ISSN: 0170-2041, 1985 *
MASJOST B ET AL: "Structure based design, synthesis and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT)", CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US, vol. 6, no. 6, 2000, pages 971 - 982, XP002978173, ISSN: 0947-6539 *
MISHRA, R. C. ET AL: "Synthesis of glycosylated .beta.-Amino hydroxamates as new class of antimalarials", BIOORGANIC & MEDICINAL CHEMISTRY , 11(24), 5363-5374 CODEN: BMECEP; ISSN: 0968-0896, 2003, XP002360610 *

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Publication number Publication date
WO2005100373A2 (fr) 2005-10-27

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