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EA018670B9 - Производные пиразоло[3,4-в]пиридина в качестве ингибиторов фосфодиэстеразы - Google Patents

Производные пиразоло[3,4-в]пиридина в качестве ингибиторов фосфодиэстеразы

Info

Publication number
EA018670B9
EA018670B9 EA200970852A EA200970852A EA018670B9 EA 018670 B9 EA018670 B9 EA 018670B9 EA 200970852 A EA200970852 A EA 200970852A EA 200970852 A EA200970852 A EA 200970852A EA 018670 B9 EA018670 B9 EA 018670B9
Authority
EA
Eurasian Patent Office
Prior art keywords
pde
type
diseases
pde type
phosphodiesterase
Prior art date
Application number
EA200970852A
Other languages
English (en)
Other versions
EA200970852A1 (ru
EA018670B1 (ru
Inventor
Сонали Рудра
Ниди Гупта
Лалит Кумар Барегама
Риту Агарвал
Винайяк Васантрао Кайрнар
Мандадапу Рагу Рамайя
Венката П. Палле
Сарала Балачандран
Атул Кондаскар
Манохар Салла
Абиджит Рай
Сунанда Г. Дастидар
Лалита Виджайкришнан
Original Assignee
Ранбакси Лабораториз Лимитед
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Publication date
Application filed by Ранбакси Лабораториз Лимитед filed Critical Ранбакси Лабораториз Лимитед
Publication of EA200970852A1 publication Critical patent/EA200970852A1/ru
Publication of EA018670B1 publication Critical patent/EA018670B1/ru
Publication of EA018670B9 publication Critical patent/EA018670B9/ru

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к ингибиторам фосфодиэстеразы (PDE) типа 4, фосфодиэстеразы (PDE) типа 7 и двойным ингибиторам PDE типа 4/PDE типа 7. Соединения, описанные в изобретении, имеющие структуру формулы I, могут быть полезны в лечении, предупреждении, ингибировании или подавлении болезней ЦНС (центральной нервной системы), например множественного склероза; различных патологических состояний, как, например, заболеваний, поражающих иммунную систему, включая СПИД (синдром приобретенного иммунодефицита), отторжение трансплантата, аутоиммунные расстройства, такие как ассоциированные с Т-клетками заболевания, например ревматоидный артрит; воспалительных заболеваний, таких как респираторные воспалительные заболевания, включая хроническую обструктивную болезнь легких (COPD), астму, бронхит, аллергический ринит, респираторный дистресс-синдром взрослых (ARDS) и другие воспалительные заболевания, включая, но этим не ограничиваясь, псориаз, шок, атопический дерматит, эозинофильную гранулёму, аллергический конъюнктивит, остеоартрит; желудочно-кишечных воспалительных заболеваний, таких как болезнь Крона, колит, панкреатит, а также различных типов рака, включая лейкоз; особенно у людей. Предложены способ получения описанных соединений, фармацевтические композиции, содержащие описанные соединения, и их применение в качестве ингибиторов PDE типа 4, PDE типа 7 и двойных ингибиторов PDE типа 4/PDE типа 7.
EA200970852A 2007-03-14 2008-03-14 Производные пиразоло[3,4-в]пиридина в качестве ингибиторов фосфодиэстеразы EA018670B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN550DE2007 2007-03-14
PCT/IB2008/050943 WO2008111010A1 (en) 2007-03-14 2008-03-14 Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
EA200970852A1 EA200970852A1 (ru) 2010-04-30
EA018670B1 EA018670B1 (ru) 2013-09-30
EA018670B9 true EA018670B9 (ru) 2014-01-30

Family

ID=39575541

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970852A EA018670B9 (ru) 2007-03-14 2008-03-14 Производные пиразоло[3,4-в]пиридина в качестве ингибиторов фосфодиэстеразы

Country Status (22)

Country Link
US (1) US8420666B2 (ru)
EP (1) EP2124944B1 (ru)
JP (1) JP5671236B2 (ru)
KR (1) KR101568884B1 (ru)
CN (2) CN103497185A (ru)
AP (1) AP2453A (ru)
AT (1) ATE545417T1 (ru)
AU (1) AU2008224541B2 (ru)
CA (1) CA2680625C (ru)
CY (1) CY1112805T1 (ru)
DK (1) DK2124944T3 (ru)
EA (1) EA018670B9 (ru)
ES (1) ES2382715T3 (ru)
HK (1) HK1138758A1 (ru)
HR (1) HRP20120361T1 (ru)
MX (1) MX2009009793A (ru)
NZ (1) NZ579645A (ru)
PL (1) PL2124944T3 (ru)
PT (1) PT2124944E (ru)
SI (1) SI2124944T1 (ru)
WO (1) WO2008111010A1 (ru)
ZA (1) ZA200906418B (ru)

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US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
US10246462B2 (en) 2016-09-09 2019-04-02 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
EA037544B1 (ru) * 2017-04-04 2021-04-12 Х. Лундбекк А/С ПРИМЕНЕНИЕ 1H-ПИРАЗОЛО[4,3-b]ПИРИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE1
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
RS62551B1 (sr) * 2017-12-14 2021-12-31 H Lundbeck As Kombinovane terapije koje obuhvataju primenu 1h-pirazolo[4,3-b]piridina
JP7194738B2 (ja) 2017-12-20 2022-12-22 ハー・ルンドベック・アクチエゼルスカベット ＰＤＥ１阻害剤としてのピラゾロ［３，４－ｂ］ピリジン及びイミダゾ［１，５－ｂ］ピリダジン
TW201927784A (zh) 2017-12-20 2019-07-16 丹麥商Ｈ 朗德貝克公司 作為pde1抑制劑之大環
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
CN113200997B (zh) * 2021-05-07 2023-10-03 上海合全医药有限公司 2,5-二氧杂-8-氮杂螺[3.5]壬烷及其盐的合成方法

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