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WO2005019169A3 - Indolin-derivate als ppar delta modulatoren - Google Patents

Indolin-derivate als ppar delta modulatoren Download PDF

Info

Publication number
WO2005019169A3
WO2005019169A3 PCT/EP2004/009175 EP2004009175W WO2005019169A3 WO 2005019169 A3 WO2005019169 A3 WO 2005019169A3 EP 2004009175 W EP2004009175 W EP 2004009175W WO 2005019169 A3 WO2005019169 A3 WO 2005019169A3
Authority
WO
WIPO (PCT)
Prior art keywords
ppar
indoline derivatives
delta modulators
delta
derivatives
Prior art date
Application number
PCT/EP2004/009175
Other languages
English (en)
French (fr)
Other versions
WO2005019169A2 (de
Inventor
Elke Dittrich-Wengenroth
Stephan Siegel
Michael Woltering
Original Assignee
Bayer Healthcare Ag
Elke Dittrich-Wengenroth
Stephan Siegel
Michael Woltering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Elke Dittrich-Wengenroth, Stephan Siegel, Michael Woltering filed Critical Bayer Healthcare Ag
Priority to CA002535960A priority Critical patent/CA2535960A1/en
Priority to JP2006523592A priority patent/JP2007502797A/ja
Priority to US10/568,887 priority patent/US20070197626A1/en
Priority to EP04764167A priority patent/EP1675825A2/de
Publication of WO2005019169A2 publication Critical patent/WO2005019169A2/de
Publication of WO2005019169A3 publication Critical patent/WO2005019169A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Die vorliegende Anmeldung betrifft neue Indolin-Derivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln, insbesondere als potente PPAR-delta aktivierende Verbindungen zur Prophylaxe und/oder Behandlung kardiovaskulärer Erkrankungen, insbesondere von Dyslipidämien, Arteriosklerose und koronaren Herzkrankheiten.
PCT/EP2004/009175 2003-08-18 2004-08-16 Indolin-derivate als ppar delta modulatoren WO2005019169A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002535960A CA2535960A1 (en) 2003-08-18 2004-08-16 Indoline derivatives
JP2006523592A JP2007502797A (ja) 2003-08-18 2004-08-16 インドリン誘導体
US10/568,887 US20070197626A1 (en) 2003-08-18 2004-08-16 Indoline derivatives
EP04764167A EP1675825A2 (de) 2003-08-18 2004-08-16 Indolin-derivate als ppar delta modulatoren

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10337839.1 2003-08-18
DE10337839A DE10337839A1 (de) 2003-08-18 2003-08-18 Indolin-Derivate

Publications (2)

Publication Number Publication Date
WO2005019169A2 WO2005019169A2 (de) 2005-03-03
WO2005019169A3 true WO2005019169A3 (de) 2005-05-12

Family

ID=34201612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/009175 WO2005019169A2 (de) 2003-08-18 2004-08-16 Indolin-derivate als ppar delta modulatoren

Country Status (6)

Country Link
US (1) US20070197626A1 (de)
EP (1) EP1675825A2 (de)
JP (1) JP2007502797A (de)
CA (1) CA2535960A1 (de)
DE (1) DE10337839A1 (de)
WO (1) WO2005019169A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2921366B1 (fr) * 2007-09-26 2009-12-04 Servier Lab Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI356705B (en) * 2007-10-25 2012-01-21 Internat Chlorella Co Ltd Extracts from chlorella sorokiniana
WO2010000353A1 (en) * 2008-06-09 2010-01-07 Sanofi-Aventis Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008188A1 (en) * 2000-07-25 2002-01-31 Merck & Co., Inc. N-substituted indoles useful in the treatment of diabetes
WO2003035603A1 (de) * 2001-10-18 2003-05-01 Bayer Healthcare Ag Essigsäurederivate
EP1310494A1 (de) * 2000-08-11 2003-05-14 Nippon Chemiphar Co., Ltd. Ppar (delta) aktivatoren
WO2003097607A1 (de) * 2002-05-17 2003-11-27 Bayer Healthcare Ag Tetrahydroisochinolin-derivate
WO2004005253A1 (de) * 2002-07-03 2004-01-15 Bayer Healthcare Ag Indolin-phenylsulfonamid-derivate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008188A1 (en) * 2000-07-25 2002-01-31 Merck & Co., Inc. N-substituted indoles useful in the treatment of diabetes
EP1310494A1 (de) * 2000-08-11 2003-05-14 Nippon Chemiphar Co., Ltd. Ppar (delta) aktivatoren
WO2003035603A1 (de) * 2001-10-18 2003-05-01 Bayer Healthcare Ag Essigsäurederivate
WO2003097607A1 (de) * 2002-05-17 2003-11-27 Bayer Healthcare Ag Tetrahydroisochinolin-derivate
WO2004005253A1 (de) * 2002-07-03 2004-01-15 Bayer Healthcare Ag Indolin-phenylsulfonamid-derivate

Also Published As

Publication number Publication date
CA2535960A1 (en) 2005-03-03
EP1675825A2 (de) 2006-07-05
DE10337839A1 (de) 2005-03-17
US20070197626A1 (en) 2007-08-23
WO2005019169A2 (de) 2005-03-03
JP2007502797A (ja) 2007-02-15

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