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WO2004050108A1 - Oil compositions obtained from non-heated plant parts, introduced ground and non-heated in the press, extracted by cold pressing - Google Patents

Oil compositions obtained from non-heated plant parts, introduced ground and non-heated in the press, extracted by cold pressing Download PDF

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Publication number
WO2004050108A1
WO2004050108A1 PCT/FR2003/003338 FR0303338W WO2004050108A1 WO 2004050108 A1 WO2004050108 A1 WO 2004050108A1 FR 0303338 W FR0303338 W FR 0303338W WO 2004050108 A1 WO2004050108 A1 WO 2004050108A1
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WO
WIPO (PCT)
Prior art keywords
plants
oils
unheated
oil
food
Prior art date
Application number
PCT/FR2003/003338
Other languages
French (fr)
Inventor
Claude Boucher
Original Assignee
Societe Celatour
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Celatour filed Critical Societe Celatour
Priority to EP03789462A priority Critical patent/EP1601369A1/en
Priority to AU2003294047A priority patent/AU2003294047A1/en
Publication of WO2004050108A1 publication Critical patent/WO2004050108A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00Production of fats or fatty oils from raw materials
    • C11B1/06Production of fats or fatty oils from raw materials by pressing
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/004Aftersun preparations

Definitions

  • the present invention relates to the use of oils from unheated plants or parts of plants, introduced crushed, unheated in the press, chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted without solvent, filtered, in dietary, food, dietary, cosmetic, pharmaceutical (therapeutic) and veterinary compositions.
  • the chemical composition of such oils includes molecules that are not very resistant to temperatures exceeding 48 °.
  • compositions can be intended for humans and animals.
  • the inventor also discovered that the oils extracted from parts of unheated plants or whole plants, introduced crushed unheated in the press, chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae ; Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted without solvent have a lighter color, organoleptic, physicochemical and dietetic properties, food, cosmetics, pharmaceuticals, veterinarians always superior to the oils obtained by cold extraction methods (room temperature), traditional or solvent.
  • oils extracted from unheated plants or parts of plants, introduced crushed unheated in the press chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringacea Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, are of superior quality to other oils which have been denatured by preheating the plant part or the plant before grinding or before introduction into the press, extraction being carried out by cold press (room temperature).
  • Evidence Improved resistance to rancidity.
  • the induction time is 15 h.
  • the induction time is 12 hours.
  • the molecule must prove that it is active in the cell, a purely chemical test will suggest it but will not demonstrate it.
  • the molecule must be effective vis-à-vis a biological oxidant, that is to say an oxidant present in cells. Certain antioxidants have a specific protective activity against certain oxidants.
  • TEST3D damage detection system
  • the DNA is adsorbed on sensitized wells (diagram, step 1), then incubated with genotoxic agents (step 2).
  • the damage caused is recognized and then repaired by the specific protein complexes present in the purified cellular extracts of human origin. Repairing the lesions involves an excision phase of the lesions and then a resynthesis of the DNA fragment or excised bases. During the restorative synthesis step, modified nucleotides are incorporated into the DNA (step 3).
  • biotinyl nu eotides are then recognized by an avidin molecule coupled to peroxidase (step 4).
  • a chemiluminous substrate for the peroxidase is then added and the signal emitted is measured by a luminometer. (step 5).
  • the intensity of the measured signal is a function of the number of lesions repaired on the DNA.
  • This system is capable of repairing all types of lesions since the different ways of repairing DNA lesions are present and active in the cell extracts prepared and used for this study. Oxidative damage is therefore recognized in this system.
  • the chemiluminous sign is detected using a Lumax2 luminometer. 20 samples were provided to us numbered from CSB 02/01 to CSB 02/20. RESULT For a better visualization of the results, these are expressed as percentage of protection or percentage of inhibition of the formation of oxidative damage on DNA. The value 0% corresponds to the signal for repair of DNA damaged by the oxidant alone. The percentage of protection in the presence of EOR (reactive oxygen species) is calculated as the relative decrease in the damage effect due to radicals
  • Nonspecific inhibition (in the absence of reactive oxygen species) of the repair signal can sometimes be observed. This may be due to a direct interaction of the compound with the DNA (desorption of the DNA from the well, non-specific association with the DNA which will mask the damage to the repair proteins ). A control consisting in incubating the agents tested with DNA previously damaged by UVC is therefore added. A decrease in signal under this condition reflects a non-specific inhibition of the compound, independent of its possible properties. antiradicaiaires.
  • the specific inhibition or specific protection is equal to the difference between the inhibition in the presence of REE (reactive oxygen species) and the non-specific inhibition. It is a reflection of the anti-free radical activity due to the molecule only.
  • RLU Relative Light Unit; arbitrary unit of quantity of light We find in the following two TESTS:
  • sample 1 Oil from unheated plants, introduced crushed unheated in the press, extracted cold or at room temperature has better activity than sample 6: Oil from crushed introduced plants heated in the press , extracted cold or at room temperature.
  • the levels of type 1 collagen secreted in the incubation medium were measured by an ELISA method after 4 days of culture.
  • the regenerating effect of the dermis by the FORAHA hut was evaluated by demonstrating stimulation of collagen synthesis.
  • Results we observe in the batch treated with Foraha oil obtained by this process a stimulation of 43% of the synthesis of collagen compared to the control against 32 and 19% for the oils obtained by the other processes.
  • the parts of plants or plants are picked, collected, sorted, to be immediately dried.
  • Quick cold drying to obtain a humidity level less than 7% can be done by forced ventilation with air whose temperature is below 35 ° and whose humidity is less than or equal to 70%.
  • the drying can also be carried out under vacuum, by microwave at low temperature in order to stop the enzymatic reactions.
  • the subject of the invention is the use of oils from whole plants and / or from parts of dried plants of the families mentioned, not heated, introduced crushed unheated in the press, cold extracted without solvent in dietetic or food compositions. , food, cosmetic, pharmaceutical (therapeutic) and veterinary supplements for human or animal use.
  • the filtration is done by using a centrifuge and / or a cone separator and / or a pocket filter, under vacuum or under nitrogen. This first filtration will be followed by filtration on plate filters, the oil being immediately packaged in barrels under vacuum or under nitrogen.
  • the oil may undergo a wintérrsation, a method which allows the components with a high melting point to be crystallized and separated in order to obtain a shiny oil at low temperature,
  • oils for each plant, retaining their organoleptic properties and their original chemical compounds.
  • the oils thus obtained always have different molecules and more especially molecules sensitive to temperatures above 48 °, to oils obtained according to conventional methods (extraction after preheating of parts of plants or plants before extraction, etc.). These molecules have properties and / or activities of interest for dietetic, food, food supplements, cosmetics, pharmaceutical (therapeutic) and veterinary applications for human or animal use.
  • These oils include a lipid fraction and a so-called fraction
  • the lipid fraction will vary according to the origins and is mainly composed:
  • - neutral lipids among others: monoacylglycerols diacylglycerols, tryacyiglycerols, sterols, ster ⁇ lesters ,. hydrocarbons, - glycotipids among others: monogatactosyldiacyglycerol, sterolglucoside, acvlmonogalàctosyldiaglyerol, monogaladosylmonocyglycerol, - phosphoiipids among others: lysophosphatidylcholine, phosphatylserine, phosphatidic acid, phosphatidylcholine,
  • the so-called "unsaponifiable" fraction can include different families of compounds, including: fatty alcohols, acids, hydrocarbons, sterols (campesterol, stigmasterol, ⁇ sitosterol, etc.), methylsterois, triterpene compounds, pro-vitamins A, tocopherols, tocotrienols, xanthophylls, coumarins and or coumarin derivatives, etc.,
  • compositions according to the invention can comprise, in addition to oils as defined above, adjuvants chosen in particular from fatty substances, organic solvents, thickeners and / or gelling agents, hydrophilic or lipophilic active agents, softeners, agents moisturizers, antioxidants, emollients, hydroxy acids, opacifiers, polymers, propellants, stabilizers, vitamins, reducers, silicones, perfumes, preservatives, fillers, sequestrants, alkalizing or acidifying agents, UV or other protective agents, dyes or other plant extracts, or any other ingredient usually used in dietetic, food formulations, food supplements, cosmetics (shampoo * lotion, etc.), pharmaceutical (therapeutic) and veterinary human or animal destination.
  • the fatty substances can consist of oils, waxes or their mixtures, fatty acids, fatty alcohols, fatty acid esters, mono, di and triglycerides of fatty acids.
  • the dietary, food, food, cosmetic, pharmaceutical (therapeutic) and veterinary compositions for human or animal use according to the invention may contain, in addition to these oils defined above, all hydrophilic or lipophilic substances, pigments or nano pigments.
  • compositions can be presented in particular in the form of a simple or complex emulsion, such as a cream, a milk, a gel or a gel-cream, powder, stick or other solid forms and optionally be packaged in aerosol and present in the form of foam or spray. It can be prepared in the form of oil-in-water or water-in-oil emulsions. Some of these oils according to the invention can also be incorporated into food emulsions having the consistency of a spread, with fat-soluble, water-soluble vitamins and trace elements and all other authorized substances, for all purposes.
  • the cosmetic, dermatological compositions for human or animal use according to the invention generally contain 0.05 to 100% by weight of oil of these oils.
  • composition according to the invention can also be a dietary food composition, a food, a food supplement containing from 0.05 to 100% by weight of such oils. It is then presented in the form of capsules, capsules, powder, tablets, gel, pasty compounds etc., and may also contain fat-soluble vitamins such as vitamins A, D and E, K and other oils.
  • the inventor further discovered during his research that the oils of certain plants of the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapagaceae, Sapotaceae Simmondsiaceae, extracted according to the invention, had a pham ⁇ acoiogique activity superior to oils of these same families extracted according to other processes. IN VIVO tests have shown the interest of these oils in the treatment of dryness, mucous membranes (eye, etc.) and in the improvement of healing processes.
  • the invention therefore also relates to a pharmaceutical (therapeutic) and veterinary composition for human or animal use containing an effective amount of such oils according to the invention, in a non-toxic carrier or excipient.
  • Such a composition can be in the form of a capsule, capsule, tablet, injectable liquid, eye drops, ointment, cream, gel, patch, suppository, ovum containing from 0.05% to 100% by weight of these oils.
  • It can be administered by oral, local, injectable route, and in general by any natural orifice of the human or animal body, conditioned in normal forms or in progressive release.
  • the duration of the treatment is variable according to the severity of the symptoms and can range between 1 and 20 weeks, continuously or discontinuously and can be renewed. Treatment is determined by the doctor.
  • oils extracted with traditional methods and / or by solvent very often present risks of irritability of the, dermis of mucous membranes.
  • the inventor also discovered that with the oils obtained by this process, these risks are greatly reduced.
  • Curcurbitaceae (Squash %), Linaceae (flax %), Onagraceae (evening primrose ..) Saxifragaceae (Cassis ..), Simmondsiaceae (Jojoba %), Myristicaceae (Brochoneura ..), Boraginaceae (Alkanna %), Onagraceae (Evening primrose ..), Sapotaceae (Argan %) and Composeae (Cynara ”). have a neutral flavor and a very light color unlike oils obtained by traditional methods (strong odor , sometimes caramel). They will not have to undergo deodorization treatment, discoloration which distorts the oils.
  • the oil of the plants of the families mentioned above and more especially of the families Clusiaceae (Foraha), Euphorbiaceae (Aleurites), Sapotacee (Arganier) have hydrating, restructuring and healing properties of the dermis and mucous membranes superior to the oils obtained by the other processes.
  • the oil from plants in the Arecaceae family (palm) contains more pro-vitamin A and derivatives and is of additional interest for dietetic, food, food supplements, cosmetic, pharmaceutical (therapeutic) uses. and veterinarians for human or animal use.
  • Oil of Foraha Foraha seed oil (Clusiaceae) 15 Oil of Jojoba Simmondsia chinensis seed oil (family 5 simmondiaceae)

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Abstract

The invention concerns the use of oils obtained from non-heated parts of plants or whole plants, introduced ground and non-heated in the press, selected among the Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae families, cold-extracted solvent-free and filtered, exhibiting resistance to rancidification, enhanced organoleptic and physico-chemical properties, as anti-oxidant, hydrating, restructuring, cicatrizing agent, in particular for the skin and mucous membranes in dietetic, cosmetic, dermatological, pharmaceutical and veterinary compositions, for humans or animals. The invention also concerns dietetic, food, food complement, cosmetic (including perfume), dermatological, pharmaceutical (therapeutic) and veterinary compositions for humans or animals containing such oils extracted from plants of the above botanical families.

Description

COMPOSITIONS D ' HUILES OBTENUES A PARTIR DE PARTIES DE PLANTES NON CHAUFEES , INTRODUITES NON CHAUFFEES BROYEES DANS LA PRESSE , EXTRAITES PAR PRESSE A FROIDCOMPOSITIONS OF OILS OBTAINED FROM PARTS OF UNHEATED PLANTS, INTRODUCED UNHEATED, GRINDED IN THE PRESS, EXTRACTED BY COLD PRESS
La présente invention a pour objet l'utilisation des huiles provenant des plantes ou parties de plantes non chauffées, introduites broyées, non chauffées dans la presse, choisies parmi les familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites à froid sans solvant, filtrées, dans les compositions diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires. La composition chimique de telles huiles comprend des molécules peu résistantes à des températures dépassant 48°. Ces compositions peuvent être destinées à l'homme comme à l'animal. L'inventeur a également découvert que les huiles extraites de parties de plantes ou de plantes entières non chauffées, introduites broyées non chauffées dans la presse, choisies parmi les familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae; Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites à froid sans solvant ont une couleur plus claire, des propriétés organoleptiques, physicochimiques et des propriétés diététiques, alimentaires,, cosmétiques, pharmaceutiques, vétérinaires toujours supérieures aux huiles obtenues par les méthodes d'extraction à froid (température ambiante), traditionnelles ou par solvant. De manière générale, les huilés extraites des plantes ou parties de plantes non chauffées, introduites broyées non chauffées dans lé presse, choisies parmi les familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, sont de qualité supérieure aux autres huiles qui ont été dénaturées par le préchauffage de la partie de plante ou de la plante avant broyage ou avant l'introduction dans la presse, l'extraction étant effectuée par presse à froid (température ambiante). Preuve: Amélioration de la résistance au rancissement . Le test RANCIMAT effectué avec l'appareil MESTROHM RANCIMAT à T de100°C avec un débit d'air de 15 l./h. nous a permis de déterminer le temps d'induction . Dans fa famille des Sapotacées, pour l'huile de PArgania spinosa obtenue à partir de plantes introduites non chauffées, extraite par presse à température ambiante (à froid) le temps d'induction est de 15 h. alors que pour l'huile obtenue à partir des mêmes plantes introduites chauffées, extraites par presse à température ambiante (à froid) le temps d'induction est de 12 heures. Nous pouvons en déduire une meilleure résistance au rancissement de l'huile extraite par presse à froid à partir de plantes non chauffées, introduites non chauffée. Cette spécificité, évidemment, aura une influence sur la durée de conservation des produits finis dans les domaines diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale.The present invention relates to the use of oils from unheated plants or parts of plants, introduced crushed, unheated in the press, chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted without solvent, filtered, in dietary, food, dietary, cosmetic, pharmaceutical (therapeutic) and veterinary compositions. The chemical composition of such oils includes molecules that are not very resistant to temperatures exceeding 48 °. These compositions can be intended for humans and animals. The inventor also discovered that the oils extracted from parts of unheated plants or whole plants, introduced crushed unheated in the press, chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae ; Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted without solvent have a lighter color, organoleptic, physicochemical and dietetic properties, food, cosmetics, pharmaceuticals, veterinarians always superior to the oils obtained by cold extraction methods (room temperature), traditional or solvent. In general, the oils extracted from unheated plants or parts of plants, introduced crushed unheated in the press, chosen from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringacea Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, are of superior quality to other oils which have been denatured by preheating the plant part or the plant before grinding or before introduction into the press, extraction being carried out by cold press (room temperature). Evidence: Improved resistance to rancidity. The RANCIMAT test carried out with the MESTROHM RANCIMAT device at T of 100 ° C with an air flow of 15 l./h. allowed us to determine the induction time. In the Sapotaceae family, for the oil of Argania spinosa obtained from unheated introduced plants, extracted by press at room temperature (cold) the induction time is 15 h. whereas for the oil obtained from the same plants introduced heated, extracted by press at room temperature (cold) the induction time is 12 hours. We can deduce a better resistance to rancidity of the oil extracted by cold press from unheated plants, introduced unheated. This specificity, obviously, will have an influence on the shelf life of finished products in the dietetic, food, food supplements, cosmetics, pharmaceutical (therapeutic) and veterinary fields for human or animal use.
Les huiles ayant des propriétés de protection contre les agents génotoxiques de nature exogène (radiations ionisantes, substances chimiques ...) et/ou de nature endogène (protection contre le radical hydroxyl et l'oxygène singulet), voient leurs propriétés antioxydantes améliorées. C'est le cas de l'huile de Foraha de la famille des Clusiaceae et de l'huile de Cynara de la famille des Composeae.Oils with protective properties against genotoxic agents of an exogenous nature (ionizing radiation, chemical substances, etc.) and / or of an endogenous nature (protection against the hydroxyl radical and singlet oxygen) have their antioxidant properties improved. This is the case for Foraha oil from the Clusiaceae family and Cynara oil from the Composeae family.
Pour caractériser une molécule ou un mélange présentant des propriétés antioxydantes ou antiradicaiaires, et donc protéger une cellule humaine des dommages oxydatifs dus aux espèces oxygénées réactives (EOR) trois critères établis par Barry Halliwell doivent être pris en compte :To characterize a molecule or mixture with antioxidant or anti-radical properties, and therefore protect a human cell from oxidative damage due to reactive oxygen species (EOR) three criteria established by Barry Halliwell must be taken into account:
- La molécule doit faire la preuve qu'elle est active dans la cellule, un test purement chimique le laissera supposer mais ne le démontrera pas. - La molécule doit être efficace vis-à-vis d'un oxydant biologique, c'est-à-dire un oxydant présent dans les cellules. Certains antioxydants ont une activité protectrice spécifique contre certains oxydants.- The molecule must prove that it is active in the cell, a purely chemical test will suggest it but will not demonstrate it. - The molecule must be effective vis-à-vis a biological oxidant, that is to say an oxidant present in cells. Certain antioxidants have a specific protective activity against certain oxidants.
- Les concentrations d'oxydants utilisées doivent être compatibles avec celles utilisées in vivo. Ces remarques de Barry Halliwell, spécialiste des oxydants, sont extraites de l'article paru en 1995 dans la revue Biochemical Pharmacology (volume 49, 1341- 1348) intitulé " Antioxidant characterization - Methodology and Mechanism ". Le TEST 3D répond bien à ces différents critères : utilisation d'oxydant biologique non cytotoxique, et action des antioxydants à l'intérieur de la cellule. Le TEST 30 permet la mise en évidence de l'effet protecteur de l'ADN par une molécule, vis-à-vis des radicaux hydroxyles générés par l'eau oxygénée, et, vis-à-vis de l'oxygène singulet généré par éclairement du bleu de méthylène. De plus, le TEST3D sur cellules répond parfaitement aux critères de Barry Halliwell. PRINCIPE DU TEST 3D- The concentrations of oxidants used must be compatible with those used in vivo. These remarks by Barry Halliwell, specialist in oxidants, are extracted from the article published in 1995 in the journal Biochemical Pharmacology (volume 49, 1341-1348) entitled "Antioxidant characterization - Methodology and Mechanism". The 3D TEST responds well to these different criteria: use of non-cytotoxic biological oxidant, and action of antioxidants inside the cell. The TEST 30 makes it possible to demonstrate the protective effect of DNA by a molecule, with respect to the hydroxyl radicals generated by hydrogen peroxide, and, with respect to the singlet oxygen generated by illumination of methylene blue. In addition, the TEST3D on cells perfectly meets the criteria of Barry Halliwell. PRINCIPLE OF THE 3D TEST
Par le développement d'un système de détection de dommages (TEST3D) sur de l'ADN capté sur microplaque (AnalytScal Biochemistry, 1995, 232, 37-42). L'ADN (devant servir de cible à des agents génotoxiques) est adsorbé sur des puits sensibilisés (schéma, étape 1), puis incubé avec des agents génotoxiques (étape 2). Les dommages engendrés sont reconnus puis réparés par les complexes protéiques spécifiques présents dans les extraits cellulaires purifiés d'origine humaine. La réparation des lésions implique une phase d'excision des lésions puis une résynthèse du fragment d'ADN ou des bases excisées. Au cours de l'étape de synthèse réparatrice, des nucléotides modifiés sont incorporés dans l'ADN (étape 3). Ces nu éotides biotinyles sont ensuite reconnus par une molécule d'avidine couplée à la peroxydase (étape 4). Un substrat chimiluminêscent de la peroxydase est ensuite ajouté et le signal émis est mesuré par un luminomètre. (étape 5). L'intensité du signal mesuré est fonction du nombre de lésions réparées sur l'ADN.By developing a damage detection system (TEST3D) on DNA captured on a microplate (AnalytScal Biochemistry, 1995, 232, 37-42). The DNA (intended to serve as a target for genotoxic agents) is adsorbed on sensitized wells (diagram, step 1), then incubated with genotoxic agents (step 2). The damage caused is recognized and then repaired by the specific protein complexes present in the purified cellular extracts of human origin. Repairing the lesions involves an excision phase of the lesions and then a resynthesis of the DNA fragment or excised bases. During the restorative synthesis step, modified nucleotides are incorporated into the DNA (step 3). These biotinyl nu eotides are then recognized by an avidin molecule coupled to peroxidase (step 4). A chemiluminous substrate for the peroxidase is then added and the signal emitted is measured by a luminometer. (step 5). The intensity of the measured signal is a function of the number of lesions repaired on the DNA.
Ce système est susceptible de réparer tous les types de lésions puisque les différentes voies de la réparation des lésions de l'ADN sont présentes et actives dans les extraits cellulaires préparés et utilisés pour cette étude. Les dommages oxydatifs sont donc reconnus dans ce système.This system is capable of repairing all types of lesions since the different ways of repairing DNA lesions are present and active in the cell extracts prepared and used for this study. Oxidative damage is therefore recognized in this system.
Ce test a permis de mettre en évidence les capacités des 20 échantillons à protéger l'ADN en utilisant des systèmes générateurs d'espèces oxygénées déjà décrits (St Cricq et al, Agri. Food Chem., 1999, 47, 425-431).This test made it possible to demonstrate the capacities of the 20 samples to protect DNA by using oxygen-generating systems already described (St Cricq et al, Agri. Food Chem., 1999, 47, 425-431).
Deux espèces oxygénées réactives ont été utilisées : l'oxygène singulet O2 et le radical hydroxyle OH°. MATERIEL ET METHODESTwo reactive oxygen species were used: singlet oxygen O2 and the hydroxyl radical OH °. MATERIAL AND METHODS
Les réactifs utilisés ont été décrits dans l'article Analytical Biochemistry, 1995.232, 37- 42,The reagents used have been described in the article Analytical Biochemistry, 1995.232, 37-42,
Le signât chimiluminêscent est détecté à l'aide d'un luminomètre Lumax2. 20 échantillons nous ont été fournis numérotés de CSB 02/01 à CSB 02/20. RESULTAT Pour une meilleure visualisation des résultats, ceux-ci sont exprimés en pourcentage de protection ou pourcentage d'inhibition de la formation de dommages oxydatifs sur l'ADN. La valeur 0% correspond au signal de la réparation de l'ADN lésé par l'oxydant seul. Le pourcentage de protection en présence de EOR (espèces oxygénées réactives) est calculé comme la baisse relative de l'effet lésionnel dû aux radicauxThe chemiluminous sign is detected using a Lumax2 luminometer. 20 samples were provided to us numbered from CSB 02/01 to CSB 02/20. RESULT For a better visualization of the results, these are expressed as percentage of protection or percentage of inhibition of the formation of oxidative damage on DNA. The value 0% corresponds to the signal for repair of DNA damaged by the oxidant alone. The percentage of protection in the presence of EOR (reactive oxygen species) is calculated as the relative decrease in the damage effect due to radicals
OH° ou 1θ2, soit :OH ° or 1 θ2, either:
[RLU oxydant seul] - [RLU (oxydant + échantillon)][RLU oxidant only] - [RLU (oxidant + sample)]
~~ — : X 100 [RLU oxydant seul]~~ - : X 100 [RLU oxidant only]
Une inhibition non spécifique (en absence d'espèces oxygénées réactives) du signal de réparation peut être parfois observée. Ceci peut être dû à une interaction directe du composé avec l'ADN (désorption de l'ADN du puits, association non spécifique avec l'ADN qui va masquer les lésions aux protéines de réparation...). Un contrôle consistant à incuber les agents testés avec de l'ADN préalablement lésé aux UVC est donc ajouté. Une diminution du signal dans cette condition reflète une inhibition non spécifique du composé, indépendante de ses possibles propriétés. antiradicaiaires.Nonspecific inhibition (in the absence of reactive oxygen species) of the repair signal can sometimes be observed. This may be due to a direct interaction of the compound with the DNA (desorption of the DNA from the well, non-specific association with the DNA which will mask the damage to the repair proteins ...). A control consisting in incubating the agents tested with DNA previously damaged by UVC is therefore added. A decrease in signal under this condition reflects a non-specific inhibition of the compound, independent of its possible properties. antiradicaiaires.
Une inhibition de la réparation en présence de EOR peut être la conséquence - d'une réelle protection - d'une diminution de l'efficacité de la réparation d'unInhibition of repair in the presence of EOR can be the consequence - of real protection - of a reduction in the effectiveness of the repair of a
ADN endommagé dû à une interaction directe de la molécule à tester avec l'ADN ou la microplaque traitéeDamaged DNA due to direct interaction of the test molecule with the treated DNA or microplate
- de la survenue simultanée de ces 2 phénomènes. L'inhibition spécifique ou protection spécifique est égale à là différence entre l'inhibition en présence de ÉOR (espèces oxygénées réactives) et l'inhibition non spécifique. Elle est le reflet .de l'activité antiradicalaire due à la molécule seulement. RLU : Relative Light Unit ; unité arbitraire de quantité de lumière Nous constatons dans les deux TESTS suivants:- the simultaneous occurrence of these 2 phenomena. The specific inhibition or specific protection is equal to the difference between the inhibition in the presence of REE (reactive oxygen species) and the non-specific inhibition. It is a reflection of the anti-free radical activity due to the molecule only. RLU: Relative Light Unit; arbitrary unit of quantity of light We find in the following two TESTS:
Figure imgf000006_0001
Figure imgf000007_0001
Figure imgf000006_0001
Figure imgf000007_0001
Interprétation des résultats: l'échantillon 1 : Huile provenant de plantes non chauffées, introduites broyées non chauffées dans la presse, extraite à froid ou température ambiante a une meilleure activité que l'échantillon 6: Huile provenant de plantes introduites broyées chauffées dans la presse, extraite à froid ou température ambiante.Interpretation of the results: sample 1: Oil from unheated plants, introduced crushed unheated in the press, extracted cold or at room temperature has better activity than sample 6: Oil from crushed introduced plants heated in the press , extracted cold or at room temperature.
Effet sur le vieillissement cutané et plus particulièrement sur la stimulation de la synthèse du collagène du type 1.Effect on skin aging and more particularly on the stimulation of type 1 collagen synthesis.
Ces effets ont été publiés et démontrés mais nous apportons une nouveauté par le fait que les huiles obtenues par ce prbcess ont des activités nouvelles.These effects have been published and demonstrated, but we bring something new by the fact that the oils obtained by this prbcess have new activities.
L'étude a été réalisée à deux concentrations différentes sur des fibroplàstes humains. Les taux de collagène de type 1 sécrété dans le milieu d'incubation ont été mesurés par une méthode ELISA après 4 jours de culture.The study was carried out at two different concentrations on human fibroblasts. The levels of type 1 collagen secreted in the incubation medium were measured by an ELISA method after 4 days of culture.
L'effet régénérant du derme par l'hutte de FORAHA a été évalué par la mise en évidence d'une stimulation de la synthèse du collagène.The regenerating effect of the dermis by the FORAHA hut was evaluated by demonstrating stimulation of collagen synthesis.
Nous le constatons dans les résultats reportés sur le graphique A annexé.We see this in the results reported in the attached graph A.
FORAHA 1 Huile obtenue par extraction à chaudFORAHA 1 Oil obtained by hot extraction
FORAHÂ 2 Huile obtenue à partir de partie de plantes chauffées et/ou introduites à chaud, extraite à froid (T°ambiante) FORAHA 3 Huile obtenue à partir de partie de plantes non chauffées, introduites non chauffées, extraite à froid (T°ambiante)FORAHÂ 2 Oil obtained from part of heated plants and / or introduced hot, extracted cold (room temperature) FORAHA 3 Oil obtained from part of unheated plants, introduced unheated, extracted cold (room temperature) )
Résultats : on constate dans le lot traité par l'huile de Foraha obtenue par ce process une stimulation de 43% de la synthèse du collagène par rapport au témoin contre 32 et 19 % pour les huiles obtenues par les autres process. Les parties de plantes ou plantes sont cueillies, ramassées, triées, pour être immédiatement séchées. Le séchage rapide à froid afin d'obtenir un taux d'humidité inférieur à 7% peut se faire par ventilation forcée avec de l'air dont la température est inférieure à 35° et dont le taux d'humidité est inférieur ou égal à 70%. Le séchage peut aussi s'effectuer sous vide, par micro-ondes à basse température afin de stopper les réactions enzymatiques. L'invention a pour objet l'utilisation d'huiles issues des plantes entières et/ou de parties de plantes séchées des familles citées, non chauffées, introduites broyées non chauffées dans la presse, extraites à froid sans solvant dans les compositions diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale.Results: we observe in the batch treated with Foraha oil obtained by this process a stimulation of 43% of the synthesis of collagen compared to the control against 32 and 19% for the oils obtained by the other processes. The parts of plants or plants are picked, collected, sorted, to be immediately dried. Quick cold drying to obtain a humidity level less than 7% can be done by forced ventilation with air whose temperature is below 35 ° and whose humidity is less than or equal to 70%. The drying can also be carried out under vacuum, by microwave at low temperature in order to stop the enzymatic reactions. The subject of the invention is the use of oils from whole plants and / or from parts of dried plants of the families mentioned, not heated, introduced crushed unheated in the press, cold extracted without solvent in dietetic or food compositions. , food, cosmetic, pharmaceutical (therapeutic) and veterinary supplements for human or animal use.
Ce process permet de préserver les propriétés naturelles optimales de l'huile, d'éviter la présence de résidus toxiques, d'acides gras trans.... L'usage de la presse à vis ou à cône sera privilégié. La filtration se fait par utilisation d'une centrifugeuse et/ou d'un séparateur à cônes et/ou d'un filtre poche, sous vide ou sous azote. Cette première filtration sera suivie d'une filtration sur filtres plaques, l'huile étant immédiatement conditionnée en fûts sous vide ou sous azote.This process makes it possible to preserve the optimal natural properties of the oil, to avoid the presence of toxic residues, trans fatty acids, etc. The use of the screw or cone press will be preferred. The filtration is done by using a centrifuge and / or a cone separator and / or a pocket filter, under vacuum or under nitrogen. This first filtration will be followed by filtration on plate filters, the oil being immediately packaged in barrels under vacuum or under nitrogen.
L'huile pourra subir une wintérrsation, méthode qui permet de cristalliser les composants à point d fusion élevé et de les séparer afin d'obtenir une huile brillante à basse Température,The oil may undergo a wintérrsation, a method which allows the components with a high melting point to be crystallized and separated in order to obtain a shiny oil at low temperature,
On obtient par ce process des huiles très spédfiques à chaque plante gardant leurs propriétés organoleptiques et leurs composés chimiques d'origine. Les huiles ainsi obtenues possèdent toujours des molécules différentes et plus spécialement des molécules sensibles aux températures supérieures à 48°, aux huiles obtenues selon les procédés classiques (extraction après préchauffage de parties de plantes ou plantes avant l'extraction ....). Ces molécules ont des propriétés et/ou des activités intéressantes pour lès applications diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale. Ces huiles comprennent une fraction lipidique et une fraction diteThis process produces very specific oils for each plant, retaining their organoleptic properties and their original chemical compounds. The oils thus obtained always have different molecules and more especially molecules sensitive to temperatures above 48 °, to oils obtained according to conventional methods (extraction after preheating of parts of plants or plants before extraction, etc.). These molecules have properties and / or activities of interest for dietetic, food, food supplements, cosmetics, pharmaceutical (therapeutic) and veterinary applications for human or animal use. These oils include a lipid fraction and a so-called fraction
"insaponifiable". La fraction lipidique variera selon les origines et est principalement constituée :"Unsaponifiable". The lipid fraction will vary according to the origins and is mainly composed:
- de lipides neutres entr'autres: monoacylglycérols diacylglycérols, tryacyiglycérols, stérols, stérόlesters,. hydrocarbones, - de glycotipîdes entr'autres: monogatactosyldiacyglycérol, stérolglucoside, acvlmonogalàctosyldiaglyeérol, monogaladosylmonocyglycérol, - de phosphoiipides entr'autres : lysophosphatidylcholine, phosphatylsérine, acide phosphatidique, phosphatidylcholine,- neutral lipids among others: monoacylglycerols diacylglycerols, tryacyiglycerols, sterols, sterόlesters ,. hydrocarbons, - glycotipids among others: monogatactosyldiacyglycerol, sterolglucoside, acvlmonogalàctosyldiaglyerol, monogaladosylmonocyglycerol, - phosphoiipids among others: lysophosphatidylcholine, phosphatylserine, phosphatidic acid, phosphatidylcholine,
- et d'esters.- and esters.
La fraction dite "insaponifiable" peut comprendre différentes familles de composés, parmi lesquelles: des alcools gras, des acides, des hydrocarbures, des stérols (campestérol, stigmastérol,β sitostérol ...), des méthylstérois, des composés triterpéniques, des pro vitamine A, tocophérols, tocotriénols, des xanthophylles, des coumarines et ou des dérivés coumariniques, etc....,The so-called "unsaponifiable" fraction can include different families of compounds, including: fatty alcohols, acids, hydrocarbons, sterols (campesterol, stigmasterol, β sitosterol, etc.), methylsterois, triterpene compounds, pro-vitamins A, tocopherols, tocotrienols, xanthophylls, coumarins and or coumarin derivatives, etc.,
Les compositions selon l'invention peuvent comprendre outre des huiles telles que définies ci-dessus, des adjuvants choisis notamment parmi les corps gras, les solvants organiques, les épaississants et/ou les gélifiants, les actifs hydrophiles ou lipophiles, les adoucissants, les agents hydratants, les antioxydants, les émollients, les hydroxyacides, les opacifiants, les polymères, les propulseurs, les stabilisants, les vitamines, les réducteurs, les silicones, les parfums, les conservateurs, les charges, les séquestrants, les agents alcalinisants ou acidifiants, les agents protecteurs UV ou autres, les colorants ou d'autres extraits de plantes, ou tout autre ingrédient habituellement utilisé en formulations diététiques, alimentaires, compléments alimentaires, cosmétiques (shampooing* lotion....), pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale. Les corps gras peuvent être constitués par des huiles, des cires ou leurs mélanges, les acides gras, les alcools gras, lés esters d'acides gras, les mono, di et triglycérides d'acides grasThe compositions according to the invention can comprise, in addition to oils as defined above, adjuvants chosen in particular from fatty substances, organic solvents, thickeners and / or gelling agents, hydrophilic or lipophilic active agents, softeners, agents moisturizers, antioxidants, emollients, hydroxy acids, opacifiers, polymers, propellants, stabilizers, vitamins, reducers, silicones, perfumes, preservatives, fillers, sequestrants, alkalizing or acidifying agents, UV or other protective agents, dyes or other plant extracts, or any other ingredient usually used in dietetic, food formulations, food supplements, cosmetics (shampoo * lotion, etc.), pharmaceutical (therapeutic) and veterinary human or animal destination. The fatty substances can consist of oils, waxes or their mixtures, fatty acids, fatty alcohols, fatty acid esters, mono, di and triglycerides of fatty acids.
Bien entendu, l'homme du métier veillera à choisir le ou les éventuels composés complémentaires et/ou leur quantité de manière telle que les propriétés avantageuses attachées intrinsèquement à la composition selon l'invention, ne soient pas, ou substantiellement pas, altérées par la ou les adjonctions envisagées.Of course, those skilled in the art will take care to choose the optional additional compound (s) and / or their quantity in such a way that the advantageous properties intrinsically attached to the composition according to the invention are not, or not substantially, affected by the or the additions envisaged.
Les compositions diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale selon l'invention, peuvent contenir, outre ces huiles ci-dessus définies, toutes substances hydrophiles ou lipophiles, des pigments ou nano pigments.The dietary, food, food, cosmetic, pharmaceutical (therapeutic) and veterinary compositions for human or animal use according to the invention, may contain, in addition to these oils defined above, all hydrophilic or lipophilic substances, pigments or nano pigments.
Ces compositions peuvent se présenter en particulier sous forme d'émufsion simple ou complexe, telle qu'une crème, un lait, un gel ou un gel-crème, de poudre, de bâtonnet ou autres formes solides et éventuellement être conditionnée en aérosol et se présenter sous forme de mousse ou de spray. Elle peut être préparée sous forme d'émulsions huile-dans-eau ou eau-dans-huile. Gertaines de ces huiles selon l'invention peuvent être également incorporées dans des émulsions alimentaires ayant la consistance de pâte à tartiner, avec des vitamines liposolubles, hydrosolubles et des oligo-éléments et toutes autres substances autorisées, pour tous objectifs. Les compositions cosmétiques, dermatologiques à destination humaine ou animale selon l'invention contiennent généralement Q,05 à 100% en poids d'huile de ces huiles.These compositions can be presented in particular in the form of a simple or complex emulsion, such as a cream, a milk, a gel or a gel-cream, powder, stick or other solid forms and optionally be packaged in aerosol and present in the form of foam or spray. It can be prepared in the form of oil-in-water or water-in-oil emulsions. Some of these oils according to the invention can also be incorporated into food emulsions having the consistency of a spread, with fat-soluble, water-soluble vitamins and trace elements and all other authorized substances, for all purposes. The cosmetic, dermatological compositions for human or animal use according to the invention generally contain 0.05 to 100% by weight of oil of these oils.
La composition selon l'invention peut également être une composition diététique alimentaire, un alicament, un complément alimentaire contenant de 0,05 à 100% en poids de telles huiles. Elle se présente alors sous forme de capsules, gélules, poudre, comprimés, gel, composés pâteux etc., et peut contenir en outre des vitamines liposolubles telles que les vitamines A, D et E, K et d'aμtres huiles.The composition according to the invention can also be a dietary food composition, a food, a food supplement containing from 0.05 to 100% by weight of such oils. It is then presented in the form of capsules, capsules, powder, tablets, gel, pasty compounds etc., and may also contain fat-soluble vitamins such as vitamins A, D and E, K and other oils.
L'inventeur a découvert en outre au cours de ses recherches que les huiles de certaines plantes des familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites selon l'invention, présentaient une activité phamαacoiogique supérieure aux huiles de ces mêmes familles extraites selon d' autres procédés. Des tests IN VIVO ont montré l'intérêt de ces huiles dans le traitement de la sécheresse, des muqueuses ( œil .. ) et dans l'amélioration des processus de cicatrisation.The inventor further discovered during his research that the oils of certain plants of the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapagaceae, Sapotaceae Simmondsiaceae, extracted according to the invention, had a phamαacoiogique activity superior to oils of these same families extracted according to other processes. IN VIVO tests have shown the interest of these oils in the treatment of dryness, mucous membranes (eye, etc.) and in the improvement of healing processes.
L'invention a donc également pour objet une composition pharmaceutique (thérapeutique) et vétérinaire à destination humaine ou animale contenant une quantité efficace de telles huiles selon l'invention, dans un support ou excipient non toxique.The invention therefore also relates to a pharmaceutical (therapeutic) and veterinary composition for human or animal use containing an effective amount of such oils according to the invention, in a non-toxic carrier or excipient.
Une telle composition peut se présenter sous forme de gélule, capsule, comprimé, liquide injectable, collyre, pommade, crème, gel, patch, suppositoire, ovule contenant de 0,05% à 100% en poids de ces huiles.Such a composition can be in the form of a capsule, capsule, tablet, injectable liquid, eye drops, ointment, cream, gel, patch, suppository, ovum containing from 0.05% to 100% by weight of these oils.
Elle peut être administrée par voie orale, locale, injectable, et en général par tout orifice naturel du corps humain ou animal, conditionnée sous des formes normales ou en libération progressive .It can be administered by oral, local, injectable route, and in general by any natural orifice of the human or animal body, conditioned in normal forms or in progressive release.
Dans l'application thérapeutique, la durée du traitement est variable suivant la gravité des symptômes et peut s'étaler entre 1 et 20 semaines, de façon continue ou discontinue et peut être renouvelée. Le traitement est déterminé par le médecin. En pratique il s'avère que les huiles extraites avec les méthodes traditionnelles et/ou par solvant présentent très souvent des risques d'irritabilité du, derme du des muqueuses. L'inventeur a découvert aussi qu'avec les huiles obtenues par ce process, ces risques sont largement diminués.In the therapeutic application, the duration of the treatment is variable according to the severity of the symptoms and can range between 1 and 20 weeks, continuously or discontinuously and can be renewed. Treatment is determined by the doctor. In practice, it turns out that oils extracted with traditional methods and / or by solvent very often present risks of irritability of the, dermis of mucous membranes. The inventor also discovered that with the oils obtained by this process, these risks are greatly reduced.
L'invention sera mieux illustrée par les exemples ci-après.The invention will be better illustrated by the examples below.
1. Les huiles des parties de plantes des familles Anacardiaceae (Anacarde ...), Moringaceae (Moringa ..), Canabaceae (Chanvre ...), Cruciferaceae (Cameϋπe1. The oils from the parts of plants of the families Anacardiaceae (Cashew ...), Moringaceae (Moringa ..), Canabaceae (Hemp ...), Cruciferaceae (Cameϋπe
...), Curcurbitaceae (Courge ...), Linaceae (lin ...), Onagraceae (onagre ..) Saxifragaceae (Cassis ..), Simmondsiaceae (Jojoba ...), Myristicaceae (Brochoneura ..), Boraginaceae (Alkanna ...), Onagraceae (Onagre ..), Sapotaceae (Argan ...) et des Composeae (Cynara ...) ont une saveur neutre et une couleur très claire contrairement aux huiles obtenues par les méthodes traditionnelles (odeur forte, parfois de caramel). Elles n'auront pas à subir de traitement de désodorisation, décoloration qui dénature les huiles....), Curcurbitaceae (Squash ...), Linaceae (flax ...), Onagraceae (evening primrose ..) Saxifragaceae (Cassis ..), Simmondsiaceae (Jojoba ...), Myristicaceae (Brochoneura ..), Boraginaceae (Alkanna ...), Onagraceae (Evening primrose ..), Sapotaceae (Argan ...) and Composeae (Cynara ...) have a neutral flavor and a very light color unlike oils obtained by traditional methods (strong odor , sometimes caramel). They will not have to undergo deodorization treatment, discoloration which distorts the oils.
2. L'huile d'une plante de la famille des Euphorbiaceae (Aleurites): dont la composition en acides gras polyinsaturés alpha linolénique est importante, supérieure à 25% présente des caractères organoleptiques supérieurs.2. The oil of a plant of the family Euphorbiaceae (Aleurites): whose composition in polyunsaturated fatty acids alpha linolenic is important, higher than 25% presents superior organoleptic characters.
3. L'huile des plantes des familles ci-dessus citées et plus spécialement des familles Clusiaceae (Foraha), Euphorbiaceae (Aleurites), Sapotacee ( Arganier) possèdent des propriétés hydratantes, restructurantes et cicatrisantes du derme et des muqueuses supérieures aux huiles obtenues par les autres process.. 4. L'huile des plantes de la famille des Arecaceae (Palme), contient davantage de pro vitamine A et dérivés et offre un intérêt supplémentaire pour les usages diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) et vétérinaires à destination humaine ou animale.3. The oil of the plants of the families mentioned above and more especially of the families Clusiaceae (Foraha), Euphorbiaceae (Aleurites), Sapotacee (Arganier) have hydrating, restructuring and healing properties of the dermis and mucous membranes superior to the oils obtained by the other processes. 4. The oil from plants in the Arecaceae family (palm) contains more pro-vitamin A and derivatives and is of additional interest for dietetic, food, food supplements, cosmetic, pharmaceutical (therapeutic) uses. and veterinarians for human or animal use.
EXEMPLE DE FORMULATIONSEXAMPLE OF FORMULATIONS
COMPOSITION DIETETIQUE EXEMPLE 1DIETETIC COMPOSITION EXAMPLE 1
Gélules d'huile végétale 610 mg (+/-1%) comprenantVegetable oil capsules 610 mg (+/- 1%) including
• Huile de Ribes nîgrum et d'Aleurites moluccana 463mg• Ribes nîgrum and Aleurites moluccana oil 463mg
• Cire d'abeille 45 mg• Beeswax 45 mg
• Vitamine E 3 mg • Excipients 99 g (gélule végétale cellulose ) COMPOSITIONS COSMETIQUES• Vitamin E 3 mg • Excipients 99 g (vegetable cellulose capsule) COSMETIC COMPOSITIONS
EXEMPLE 2EXAMPLE 2
LAIT APRES SOLEIL, APAISANT et RESTRUCTURANTAFTER SUN MILK, SOOTHING AND RESTRUCTURING
Nom commercial Nomenclature INCI ou latinTrade name INCI or Latin nomenclature
PHASE 1PHASE 1
Aqua Aqua qqsAqua Aqua some
Montanov L C14-22 alkylalcohol and C12-20 alkylglucoside 3 Montane 80 VG Sorbitan monooléate 1,5Montanov L C14-22 alkylalcohol and C12-20 alkylglucoside 3 Montane 80 VG Sorbitan monooleate 1.5
PHASE 2PHASE 2
Huile de Bakoly Aleurites moluccana seed oil (famille euphorbiacae) 10 Huile de Jojoba oïl Simmondsla chinensis seed oil (famille 5 sim ondiaceae)Bakoly oil Aleurites moluccana seed oil (family euphorbiacae) 10 Jojoba oil oïl Simmondsla chinensis seed oil (family 5 sim ondiaceae)
PHASE 3PHASE 3
Fragance Perfume 0.3 Sepicide HB Phenoxyethanol : Methyl, propyl-, ethyl-, butylparaben 0,3Fragrance Perfume 0.3 Sepicide HB Phenoxyethanol: Methyl, propyl-, ethyl-, butylparaben 0.3
EXEMPLE 3EXAMPLE 3
SPRAY, APAISANT et hydratantSPRAY, SOOTHING and hydrating
Nom commercial Nomenclature INCI ou latinTrade name INCI or Latin nomenclature
PHASE 1PHASE 1
Aqua Aqua qqs Xyliance Cetearyl wheat straw glycosides, Cetearyl alcohol 0,5Aqua Aqua qqs Xyliance Cetearyl wheat straw glycosides, Cetearyl alcohol 0,5
PHASE 2PHASE 2
Huile de Bakoly Aleurites moluccana seed oil (famille euphorbiacae) 10 Huile de Argan Argania spinosa seed oil (famille sapotacées) 5 Huile de Jojoba Simmondsia chinensis seed oil 2,5 (famille simmondiaceae)Bakoly oil Aleurites moluccana seed oil (family euphorbiacae) 10 Argan oil Argania spinosa seed oil (family sapotaceae) 5 Jojoba oil Simmondsia chinensis seed oil 2,5 (family simmondiaceae)
PHASE 3PHASE 3
Fragance 0,3 Sepicide HB Phenoxyethanol : Methyl, propyl-, ethyl-, butylparaben 0,3 Sepicide Cl Imidazolidinyl urea 0,2Fragrance 0.3 Sepicide HB Phenoxyethanol: Methyl, propyl-, ethyl-, butylparaben 0.3 Sepicide Cl Imidazolidinyl urea 0.2
PROTOCOLE valable pour toutes les formules COSMETIQUES et THERAPEUTIQUESPROTOCOL valid for all COSMETICS and THERAPEUTICS formulas
Phase 1 Chauffer au bain marie à 70° tout en agitant, bien faire fondre te tensio actif.Phase 1 Heat in a water bath to 70 ° while stirring, melt the surfactant well.
Phase 2 Laisser refroidir, introduire les ingrédients, agiter fortement.Phase 2 Let cool, introduce the ingredients, shake vigorously.
Phase 3 Introduire, agiter quelques minutes. COMPOSITIONS J[ΗERAPEUTIOUESPhase 3 Introduce, shake a few minutes. COMPOSITIONS J [APEERAPEUTIOUES
EXEMPLE 4 CREME BRULUREEXAMPLE 4 CREAM BURNING
PHASE 1 Aqua purifée Aqua qqsPHASE 1 Aqua purified Aqua qqs
Montanox 80 VG PHA Polysorbate 80 2,5 - 3 Montane 80 PHA Sorbitan monooléate 2,5 - 3Montanox 80 VG PHA Polysorbate 80 2.5 - 3 Montane 80 PHA Sorbitan monooleate 2.5 - 3
PHASE 2PHASE 2
Huile de Foraha Foraha seed oil (Clusiaceae) 15 Huile de Jojoba Simmondsia chinensis seed oil (famille 5 simmondiaceae)Oil of Foraha Foraha seed oil (Clusiaceae) 15 Oil of Jojoba Simmondsia chinensis seed oil (family 5 simmondiaceae)
Huile de Bakoly Aleurites moluccana seed oil (famille euphorbiacae) 5Bakoly oil Aleurites moluccana seed oil (family euphorbiacae) 5
PHASE 3PHASE 3
Vitamine E Alpha tocophérol 0.3 Conservateur Conservateur 0,3Vitamin E Alpha tocopherol 0.3 Conservative Conservative 0.3
EXEMPLE 5EXAMPLE 5
CREME maux de gorge, sinusiteCREAM sore throat, sinusitis
PHASE 1 Aqua purifée Aqua qqsPHASE 1 Aqua purified Aqua qqs
Montanov 68 PHA Cetearyl alcohol cetearyl glucuside 5Montanov 68 PHA Cetearyl alcohol cetearyl glucuside 5
PHASE 2PHASE 2
Huile de Rara Brochoneura acuminata seed oil (Myristicaceae) 15 Huile de Bakoly Aleurites moluccana seed oil (famille euphorbiacae) 5Rara Brochoneura acuminata seed oil (Myristicaceae) 15 Bakoly oil Aleurites moluccana seed oil (family euphorbiacae) 5
PHASE 3PHASE 3
Vitamine E Alpha tocophérol 0.3 HE Faux Essential oil Cinnamomum camphora Madagascar 0,5 Camphrier Conservateur Conservateur 0,3Vitamin E Alpha tocopherol 0.3 HE False Essential oil Cinnamomum camphora Madagascar 0.5 Camphor tree Conservative Conservative 0.3
EXEMPLE 6EXAMPLE 6
COLLYREEYE DROPS
PHASE 1 Aqua purifée PPt Aqua qqs Montanov 68 PHA Cetearyl/alcolol/cetearyl/glucosyde 0,5PHASE 1 Aqua purified PPt Aqua qqs Montanov 68 PHA Cetearyl / alcolol / cetearyl / glucosyde 0.5
PHASE 2 Huile de Foraha Foraha seed oil (Clusiaceae) 2 Vitamine E Tocophérol 0,05 à 0,1PHASE 2 Foraha Oil Foraha seed oil (Clusiaceae) 2 Vitamin E Tocopherol 0.05 to 0.1
PHASE 3PHASE 3
Ciclosporin 0,1 à 2 Conservateur Conservateur 0,3 Ciclosporin 0.1 to 2 Preservative Preservative 0.3

Claims

REVENDICATIONS
1. Composition diététiques, alimentaires, compléments alimentaires, cosmétiques, pharmaceutiques (thérapeutiques) destinée à usage vétérinaire et humain comprenant une huile ou un mélange d'huiles provenant de plantes ou parties de plantes non chauffées, introduites broyées non chauffées dans la presse, issues des familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites à froid et filtrées immédiatement après extraction, la composition chimique de telles huiles comprend des molécules sensibles aux températures supérieures à 48°.1. Dietetic, food, food, cosmetic, pharmaceutical (therapeutic) compositions intended for veterinary and human use comprising an oil or a mixture of oils coming from unheated plants or parts of plants, introduced crushed unheated in the press, from of the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, cold extracts and extracts, chemical extracts and extracts after cold extracts molecules sensitive to temperatures above 48 °.
2. Utilisation d'huile ou d'un mélange d'huiles provenant de plantes ou parties de plantes non chauffées, introduites J royées non chauffées dans la presse, des familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites à froid et filtrées immédiatement après extraction, par suite d'une résistance au rancissement supérieure aux huiles extraites selon les autres procédés, pour la préparation d'une composition alimentaire, diététique, cosmétique (dont parfumerie), pharmaceutique (thérapeutique) destinée à usage vétérinaire et humain.2. Use of oil or a mixture of oils from unheated plants or parts of plants, introduced into the unheated royal presses, from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae , Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted and filtered immediately after extraction, due to superior rancidity to oils extracted by other methods, for the preparation of a composition food, dietetics, cosmetics (including perfumery), pharmaceutical (therapeutic) intended for veterinary and human use.
3. Utilisation d'huile ou d'un mélange d'huiles provenant de plantes ou parties de plantes non chauffées, introduites broyées non chauffées dans la presse, des familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, extraites à froid et filtrées immédiatement après extraction en tant qu'agent intervenant dans l'amélioration de la sécheresse de la peau et des muqueuses (vaginale, œil), pour la préparation d'une composition pharmaceutique (thérapeutique) destinée à usage vétérinaire et humain.3. Use of oil or a mixture of oils from unheated plants or parts of plants, introduced crushed unheated in the press, from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae, Sapotaceae, Saxifragaceae, Simmondsiaceae, cold extracted and filtered immediately after extraction as an agent intervening in the improvement of the dryness of the skin and mucous membranes (vaginal, eye), for the preparation of a pharmaceutical (therapeutic) composition intended for veterinary and human use.
4. Utilisation d'huile ou d'un mélange d'huiles provenant de plantes ou parties de plantes non chauffées, introduites broyées non chauffées dans la presse, des familles Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae Sapotaceae, Saxifragaceae Simmondsiaceae, extraites à froid et filtrées immédiatement après extraction en tant qu 'agent restructurant et favorisant une meilleure cicatrisation pour la préparation d'une composition pharmaceutique (thérapeutique) destinée à usage vétérinaire et humain.4. Use of oil or a mixture of oils from unheated plants or parts of plants, introduced crushed unheated in the press, from the families Anacardiaceae, Arecaceae, Boraginaceae, Canabaceae, Clusiaceae, Composeae, Cruciferaceae, Curcurbitaceae, Euphorbiaceae, Linaceae, Moringaceae, Myristicaceae, Onagraceae Sapotaceae, Saxifragaceae Simmondsiaceae, cold extracted and filtered immediately after extraction as a restructuring agent and promoting better healing for the preparation of a pharmaceutical (therapeutic) composition intended for veterinary and human use.
5. Composition alimentaire, diététique, cosmétique (dont parfumerie), pharmaceutique (thérapeutique), destinée à usage vétérinaire et humain telle que décrite dans l'une des revendications 1 et 4, caractérisée par le fait qu'elle comprend en outre au moins un adjuvant choisi parmi les corps gras, les solvants organiques, les épaississants et/ou les gélifiants, les actifs hydrophiles ou lipophiles, les adoucissants, les agents hydratants, les antioxydants, émollients, les hydroxyacides, les opacifiants, les polymères, les propulseurs, les stabilisants, les vitamines, les réducteurs, les silicones, les parfums, les conservateurs, les charges, les séquestrants, les agents alcalinisants ou acidifiants, les agents protecteurs UV ou autres, les colorants, des extraits de plantes ou tout autre ingrédient.5. Food, dietetic, cosmetic (including perfumery), pharmaceutical (therapeutic) composition, intended for veterinary and human use as described in one of claims 1 and 4, characterized in that it also comprises at least one adjuvant chosen from fatty substances, organic solvents, thickeners and / or gelling agents, hydrophilic or lipophilic active agents, softeners, hydrating agents, antioxidants, emollients, hydroxy acids, opacifiers, polymers, propellants, stabilizers, vitamins, reducers, silicones, perfumes, preservatives, fillers, sequestrants, basifying or acidifying agents, UV or other protective agents, dyes, plant extracts or any other ingredient.
6. Compositions cosmétiques (dont parfumerie, fragrance), ou dermatologiques à destination humaine et animale, selon la revendication 5, caractérisées par le fait qu'elles se présentent sous forme solide, liquide ou pâteuse, tel qu'un shampooing, une émulsion, une dispersion, une lotion, une huile, une poudre, une mousse, un spray, un bâtonnet solide ou un patch.6. Cosmetic (including perfumery, fragrance) or dermatological compositions for human and animal use, according to claim 5, characterized in that they are in solid, liquid or pasty form, such as a shampoo, an emulsion, a dispersion, a lotion, an oil, a powder, a foam, a spray, a solid stick or a patch.
7. Compositions cosmétiques (dont parfumerie, fragrance), dermatologiques à destination humaine ou animale selon la revendication 5, caractérisée par le fait qu'elles contiennent 0,05 à 100% en poids de telles huiles.7. Cosmetic (including perfumery, fragrance), dermatological compositions for human or animal use according to claim 5, characterized in that they contain 0.05 to 100% by weight of such oils.
8. Compositions alimentaires, diététiques, compléments alimentaires à destination humaine et animale selon la revendication 5, caractérisées par le fait qu'elles se présentent sous forme d'huile, d'émulsion, de dispersion, de gélules, de capsules ou de comprimés.8. Food, dietetic compositions, food supplements for human and animal use according to claim 5, characterized in that they are in the form of oil, emulsion, dispersion, capsules, capsules or tablets.
9. Compositions alimentaires, diététiques, compléments alimentaires à destination humaine ou animale selon les revendications 8, caractérisées en ce qu'elles contiennent 0,05 à 100% en poids de telles huiles.9. Food, dietetic compositions, food supplements for human or animal use according to claims 8, characterized in that they contain 0.05 to 100% by weight of such oils.
10. Compositions pharmaceutiques (thérapeutique), vétérinaires selon la revendication 5, caractérisées en ce qu'elles se présentent sous forme de gélules, capsules, patchs, comprimés, suppositoires, ovules, crèmes, gels ou liquides injectables.10. Pharmaceutical (therapeutic), veterinary compositions according to claim 5, characterized in that they are presented under capsules, capsules, patches, tablets, suppositories, eggs, creams, gels or injectable liquids.
11. Compositions pharmaceutiques (thérapeutique), vétérinaires selon la revendication 10 caractérisées en ce qu'elles contiennent 0,05 à 100% en poids de telles huiles.11. Pharmaceutical (therapeutic), veterinary compositions according to claim 10 characterized in that they contain 0.05 to 100% by weight of such oils.
12. Procédé d'obtention d'une composition selon les revendications 5 à 11 , caractérisé en ce que l'huile utilisée est obtenue à partir de plantes ou parties de plantes non chauffées, introduites broyées non chauffées dans la presse, extraites à froid et filtrées immédiatement après extraction.12. Method for obtaining a composition according to claims 5 to 11, characterized in that the oil used is obtained from unheated plants or parts of plants, introduced crushed unheated in the press, cold extracted and filtered immediately after extraction.
13. Procédé d'obtention d'une composition selon la revendication 12, caractérisé par le fait que les plantes ou parties de plantes sont cueillies ou ramassées, triées pour être immédiatement séchées à froid par ventilation forcée avec de l'air dont la température est inférieur à 35° et à un taux d'humidité égale ou inférieur à 70%, le séchage peut aussi s'effectuer sous vide, par micro-ondes mais toujours à basse température, les plantes ou parties de plantes non chauffées sont ensuite introduites broyées, non chauffées dans la presse, extraites à froid sans solvant. 13. A method of obtaining a composition according to claim 12, characterized in that the plants or parts of plants are picked or picked, sorted to be immediately cold dried by forced ventilation with air whose temperature is lower than 35 ° and at a humidity level equal to or lower than 70%, drying can also be carried out under vacuum, by microwave but always at low temperature, the plants or parts of plants not heated are then introduced crushed , not heated in the press, cold extracted without solvent.
PCT/FR2003/003338 2002-11-25 2003-11-07 Oil compositions obtained from non-heated plant parts, introduced ground and non-heated in the press, extracted by cold pressing WO2004050108A1 (en)

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EP03789462A EP1601369A1 (en) 2002-11-25 2003-11-07 Oil compositions obtained from non-heated plant parts, introduced ground and non-heated in the press, extracted by cold pressing
AU2003294047A AU2003294047A1 (en) 2002-11-25 2003-11-07 Oil compositions obtained from non-heated plant parts, introduced ground and non-heated in the press, extracted by cold pressing

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FR0214723A FR2847476B1 (en) 2002-11-25 2002-11-25 USE OF OILS OBTAINED FROM PARTS OF NON-HEATED PLANTS, INTRODUCED NOT HEATED MILLED IN THE PRESS, COLD EXTRACTED IN THE COMPOSITIONS
FR02/14723 2002-11-25

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EP2025242A1 (en) * 2007-07-25 2009-02-18 Universität Hohenheim Feed and feed additive for herbivores, and method for manufacturing the same
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US10780041B2 (en) 2011-12-19 2020-09-22 Mary Kay Inc. Combination of plant extracts to improve skin tone
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KR20190133636A (en) * 2018-05-23 2019-12-03 한국식품연구원 Composition for improving asthma or chronic obstructive pulmonary disease using an extract of Epilobium pyrricholophum
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EP1601369A1 (en) 2005-12-07

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