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WO2003004608A3 - Drug metabolizing enzymes - Google Patents

Drug metabolizing enzymes Download PDF

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Publication number
WO2003004608A3
WO2003004608A3 PCT/US2002/021105 US0221105W WO03004608A3 WO 2003004608 A3 WO2003004608 A3 WO 2003004608A3 US 0221105 W US0221105 W US 0221105W WO 03004608 A3 WO03004608 A3 WO 03004608A3
Authority
WO
WIPO (PCT)
Prior art keywords
dme
metabolizing enzymes
drug metabolizing
polynucleotides
agonists
Prior art date
Application number
PCT/US2002/021105
Other languages
French (fr)
Other versions
WO2003004608A2 (en
Inventor
Jennifer A Griffin
Jayalaxmi Ramkumar
Brooke M Emerling
Thomas W Richardson
Joana X Li
Bridget A Warren
Cynthia D Honchell
Mariah R Baughn
Y Tom Tang
Ernestine A Lee
Vicki S Elliott
Henry Yue
Sally Lee
Anita Swarnakar
Ian J Forsythe
Madhusudan M Sanjanwala
Monique G Yao
Yeganeh Zebarjadian
Ann E Gorvad
Shanya D Becha
Neil Burford
Original Assignee
Incyte Genomics Inc
Jennifer A Griffin
Jayalaxmi Ramkumar
Brooke M Emerling
Thomas W Richardson
Joana X Li
Bridget A Warren
Cynthia D Honchell
Mariah R Baughn
Y Tom Tang
Ernestine A Lee
Vicki S Elliott
Henry Yue
Sally Lee
Anita Swarnakar
Ian J Forsythe
Madhusudan M Sanjanwala
Monique G Yao
Yeganeh Zebarjadian
Ann E Gorvad
Shanya D Becha
Neil Burford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Jennifer A Griffin, Jayalaxmi Ramkumar, Brooke M Emerling, Thomas W Richardson, Joana X Li, Bridget A Warren, Cynthia D Honchell, Mariah R Baughn, Y Tom Tang, Ernestine A Lee, Vicki S Elliott, Henry Yue, Sally Lee, Anita Swarnakar, Ian J Forsythe, Madhusudan M Sanjanwala, Monique G Yao, Yeganeh Zebarjadian, Ann E Gorvad, Shanya D Becha, Neil Burford filed Critical Incyte Genomics Inc
Priority to JP2003510767A priority Critical patent/JP2005508614A/en
Priority to CA002453075A priority patent/CA2453075A1/en
Priority to AU2002312624A priority patent/AU2002312624A1/en
Priority to EP02740014A priority patent/EP1572877A3/en
Publication of WO2003004608A2 publication Critical patent/WO2003004608A2/en
Publication of WO2003004608A3 publication Critical patent/WO2003004608A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)

Abstract

Various embodiments of the invention provide human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.
PCT/US2002/021105 2001-07-06 2002-07-05 Drug metabolizing enzymes WO2003004608A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003510767A JP2005508614A (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes
CA002453075A CA2453075A1 (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes
AU2002312624A AU2002312624A1 (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes
EP02740014A EP1572877A3 (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US30374501P 2001-07-06 2001-07-06
US60/303,745 2001-07-06
US30540201P 2001-07-13 2001-07-13
US60/305,402 2001-07-13
US30815801P 2001-07-27 2001-07-27
US60/308,158 2001-07-27
US32212701P 2001-09-14 2001-09-14
US60/322,127 2001-09-14

Publications (2)

Publication Number Publication Date
WO2003004608A2 WO2003004608A2 (en) 2003-01-16
WO2003004608A3 true WO2003004608A3 (en) 2005-08-18

Family

ID=27501837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021105 WO2003004608A2 (en) 2001-07-06 2002-07-05 Drug metabolizing enzymes

Country Status (5)

Country Link
EP (1) EP1572877A3 (en)
JP (1) JP2005508614A (en)
AU (1) AU2002312624A1 (en)
CA (1) CA2453075A1 (en)
WO (1) WO2003004608A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892882A (en) * 2010-05-12 2013-01-23 天野酶株式会社 Reducing agent from microorganism belonging to genus bacillus and application for same
CN102727752A (en) * 2012-06-19 2012-10-17 卞毓平 Application of Wu Hu Dan capsules in preparing medicine used for treating gout
WO2021158921A2 (en) 2020-02-05 2021-08-12 The Broad Institute, Inc. Adenine base editors and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002040651A2 (en) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft A human trna-specific adenosine deaminase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002040651A2 (en) * 2000-11-17 2002-05-23 Bayer Aktiengesellschaft A human trna-specific adenosine deaminase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADAMS M.D. ET AL.: "The genome sequence of drosophila melanogaster.", SCIENCE., vol. 287, 24 March 2000 (2000-03-24), pages 2185 - 2195, XP002144875 *

Also Published As

Publication number Publication date
JP2005508614A (en) 2005-04-07
EP1572877A2 (en) 2005-09-14
AU2002312624A1 (en) 2003-01-21
AU2002312624A8 (en) 2005-11-17
EP1572877A3 (en) 2005-10-05
WO2003004608A2 (en) 2003-01-16
CA2453075A1 (en) 2003-01-16

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