WO2000002905A3 - Methods for accelerating bone and cartilage growth and repair - Google Patents
Methods for accelerating bone and cartilage growth and repair Download PDFInfo
- Publication number
- WO2000002905A3 WO2000002905A3 PCT/US1999/015735 US9915735W WO0002905A3 WO 2000002905 A3 WO2000002905 A3 WO 2000002905A3 US 9915735 W US9915735 W US 9915735W WO 0002905 A3 WO0002905 A3 WO 0002905A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cartilage
- analogues
- aii
- repair
- bone
- Prior art date
Links
- 210000000845 cartilage Anatomy 0.000 title abstract 5
- 210000000988 bone and bone Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 5
- ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 4
- 102000005862 Angiotensin II Human genes 0.000 abstract 3
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 3
- 229950006323 angiotensin ii Drugs 0.000 abstract 3
- 101800000734 Angiotensin-1 Proteins 0.000 abstract 2
- 102400000344 Angiotensin-1 Human genes 0.000 abstract 2
- 102000004881 Angiotensinogen Human genes 0.000 abstract 1
- 108090001067 Angiotensinogen Proteins 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/32—Angiotensins [AT], angiotensinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU49869/99A AU756785B2 (en) | 1998-07-13 | 1999-07-12 | Methods for accelerating bone and cartilage growth and repair |
JP2000559134A JP3686335B2 (en) | 1998-07-13 | 1999-07-12 | Methods for promoting bone and cartilage growth and repair |
DE69911609T DE69911609T2 (en) | 1998-07-13 | 1999-07-12 | PROCESS FOR ACCELERATING THE GROWTH AND HEALING OF BONES AND CARTILES |
AT99933921T ATE250423T1 (en) | 1998-07-13 | 1999-07-12 | METHOD FOR ACCELERATING BONES AND CARTILAGE GROWTH AND HEALING |
CA002328871A CA2328871C (en) | 1998-07-13 | 1999-07-12 | Methods for accelerating bone and cartilage growth and repair |
EP99933921A EP1094829B8 (en) | 1998-07-13 | 1999-07-12 | Methods for accelerating bone and cartilage growth and repair |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9265398P | 1998-07-13 | 1998-07-13 | |
US60/092,653 | 1998-07-13 | ||
US13085599P | 1999-04-22 | 1999-04-22 | |
US60/130,855 | 1999-04-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000002905A2 WO2000002905A2 (en) | 2000-01-20 |
WO2000002905A3 true WO2000002905A3 (en) | 2000-02-24 |
Family
ID=26785912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/015735 WO2000002905A2 (en) | 1998-07-13 | 1999-07-12 | Methods for accelerating bone and cartilage growth and repair |
Country Status (9)
Country | Link |
---|---|
US (1) | US6258778B1 (en) |
EP (1) | EP1094829B8 (en) |
JP (2) | JP3686335B2 (en) |
AT (1) | ATE250423T1 (en) |
AU (1) | AU756785B2 (en) |
CA (1) | CA2328871C (en) |
DE (1) | DE69911609T2 (en) |
ES (1) | ES2207258T3 (en) |
WO (1) | WO2000002905A2 (en) |
Cited By (1)
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---|---|---|---|---|
US8920842B2 (en) | 1999-11-15 | 2014-12-30 | Piramal Healthcare (Canada) Ltd. | Temperature controlled and pH dependent self gelling biopolymeric aqueous solution |
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US6335195B1 (en) * | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
BR0007892A (en) * | 1999-02-01 | 2001-10-30 | Genetics Inst | Processes and compositions for healing and repairing articular cartilage |
US6730775B1 (en) | 1999-03-23 | 2004-05-04 | University Of Southern California | Methods for limiting scar and adhesion formation |
US6747008B1 (en) | 2000-06-19 | 2004-06-08 | University Of Southern California | Methods for treating and preventing alopecia |
CN1471412B8 (en) | 2000-06-29 | 2016-06-15 | 生物合成技术加拿大公司 | For repairing and regeneration of cartilage and the composition of other tissue and the purposes of said composition |
US20060094112A1 (en) * | 2001-03-07 | 2006-05-04 | Omotunde Babalola | Biological scaffold |
DE60222409T2 (en) | 2001-05-31 | 2008-09-25 | Vicore Pharma Ab | TRICYCLIC CONNECTIONS, USEFUL AS ANGIOTENSIN II AGONISTS |
EP1467732A1 (en) * | 2002-01-22 | 2004-10-20 | Pfizer Limited | 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases |
EP1485116A4 (en) * | 2002-02-27 | 2006-06-07 | Univ Wake Forest | ANGIOTENSIN (1-7) AND ANGIOTENSIN (1-7) AGONISTS FOR INHIBITING CANCER GROWTH |
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US20080194472A1 (en) * | 2003-03-27 | 2008-08-14 | Jeffrey Allen Whitsett | Use of Fgf-18 Protein, Target Proteins and Their Respective Encoding Nucleotide Sequences to Induce Cartilage Formation |
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US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US8796017B2 (en) * | 2003-05-21 | 2014-08-05 | Jms Co., Ltd. | Container for preparing serum and regenerative medical process using the same |
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WO2006020981A2 (en) * | 2004-08-12 | 2006-02-23 | University Of Southern California | Methods for accelerating bone growth and repair |
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US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
EP1926459B1 (en) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
CA2651827C (en) | 2006-05-26 | 2013-11-26 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
WO2007148334A1 (en) | 2006-06-20 | 2007-12-27 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic peptides and hydrogel matrices thereof for bone repair |
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US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
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US9457056B2 (en) | 2007-12-04 | 2016-10-04 | Ben-Gurion University Of The Negev Research And Development Authority | Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis |
EP2265220A1 (en) | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
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- 1999-07-12 EP EP99933921A patent/EP1094829B8/en not_active Expired - Lifetime
- 1999-07-12 US US09/352,191 patent/US6258778B1/en not_active Expired - Lifetime
- 1999-07-12 ES ES99933921T patent/ES2207258T3/en not_active Expired - Lifetime
- 1999-07-12 DE DE69911609T patent/DE69911609T2/en not_active Expired - Lifetime
- 1999-07-12 CA CA002328871A patent/CA2328871C/en not_active Expired - Fee Related
- 1999-07-12 JP JP2000559134A patent/JP3686335B2/en not_active Expired - Fee Related
- 1999-07-12 AT AT99933921T patent/ATE250423T1/en not_active IP Right Cessation
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US8920842B2 (en) | 1999-11-15 | 2014-12-30 | Piramal Healthcare (Canada) Ltd. | Temperature controlled and pH dependent self gelling biopolymeric aqueous solution |
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AU756785B2 (en) | 2003-01-23 |
CA2328871C (en) | 2002-10-01 |
EP1094829A2 (en) | 2001-05-02 |
EP1094829B8 (en) | 2004-09-22 |
DE69911609T2 (en) | 2004-07-01 |
EP1094829B1 (en) | 2003-09-24 |
JP2002520334A (en) | 2002-07-09 |
JP2005120094A (en) | 2005-05-12 |
WO2000002905A2 (en) | 2000-01-20 |
ATE250423T1 (en) | 2003-10-15 |
DE69911609D1 (en) | 2003-10-30 |
CA2328871A1 (en) | 2000-01-20 |
ES2207258T3 (en) | 2004-05-16 |
JP3686335B2 (en) | 2005-08-24 |
US6258778B1 (en) | 2001-07-10 |
AU4986999A (en) | 2000-02-01 |
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