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WO2001057082A3 - Extraction of growth factors from tissue - Google Patents

Extraction of growth factors from tissue Download PDF

Info

Publication number
WO2001057082A3
WO2001057082A3 PCT/US2001/003474 US0103474W WO0157082A3 WO 2001057082 A3 WO2001057082 A3 WO 2001057082A3 US 0103474 W US0103474 W US 0103474W WO 0157082 A3 WO0157082 A3 WO 0157082A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
growth factors
extraction
methods
disclosed
Prior art date
Application number
PCT/US2001/003474
Other languages
French (fr)
Other versions
WO2001057082A2 (en
Inventor
Russell S Donda
John F Wironen
Christopher Seid
Original Assignee
Regeneration Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneration Tech Inc filed Critical Regeneration Tech Inc
Priority to AU2001236632A priority Critical patent/AU2001236632A1/en
Publication of WO2001057082A2 publication Critical patent/WO2001057082A2/en
Publication of WO2001057082A3 publication Critical patent/WO2001057082A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Diclosed herein are novel methods of obtaining osteogenic and other growth factor compositions from alternative nonbone sources such as tissue or bone marrow, and methods of using the same. Also disclosed are implants infused with growth factors obtained from the methods disclosed herein.
PCT/US2001/003474 2000-02-03 2001-02-02 Extraction of growth factors from tissue WO2001057082A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001236632A AU2001236632A1 (en) 2000-02-03 2001-02-02 Extraction of growth factors from tissue

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US18006700P 2000-02-03 2000-02-03
US60/180,067 2000-02-03
US20084200P 2000-05-01 2000-05-01
US60/200,842 2000-05-01
US21591200P 2000-07-03 2000-07-03
US60/215,912 2000-07-03

Publications (2)

Publication Number Publication Date
WO2001057082A2 WO2001057082A2 (en) 2001-08-09
WO2001057082A3 true WO2001057082A3 (en) 2002-02-21

Family

ID=27391212

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/003474 WO2001057082A2 (en) 2000-02-03 2001-02-02 Extraction of growth factors from tissue

Country Status (3)

Country Link
US (1) US20010041792A1 (en)
AU (1) AU2001236632A1 (en)
WO (1) WO2001057082A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20060204544A1 (en) * 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US7622562B2 (en) * 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7241874B2 (en) * 2002-06-26 2007-07-10 Zimmer Ortho Biologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
EP1558748A4 (en) * 2002-11-01 2008-10-22 Promega Corp Cell lysis compositions, methods of use, apparatus, and kit
US20070280959A1 (en) * 2004-05-05 2007-12-06 Thomas Meury Use Of Platelets Or Platelet Rich Plasma(Prp)
US20060051865A1 (en) * 2004-08-31 2006-03-09 Higgins Joel C Systems and methods for isolating stromal cells from adipose tissue and uses thereof
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8034014B2 (en) 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
US10105441B2 (en) * 2007-08-16 2018-10-23 The Schepens Eye Research Institute, Inc. Method for inhibiting or reducing dry eye disease by IL-1Ra
US20110118850A1 (en) * 2008-12-13 2011-05-19 Amit Prakash Govil Bioactive Grafts and Composites
EP2385839B1 (en) 2009-01-09 2014-11-26 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of corneal disorders
BR122018072218B1 (en) 2009-12-13 2020-03-17 Advanced Biologics, Llc OSTEOCONDUCTIVE ORTHOPEDIC IMPLANT WITH POROUS FORMAT MEMORY, ORTHOPEDIC IMPLANT COATING, IMPLANT AND ORTHOPEDIC IMPLANT
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
DK2598526T3 (en) 2010-07-29 2018-11-19 Eleven Biotherapeutics Inc CHEMICAL IL-1 RECEPTOR TYPE-I AGONISTS AND ANTAGONISTS
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
CN105392494A (en) 2013-03-13 2016-03-09 十一生物治疗股份有限公司 Chimeric cytokine formulations for ocular delivery
KR20160027127A (en) * 2013-07-01 2016-03-09 아미트 프라카시 고빌 Soft tissue implant
WO2015049549A1 (en) * 2013-10-01 2015-04-09 Beauty Thru Science Limited A method for stimulating scalp hair re-growth
WO2016187413A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
CN106967170A (en) * 2017-05-31 2017-07-21 南宁学院 A kind of method that collagen is extracted from ox-hide
RU2692452C1 (en) * 2018-01-22 2019-06-24 Адальби Заурбиевич Хашукоев Method of jaw bone defects replacement
WO2022231904A1 (en) * 2021-04-27 2022-11-03 Avita Medical, Inc. Regenerative bioactive suspension derived from freshly disaggregated tissue and methods of use in clinical therapies
WO2024086171A1 (en) * 2022-10-17 2024-04-25 Lifenet Health Bone grafts

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533438A2 (en) * 1979-12-27 1984-03-30 Sederma Sarl Use of growth factors and biological extracts containing the latter in cosmetology
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
EP0361896A2 (en) * 1988-09-29 1990-04-04 Collagen Corporation Method for improving implant fixation
DE4130546A1 (en) * 1990-01-12 1993-03-18 Baylink David J BONE GROWTH SUPPORTING COMPOSITION
WO1998025964A1 (en) * 1996-12-10 1998-06-18 Purdue Research Foundation Submucosa extracts
WO1998040113A1 (en) * 1997-03-13 1998-09-17 University Of Florida Tissue Bank, Inc. Bone paste
US5834418A (en) * 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533438A2 (en) * 1979-12-27 1984-03-30 Sederma Sarl Use of growth factors and biological extracts containing the latter in cosmetology
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
EP0361896A2 (en) * 1988-09-29 1990-04-04 Collagen Corporation Method for improving implant fixation
DE4130546A1 (en) * 1990-01-12 1993-03-18 Baylink David J BONE GROWTH SUPPORTING COMPOSITION
US5834418A (en) * 1996-03-20 1998-11-10 Theratechnologies, Inc. Process for the preparation of platelet growth factors extract
WO1998025964A1 (en) * 1996-12-10 1998-06-18 Purdue Research Foundation Submucosa extracts
WO1998040113A1 (en) * 1997-03-13 1998-09-17 University Of Florida Tissue Bank, Inc. Bone paste

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOENER MC &VARON S: "Effects of Sodium Chloride, Triton X-100, and Alkaline pH on the Measurable Contents and Sedimentability of the Nerve Growth Factor (NGF) Antigen in Adult Rat Hippocampal Tissue Extracts", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 49, 1997, pages 508 - 514, XP002174392 *
KOUTSILIERIS M ET AL.: "Selective Osteoblast Mitogens Can Be Extracted from Prostatic Tissue", THE PROSTATE, vol. 9, 1986, pages 109 - 115, XP001014581 *
NICE EC ET AL.: "The Major Colonic Cell Mitogen Extractable from Colonic Mucosa Is an N Terminally Extended Form of Basic Fibroblast Growth Factor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 22, 5 August 1991 (1991-08-05), pages 14425 - 14430, XP002063375 *
WERZ ET AL.: "Purification of transforming growth factor beta1 from human platelets", PHARMAZIE, vol. 51, 1996, pages 893 - 896, XP002174513 *

Also Published As

Publication number Publication date
AU2001236632A1 (en) 2001-08-14
US20010041792A1 (en) 2001-11-15
WO2001057082A2 (en) 2001-08-09

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