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WO1998018339A1 - Composition de chewing-gum et procede de production - Google Patents

Composition de chewing-gum et procede de production Download PDF

Info

Publication number
WO1998018339A1
WO1998018339A1 PCT/JP1997/003973 JP9703973W WO9818339A1 WO 1998018339 A1 WO1998018339 A1 WO 1998018339A1 JP 9703973 W JP9703973 W JP 9703973W WO 9818339 A1 WO9818339 A1 WO 9818339A1
Authority
WO
WIPO (PCT)
Prior art keywords
bone
chewing gum
calcium
hydroxyapatite
tricalcium phosphate
Prior art date
Application number
PCT/JP1997/003973
Other languages
English (en)
Japanese (ja)
Inventor
Hideki Aoki
Marehito Aoki
Original Assignee
Hideki Aoki
Marehito Aoki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hideki Aoki, Marehito Aoki filed Critical Hideki Aoki
Priority to JP52030298A priority Critical patent/JP3911526B2/ja
Priority to AU47264/97A priority patent/AU4726497A/en
Publication of WO1998018339A1 publication Critical patent/WO1998018339A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums

Definitions

  • the present invention relates to a chewing gum composition and a method for producing the same. More specifically, the present invention relates to a chewing gum composition which is safe and effective for whitening teeth, enhancing tooth quality, preventing bad breath and the like while supplementing calcium, and a method for producing the same. Background art
  • various calcium salts such as inorganic calcium salts such as calcium carbonate and organic calcium salts such as calcium citrate, calcium malate and calcium lactate are used as a calcium source.
  • inorganic calcium salt calcium carbonate is used relatively frequently, but when dissolved in stomach acid, it produces carbon dioxide and strong alkali lime. This quicklime is immediately neutralized by acid in the stomach to form a salt such as calcium chloride. However, if ingested in large amounts, the quicklime remaining unneutralized may cause the pH in the stomach to rise excessively.
  • Organic calcium salts such as calcium citrate, calcium malate, calcium lactate, etc. have good absorbency but low content of calcium per unit weight. In addition, all of the above substances conventionally used are for calcium supplementation alone.
  • the substance that constitutes the inorganic components of the human skeleton and teeth consists of a calcium phosphate compound called apatite (bone apatite) composed of calcium, phosphorus, and water. Therefore, it is considered reasonable to supplement with a substance containing calcium and phosphorus at the same time, rather than supplementing with calcium alone, in order to strengthen tooth quality and increase bone strength. Furthermore, in recent times, diversification of lifestyles has led to an increase in demand for functional foods containing various types of nutrients that can be easily ingested.
  • apatite bone apatite
  • an object of the present invention is to provide a chewing gum composition as a functional food which is capable of safely supplementing calcium, and at the same time, is effective for strengthening teeth, increasing bone strength, and whitening teeth. It is in.
  • Another object of the present invention is to provide a method for producing the above chewing gum composition.
  • the present inventors have conducted intensive studies and as a result, have solved the above-mentioned problems by including bone mineral, at least one of tricalcium phosphate and hydroxyapatite in a gum base.
  • the inventor has found that the present invention can be obtained, and based on this, has completed the present invention. Disclosure of the invention
  • the present invention relates to a chewing gum composition characterized in that the gum base contains bone mineral and tricalcium phosphate and z or hydroxyapatite.
  • the present invention provides a chewing gum production method comprising (I) a gum base production step, and (II) a step of adding and adding an ingredient to the gum base and forming and processing the same, wherein the bone mineral, tricalcium phosphate and
  • the present invention relates to a method for producing a chewing gum composition, characterized in that it contains a hydroxyapatite.
  • the chewing gum composition of the present invention contains bone mineral, tricalcium phosphate and Z or hydroxyapatite in a gum base.
  • bone mineral refers to vertebrate bones such as sea urchins, bush, chickens, and various fishes that are chemically treated or heat-treated to remove organic substances and contain substantially only inorganic substances. It means what you have. Generally, when bones of animals and fish are dried to remove water, about 70% by weight of a substance called bone apatite containing phosphorus, potassium, and trace metal elements, and about 30% by weight of organic substances mainly composed of collagen Powder. Bone mineral refers to a powder obtained by removing the latter organic substance from the powder and extracting only bone abate containing trace metal elements. These bone minerals are preferable because they contain trace amounts of metals useful in human organisms, such as magnesium, stodium, iron, manganese, and zinc.
  • metals useful in human organisms such as magnesium, stodium, iron, manganese, and zinc.
  • Animal bones used to obtain bone minerals are not particularly limited, but they are characterized by the ease of processing, the uniformity of the calcium and phosphorus composition, and the availability of stable supplies. Therefore, those derived from fish are preferred.
  • Fish include, for example, bonito, tuna, eso, cod, etc., but among them, mass production has already been established as a food additive, with little impurities and uniform composition (Cadiformes). Bone from the origin (cod bone), tuna, bonito and the like are preferred.
  • Specific examples of cod include Madara, Alaska pollack, Sokodara, Chigodara and the like.
  • the composition ratio of calcium and phosphorus (CaZP) in cod bone is 1.67, which is very similar to that in human bone.
  • a bone mineral using cod can be obtained by the following method.
  • the cod is heated, and the middle bone from which the fish meat has been removed is treated with an autoclave at a high temperature (around 120 ° C) and at a high pressure (about 2 atm or less) with hot water, and then treated with protease.
  • a biochemical treatment such as a protein degradation treatment is performed, and a heat treatment is further performed to remove organic substances and to extract white bone apatite containing trace metal elements.
  • Fish bones such as cod bones are small and fine, so biochemical treatment is weak.
  • organic substances are completely removed by heat treatment at a low temperature of 800 ° C or less, and bone apatite with high whiteness, which is less likely to be gray due to incomplete firing, can be obtained. There are few impurities.
  • This bone apatite is classified as a food additive into calcined fish bone powder, calcined bone calcium powder and the like.
  • tricalcium phosphate [C a 3 (P 0 4) 2 ], one of hydroxyapatite [C a 1 () (P 0 4) 6 (OH) 2 ] 1 or more Above. All of these are safe and have high biocompatibility because the ratio of calcium to phosphorus is the same as or close to that of human bone.
  • These tricalcium phosphate and hydroxyamate can be synthesized and produced by a known method.
  • tricalcium phosphate and hydroxyapatite are preferably amorphous rather than crystalline.
  • an amorphous material has a regular three-dimensional arrangement of atoms (the size of crystallites; almost the same as the size of primary particles in ceramics) is less than 200 nm (0.2 m). Is the name given to the substance. It is well known that calcium phosphate, such as hydroxyapatite, adsorbs proteins such as plaque, lipids, sugars, etc., especially when the specific surface area is large, it removes plaque that leads to whitening of teeth, It is effective for remineralization which leads to quality enhancement.
  • Powder particle size of hydroxyapatite Ya tricalcium phosphate is found using the present invention in the following amorphous 1 / m, preferably in the range specific surface area of about 1 0 ⁇ 1 0 O m 2, to disperse additives In this case, it is desirable that the fine particles have a secondary particle diameter of 50 or less.
  • Bone apatite (bone mineral) and hydroxyapatite are different in composition and are distinguished. Pure hydroxyapatite is represented by C a 1 0 (P 0 4 ) 6 (OH) 2.
  • bone apatite is a type of carbonated hydroxyapatite in which the phosphate group of pure hydroxyapatite is substituted with 1 to 3% of carbonic acid groups (mineral name: darite). High solubility. Bone apatite has less calcium than pure hydroxyapatite, and is replaced by atoms such as hydrogen, magnesium, and sodium, and is called calcium-deficient apatite (h).
  • hydroxyl groups are replaced by carbonic acid groups, chlorine atoms, fluorine atoms, etc.
  • Those in which all of the hydroxyl groups are replaced by chlorine atoms are called chloroapatite, and those in which they are replaced by fluorine atoms are called fluorapatite.
  • the “bone mineral” of the present invention includes those in which part or all of these hydroxyl groups are substituted with other atoms or the like.
  • the total amount of the bone mineral, the calcium phosphate and / or the hydroxyapatite is preferably 1 to 20% by weight, more preferably 4 to 10% by weight in the chewing gum composition. %. If the amount is too small, it is difficult to obtain a sufficient effect of the present invention. As a result, there is a risk of causing an adverse effect of excessive calcium, and the texture becomes inferior.
  • the mixing ratio (weight ratio) of bone mineral: (tricalcium phosphate and / or hydroxyapatite) is preferably 10:;! To 1:10, more preferably 7: 3 to 3: 7
  • calcium phosphates such as tricalcium phosphate and hydroxyapatite alone do not contain minerals that increase bone strength. Bone minerals vary considerably in impurities and whiteness depending on the type of animal or fish, and when added to food, have a considerable effect on the appearance and the like.
  • about 40% by weight of bone mineral, tricalcium phosphate, and hydroxyapatite is calcium.
  • 60 O mg of bone mineral and calcium phosphate contain 24 O mg of calcium. More than 50% by weight of this calcium amount is adsorbed and left on the gum base, and usually less than 50% by weight enters the oral cavity. Therefore, the amount of calcium that can be consumed from one chewing gum is less than 12 O mg. This is 1/5 to 1777 of the daily calcium required by adults, 600 to 800: 11. Excessive calcium intake is considered safe and appropriate as the amount of calcium consumed by a single chewing gum because of the concern of over-neutralizing stomach acid and promoting the formation of pathological stones such as urinary stones.
  • the chewing gum composition of the present invention may optionally contain additional components that can be usually contained in the chewing gum composition as long as the effects of the present invention are not impaired. Further, the effects of the present invention can be further enhanced by blending, for example, vitamin C, vitamin D, dextranase, and the like.
  • the chewing gum of the present invention has a combined effect of preventing osteoporosis, promoting the development of teeth and jawbones, and whitening and strengthening teeth.
  • the method for producing a chewing gum composition of the present invention includes a step of producing a gum base, a step of adding an additive component to the gum base, and forming and processing the same.
  • a natural resin which is usually used for a gum base
  • a stirrer stirrer
  • the heating temperature is about 110 to 13 o ° c
  • the dehydration is performed for about 10 to 15 hours.
  • the dehydrated natural resin and the desired gum base material are sequentially charged into the heated kneader. Mix and dissolve them at about 110 to 130 ° C for 3 to 5 hours until uniform.
  • this gum base contains bone mineral and tricalcium phosphate and Z or hydroxyapatite.
  • the gum base thus obtained is formed and processed.
  • mix the gum base and other optional ingredients such as sugars
  • a mixer For example, when adding saccharides, usually, 1 to 2 of the compounding amount is added, kneaded for about 10 minutes, and then the remaining saccharides and a softener are added. The mixture is stirred for 30 to 40 minutes and finally the flavor is added, stirred for 1 to 2 minutes and removed.
  • the finishing temperature of the gum is preferably about 40 to 60 ° C.
  • This gum is put into an extruder and extruded into a strip with a thickness of 20 to 40 mm and a width of 400 to 47 mm, and then rolled while dusting the powdered sugar on the front and back surfaces. Through to a sheet of 1.5-2.5 mm thickness. This is cut into a desired size, aged and then packaged to obtain a chewing gum composition.
  • a chewing gum having the composition (% by weight) shown in Table 1 below was produced by a conventional method.
  • the average particle size of the used tricalcium phosphate and hydroxyapatite (1 Secondary particle diameter) was about 0.2 m.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition de chewing-gum comprenant une gomme de base, des minéraux osseux, et, soit du phosphate tricalcique, soit de l'hydroxyapathite, voire les deux. Cette composition convient particulièrement notamment pour renforcer la structure osseuse, pour renforcer les tissus dentaires, et pour blanchir les dents. L'invention concerne également un procédé de production d'une telle composition.
PCT/JP1997/003973 1996-10-31 1997-10-31 Composition de chewing-gum et procede de production WO1998018339A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP52030298A JP3911526B2 (ja) 1996-10-31 1997-10-31 チューインガム組成物およびその製造方法
AU47264/97A AU4726497A (en) 1996-10-31 1997-10-31 Chewing gum composition and process for the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30588096 1996-10-31
JP8/305880 1996-10-31

Publications (1)

Publication Number Publication Date
WO1998018339A1 true WO1998018339A1 (fr) 1998-05-07

Family

ID=17950443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/003973 WO1998018339A1 (fr) 1996-10-31 1997-10-31 Composition de chewing-gum et procede de production

Country Status (4)

Country Link
JP (1) JP3911526B2 (fr)
CN (1) CN1086917C (fr)
AU (1) AU4726497A (fr)
WO (1) WO1998018339A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6471945B2 (en) 2000-03-10 2002-10-29 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US6485739B2 (en) 2000-03-10 2002-11-26 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US6869614B2 (en) 1999-09-20 2005-03-22 Jack Barreca Chewing gum containing calcium
WO2006038315A1 (fr) * 2004-10-07 2006-04-13 Kabushiki Kaisha Sangi Préparation pour absorption percutanée/permuqueuse
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
US8133476B2 (en) 2006-04-05 2012-03-13 Cadbury Adams Usa Llc Calcium phosphate complex and salts in oral delivery systems
US8252269B2 (en) 2006-04-05 2012-08-28 Cadbury Adams Usa, Llc Impact of calcium phosphate complex on dental caries
US8293274B2 (en) 2005-04-06 2012-10-23 Kabushiki Kaisha Sangi Intestinal absorptive anti-tumor agent
US9253991B2 (en) 1999-09-20 2016-02-09 Jack Barreca Chewing gum with B vitamins
US9271904B2 (en) 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems
US9387168B2 (en) 1999-09-20 2016-07-12 Jack Barreca Chewing gum with tomatidine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8590116B2 (en) 2009-12-24 2013-11-26 Jeffery Dahl Loop rope assembly
DE202013001426U1 (de) * 2013-02-14 2013-04-10 Sandro Raisun Vitaminhaltiger Kaugummi

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57125676A (en) * 1981-01-29 1982-08-05 Hideki Sugioka Preparation of powdered calcium compound used as a food additive
JPS6371151A (ja) * 1986-09-09 1988-03-31 ワ−ナ−‐ランバ−ト・コンパニ− チューインガム
JPH03133341A (ja) * 1989-10-18 1991-06-06 Sangi:Kk カルシウム補給用チューインガム
JPH04121166A (ja) * 1990-09-10 1992-04-22 San Beesu Food Kk 食用骨粉の製造方法
JPH05252904A (ja) * 1992-03-12 1993-10-05 Yamanouchi Pharmaceut Co Ltd 焼成骨粉の顆粒及びその製造方法
JPH05276873A (ja) * 1992-04-02 1993-10-26 Fujimi Green Eng Kk 歯磨ガム

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57125676A (en) * 1981-01-29 1982-08-05 Hideki Sugioka Preparation of powdered calcium compound used as a food additive
JPS6371151A (ja) * 1986-09-09 1988-03-31 ワ−ナ−‐ランバ−ト・コンパニ− チューインガム
JPH03133341A (ja) * 1989-10-18 1991-06-06 Sangi:Kk カルシウム補給用チューインガム
JPH04121166A (ja) * 1990-09-10 1992-04-22 San Beesu Food Kk 食用骨粉の製造方法
JPH05252904A (ja) * 1992-03-12 1993-10-05 Yamanouchi Pharmaceut Co Ltd 焼成骨粉の顆粒及びその製造方法
JPH05276873A (ja) * 1992-04-02 1993-10-26 Fujimi Green Eng Kk 歯磨ガム

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9253991B2 (en) 1999-09-20 2016-02-09 Jack Barreca Chewing gum with B vitamins
US6869614B2 (en) 1999-09-20 2005-03-22 Jack Barreca Chewing gum containing calcium
US9387168B2 (en) 1999-09-20 2016-07-12 Jack Barreca Chewing gum with tomatidine
US7351425B2 (en) 1999-09-20 2008-04-01 Jack Barreca Confectionary product containing functional ingredients
US6485739B2 (en) 2000-03-10 2002-11-26 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US6696044B2 (en) 2000-03-10 2004-02-24 Cadbury Adams Usa Llc Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US6471945B2 (en) 2000-03-10 2002-10-29 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US9271904B2 (en) 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
JPWO2006038315A1 (ja) * 2004-10-07 2008-07-31 株式会社サンギ 経皮・経粘膜吸収製剤
WO2006038315A1 (fr) * 2004-10-07 2006-04-13 Kabushiki Kaisha Sangi Préparation pour absorption percutanée/permuqueuse
US8293274B2 (en) 2005-04-06 2012-10-23 Kabushiki Kaisha Sangi Intestinal absorptive anti-tumor agent
US8252269B2 (en) 2006-04-05 2012-08-28 Cadbury Adams Usa, Llc Impact of calcium phosphate complex on dental caries
US8133476B2 (en) 2006-04-05 2012-03-13 Cadbury Adams Usa Llc Calcium phosphate complex and salts in oral delivery systems

Also Published As

Publication number Publication date
JP3911526B2 (ja) 2007-05-09
AU4726497A (en) 1998-05-22
CN1086917C (zh) 2002-07-03
CN1235519A (zh) 1999-11-17

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