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UY32622A - Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) - Google Patents

Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Info

Publication number
UY32622A
UY32622A UY0001032622A UY32622A UY32622A UY 32622 A UY32622 A UY 32622A UY 0001032622 A UY0001032622 A UY 0001032622A UY 32622 A UY32622 A UY 32622A UY 32622 A UY32622 A UY 32622A
Authority
UY
Uruguay
Prior art keywords
beta
treatment
new compounds
pathologies related
relates
Prior art date
Application number
UY0001032622A
Other languages
English (en)
Inventor
Lo-Alfredsson Yvonne
Rakos Laszlo
Paulsen Kim
Waldman Magnus
Rotticci Didier
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32622A publication Critical patent/UY32622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a novedosos compuestos de fórmula I y II y sales terapéuticamente aceptables de los mismos, sus composiciones farmacéuticas, procesos para prepararlos y su uso en métodos terapéuticos para el tratamiento y/o la prevención de distintas enfermedades. En particular, la invención se refiere a compuestos que interfieren con la y-secretasa y/o su sustrato y, por consiguiente, modulan la formación de péptidos AB(beta).
UY0001032622A 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) UY32622A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17730509P 2009-05-12 2009-05-12
US28960009P 2009-12-23 2009-12-23

Publications (1)

Publication Number Publication Date
UY32622A true UY32622A (es) 2010-12-31

Family

ID=43069012

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032622A UY32622A (es) 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Country Status (5)

Country Link
US (1) US20100292210A1 (es)
AR (1) AR076760A1 (es)
TW (1) TW201043635A (es)
UY (1) UY32622A (es)
WO (1) WO2010132015A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2742897A1 (en) * 2008-11-06 2010-05-14 Astrazeneca Ab Modulators of amyloid beta.
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
US20120122843A1 (en) * 2010-11-11 2012-05-17 Astrazeneca Ab Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases
US8865716B2 (en) 2012-02-23 2014-10-21 Boehringer Ingelheim International Gmbh Dihydropteridinones II
US9006226B2 (en) 2012-02-23 2015-04-14 Boehringer Ingelheim International Gmbh Dihydropteridinones I
EP2958919B1 (en) 2013-02-21 2019-05-22 Boehringer Ingelheim International GmbH Dihydropteridinones i
JP6072308B2 (ja) 2013-02-21 2017-02-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンｉｉ
US9439904B2 (en) 2013-06-04 2016-09-13 Acturum Life Science AB Pyrimidine compounds and their use as gamma secretase modulators
DK3004080T3 (da) 2013-06-04 2019-01-02 Acturum Real Estate Ab Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer
EP3004081B1 (en) 2013-06-04 2017-11-15 Acturum Real Estate AB Triazole compounds and their use as gamma secretase modulators
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
ME03726B (me) * 2016-05-06 2021-01-20 Esteve Pharmaceuticals Sa Jedinjenja tetrahidropirimidodiazepina i tetrahidropirido-diazepina za lečenje bola i stanja povezanih sa bolom
EP3564232B1 (en) 2016-12-27 2022-01-26 Riken Bmp-signal-inhibiting compound
EP3762385A4 (en) 2018-03-09 2021-11-24 Recurium IP Holdings, LLC SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDINE-3-ONE
WO2022055168A1 (ko) * 2020-09-09 2022-03-17 서울대학교산학협력단 신규 피리미도디아제핀 유도체 및 이의 용도
EP4329766A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Ripk1 inhibitors and methods of use
US20240208986A1 (en) * 2021-04-27 2024-06-27 Merck Sharp & Dohme Llc Phenyl azepines as ripk1 inhibitors and methods of use thereof
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011300B1 (ru) * 2003-07-16 2009-02-27 Янссен Фармацевтика Н.В. Производные триазолопиримидина в качестве ингибиторов киназы гликогенсинтазы-3
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
TWI335816B (en) * 2004-05-26 2011-01-11 Eisai R&D Man Co Ltd Cinnamide compound
JPWO2007135969A1 (ja) * 2006-05-19 2009-10-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア系−シンナミド誘導体
WO2007135970A1 (ja) * 2006-05-19 2007-11-29 Eisai R & D Management Co., Ltd. ヘテロ環系－シンナミド誘導体
US20090099195A1 (en) * 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
WO2008138753A1 (en) * 2007-05-11 2008-11-20 F. Hoffmann-La Roche Ag Hetarylanilines as modulators for amyloid beta
EP2185522A1 (en) * 2007-08-06 2010-05-19 Schering Corporation Gamma secretase modulators
CA2742897A1 (en) * 2008-11-06 2010-05-14 Astrazeneca Ab Modulators of amyloid beta.

Also Published As

Publication number Publication date
TW201043635A (en) 2010-12-16
AR076760A1 (es) 2011-07-06
WO2010132015A1 (en) 2010-11-18
US20100292210A1 (en) 2010-11-18

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Legal Events

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Effective date: 20130123