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UY31831A - Derivados de indazoles sustituidos con fenilo o piridinilo - Google Patents

Derivados de indazoles sustituidos con fenilo o piridinilo

Info

Publication number
UY31831A
UY31831A UY0001031831A UY31831A UY31831A UY 31831 A UY31831 A UY 31831A UY 0001031831 A UY0001031831 A UY 0001031831A UY 31831 A UY31831 A UY 31831A UY 31831 A UY31831 A UY 31831A
Authority
UY
Uruguay
Prior art keywords
derivatives
indazols
piridinyl
phenyll
replaced
Prior art date
Application number
UY0001031831A
Other languages
English (en)
Inventor
Berger Markus
Rehwinkel Hartmut
Lepisto Matti
Johansson Henrik
Jan Dahmen
Thomas G Hansson
Nilsson Stinabritt
Hossain Nafizal
Hemmerling Martin
Edman Karl
Original Assignee
Astrazeneca Ab
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41340347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31831(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Bayer Schering Pharma Ag filed Critical Astrazeneca Ab
Publication of UY31831A publication Critical patent/UY31831A/es

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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Un compuesto de fórmula I La presente invención s e refiere a nuevos derivados de indazolilo, a composiciones farmacéuticas que comprenden tales derivados, a procesos para preparar dichos nuevos derivados y al uso de tales derivados como medicamentos.
UY0001031831A 2008-05-20 2009-05-19 Derivados de indazoles sustituidos con fenilo o piridinilo UY31831A (es)

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UY0001031832A UY31832A (es) 2008-05-20 2009-05-19 Derivados de indazol sustituidos con fenilo y benzodioxinilo

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2754B1 (en) * 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
US8338447B2 (en) 2008-03-24 2012-12-25 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
UY31831A (es) * 2008-05-20 2010-01-05 Astrazeneca Ab Derivados de indazoles sustituidos con fenilo o piridinilo
EP2424862B1 (en) 2009-04-30 2014-10-08 Basf Se Process for preparing substituted isoxazoline compounds and their precursors
WO2011061527A1 (en) * 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
FR2955105B1 (fr) 2010-01-11 2012-04-20 Arkema France Procede de preparation d'aminoethyl imidazolidone ou de son thiocarbonyle
US9085541B2 (en) 2010-06-23 2015-07-21 Basf Se Process for producing imine compounds for combating invertebrate pests
WO2012059441A2 (en) 2010-11-03 2012-05-10 Basf Se Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
BR112013021126A2 (pt) 2011-02-18 2019-09-24 Medivation Technologies Inc método para reduzir a pressão sanguínea, método para aumentar o fluxo sanguíneo renal ou diminuir a reabsorção de sódio, método para tratar uma doença, kit, composto e composição farmacêutica
US9974759B2 (en) 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
ES2751640T3 (es) * 2014-09-26 2020-04-01 Astrazeneca Ab Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y uso como moduladores de SGRM
WO2016124722A1 (en) * 2015-02-06 2016-08-11 Astrazeneca Ab A process for the preparation of 3-5-{[(1r,2s)-2-[(2,2-difluoropropanyl)amino]-1 -(2,3-dihydro-1,4-benzodioxin-6-yl]propyl]oxy}-1h-indazol-1-yl)-n-[(3r)-tetrahydrofuran-3-yl] benzamide
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
AU2016323254B2 (en) * 2015-09-15 2020-08-20 Leo Pharma A/S Non-steroidal glucocorticoid receptor modulators for local drug delivery
WO2017161518A1 (en) 2016-03-23 2017-09-28 Astrazeneca Ab New physical form
RU2018135607A (ru) 2016-03-24 2020-04-24 Астразенека Аб Кристаллическая форма
CN106083837B (zh) * 2016-05-27 2018-08-31 浙江普洛得邦制药有限公司 一种噁唑烷酮类抗菌药物及其中间体的制备方法
AR113967A1 (es) 2017-12-18 2020-07-01 Gruenenthal Gmbh Pirrolidinamidas i sustituidas
TW201927769A (zh) 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ii
WO2020144375A1 (en) * 2019-01-11 2020-07-16 Grünenthal GmbH Substituted pyrrolidine amides iii
WO2020254551A1 (en) 2019-06-19 2020-12-24 Grünenthal GmbH Substituted pyrrolidine amides iv
WO2020254552A2 (en) 2019-06-19 2020-12-24 Grünenthal GmbH Substituted pyrrolidine amides v
US20230167068A1 (en) * 2019-12-31 2023-06-01 Medshine Discovery Inc. Benzopyrazole compound
WO2022008705A1 (en) 2020-07-09 2022-01-13 Grünenthal GmbH Substituted pyrrolidine amines and amides as mediator of the glucocortoid receptor
WO2023274040A1 (zh) * 2021-06-28 2023-01-05 南京明德新药研发有限公司 一种三唑并吡啶取代的吲唑类化合物的晶型及其制备方法
KR102571432B1 (ko) * 2023-02-08 2023-08-29 주식회사 에스씨엘테라퓨틱스 인다졸릴에스테르 및 아미드 유도체를 포함하는 암 치료용 조성물

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB607840A (en) 1946-02-12 1948-09-06 Bristol Aeroplane Co Ltd Improvements in or relating to means for feeding ammunition to automatic fire arms
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
DE3000377A1 (de) 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3514696A1 (de) 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
TW224462B (es) 1992-02-24 1994-06-01 Squibb & Sons Inc
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
CA2114981A1 (en) 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4323916A1 (de) 1993-07-16 1995-01-19 Basf Ag Substituierte 2-Phenylpyridine
US5834462A (en) 1993-07-26 1998-11-10 Eisai Co., Ltd. Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives
ES2173121T3 (es) 1993-08-30 2002-10-16 Bosch Robert Corp Combinacion de ventilador y carcasa.
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
US5545669A (en) 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
WO1996036595A1 (en) 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
TW542822B (en) 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
AR014195A1 (es) 1997-12-29 2001-02-07 Ortho Mcneil Pharm Inc Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos
CA2318731C (en) 1998-01-29 2012-05-29 Tularik Inc. Ppar-gamma modulators
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
CN1350452A (zh) 1999-05-13 2002-05-22 盐野义制药株式会社 糖尿病的预防或治疗药
US6569885B1 (en) 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
WO2002020474A2 (en) 2000-09-11 2002-03-14 Pfizer Products Inc. Resorcinol derivatives
FR2815030A1 (fr) 2000-10-05 2002-04-12 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
US6838074B2 (en) * 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
CA2460594A1 (en) 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
EP1447401A1 (en) 2001-11-22 2004-08-18 Ono Pharmaceutical Co., Ltd. Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient
CA2476186C (en) 2002-03-13 2011-07-19 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
US7282591B2 (en) 2002-04-11 2007-10-16 Merck & Co., Inc. 1h-benzo{f}indazol-5-yl derivatives as selective glucocorticoid receptor modulators
CA2485681C (en) 2002-05-24 2012-10-16 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
JP2004059116A (ja) 2002-07-31 2004-02-26 Sharp Corp ディスプレイ用基板収納用トレイ及びディスプレイ用基板の取り出し機構並びにディスプレイ用基板の取り出し方法
US20050113450A1 (en) 2002-08-23 2005-05-26 Atli Thorarensen Antibacterial agents
BR0313923A (pt) 2002-08-29 2005-07-12 Boehringer Ingelheim Pharma Derivados de 3-(sulfonamidoetil)-indol para uso como miméticos de glicocorticóide no tratamento de doenças inflamatórias, alérgicas e proliferativas
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
AU2004212985B2 (en) 2003-02-20 2010-10-14 Encysive Pharmaceuticals Inc. Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7297709B2 (en) * 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US20040235892A1 (en) * 2003-05-22 2004-11-25 Yujia Dai Indazole and benzisoxazole kinase inhibitors
BRPI0411275A (pt) 2003-06-10 2006-08-01 Kalypsys Inc compostos de carbonila como inibidores de histona deacetilase para tratamento de doenças; composição farmacêutica; método de modular a atividade catalìtica de hdac; método de tratar doença em um indivìduo; utilização de um composto ou composição; método de inibir hdac
EP1643960A2 (en) 2003-07-02 2006-04-12 Merck & Co., Inc. Arylsulfonamide derivatives
KR20060101772A (ko) 2003-12-19 2006-09-26 화이자 인코포레이티드 당뇨병 및 비만을 치료하기 위한,11-베타-하이드록시스테로이드 데하이드로게나제 유형1(11-베타-hsd-1)의 저해제로서의벤젠설폰일아미노-피리딘-2-일 유도체 및 관련 화합물
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
AU2005221140A1 (en) 2004-03-08 2005-09-22 Amgen Inc. Therapeutic modulation of PPAR (gamma) activity
DE102004028862A1 (de) 2004-06-15 2005-12-29 Merck Patent Gmbh 3-Aminoindazole
SE0402635D0 (sv) 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
US20090093485A1 (en) 2004-10-29 2009-04-09 Astrazeneca Ab Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases
SE0402636D0 (sv) * 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
WO2006108699A1 (en) 2005-04-14 2006-10-19 Glaxo Group Limited Indazoles as glucocorticoid receptor ligands
KR20080027828A (ko) 2005-06-10 2008-03-28 베링거 인겔하임 인터내셔날 게엠베하 글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
TW200815361A (en) 2005-10-20 2008-04-01 Astrazeneca Ab Chemical compounds
GB0522880D0 (en) 2005-11-09 2005-12-21 Glaxo Group Ltd Novel compounds
WO2007114763A1 (en) 2006-03-31 2007-10-11 Astrazeneca Ab Sulphonamide derivates as modulators of the glucocorticoid receptor
AU2007242851A1 (en) 2006-04-20 2007-11-01 Glaxo Group Limited Novel compounds
GB0607840D0 (en) 2006-04-20 2006-05-31 Glaxo Group Ltd Novel compounds
AU2007272504B2 (en) 2006-07-14 2012-06-28 Eli Lilly And Company Glucocorticoid receptor modulator and methods of use
GB0620385D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
GB0620406D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
ATE538099T1 (de) 2006-10-23 2012-01-15 Merck Sharp & Dohme 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden
US8067447B2 (en) 2006-11-01 2011-11-29 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、AP−1、および/またはNF−κB活性の調節剤、並びにその使用
US20120065173A1 (en) 2006-11-23 2012-03-15 Markus Berger Chemical compounds
TW200829578A (en) * 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
US8658637B2 (en) 2006-12-06 2014-02-25 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2008079073A1 (en) 2006-12-22 2008-07-03 Astrazeneca Ab Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders
WO2008124665A1 (en) 2007-04-10 2008-10-16 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2008124745A1 (en) 2007-04-10 2008-10-16 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB0708858D0 (en) 2007-05-08 2007-06-13 Glaxo Group Ltd Novel compounds
DE102007029419A1 (de) 2007-06-26 2009-01-02 Emsland-Stärke GmbH Filamentfaserschlichtemittel und Verwendung desselben
GB0720556D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720544D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720549D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720546D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720557D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0722211D0 (en) 2007-11-12 2007-12-27 Glaxo Group Ltd Novel compounds
GB0724254D0 (en) 2007-12-12 2008-01-23 Glaxo Group Ltd Novel compounds
WO2009108525A2 (en) 2008-02-26 2009-09-03 Merck & Co., Inc. Hexahydrocyclopentyl[f]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators
US8299048B2 (en) 2008-03-06 2012-10-30 Merck Sharp & Dohme Corp. Hexahydrocyclopentyl[f]indazole sulfonamides and derivatives thereof as selective glucocorticoid receptor modulators
UY31831A (es) 2008-05-20 2010-01-05 Astrazeneca Ab Derivados de indazoles sustituidos con fenilo o piridinilo

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