UY30882A1 - NAPADISILATE SALT DE5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLETOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONE AS ADRENERICAL RECEIVER AGONIST B2 - Google Patents
NAPADISILATE SALT DE5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLETOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONE AS ADRENERICAL RECEIVER AGONIST B2Info
- Publication number
- UY30882A1 UY30882A1 UY30882A UY30882A UY30882A1 UY 30882 A1 UY30882 A1 UY 30882A1 UY 30882 A UY30882 A UY 30882A UY 30882 A UY30882 A UY 30882A UY 30882 A1 UY30882 A1 UY 30882A1
- Authority
- UY
- Uruguay
- Prior art keywords
- difluoro
- amino
- hydroxyethyl
- phenyletoxi
- adrenerical
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 239000000556 agonist Substances 0.000 title 1
- 108700001623 hexadecaisoleucinomycin Proteins 0.000 title 1
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 title 1
- 229950005216 napadisilate Drugs 0.000 title 1
- -1 2,2-difluoro-2-phenylethoxy Chemical group 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60R—VEHICLES, VEHICLE FITTINGS, OR VEHICLE PARTS, NOT OTHERWISE PROVIDED FOR
- B60R21/00—Arrangements or fittings on vehicles for protecting or preventing injuries to occupants or pedestrians in case of accidents or other traffic risks
- B60R21/02—Occupant safety arrangements or fittings, e.g. crash pads
- B60R21/12—Occupant safety arrangements or fittings, e.g. crash pads which protect the occupants against personal attack from the inside or the outside of the vehicle
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Body Structure For Vehicles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sal de napasdisilato de 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]amino}-1-hidroxietil-8-hidroquinolin-2(1h)ona como agonista del receptor andrenérgico 2. La presente invencion se refiere a sales cristalinas novedosas del ácido naftaleno-1,5-disulfonico (napadisilatos) de 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]amino]-1hidroxietil)-8-hidroquinolin-2(1H)ona, sus enantiomeros y sus solvatos de formula general (I.La invencion tambien se refiere a composiciones farmaceuticas que comprendedn las sales cristalinas, procedimientos de usarlas para tratar enfermedades respiratorias asociadas a la actividad de los receptores adrenergicos 2 y procedimientos e intermedios utiles para preparar tales sales.Napasdisilate salt of 5- (2 - {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1-hydroxyethyl-8-hydroquinolin-2 (1h) one as an andrenergic receptor agonist 2. The The present invention relates to novel crystalline salts of naphthalene-1,5-disulfonic acid (napadisylates) of 5- (2 - {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino] -1hydroxyethyl) -8 -hydroquinolin-2 (1H) one, its enantiomers and its general formula solvates (I. The invention also relates to pharmaceutical compositions comprising crystalline salts, methods of using them to treat respiratory diseases associated with the activity of adrenergic receptors 2 and procedures and intermediates useful for preparing such salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200600362A ES2300178B1 (en) | 2006-02-16 | 2006-02-16 | SAFETY SHEET FOR VEHICLES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30882A1 true UY30882A1 (en) | 2008-07-31 |
Family
ID=39400657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30882A UY30882A1 (en) | 2006-02-16 | 2008-01-24 | NAPADISILATE SALT DE5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLETOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONE AS ADRENERICAL RECEIVER AGONIST B2 |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2300178B1 (en) |
| UY (1) | UY30882A1 (en) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4509788A (en) * | 1982-12-14 | 1985-04-09 | Jan Ping Shuenn | Safety arrangement in a taxi |
| BR6602562U (en) * | 1986-12-30 | 1988-07-12 | Satoru Inomae | CAB FOR PROTECTION AGAINST THEFT IN VEHICLES |
| DE4302265A1 (en) * | 1993-01-28 | 1994-08-04 | Josef Mueller | Protective cage for driver in public service vehicle |
| ES1024458Y (en) * | 1993-04-07 | 1994-04-16 | Distribuciones Especiales Rome | PERFECTED WINDOW. |
| ES2183722B1 (en) * | 2001-06-21 | 2008-10-16 | Oscar Bujalance España | PROTECTIVE WALL FOR TAXI BY PARTS. |
| CN2513839Y (en) * | 2001-09-29 | 2002-10-02 | 仲蕴 | Anti-hijack isolating device for taxi |
| CN2590809Y (en) * | 2002-12-06 | 2003-12-10 | 张宝库 | Vehicle driver lower position antirobbing protective screen |
| CA2424286C (en) * | 2003-04-01 | 2005-06-21 | Glen Naylor | Automotive partition to separate and protect driver from other passengers |
| CN2827792Y (en) * | 2005-09-28 | 2006-10-18 | 上海大众汽车有限公司 | Fender rail on taxi |
-
2006
- 2006-02-16 ES ES200600362A patent/ES2300178B1/en not_active Expired - Fee Related
-
2008
- 2008-01-24 UY UY30882A patent/UY30882A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2300178B1 (en) | 2009-05-01 |
| ES2300178A1 (en) | 2008-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013032415A2 (en) | "trans-7-oxo-6- (sulfooxy) -1,6-diazabicyclo [3,2,1] octane-2-carboxyamide and ({[(2s, 5r) -2-carbamoyl-7-oxo] 1,6-diazabicyclo [3.2.1] oct-6-5 yl] oxy} sulfonyl) oxidanide, processes for their preparation, and intermediates ". | |
| CO6531496A2 (en) | AMIDAS REPLACED WITH HALOGENOQUALOUS AS INSECTICIDES AND ACARICIDES | |
| PE20110672A1 (en) | 4-PHENYL-1-H-PYRAZOLES INSECTICIDES | |
| BRPI0918370B8 (en) | 5-(2-{[6-(2,2-difluoro-2-phenylaethoxy)hexyl]amine}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one mesylate salt as a b2 adrenergic receptor agonist and pharmaceutical composition | |
| AR072557A1 (en) | PROCESS TO PREPARE COMPOSITIONS OF DRUGS CONTAINING DABIGATRAN | |
| CO6311079A2 (en) | AMINODIHYDROTIAZINE DERIVATIVES AS INHIBITORS OF THE BACE ENZYME FOR THE TREATMENT OF ALZHEIMER'S DISEASE | |
| BR112015021336A2 (en) | perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use | |
| CR11393A (en) | NEW AGONISTS OF GLUCOCORTICOID RECEPTORS | |
| PE20151602A1 (en) | SALTS OF DERIVATIVES OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2 (1H) -ONE THAT HAVE AGONISTIC ACTIVITY OF THE B (beta) 2 ADRENERGIC RECEPTOR AS WELL AS ANTAGONIST ACTIVITY OF THE MUSCARINIC RECEPTOR M3 | |
| TR201903556T4 (en) | Diamide compounds with muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity. | |
| DE602006019595D1 (en) | BENZIMIDAZOLONCARBOXYL ACID AMID COMPOUNDS AS AGONISTS OF THE 5-HT4 RECEPTOR | |
| BR112015028452A2 (en) | somastatin subtype 4 receptor agonists (sstr4) | |
| PE20090891A1 (en) | DIPEPTOID PRO-DRUGS AS AGONISTS OF ADENOSINE A1 RECEPTORS | |
| PE20160173A1 (en) | 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2 (1H) -ONE DERIVATIVE SALTS THAT HAVE ANTAGONISTIC ACTIVITY OF MUSCARINIC RECEPTORS AS WELL AS AGONIST ACTIVITY OF THE ß2 ADRENERGIC RECEPTOR | |
| NI200700319A (en) | NIACINE RECEIVER AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND TREATMENT PROCEDURES. | |
| CY1119452T1 (en) | A METHOD OF PREPARATION OF 2-ETHOXY-1- (2 '- (((HYDROXYAMINO) IMINOMETHYL) DIFFINYL-4-YL) METHYL) -1H-Benzo (D) imidazolu-7-carboxyl | |
| ECSP11011485A (en) | SPIRO-EPOXIDS AS INTERMEDIATE PRODUCTS. | |
| CU20220064A7 (en) | HETEROCYCLIC COMPOUNDS AS AGONISTS OF THE ACTIVATION RECEPTOR EXPRESSED ON MYELOID CELLS 2 | |
| CL2020001589A1 (en) | Process for the preparation of quinoline derivatives. | |
| CU20220065A7 (en) | HETEROCYCLIC COMPOUNDS AS AGONISTS OF THE ACTIVATION RECEPTOR EXPRESSED ON MYELOID CELLS 2 | |
| EA201290558A1 (en) | AGONISTS MGLU2 | |
| MA35188B1 (en) | Cycloalkylated tetrahydroquinolines as modulators of crth2 receptor activity | |
| CO2017003305A2 (en) | 2- [Pyridin-3-yl] -2,3-dihydro-benzo [1,4] dioxin-5-carboxylic acid or 2- [pyridin-3-yl] -2,3-dihydro amide derivatives -benzo [1,4] dioxin-5-carbonitrile as aldosterone synthase inhibitors | |
| PH12014502097B1 (en) | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the �2 adrenergic receptor. | |
| GT200800255A (en) | METHOD FOR PREPARING 4-HALOGENATED QUINOLINE INTERMEDIATES |