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US3882863A - Hypodermic injection device having cannula covered with resilient sheath - Google Patents

Hypodermic injection device having cannula covered with resilient sheath Download PDF

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Publication number
US3882863A
US3882863A US384682A US38468273A US3882863A US 3882863 A US3882863 A US 3882863A US 384682 A US384682 A US 384682A US 38468273 A US38468273 A US 38468273A US 3882863 A US3882863 A US 3882863A
Authority
US
United States
Prior art keywords
cannula
sheath
cartridge
sleeve
holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US384682A
Other languages
English (en)
Inventor
Stanley J Sarnoff
George B Calkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meridian Medical Technologies Inc
Original Assignee
Survival Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Survival Technology Inc filed Critical Survival Technology Inc
Priority to US384682A priority Critical patent/US3882863A/en
Priority to NL7410081.A priority patent/NL160725C/xx
Priority to DE2436000A priority patent/DE2436000C2/de
Priority to CH1042074A priority patent/CH573753A5/xx
Priority to SE7409781A priority patent/SE406269B/xx
Priority to BR6227/74A priority patent/BR7406227D0/pt
Priority to IT69409/74A priority patent/IT1016723B/it
Priority to PH16108A priority patent/PH11120A/en
Priority to IT69410/74A priority patent/IT1016724B/it
Priority to GB3343074A priority patent/GB1449986A/en
Priority to AT621774A priority patent/AT353944B/de
Priority to DK405374A priority patent/DK154472C/da
Priority to AR254967A priority patent/AR202226A1/es
Priority to ES428770A priority patent/ES428770A1/es
Priority to BE147099A priority patent/BE818268A/xx
Priority to AU71854/74A priority patent/AU484902B2/en
Priority to FR7426748A priority patent/FR2239258B1/fr
Priority to JP49087595A priority patent/JPS5038983A/ja
Priority to IN1768/CAL/74A priority patent/IN140663B/en
Application granted granted Critical
Publication of US3882863A publication Critical patent/US3882863A/en
Priority to HK102/78A priority patent/HK10278A/xx
Priority to JP1982144849U priority patent/JPS5892950U/ja
Assigned to FIRST PENNSYLVANIA BANK N.A. reassignment FIRST PENNSYLVANIA BANK N.A. SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SURVIVAL TECHNOLOGY, INC., A DE CORP.
Assigned to SURVIVAL TECHNOLOGY, INC. reassignment SURVIVAL TECHNOLOGY, INC. RELEASED BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: FIRST PENNSYLVANIA BANK N.A.
Anticipated expiration legal-status Critical
Assigned to SURVIVAL TECHNOLOGY INC. reassignment SURVIVAL TECHNOLOGY INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: ESTATE OF STANLEY J. SARNOFF C/O ROBERT E. HERZSTEIN SHEARMAN & STERLING
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock

Definitions

  • Fie'ld 218 DA poule including a cylindrical sleeve slidably carrying a 128/218 NV M R piston, the sleeve being open at one end and having a 218 g necked portion at the other end to receive a hub mounting the cannula, fluid medicament in the sleeve between the piston and cannula, a spring power as- [56] References cued sembly for moving the cartridge forward and for in- UNITED STATES PATENTS jecting the fluid medicament carried in the ampoule, a 2,752,918 7/1956 Uytenbogaart 128/218 F afety assembly for controlling actuation of the spring 2,847,995 8/1958 Adams 128/218 N power assembly, and a resilient sheath Covering the ;6 cannula to maintain the cannula in
  • HYPODERMIC INJECTION DEVICE HAVING CANNULA COVERED WITH RESILIENT SHEATH SUMMARY OF THE INVENTION This invention relates to injection devices of the gun type wherein spring power means drives an ampoule and cannula to insert the cannula and then inject the medicament.
  • the cannula is provided with a resilient sheath to maintain the cannula in sterile condition at 'all times prior to injection.
  • the ampoule and attached cannula are slidably carried in a cylindrical holder which is closed at the end housing the cannula except for an aperture through which the cannula passes when the unit is actuated.
  • a spring power assembly drives a plunger which engages the ampoule to drive the ampoule and cannula forward causing the cannula to travel out through the aperture in the closed end of the cylindrical holder and to enter the locus which is to receive the fluid medicament.
  • the resilient sheath positioned on and over the cannula is held within the closed end of the cylindrical holder and is pierced by the end of the cannula as it proceeds forwardly.
  • the sheath is compressed between the closed end of the cylindrical holder and the cannula hub. This action continues until the cannula is fully extended, at which time the sheath is not quite fully compressed, thus making it possible for the sheath to act as a shock absorber at all times during forward travel of the cannula.
  • the forward travel of the power spring is such that its energy is less than that now stored in the compressed sheath. Therefore, a. slight retraction of the cannula occurs during the terminal portion of the injection.
  • FIG. 1 is a longitudinal broken away view, partly in section, illustrating the sheath as applied to the cannula when the injection device is in ready position;
  • FIG. 2 is a view similar to FIG. 1, showing the compressed sheath after firing of the injection device with the cartridge fully projected and just prior to the forward movement of the plunger and injection of the medicament;
  • FIG. 3 is a view similar to FIG. 2, illustrating a slight retraction of the cannula from the fully extended position of FIG. 2 which .retraction occurs during the terminal portion of the injection.
  • a cartridge assembly 106 is assembled in the shouldered end of the outer sleeve 100.
  • the cartridge assembly 106 includes a cartridge holder sleeve 104 fitted within the sleeve 100 and having a decreased forward end portion 153 forming a shoulder 154 which fits against seat 112 provided by outer sleeve shoulder 110.
  • the extreme forward end portion 156 of the holder sleeve 104 is tapered to form a small circular aperture.
  • the cartridge 135 includes an ampoule cylinder 136 with liquid medicament 146 there within and a piston 148 at one end with a cannula 150 at the other end.
  • the ampoule cylinder 136 has a necked portion with a diameter less than that of the cylinder I36 and terminates in an enlarged annular flange.
  • the cannula 150 is secured to a cannula hub 81 which in turn is affixed to the enlarged flange on the necked portion 80. More specifically, cannula hub 81 comprises a reduced diameter portion 84 which is secured to cannula 150 and an intermediate body 86 connected to enlarged body 88.
  • the enlarged body 88 fits over and is secured to the annular flange of the necked portion 80 of the ampoule cylinder.
  • a fluid pressure rupturable diaphragm generally like that described in US. Pat. No. 3,391,695 to Sarnoff.
  • the cartridge assembly 106 is assembled in the outer sleeve with the cannula 150 spaced from the apertured end of the holder 104.
  • the overall length of the ampoule and cannula is such that it is all contained within the holder sleeve 104, as illustrated in FIG. 1.
  • the outer sleeve 100 is of such length that it accommodates the cartridge assembly 106 in one end and receives the gun assembly 200 in the other to complete the device.
  • the gun assembly 200 comprises an inner gun sleeve 101 having an out turned flange 103 which fits up against the end of the cartridge holder sleeve 104 when the gun assembly is inserted in the outer sleeve 100.
  • the other end of the inner gun sleeve 101 is centrally apertured to form a hole 120.
  • the rear outer face 122 of the inner gun sleeve 10] is planar and perpendicular to the longitudinal axis of the sleeve for a purpose to be brought out later.
  • a plunger 162 fits within the out turned flange end of the inner gun sleeve 101.
  • This plunger has a cylindrical body portion 163 and a circular head portion 164 of a diameter larger than the body portion 163 and generally slightly less than that of the piston 148 in the ampoule 135.
  • the head 164 has an opening which is sized to align and correspond to the through hole 166 in the plunger body 163.
  • the plunger head 164 is provided with a plurality of circumferentially spaced, radially extending tabs 168. These tabs 168 form a diameter greater than that of the plunger head 164 so that the tabs will engage the end of the ampoule cylinder 136.
  • Longitudinal slots 172 are formed in the plunger head 164 immediately behind the tabs 168. These slots are sized so that they will accommodate the tabs 168 when they are later broken off or bent rearwardly in the operation of the device. These slots extend throughout the length of the head behind the tabs.
  • a locking detent 176 is fitted through the hole 166 in the plunger 162 and has a central body portion 178 with outwardly extending lugs 180 on one end fitting an annular shoulder 182 of the plunger head 164.
  • the other end of the locking detent 176 is provided with four equally spaced, longitudinally extending springy detent arms terminating in frusto-conical detent heads 186.
  • This locking detent 176 maintains the plunger 162 and inner gun sleeve 101 in assembled position with a coil spring 138 compressed therebetween as follows: A coil spring 138 is positioned over the plunger body 163 and abuts the plunger head 164 at one end and the inner face of the end wall of the inner sleeve 101 at the other. Upon compressing of the coil spring 138 sufficiently, the detent heads 186 will be cammed inwardly by engaging the periphery of the end wall opening 120 and pass therethrough whereupon the bases of the detent heads 186 will come to rest on the planar face 122 of the inner gun sleeve 101 to retain the plunger and inner gun sleevein assembled condition with the coil spring 138 compressed therebetween.
  • the rear planar surface 122 of the inner sleeve 101 may be overlaid with a metal washer 127, in which case it is advan tageous to provide a guide and holding flange 128 to surround the opening 120.
  • the flange 128 is provided with a lip portion to retain the washer in place.
  • the inner gun sleeve 101 has a plurality of longitudinally extending raised ribs 129 running from the flange 103 approximately one-half the length of the said sleeve.
  • An outer gun sleeve 192 fits over inner gun sleeve 101 and is sized to frictionally engage ribs 129.
  • the outer sleeve 192 has a closed end 194 with a central aperture 196 from which extends a frusto-conical cam surface 198 sized and shaped to cooperate with frusto-conical detent heads 186 to cam said heads radially inwardly.
  • the outer gun sleeve 192 is provided with a circumferential locking rib 199 which fits in groove 113 in the outer sleeve 102 to retain the gun assembly 200 in position in said outer sleeve. It should be noted that the length of outer gun sleeve 192 is slightly less than that of the inner gun sleeve 101 so as to make certain that there will be space between the inner wall of the outer gun sleeve 192 and the flange 103 of the inner gun sleeve 101 so that the two gun sleeves may move relative to each other to ca'm frusto-conical detent heads 186 inwardly in operating the device.
  • a safety pin assembly is provided.
  • This safety pin assembly comprises a cap 142 having a cylindrical sleeve 143 sized to fit over the end portion of outer gun sleeve 192.
  • a safety pin 144 extends inwardly from the center of the cap 142 into the opening formed by the inner portions of the detent heads 186 to thereby prevent inward movement of said detent heads.
  • the cap 142 is provided internally with a plurality of spacer abutments 145 to assure proper positioning of the cap on the outer abuts the shoulder 82 formed by hub portions 84 and 86.
  • the length of the sheath is such that its closed end is slightly beyond or spaced from the end of cannula 150.
  • a plurality of ribs 157 is formed on the inner face of tapered holder portion 156 surrounding said aperture.
  • the cartridge assembly 106 moves forward whereby the sheath 250 is compressed between the cannula end of the cartridge holder sleeve 104 and the hub shoulder 82, as illustrated in FIG. 2.
  • the cannula sheath in being compressed, acts as a shock absorber to gradually absorb some of the energy provided by the power spring 138 as it drives the cartridge assembly 106 forward. It should be noted that at no time, even when the cannula is fully extended, is the sheath compressed to such an extent that it would act as a solid and thereby provide no shock absorbing in such a condition.
  • the cannula sheath 250 When the cannula 150 is fully extended as shown in FIG. 2, the cannula sheath 250 will be compressed the greatest amount hence the largest reactionary force will exist in the compressed sheath in such position. As illustrated in FIG. 2, the cartridge has completed its travel under the force of spring 138 and the forward movementaof piston 148 commences under the action of spring 138 to start the injection cycle.
  • the size of the sheath is such that in the maximum compressed condition, as in FIG. 2, the forces stored in the sheath are greater than those in spring 138 when it has reached a point just short of full piston travel.
  • the compressed sheath 250 takes over and causes the cartridge 135 and attached cannula 150 to retract slightly, as shown in FIG. 3, while the last stage of injection takes place. It is at this stage that the forces of the compressed sheath and the spring 138 are counterbalanced.
  • the sheath 250 and its multiple features is even more important when consideration is taken of the fact that most of the ampoule cylinders (i.e. cylinder 136 of the device illustrated) are made of glass and hence are subject to breakage under certain amounts and types of shock.
  • the shock absorbing feature enjoyed by the use of the cannula sheath of this invention contributes substantially to overall quality and reliability.
  • the covering of the cannula with the sheath provides greater ease in assembly since it is not necessary to maintain any of the inner portions of the holder and associated elements in sterile condition.
  • the type of material from which the sheath 250 can be made varies substantially. Even so, the preferred material would be one having good resilient characteristics such as various types of rubber and synthetics. Shelf life is also important. By this it is meant that the material should retain its characteristics over a substantial period of time and under varied conditions.
  • a hypodermic injection device comprising a gun, a cartridge holder in operative relationship to the gun, a cartridge within the holder, said gun comprising a sleeve open at one end thereof, a plunger positioned within the sleeve, spring power means acting on said plunger tending to move it out the open end of the sleeve, restraining means cooperating with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative, said cartridge holder comprising a hollow shell acting as a prolongation of the gun sleeve, said cartridge including an ampoule comprising a hollow cylindrical sleeve, a piston slidably positioned in one end thereof and means mounting a cannula extending from and closing off the other end, a fluid within the cylindrical sleeve between the piston and the cannula, the cartridge fitting within the cartridge holder with the free end of the cannula within the end of the holder remote from the gun, the improvement comprising
  • a resilient sheath covering the cannula, said sheath having a closed end and an open end, the length of the sheath being sized such that when assembled on the cannula the closed end of the sheath is not pierced by the cannula end, and means for preventing forward movement of the closed end of the sheath whereby when the power means forces the cartridge forward the cannula will pierce the closed end of the sheath and deliver the fluid medicament from the ampoule sleeve.
  • the resilient sheath comprises a resilient cylinder having a closed and an open end, the length of the sheath being sized such that the closed end thereof is spaced from the cannula end.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US384682A 1973-08-01 1973-08-01 Hypodermic injection device having cannula covered with resilient sheath Expired - Lifetime US3882863A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
US384682A US3882863A (en) 1973-08-01 1973-08-01 Hypodermic injection device having cannula covered with resilient sheath
DE2436000A DE2436000C2 (de) 1973-08-01 1974-07-26 Selbsttätige Injektionsspritze
NL7410081.A NL160725C (nl) 1973-08-01 1974-07-26 Automatische injectiespuit.
SE7409781A SE406269B (sv) 1973-08-01 1974-07-29 Injiceringsanordning
CH1042074A CH573753A5 (ja) 1973-08-01 1974-07-29
IT69409/74A IT1016723B (it) 1973-08-01 1974-07-29 Siringa per iniezioni ipodermiche con cannula coperta con guaina ela stica
PH16108A PH11120A (en) 1973-08-01 1974-07-29 Hypodermic injection device having cannula covered with resilient sheath
IT69410/74A IT1016724B (it) 1973-08-01 1974-07-29 Siringa per iniezioni ipodermiche con cannula coperta con guaina ela stica
GB3343074A GB1449986A (en) 1973-08-01 1974-07-29 Hypodermic syringe
AT621774A AT353944B (de) 1973-08-01 1974-07-29 Injektionsvorrichtung
DK405374A DK154472C (da) 1973-08-01 1974-07-29 Injektionsproejte
BR6227/74A BR7406227D0 (pt) 1973-08-01 1974-07-29 Aperfeicoamento em dispositivo para injecao hipoderimica
AR254967A AR202226A1 (es) 1973-08-01 1974-07-30 Dispositivo de inyeccion hipodermica que tiene una canula cubierta con una funda elastica
ES428770A ES428770A1 (es) 1973-08-01 1974-07-30 Perfeccionamientos introducidos en un dispositivo de inyec- cion hipodermica.
BE147099A BE818268A (fr) 1973-08-01 1974-07-30 Dispositif d'injection
AU71854/74A AU484902B2 (en) 1973-08-01 1974-07-31 Hypodermic injection device having cannula covered with resilient sheath
JP49087595A JPS5038983A (ja) 1973-08-01 1974-08-01
FR7426748A FR2239258B1 (ja) 1973-08-01 1974-08-01
IN1768/CAL/74A IN140663B (ja) 1973-08-01 1974-08-06
HK102/78A HK10278A (en) 1973-08-01 1978-02-23 Hypodermic syringe
JP1982144849U JPS5892950U (ja) 1973-08-01 1982-09-27 皮下注射装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US384682A US3882863A (en) 1973-08-01 1973-08-01 Hypodermic injection device having cannula covered with resilient sheath

Publications (1)

Publication Number Publication Date
US3882863A true US3882863A (en) 1975-05-13

Family

ID=23518311

Family Applications (1)

Application Number Title Priority Date Filing Date
US384682A Expired - Lifetime US3882863A (en) 1973-08-01 1973-08-01 Hypodermic injection device having cannula covered with resilient sheath

Country Status (18)

Country Link
US (1) US3882863A (ja)
JP (2) JPS5038983A (ja)
AR (1) AR202226A1 (ja)
AT (1) AT353944B (ja)
BE (1) BE818268A (ja)
BR (1) BR7406227D0 (ja)
CH (1) CH573753A5 (ja)
DE (1) DE2436000C2 (ja)
DK (1) DK154472C (ja)
ES (1) ES428770A1 (ja)
FR (1) FR2239258B1 (ja)
GB (1) GB1449986A (ja)
HK (1) HK10278A (ja)
IN (1) IN140663B (ja)
IT (2) IT1016724B (ja)
NL (1) NL160725C (ja)
PH (1) PH11120A (ja)
SE (1) SE406269B (ja)

Cited By (88)

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US4031893A (en) * 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4484910A (en) * 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
WO1986001120A1 (en) * 1984-08-08 1986-02-27 Survival Technology, Inc. Injection method and apparatus with electrical blood absorbing stimulation
US4624660A (en) * 1984-11-02 1986-11-25 Duphar International Research B.V. Automatic injection device
US4658830A (en) * 1984-08-08 1987-04-21 Survival Technology, Inc. Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms
US4678461A (en) * 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
US4723937A (en) * 1985-05-20 1988-02-09 Survival Technology, Inc. Plural dosage automatic injector with a by-pass fitment
US4795433A (en) * 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
US4822340A (en) * 1985-10-11 1989-04-18 Duphar International Research B.V. Automatic injector
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
DE4037418A1 (de) * 1989-11-28 1991-05-29 Glaxo Group Ltd Zufuehrvorrichtung fuer fluessige medikamente
US5026349A (en) * 1988-10-05 1991-06-25 Autoject Systems Inc. Liquid medicament injector system
WO1991016094A1 (en) * 1990-04-12 1991-10-31 Survival Technology, Inc. Dispersion multi-chamber auto-injector
US5085642A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5085641A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US5092842A (en) * 1987-05-08 1992-03-03 Wilhelm Haselmeier Gmbh & Co. Injection device with a cocking element and a second setting element
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5167641A (en) * 1991-05-29 1992-12-01 Arnis, Inc. Auto-retracting needle injector system
US5167632A (en) * 1992-01-24 1992-12-01 New Potency Products, Inc. Syringe
US5273544A (en) * 1991-06-13 1993-12-28 Duphar International Research B.V. Injection device
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US5391151A (en) * 1991-01-15 1995-02-21 Survival Technology, Inc. Subcutaneous injector
US5405362A (en) * 1991-04-29 1995-04-11 The Board Of Regents For The University Of Texas System Interactive external defibrillation and drug injection system
JPH07308386A (ja) * 1993-11-15 1995-11-28 Phase Medical Inc 医療器具を挿入しその後保護する安全装置
US5478316A (en) * 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
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US5599315A (en) * 1995-12-01 1997-02-04 Charles J. McPhee Syringe actuation device
US5800405A (en) * 1995-12-01 1998-09-01 I-Flow Corporation Syringe actuation device
WO1999020327A2 (en) 1997-10-21 1999-04-29 I-Flow Corporation Spring-actuated infusion syringe
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US20040002684A1 (en) * 1991-12-18 2004-01-01 Lopez George A. Fluid transfer device and method of use
US20040039337A1 (en) * 2002-08-21 2004-02-26 Letzing Michael Alexander Portable safety auto-injector
US6712794B2 (en) 2001-08-21 2004-03-30 Spinal Specialties, Inc. Apparatus for delivering a viscous liquid to a surgical site
US20040215151A1 (en) * 2001-07-28 2004-10-28 Jeremy Marshall Injection devices
US20050038392A1 (en) * 2003-08-11 2005-02-17 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
US20050171477A1 (en) * 2002-05-23 2005-08-04 Seedlings Life Science Ventures Apparatus and method for rapid auto-injection of medication
US20050222539A1 (en) * 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
US20050277895A1 (en) * 2000-08-02 2005-12-15 Becton, Dickinson And Company Pen needle and safety system
US20050283115A1 (en) * 2000-08-02 2005-12-22 Lucio Giambattista Pen needle and safety shield system
US20060178634A1 (en) * 2004-12-06 2006-08-10 Wyrick Ronald S Medicine injection devices and methods
US20070017533A1 (en) * 2004-12-06 2007-01-25 Washington Biotech Corporation Method and apparatus for delivering epinephrine
US20070203247A1 (en) * 2006-02-28 2007-08-30 Elaine Phillips Epinephrine dosing regimens
US20070293582A1 (en) * 2006-06-05 2007-12-20 Malcolm Hill Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms
US20080039789A1 (en) * 2004-12-06 2008-02-14 Wyrick Ronald E Medicine injection devices and methods
US20080051715A1 (en) * 2004-08-06 2008-02-28 Young Matthew E Automatic injector with kickback attenuation
US20080097312A1 (en) * 2006-10-18 2008-04-24 Wilmot John G Autoinjector with needle depth adapter
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DE2436000C2 (de) 1983-10-13
BE818268A (fr) 1975-01-30
ATA621774A (de) 1979-05-15
DK405374A (ja) 1975-03-24
SE7409781L (ja) 1975-02-03
FR2239258A1 (ja) 1975-02-28
IT1016724B (it) 1977-06-20
AT353944B (de) 1979-12-10
DE2436000A1 (de) 1975-02-13
BR7406227D0 (pt) 1975-05-20
AR202226A1 (es) 1975-05-23
DK154472B (da) 1988-11-21
DK154472C (da) 1989-04-10
NL160725B (nl) 1979-07-16
CH573753A5 (ja) 1976-03-31
JPS5892950U (ja) 1983-06-23
IT1016723B (it) 1977-06-20
AU7185474A (en) 1976-02-05
NL160725C (nl) 1979-12-17
GB1449986A (en) 1976-09-15
SE406269B (sv) 1979-02-05
PH11120A (en) 1977-10-27
ES428770A1 (es) 1977-01-16
IN140663B (ja) 1976-12-11
HK10278A (en) 1978-03-03
FR2239258B1 (ja) 1981-12-24
NL7410081A (nl) 1975-02-04
JPS5038983A (ja) 1975-04-10

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