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US2543248A - Device for the medical treatment of persons with high-frequency energy - Google Patents

Device for the medical treatment of persons with high-frequency energy Download PDF

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US2543248A
US2543248A US683593A US68359346A US2543248A US 2543248 A US2543248 A US 2543248A US 683593 A US683593 A US 683593A US 68359346 A US68359346 A US 68359346A US 2543248 A US2543248 A US 2543248A
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energy
frequency
patient
treatment
frequency energy
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Ledeboer Johan Marie
Fransen Jacobus
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Hartford National Bank and Trust Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Definitions

  • the invention relates to a device for the medical treatment of persons by means of high-frequency energy.
  • Such a device usually consists of a high-frequency oscillator which serves to generate the high-frequency energy required for the treatment and of a treating element, for example a coil or a set of condenser electrodes for producing a magnetic or electric field of high frequency, by means of which the high-frequency energy is supplied to that part of the patients body which is to be treated.
  • a treating element for example a coil or a set of condenser electrodes for producing a magnetic or electric field of high frequency, by means of which the high-frequency energy is supplied to that part of the patients body which is to be treated.
  • the invention has for its object to remove this drawback. According to the invention, there is provided to that end a regulating device which serves to keep the high-frequency energy supplied to the treating element automatically constant or at least substantially constant.
  • the treating physician has the assurance that the amount of energy supplied to the patient (dose) is really equal to the treatment energy adjusted before-hand multiplied by the duration of the treatment.
  • the time constant ofthe regulating device should be sumciently small or in other words that the rapidity of the regulation should be great enough to be able to follow any movement of the patient, for example the breathing movement or movements of fright of nerve-patients.
  • the time constant of the regulating device is of the order of magnitude of 0.5 second; in practice, however, the optimum value may appreciably differ from the given value; it may be, for example,ten times as large or ten times as small as that value.
  • the regulating device is preferably controlled by a regulating magnitude (regulating voltage or current) which depends on the energy supplied to the treating element (treatment energy),
  • ther possibility consists in that the regulating voltage is derived from the energy which is taken up by the high-frequency oscillator from the source of supply current to which the de vice is connected, said energy being also approximately proportional to the treatment energy.
  • This energy may be maintained constant by automatically regulating the energy generated 1 by the oscillator.
  • the regulating voltage may be supplied to one or more electrodes whose bias voltages act upon the en ergy generated, for example to one or more grids, of one or more oscillator tubes. It is .also possible to have the coupling between the load impedance and the oscillator, which coupling infiuences the energy supplied by the oscillator to the treating element, controlled by the regulating voltage.
  • a third possibility is to have the regulating voltage act upon the tuning of the device.
  • the latter form of construction of the regulating device may be utilized if the impedance formed by the treating element and the part of the body to be treated forms part of a separate oscillatory circuit which is coupled to the high-frequency oscillator and which is tuned to a frequency located in the neighbourhood of the frequency of the generated oscilla tions (load circuit).
  • the regulating voltage preferably controls in this case the tuning of the load circuit, in which event the energy supplied to the treating element is regulated by more or less great detuning of the load circuit with respect to the frequency of the generated oscillations.
  • the device represented in the figure comprises a tube I which is connected in the ordinary manner as an inductivelv back-coupled oscillator having a coil 3 included in the anode circuit coupled, by means of a coupling coil 5 and a transmission line I, to a treating element which is constituted in the instance illustrated by two condenser electrodes 9-9 which are arranged on either side of the part of the body that is to be treated.
  • the coil 5, the transmission line 1-4 and the electrodes 9-9 form a separate oscillatory circuit (load circuit) which may be tuned, by means of a condenser H] which is connected in parallel with the coil 5, to the frequency of the oscillations generated by the oscillator I.
  • the load impedance present between the electrodes 9-9 varies with the result that the tuned load circuit 5-l-9l0 loses its exact adjustment.
  • the variation of the load impedance consists in a variation of the resistance component and/or of the reactive component of this impedance; they both cause a variation of the treatment energy.
  • means are utilized for automatically maintaining the treatment energy substantially constant.
  • these means include a condenser 12 which is formed by two concentric metal cylinders H and I3 and which can be connected in parallel with the tuning condenser H] by means of a switch l5.
  • the capacity of the condenser I2 can be varied by filling the space between the cylinders H and G3 with a liquid having a high dielectric constant, for example with oil.
  • this space communicates with a pump cylinder I! provided with a piston 19 whose movement is controlled by a driving device dependent upon the anode current of the tube l.
  • the driving device comprises arm 24 coupled to piston l9 and to an armature 23 of electromagnet 22.
  • the armature 23 is loaded by means of spring 25 which is capable of exerting a varying tension by means of screw adjustment 26. Armature 23 is drawn into the coil 22 to a varying degree depending upon the strength of anode current flowing through the coil.
  • the treatment is started by adjusting condenser I so that the treatment energy supplied to the electrodes 9 is at its maximum, which fact can be ascertained with the aid of a suitable measuring instrument (not shown).
  • the condenser [2 which is now, for example, halfway filled with oil, is connected in parallel with the condenser ID by means of the switch [5, with the result that the oscillatory circuit 5l0 is detuned and the treatment energy decreases. This decreased value is then maintained by the device according to the invention.
  • the treatment energy increases the anode current of the tube I also increases, which causes such a displacement of the piston i9 that the capacity of the condenser l2 and therefore the detuning of the oscillatory circuit 5
  • a therapeutic device for the treatment of a patient by means of high frequency energy comprising a generator of high frequency energy, means to supply power to said generator, an oscillatory circuit coupled to said generator and comprising a variable capacitor and means for applying the high frequency energy to said patient, said patient constituting an impedance across said oscillatory circuit which is subject to variation, said oscillatory circuit being tuned by means of said variable capacitor to a frequency approximating the frequency of the generated energy, said variable capacitor comprising two spaced conductors and a liquid of high dielectric constant interposed between said conductors, and means responsive to the power supplied to said generator to vary the amount of said liquid interposed between said conductors to adjust the frequency of said oscillatory circuit and maintain the energy applied to said patient at a substantially constant value regardless of variations in said impedance.
  • a therapeutic device for the treatment of a patient by means of high frequency energy comprising a generator of high frequency energy, means to supply power to said generator, an oscillatory circuit coupled to said generator and comprising a variable capacitor and means for applying the high frequency energy to said patient, said patient constituting an impedance across said oscillatory circuit which is subject to variation, said oscillatory circuit being tuned to a frequency approximating the frequency of the generated energy, said variable capacitor comprising two spaced concentric conductors electrically insulated from each other and a liquid of high dielectric constant interposed between said conductors, and means responsive to the power supplied to said generator to vary the amount of said liquid between said conductors to vary the frequency of said oscillatory circuit and maintain the energy applied to said patient at a substantially constant value regardless of variations in said impedance.
  • a therapeutic device for treating a patient with high-frequency energy comprising a generator producing high frequency energy including an electron discharge tube having a cathode, a control electrode and an anode, a resonant output circuit coupled between said cathode and said anode, and means establishing direct-current flow between said cathode and said anode; a load circuit coupled to said output circu t for applying high-frequency energy to said patient, said patient constituting in said load circuit an impedance subject to variation; means in the circuit for tuning said load circuit; and means coupled to the output circuit responsive to variations in said direct-current flow for adjusting said tuning means to maintain constant the energy supplied to said patient.
  • a therapeutic device for treating a patient with high-frequency energy comprising a generator producing high-frequency wave energy including an electron discharge tube having a cathode, a grid and an anode, a resonant out put circuit coupled between said cathode and said anode, and means establishing direct-current flow between said cathode and said anode; a load circuit coupled to said output circuit for applying high-frequency energy to said patient; a variable condenser coupled to said load circuit 5 6 for tuning same, said patient constituting in said UNITED STATES PATENTS load circuit an impedance subject to variation; Number Name Date and means including an electro-magnet respon- 2 076 289 Bechmann et Apt 6 1937 sive to variations in said direct-current flow for 2099511 Caesar "'i 1937 adjusting said condenser to an extent and in a 5 2l05096 1938 direction inaintaining ii'esrtmancetbetween said 2114036 smith et 1938 load circui

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)

Description

Feb. 27, 1951 J. M. LEDEBOER ET AL 2,543,248
DEVICE FOR THE MEDICAL TREATMENT OF PERSONS WITH HIGH-FREQUENCY ENERGY Filed July 15, 1946 AGEN Patented Feb. 27, 1951 DEVICE FOR THE MEDICAL TREATMENT OF PERSONS WITH HIGH-FREQUENCY ENERGY Johan Marie Ledeboer and Jacobus Fransen, Eindhoven, Netherlands, assignors to Hartford National Bank and Trust Company, Hartford,
Conn., as trustee Application July 15, 1946, Serial No. 683,593 In the Netherlands November 12, 1942 Section 1, Public Law 690, August 8, 1946 Patent expires November 12, 1962 4 Claims.
The invention relates to a device for the medical treatment of persons by means of high-frequency energy.
Such a device usually consists of a high-frequency oscillator which serves to generate the high-frequency energy required for the treatment and of a treating element, for example a coil or a set of condenser electrodes for producing a magnetic or electric field of high frequency, by means of which the high-frequency energy is supplied to that part of the patients body which is to be treated.
With devices of this kind there arises in practice the drawback that the impedance formed by the treating element and the part of the body to be treated load impedance) varies during the treatment due to movements of the treated patient with the result that the device repeatedly loses its exact adjustment, which repeatedly causes variation of the energy supplied to the treating element, which energy is transferred by this element to the patient. This entails the drawback that the amount of energy to be supplied to the patient (dose) cannot be adjusted with sufficient reliability.
The invention has for its object to remove this drawback. According to the invention, there is provided to that end a regulating device which serves to keep the high-frequency energy supplied to the treating element automatically constant or at least substantially constant.
With the device according to the invention the treating physician has the assurance that the amount of energy supplied to the patient (dose) is really equal to the treatment energy adjusted before-hand multiplied by the duration of the treatment. In order to keep the energy supplied to the patient as-constant as possible-it is desirable that the time constant ofthe regulating device should be sumciently small or in other words that the rapidity of the regulation should be great enough to be able to follow any movement of the patient, for example the breathing movement or movements of fright of nerve-patients. This condition can practically be considered fulfilled if the time constant of the regulating device is of the order of magnitude of 0.5 second; in practice, however, the optimum value may appreciably differ from the given value; it may be, for example,ten times as large or ten times as small as that value.
The regulating device is preferably controlled by a regulating magnitude (regulating voltage or current) which depends on the energy supplied to the treating element (treatment energy),
ther possibility consists in that the regulating voltage is derived from the energy which is taken up by the high-frequency oscillator from the source of supply current to which the de vice is connected, said energy being also approximately proportional to the treatment energy.
This energy may be maintained constant by automatically regulating the energy generated 1 by the oscillator. For this purpose the regulating voltage may be supplied to one or more electrodes whose bias voltages act upon the en ergy generated, for example to one or more grids, of one or more oscillator tubes. It is .also possible to have the coupling between the load impedance and the oscillator, which coupling infiuences the energy supplied by the oscillator to the treating element, controlled by the regulating voltage. A third possibility is to have the regulating voltage act upon the tuning of the device. The latter form of construction of the regulating device may be utilized if the impedance formed by the treating element and the part of the body to be treated forms part of a separate oscillatory circuit which is coupled to the high-frequency oscillator and which is tuned to a frequency located in the neighbourhood of the frequency of the generated oscilla tions (load circuit). The regulating voltage preferably controls in this case the tuning of the load circuit, in which event the energy supplied to the treating element is regulated by more or less great detuning of the load circuit with respect to the frequency of the generated oscillations.
The invention will be explained more fully with reference to the accompanying drawing wherein the single figure illustrates schematically a preferred embodiment of the invention.
The device represented in the figure comprises a tube I which is connected in the ordinary manner as an inductivelv back-coupled oscillator having a coil 3 included in the anode circuit coupled, by means of a coupling coil 5 and a transmission line I, to a treating element which is constituted in the instance illustrated by two condenser electrodes 9-9 which are arranged on either side of the part of the body that is to be treated. The coil 5, the transmission line 1-4 and the electrodes 9-9 form a separate oscillatory circuit (load circuit) which may be tuned, by means of a condenser H] which is connected in parallel with the coil 5, to the frequency of the oscillations generated by the oscillator I.
In practice it has been found that upon a movement of the person under treatment the load impedance present between the electrodes 9-9 varies with the result that the tuned load circuit 5-l-9l0 loses its exact adjustment. The variation of the load impedance consists in a variation of the resistance component and/or of the reactive component of this impedance; they both cause a variation of the treatment energy. According to the invention, in order to avoid this harmful variation, means are utilized for automatically maintaining the treatment energy substantially constant. In the shown embodiment of the device according to the invention these means include a condenser 12 which is formed by two concentric metal cylinders H and I3 and which can be connected in parallel with the tuning condenser H] by means of a switch l5. The capacity of the condenser I2 can be varied by filling the space between the cylinders H and G3 with a liquid having a high dielectric constant, for example with oil. For this purpose, this space communicates with a pump cylinder I! provided with a piston 19 whose movement is controlled by a driving device dependent upon the anode current of the tube l. The driving device comprises arm 24 coupled to piston l9 and to an armature 23 of electromagnet 22. The armature 23 is loaded by means of spring 25 which is capable of exerting a varying tension by means of screw adjustment 26. Armature 23 is drawn into the coil 22 to a varying degree depending upon the strength of anode current flowing through the coil.
After the patient is placed between the electrodes 99 the treatment is started by adjusting condenser I so that the treatment energy supplied to the electrodes 9 is at its maximum, which fact can be ascertained with the aid of a suitable measuring instrument (not shown). Then the condenser [2, which is now, for example, halfway filled with oil, is connected in parallel with the condenser ID by means of the switch [5, with the result that the oscillatory circuit 5l0 is detuned and the treatment energy decreases. This decreased value is then maintained by the device according to the invention. If, for example, the treatment energy increases the anode current of the tube I also increases, which causes such a displacement of the piston i9 that the capacity of the condenser l2 and therefore the detuning of the oscillatory circuit 5|9-l0 increases until the decrease of the treatment energy, which decrease is due to this additional detuning, has counterbalanced or at least substantially counterbalanced the initial increase of this energy.
The use of a condenser of the type of the condenser !2 for regulating the treatment energy offers, on the one hand, the advantage of a rapid adjustment owing to the fact that the mass of the movable condenser portion, in the present case the oil, need only be small whereas, on the other hand, the viscosity of the oil also causes a mechanical damping of the regulating movement, which is desirable in such regulations.
What we claim is:
1. A therapeutic device for the treatment of a patient by means of high frequency energy, comprising a generator of high frequency energy, means to supply power to said generator, an oscillatory circuit coupled to said generator and comprising a variable capacitor and means for applying the high frequency energy to said patient, said patient constituting an impedance across said oscillatory circuit which is subject to variation, said oscillatory circuit being tuned by means of said variable capacitor to a frequency approximating the frequency of the generated energy, said variable capacitor comprising two spaced conductors and a liquid of high dielectric constant interposed between said conductors, and means responsive to the power supplied to said generator to vary the amount of said liquid interposed between said conductors to adjust the frequency of said oscillatory circuit and maintain the energy applied to said patient at a substantially constant value regardless of variations in said impedance.
2. A therapeutic device for the treatment of a patient by means of high frequency energy, comprising a generator of high frequency energy, means to supply power to said generator, an oscillatory circuit coupled to said generator and comprising a variable capacitor and means for applying the high frequency energy to said patient, said patient constituting an impedance across said oscillatory circuit which is subject to variation, said oscillatory circuit being tuned to a frequency approximating the frequency of the generated energy, said variable capacitor comprising two spaced concentric conductors electrically insulated from each other and a liquid of high dielectric constant interposed between said conductors, and means responsive to the power supplied to said generator to vary the amount of said liquid between said conductors to vary the frequency of said oscillatory circuit and maintain the energy applied to said patient at a substantially constant value regardless of variations in said impedance.
3. A therapeutic device for treating a patient with high-frequency energy comprising a generator producing high frequency energy including an electron discharge tube having a cathode, a control electrode and an anode, a resonant output circuit coupled between said cathode and said anode, and means establishing direct-current flow between said cathode and said anode; a load circuit coupled to said output circu t for applying high-frequency energy to said patient, said patient constituting in said load circuit an impedance subject to variation; means in the circuit for tuning said load circuit; and means coupled to the output circuit responsive to variations in said direct-current flow for adjusting said tuning means to maintain constant the energy supplied to said patient.
4. A therapeutic device for treating a patient with high-frequency energy comprising a generator producing high-frequency wave energy including an electron discharge tube having a cathode, a grid and an anode, a resonant out put circuit coupled between said cathode and said anode, and means establishing direct-current flow between said cathode and said anode; a load circuit coupled to said output circuit for applying high-frequency energy to said patient; a variable condenser coupled to said load circuit 5 6 for tuning same, said patient constituting in said UNITED STATES PATENTS load circuit an impedance subject to variation; Number Name Date and means including an electro-magnet respon- 2 076 289 Bechmann et Apt 6 1937 sive to variations in said direct-current flow for 2099511 Caesar "'i 1937 adjusting said condenser to an extent and in a 5 2l05096 1938 direction inaintaining ii'esrtmancetbetween said 2114036 smith et 1938 load circui and said Pu circui 2,114,345 Hayford Ln III. Apr: 19: 1938 JOHAN MARIE LEDEBOER" 2,261,153 Gieringer Nov. 4, 1941 JACOBUS ERANSEN- My 2,333,760 Babo et a1 Nov. 9, 1943 2,376,667 Cunningham et a1. May 22, 1945 REFERENCES CITED 2,381,057 Hutcheson Aug. 7, 1945 The following references are of record in the 2,381,496 Hansell Aug. 7, 1945 file of this patent: 2,415,799 Reifel Feb. 11, 1947 2,473,188 Albin June 14, 1949
US683593A 1942-11-12 1946-07-15 Device for the medical treatment of persons with high-frequency energy Expired - Lifetime US2543248A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773192A (en) * 1951-04-18 1956-12-04 Hartford Nat Bank & Trust Co Stabilized oscillator
US2864371A (en) * 1954-06-14 1958-12-16 Casther S A Device for the control of electrical supply for electrotherapeutic purposes, especially for stimulotherapy
US2937640A (en) * 1951-11-02 1960-05-24 Siemens Reiniger Werke Ag Ultrasonic apparatus for medical treatment purposes
US3064109A (en) * 1959-01-15 1962-11-13 Ohio Crankshaft Co Automatic control of induction heating circuits having a magnetic load
US20050251076A1 (en) * 2004-04-09 2005-11-10 Branch Thomas P Method and apparatus for multidirectional positioning of a shoulder
US7510555B2 (en) 2004-05-07 2009-03-31 Therm Med, Llc Enhanced systems and methods for RF-induced hyperthermia
US7627381B2 (en) 2004-05-07 2009-12-01 Therm Med, Llc Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy
US20090294300A1 (en) * 2006-11-13 2009-12-03 Kc Energy, Llc Rf systems and methods for processing salt water

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE968044C (en) * 1949-10-28 1958-01-09 Elektro Mechanik G M B H Hydraulic or pneumatic vibrator
DE3024753C2 (en) * 1980-06-30 1983-12-08 PKM Projektionsgesellschaft für Kunststoffverarbeitungsmaschinen mbH, 7140 Ludwigsburg Circuit arrangement for high frequency welding

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2076289A (en) * 1932-11-21 1937-04-06 Telefunken Gmbh Frequency modulation
US2099511A (en) * 1933-03-16 1937-11-16 Caesar Viktor Oscillator for the biological treatment of living tissue
US2105096A (en) * 1931-06-05 1938-01-11 Rca Corp Frequency compensator for an oscillation generator
US2114036A (en) * 1936-10-17 1938-04-12 Bell Telephone Labor Inc Frequency stabilization system
US2114345A (en) * 1934-04-10 1938-04-19 Joseph K Davidson Radio-frequency applicator with electroscopic control
US2261153A (en) * 1941-05-22 1941-11-04 Liebel Flarsheim Co Protective circuits for electron tubes
US2333760A (en) * 1941-09-02 1943-11-09 Birtcher Corp Therapy apparatus
US2376667A (en) * 1943-03-29 1945-05-22 Rca Corp Automatic tuning of transmitters
US2381057A (en) * 1942-11-05 1945-08-07 Westinghouse Electric Corp Oscillator circuit for inductive heating
US2381496A (en) * 1942-10-10 1945-08-07 Rca Corp Method of generating currents for nonsignaling purposes
US2415799A (en) * 1945-03-09 1947-02-11 Stevens Arnold Company Inc Automatic means for controlling the power fed to an oscillator load
US2473188A (en) * 1944-06-17 1949-06-14 Rca Corp Radio-frequency dielectric heater with constant heating rate control

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2105096A (en) * 1931-06-05 1938-01-11 Rca Corp Frequency compensator for an oscillation generator
US2076289A (en) * 1932-11-21 1937-04-06 Telefunken Gmbh Frequency modulation
US2099511A (en) * 1933-03-16 1937-11-16 Caesar Viktor Oscillator for the biological treatment of living tissue
US2114345A (en) * 1934-04-10 1938-04-19 Joseph K Davidson Radio-frequency applicator with electroscopic control
US2114036A (en) * 1936-10-17 1938-04-12 Bell Telephone Labor Inc Frequency stabilization system
US2261153A (en) * 1941-05-22 1941-11-04 Liebel Flarsheim Co Protective circuits for electron tubes
US2333760A (en) * 1941-09-02 1943-11-09 Birtcher Corp Therapy apparatus
US2381496A (en) * 1942-10-10 1945-08-07 Rca Corp Method of generating currents for nonsignaling purposes
US2381057A (en) * 1942-11-05 1945-08-07 Westinghouse Electric Corp Oscillator circuit for inductive heating
US2376667A (en) * 1943-03-29 1945-05-22 Rca Corp Automatic tuning of transmitters
US2473188A (en) * 1944-06-17 1949-06-14 Rca Corp Radio-frequency dielectric heater with constant heating rate control
US2415799A (en) * 1945-03-09 1947-02-11 Stevens Arnold Company Inc Automatic means for controlling the power fed to an oscillator load

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773192A (en) * 1951-04-18 1956-12-04 Hartford Nat Bank & Trust Co Stabilized oscillator
US2937640A (en) * 1951-11-02 1960-05-24 Siemens Reiniger Werke Ag Ultrasonic apparatus for medical treatment purposes
US2864371A (en) * 1954-06-14 1958-12-16 Casther S A Device for the control of electrical supply for electrotherapeutic purposes, especially for stimulotherapy
US3064109A (en) * 1959-01-15 1962-11-13 Ohio Crankshaft Co Automatic control of induction heating circuits having a magnetic load
US20050251076A1 (en) * 2004-04-09 2005-11-10 Branch Thomas P Method and apparatus for multidirectional positioning of a shoulder
US7686775B2 (en) 2004-04-09 2010-03-30 Branch Thomas P Method and apparatus for multidirectional positioning of a shoulder
US7510555B2 (en) 2004-05-07 2009-03-31 Therm Med, Llc Enhanced systems and methods for RF-induced hyperthermia
US7627381B2 (en) 2004-05-07 2009-12-01 Therm Med, Llc Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy
US20090294300A1 (en) * 2006-11-13 2009-12-03 Kc Energy, Llc Rf systems and methods for processing salt water

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GB616843A (en) 1949-01-27
BE453137A (en)
FR899534A (en) 1945-06-04
CH243475A (en) 1946-07-15

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